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Davan R.,Health Science University | Davan R.,La Trobe University | Prasad R.G.S.V.,Health Science University | Jakka V.S.,Health Science University | And 5 more authors.
Journal of Bionanoscience | Year: 2012

We prepared cerium oxide nanoparticles having size range of 160 nm by using simple and effective sol-gel process and evaluated its wound healing potential. Quite interestingly we found that 2% nanoceria enhanced wound healing activity to a considerable extent which could be supported by increased amount of Hydroxylproline content (4.7 μg/ml), wound tensile strength of 44.88 N/cm2 and wound closure time, which are quite high when compared to other treated groups. Histopathology also showed no inflammation and increased amount of collagen production in group treated with 2% nanoceria. The prepared nanoparticles were characterized by SEM and XRD. The probable mechanism may be due to the dual oxidation state of cerium oxide which will help in scavenging ROS and reduce oxidative stress locally which is required for wound healing. Copyright © 2012 American Scientific Publishers.

Prasad R.G.S.V.,Nano Ram Technologies | Phani A.R.,Nano Ram Technologies | Jacob B.,Center for Innovative Technologies and Community Empowerment | Salins P.C.,Center for Innovative Technologies and Community Empowerment
Trends in Biomaterials and Artificial Organs | Year: 2012

Apatite derived materials are currently used in various orthopedic applications like replacement of femoral heads, acetabular cups for hip replacement and dental implants. Nanoapatite based ceramics with enhanced mechanical properties; biocompatibility and stability are desirable for in vivo applications. Various forms of nanocalcium phosphates are extensively being tested as bone llers, bone cements, coatings, and scaffolds for bone tissue engineering and regenerative medicine. The size of the nanoparticles can be controlled by altering various parameters like surfactant concentration, annealing temperature and time. These prepared nanoparticles can be surface modified for better cell adhesion and proliferation. Cellseeded biodegradable HA/ biopolymer hybrid composites and 3D scaffolds incorporated with growth factors and biological clues will give a new horizon which can mimic the bone native structure and can act as perfect bone substitutes for tissue engineering ,creating a new generation of regeneration materials. Further challenges include optimization of scaffold fabrication for better bone tissue engineering applications.

Begum S.K.R.,Nanotechnology Research Center | Varma M.M.,Nanotechnology Research Center | Raju D.B.,Nanotechnology Research Center | Prasad R.G.S.V.,Health Science University | And 3 more authors.
Advances in Natural Sciences: Nanoscience and Nanotechnology | Year: 2012

The use of electrospun nanofibers to enhance dissolution of poorly soluble drugs could be a novel strategy in future for pharmaceutical applications. In the present work electrospun nanofibers were prepared as a novel system for enhancing the delivery of piroxicam, a non-steroidal anti-inflammatory drug (NSAID). These nanofibers were prepared from polyvinyl pyrrolidone (PVP) (pharmaceutical grade), a biodegradable polymer, to obtain a solution with drug:polymer ratio of 1:4. The release rate of the piroxicam nanofibers was studied in simulated gastric fluid. Fourier transform infrared (FTIR) and scanning electron microscopy (SEM) are used to evaluate the chemical and physical nature. The results showed that the release rates were twice increased in comparison with the pure drug. However, the blend of drug and polymer could be varied to optimize the release rates depending upon the need and formulation. © 2012 Vietnam Academy of Science & Technology.

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