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Xu L.,Academy of Military Medical Science | Zhang F.,Center for Disease Control and Prevention of Chengdu Military Region | Yang W.,Yunnan Institute of Endemic Diseases Control and Prevention | Jiang T.,Northeast Normal University | And 12 more authors.
Virologica Sinica | Year: 2016

Bats have been implicated as important reservoir hosts of alpha- and betacoronaviruses. In this study, diverse coronaviruses (CoVs) were detected in 50 of 951 (positive rate 5.3%) intestinal specimens of eight bat species collected in four provinces and the Tibet Autonomous Region of China by pan-coronavirus RT-PCR screening. Based on 400-nt RNA-dependent RNA polymerase (RdRP) sequence analysis, eight belonged to genus Alphacoronavirus and 42 to Betacoronavirus. Among the 50 positive specimens, thirteen gave rise to CoV full-length RdRP gene amplification for further sequence comparison, of which three divergent sequences (two from a unreported province) were subjected to full genome sequencing. Two complete genomes of betacoronaviruses (JTMC15 and JPDB144) and one nearly-complete genome of alphacoronavirus (JTAC2) were sequenced and their genomic organization predicted. The present study has identified additional numbers of genetically diverse bat-borne coronaviruses with a wide distribution in China. Two new species of bat CoV, identified through sequence comparison and phylogenetic analysis, are proposed.[Figure not available: see fulltext.] © 2016, Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore.

Sun H.,Academy of Military Medical Science | Wang Y.,Center for Disease Control and Prevention of Chengdu Military Region | Zhang Y.,Academy of Military Medical Science | Ge W.,Academy of Military Medical Science | And 8 more authors.
Applied and Environmental Microbiology | Year: 2013

We detected Toxoplasma gondii in 29.3% (95% confidence interval [CI], 25.5% to 33.1%) of 550 insectivorous bats collected in Myanmar. The genotyping of these positive samples revealed they were closely related to or belong to clonal type I, which is highly virulent in mice, showing that these bats are potential reservoirs for T. gondii transmission. © 2013, American Society for Microbiology.

He B.,Academy of Military Medical Science | He B.,Jiangsu Electric Power Company | Zhang F.,Center for Disease Control and Prevention of Chengdu Military Region | Xia L.,Academy of Military Medical Science | And 10 more authors.
Archives of Virology | Year: 2015

Bats in Myanmar, Gabon, and Panama have been found to harbor diverse hepadnaviruses. Here, we report a novel hepadnavirus in 4 of 20 pomona roundleaf bats from Yunnan province, China. This virus contains 3,278 nucleotides (nt) in the full circularized genome, with four predicted open frames (ORFs) reading in the same direction. Full genomic sequence comparisons and evolutionary analysis indicate that this virus is a member of a new species within the genus Orthohepadnavirus. © 2014, Springer-Verlag Wien.

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