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Gao L.-Z.,Center for Gastrointestinal Tumor | Gao E.-M.,Center for Gastrointestinal Tumor | Bai Y.-F.,Center for Gastrointestinal Tumor | Su H.-L.,Center for Gastrointestinal Tumor | And 4 more authors.
Tumor | Year: 2012

Objective: To evaluate the curative efficacy and the toxicity of hyperthermic intraperitoneal chemoperfusion (HIPEC) plus high-frequency diathermic therapy followed by intravenous chemotherapy versus intravenous chemotherapy alone after radical operation of gastrointestinal cancer. Methods: Fiftytwo patients with gastrointestinal carcinoma receiving radical operation between April 2005 and April 2010 were recruited in this study. These 52 patients were assigned to two groups: 25 patients were treated with HIPEC plus high-frequency diathermic therapy followed by intravenous chemotherapy (study group); and 27 patients were treated with intravenous chemotherapy alone (control group). The HIPEC regimen included cisplatin 100 mg/m 2 plus 5-fluorouracil 3 g/m 2 divided by three times administered at d1, d5 and d9, respectively. The adverse reactions, time to progression (TTP) and overall survival (OS) were compared between the two groups. Results: The postoperative one-year and 40-month progressionfree survival rates in the study group were 72.0% and 54.0%, respectively; and the median TTP was 40.1 months. The postoperative one-year and 40-month progression-free survival rates in the control group were 65.8% and 11.5%, respectively; and the median TTP was 18.5 months. The median TTP in the study group was longer than that in the control group (P = 0.027). The postoperative one-year and 20-month OS rates were 88.0% and 78.0% respectively in the study group, which in the control group were 92.6% and 72.7%, respectively. There was no significant difference in OS between the two groups (P = 0.108). No statistically significant differences were found in the adverse reactions and complications between the two groups (P>0.05). Conclusion: In patients with gastrointestinal cancer after radical operation, HIPEC plus high-frequency diathermic therapy followed by intravenous chemotherapy leads to superior TTP as compared with intravenous chemotherapy only; meanwhile, no more complications and adverse reactions are observed. Copyright© 2012 by TUMOR. Source

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