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PubMed | Center for Drug Safety Evaluation and Research and Shanghai University of Traditional Chinese Medicine
Type: | Journal: Toxicological sciences : an official journal of the Society of Toxicology | Year: 2017

The metabolic mechanisms underlying aristolochic acid (AA)-induced nephrotoxicity are inconclusive. A GC-MS-based metabolomic study was performed to analyze urinary metabolites in AA-treated rats at different dosages (10, 20, and 40mg/kg) and time points (2, 4, and 6 days). Serum BUN, creatinine and kidney injury were significantly changed only on the 6

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