Chau B.A.,Center for Free Radical Chemistry and Biotechnology |
Chau B.A.,Monash University |
Drummond G.,Monash University |
Jackson W.R.,Center for Free Radical Chemistry and Biotechnology |
And 11 more authors.
MedChemComm | Year: 2015
Six derivatives containing mexiletine and its 2,6-dichloro analogue to which the potential antioxidant moiety isoindoline, its N-oxide and the N-hydroxy derivatives have been attached, have been evaluated as cardioprotective agents. Four of the derivatives at different oxidation states, NH, NO and NOH had significant cardioprotective properties in an in vitro ischaemia model. In contrast to previous reports the NH compounds were not the most active. This journal is © The Royal Society of Chemistry 2015.