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Fernandez Ledesma E.,Engineering and Chemical Research Center | Rodriguez Acosta C.,Engineering and Chemical Research Center | Liva Garrido M.,University of Habana | Diaz Polanco I.,Center for Research and Drug Development | Cazanave Guarnaluce D.,Center for Research and Drug Development
Journal of Materials and Environmental Science | Year: 2015

The pharmaceutical industry employs Aerosil 200V as an excipient in various formulations in a range of concentrations from 0.5 to 20%. The objective of the present work is to evaluate the behavior of silicon dioxide obtained from rice husk as a substitute for Aerosil 200V in the formulation of Valsartan 160 mg tablets. This new material was characterized and recognized its physical, mechanical and technological properties. Three pilot batches of tablets were manufactured and evaluated employing the rice husk ash and Aerosil 200V. Stability studies were done during six months including moisture influence during storage period. The rice husk ash meets established quality specifications in the pharmacopoeia USP and BP to colloidal silicon dioxide. At zero and six months the analyzed parameters were within the ranges established in the manufactured tablets with the two materials. It is possible to use silicon dioxide obtained from rice husk as an excipient in the Valsartan 160 mg tablets formulation as a substitute for Aerosil 200V and so decreasing agro-industrial waste. Source

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