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Yeon J.-T.,Sunchon National University | Kim H.,Center for Marine Natural Products and Drug Discovery | Kim K.-J.,Sunchon National University | Lee J.,Center for Marine Natural Products and Drug Discovery | And 6 more authors.
Journal of Natural Products | Year: 2016

A new inhibitor, acredinone C (1), of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation was isolated from the culture broth of the fungus Acremonium sp. (F9A015) along with acredinones A (2) and B (3). The structure of acredinone C (1), which incorporates benzophenone and xanthone moieties, was established by the analyses of combined spectroscopic data including 1D and 2D NMR and MS. All of the acredinones studied efficiently inhibited the RANKL-induced formation of TRAP+-MNCs in a dose-dependent manner without any cytotoxicity up to 10 μM. Acredinone A showed dual activity in both osteoclast and osteoblast differentiation in vitro and good efficacy in an animal disease model of bone formation. © 2016 The American Chemical Society and American Society of Pharmacognosy.


Kim H.,Center for Marine Natural Products and Drug Discovery | Yang I.,Center for Marine Natural Products and Drug Discovery | Patil R.S.,Center for Marine Natural Products and Drug Discovery | Kang S.,Sunchon National University | And 6 more authors.
Journal of Natural Products | Year: 2014

Intensive investigation of the chemical components of a Streptomyces sp. isolated from mudflat sediments collected on the southern coast of the Korean peninsula led to the isolation of three new compounds, anithiactins A-C (1-3). The chemical structures of anithiactins A and C were determined by interpretation of NMR data analyses, while the chemical structure of anithiactin B was established from a combination of NMR spectroscopic and crystallographic data analyses. The structure of anithiactin A was also confirmed by total synthesis. These three anithiactins displayed moderate acetylcholinesterase inhibitory activity with no significant cytotoxicity. © 2014 The American Chemical Society and American Society of Pharmacognosy.

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