Center for Laser Diagnostics and Therapy

Bytom, Poland

Center for Laser Diagnostics and Therapy

Bytom, Poland
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Kawczyk-Krupka A.,Center for Laser Diagnostics and Therapy | Kawczyk-Krupka A.,Silesian Medical University | Bugaj A.M.,Center for Laser Diagnostics and Therapy | Bugaj A.M.,Silesian Medical University | And 6 more authors.
Photodiagnosis and Photodynamic Therapy | Year: 2015

Vascular targeted photodynamic therapy (VTP), with use of verteporfin as a photosensitizer is one of the few therapies, which has been shown to effectively slow the progression of the "wet" form of age-related macular degeneration (AMD), and even to stabilize visual acuity over many years. Although, due to considerable advance of AMD treatment, it is currently not recommended in monotherapy of AMD, however, its combination with steroids and anti-angiogenic biologic drugs may reveal high therapeutic potential in the treatment of neovascular AMD. The future of VTP as a method of AMD treatment is development of new selective and targeted photosensitizer and combination of this method with other therapeutic strategies targeting cellular structures or pathways involved in AMD progression. © 2015 Elsevier B.V.

Piecuch J.,University of Silesia | Wiewiora M.,University of Silesia | Latos W.,Center for Laser Diagnostics and Therapy
Wideochirurgia I Inne Techniki Maloinwazyjne | Year: 2013

A female patient was operated upon due to cervical oesophageal stricture induced by a tumour located just below the throat. Local excision of the tumour and reconstruction of the oesophageal wall was performed using the pre-vertebral fascia due to the presence of extensive oesophageal mucosa damage. The patient also required temporary alimentation by the gastrostomy route due to swallowing disturbances. The oesophagram depicted a contrasting airway passage without any evidence of fistula and contrast medium leakage through the oesophageal lumen. Four months after the operation, the patient did not report any issue with oral intake. The postoperative histopathological and immunohistochemical examinations provided evidence of a granular cell tumour (GCT). We believe that local excision of the tumour should always be considered in cases of tumours located close to the throat because it is less invasive than partial resection of a GCT in the oesophagus or oesophagogastrectomy. © 2013 Termedia Sp. z o.o.

Szliszka E.,Jordana Street | Szliszka E.,Medical University of Silesia, Katowice | Kawczyk-Krupka A.,Medical University of Silesia, Katowice | Kawczyk-Krupka A.,Center for Laser Diagnostics and Therapy | And 4 more authors.
Central European Journal of Urology | Year: 2011

Introduction. Photodynamic therapy (PDT), an alternative treatment modality for superficial bladder tumors is based on the interaction of a photosensitizer with light. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for anticancer therapy due to its ability to selectively induce apoptosis in cancer cells. However, not all tumor cells are sensitive to TRAIL. TRAILresistant cancer cells can be sensitized to TRAIL induced apoptosis by anticancer agents. Objective. We investigated the combined cytotoxic effect of TRAIL and PDT with 5-aminolevulinic acid (ALA) on bladder cancer cells. Materials and methods. Three human bladder transitional cancer cell lines: T24, 647V, and SW780 were treated with TRAIL and/or ALA-mediated PDT. Cytotoxicity was determined by MTT and LDH assay. Results. Our study confirmed that T24 and 647V bladder cancer cells were resistant to TRAIL, whereas SW780 cells were sensitive to TRAIL. We therefore examined the cytotoxic effect of TRAIL in combination with ALA-mediated PDT on bladder cancer cells. We showed for the first time that pretreatment with low dose of PDT significantly sensitizes bladder cancer cells to TRAIL induced cytotoxicity. Conclusion. ALA-mediated PDT augments the cytotoxic effect of TRAIL on transitional cancer cells of bladder. The obtained results suggest that combined treatment of TRAIL and PDT may provide the basis for a new strategy to induce cytotoxicity in bladder cancer cells.

Pietka E.,Silesian University of Technology | Sieron A.,Center for Laser Diagnostics and Therapy | Spinczyk D.,Silesian University of Technology | Szabelak P.,Silesian University of Technology | And 2 more authors.
Advances in Intelligent and Soft Computing | Year: 2010

There is a rapidly growing interest in electronic atlases including images with medical reports and quantitative description of pathological regions of interest. The e-atlases are mostly used by students and residents for teaching and training. However, an atlas my also be employed in everyday clinical practice. An imaging system that integrates an e-atlas of photodynamic studies with computer assisted diagnostic and therapeutic procedures is presented. Image processing results are stored in the database and may also be applied in the teaching and training process. The e-atlas includes photodynamic studies with clinical reports, location of the biopsy enter, selected points of the highest autofluorescence intensity to be subjected to the therapeutic light exposure. © 2010 Springer-Verlag Berlin Heidelberg.

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