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Kim D.H.,Center for Efficacy Assessment | Choi M.-R.,Center for Efficacy Assessment | Hong J.E.,Center for Efficacy Assessment | Lee J.-Y.,Center for Efficacy Assessment | And 4 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2014

In the present study, we examined the effects of a mixture of three strains, Lactobacillus plantarum CECT 7527, 7528, and 7529 (L. plantarum mixture), on body weight and lipid metabolism in Sprague-Dawley rats fed a high-fat diet. Rats were fed a high-fat diet and subjected to oral gavage with vehicle or the L. plantarum mixture (0.6×109, 1.2×109, 2.4×109 colony-forming units (CFU)/day/rat, respectively) for 8 weeks. In rats fed a high-fat diet, oral administration of 2.4×109 CFU/day of the L. plantarum mixture significantly reduced body weight gain as well as weights of liver and epididymal fat. Leptin levels in sera were significantly reduced by oral administration of 2.4×109 CFU/day of the L. plantarum mixture. The L. plantarum mixture (1.2×109 or 2.4×109 CFU/day) also reduced the concentrations of total cholesterol and LDL-cholesterol in sera when it administered orally. Further, the L. plantarum mixture significantly reduced the atherogenic index and cardiac risk factor. In addition, oral administration of 2.4×109 CFU/day of the L. plantarum mixture markedly reduced levels of total lipids, triglycerides, and total cholesterol in the liver. The results of this study indicate that the L. plantarum mixture may exhibit anti-obesity and cholesterol-lowering effects, which suggest that the L. plantarum mixture has the potential to be a probiotic in the management of obesity and hypercholesterolemia. © 2014, Korean Society of Food Science and Nutrition. All rights reserved.

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