Center for Drug Discovery Technology

Yuseong gu, South Korea

Center for Drug Discovery Technology

Yuseong gu, South Korea
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Jeong S.Y.,Chungnam National University | Kim H.J.,Center for Drug Discovery Technology | Kwak B.-K.,Chung - Ang University | Lee H.-Y.,Center for Drug Discovery Technology | And 5 more authors.
Nanoscale Research Letters | Year: 2010

Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C 16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C 16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ( 1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C 16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C 16-ED-DOTA-Gd. © 2010 The Author(s).

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