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Tekieli L.M.,Jagiellonian University | Maciejewski D.R.,Jagiellonian University | Dzierwa K.,Jagiellonian University | Kablak-Ziembicka A.,Jagiellonian University | And 6 more authors.
Postepy w Kardiologii Interwencyjnej | Year: 2015

Introduction: Fibromuscular dysplasia (FMD) is an infrequent non-inflamatory disease of unknown etiology that affects mainly medium-size arteries. The prevalence of FMD among patients scheduled for endovascular treatment of carotid artery stenosis is unknown. Aim: To evaluate the prevalence and treatment options of carotid FMD in patients scheduled for carotid artery stenting (CAS). Material and methods: Between Jan 2001 and Dec 2013, 2012 CAS procedures were performed in 1809 patients (66.1% men; age 65.3 ±8.4 years, 49.2% symptomatic). In case of FMD suspicion in Doppler-duplex ultrasound (DUS), computed tomography angiography was performed for aortic arch and extracranial and intracranial artery imaging. For invasive treatment of FMD carotid stenosis, balloon angioplasty was considered first. If the result of balloon angioplasty was not satisfactory (> 30% residual stenosis, dissection), stent placement was scheduled. All patients underwent follow-up DUS and neurological examination 3, 6 and 12 months after angioplasty, then annually. Results: There were 7 (0.4%) (4 symptomatic) cases of FMD. The FMD group was younger (47.9 ±7.5 years vs. 67.2 ±8.9 years, p = 0.0001), with higher prevalence of women (71.4% vs. 32.7%, p = 0.0422), a higher rate of dissected lesions (57.1% vs. 4.6%, p = 0.0002) and less severe stenosis (73.4% vs. 83.9%, p = 0.0070) as compared to the non-FMD group. In the non-FMD group the prevalence of coronary artery disease was higher (65.1% vs. 14.3% in FMD group, p = 0.009). All FMD patients underwent successful carotid artery angioplasty with the use of neuroprotection devices. In 4 cases angioplasty was supported by stent implantation. Conclusions: Fibromuscular dysplasia is rare among patients referred for CAS. In case of significant FMD carotid stenosis, it may be treated with balloon angioplasty (stent supported if necessary) with optimal immediate and long-term results. Source


Stepien E.,Laboratory for Molecular Biology and Research | Stepien E.,Jagiellonian University | Miszalski-Jamka T.,Center for Diagnosis Prevention and Telemedicine | Kapusta P.,Laboratory for Molecular Biology and Research | And 2 more authors.
Journal of Thrombosis and Thrombolysis | Year: 2011

To examine the associations between cigarette smoking and preferable clot properties. Plasma fibrin clots from 21 randomly selected current smokers (n = 7), former smokers (n = 7) and non-smokers (n = 7) were analyzed, using scanning electron microscopy (SEM). With the use of the turbidimetric clotting and lysis assay in plasma, the maximum absorbance (MaxAbsC, MaxAbs L) was measured and lysis time (Lys50%) was calculated. Smoking cessation significantly influenced fibrin fiber branching and density. Median fiber diameter was not changed. Lys50%) was the highest in current smokers and was reduced in former smokers to the non-smoker level (2120 ± 385 versus 1771 ± 122 and 1724 ± 272 s; P = 0.04). Smoking cessation improves fibrin clot architecture which results in the lesser resistance to lysis. © Springer Science+Business Media, LLC 2011. Source


Mikolajska A.,Academy of Fine Arts in Cracow | Walczak M.,Academy of Fine Arts in Cracow | Kaszowska Z.,Academy of Fine Arts in Cracow | Zawadzka M.U.,Center for Diagnosis Prevention and Telemedicine | Banys R.P.,Center for Diagnosis Prevention and Telemedicine
Nukleonika | Year: 2012

For over a century, X-ray radiation has played an important role in the area of the conservation and restoration of cultural heritage objects. X-ray techniques are amongst the most fundamental and helpful methods used in the investigation of art works. This paper reviews the application of traditional radiography, X-ray dual source computed tomography (DSCT) and scanning electron microscopy combined with energy dispersed X-ray spectroscopy (SEM--EDX) to the investigation of a wooden, Gothic sculpture, The risen Christ. Thanks to the properties of X-ray radiation (different absorption by various materials) first two methods allow the assessment of the preservation state and the observation of the internal structure of an object in 3-D. While SEM-EDX analysis permits the elemental analysis of the polychrome layers. As a result 2-D and 3-D images, permitting the full volume inspection of an object, were taken in a totally non-destructive way. The morphological and physical information about the inner structure of the investigated wooden sculpture was obtained, revealing changes related to previous restorations, as well as ageing effects. Employing the SEM-EDX, painting materials (pigments and filers), were identified. Gained data is essential for restorers to understand the whole structure of the studied object and to decide which further investigation and restoration steps have to be undertaken. Source


Stpien E.,Jagiellonian University | Fedak D.,Jagiellonian University | Klimeczek P.,Center for Diagnosis Prevention and Telemedicine | Wilkosz T.,Center for Diagnosis Prevention and Telemedicine | And 4 more authors.
Hypertension Research | Year: 2012

We conducted a cross-sectional observation study that included 500 asymptomatic subjects to investigate the relationship between bone metabolism and coronary artery calcification (CAC) in hypertensive conditions. Osteoprotegerin (OPG) and osteopontin (OPN) levels and their associations with hypertension were analyzed to predict CAC in 316 subjects. Multislice computed tomography was used to quantify CAC. Multivariate analysis of variance was used to test the non-interactive effects of hypertension, CAC severity and biomarker levels, and the logistic regression model was applied to predict the risk of CAC. OPG and OPN concentrations were significantly higher in the hypertensive than the normotensive subjects, at 3.0 (2.3-4.0) pmol l -1 and 51 (21-136) ng ml -1 vs. 2.4 (2.0-3.0) pmol l -1 and 41 (13-63) ng ml -1, respectively. The OPG level, but not OPN level, increased with age (r0.29; P=0.0001). Zero or minimal CAC (10 Agatston units (AU)) was observed in 63% of the subjects, mild (11-100 AU) in 17%, moderate (101-400 AU) in 12% and severe (401-1000 AU)-to-extensive (> 1000 AU) in 8%. In hypertensive subjects, only glomerular filtration rate (GFR) (Β=-0.67) and gender (Β=0.52) were significant predictors for CAC (R=0.68). In normotensive patients, GFR (Β=-0.81), gender (Β=0.48) and log-transformed OPG levels (Β=-0.15) were significant predictors for CAC. OPG levels were associated with an increased risk of CAC in normotensive subjects only (odds ratio: 3.37; 95% confidence interval (1.63-6.57); P=0.0002). OPG predicted a premature state of vascular calcification in asymptomatic normotensive individuals, and renal function significantly contributed to this process in both hypertensive and normotensive subjects. © 2012 The Japanese Society of Hypertension All rights reserved. Source


Stepien E.,Laboratory for Molecular Biology and Research | Stepien E.,Jagiellonian University | Wypasek E.,Laboratory for Molecular Biology and Research | Wypasek E.,Jagiellonian University | And 4 more authors.
Clinical Biochemistry | Year: 2011

Objectives: Osteoprotegerin (OPG) and osteopontin (OPN) are bone metabolism biomarkers which are involved in the regulation of vascular calcification processes and prediction of future adverse cardiac events. Design and methods: OPG, OPN levels and classic risk factors were determined in 130 asymptomatic and hypertensive subjects. Receiver operator characteristic (ROC) analysis was performed and the area under the curve (AUC) was calculated. Results: The hypertensive subjects had elevated OPG, OPN, fibrinogen, CRP and fasting glucose levels in comparison to the normotensive ones. There were significant correlations between age, CRP and OPG. Multiple regression analysis showed that as well as inflammation (CRP), age and hypertension were predictors of increased OPG levels. OPN increase was correlated with CRP and glucose levels. The AUCs were similar for OPG and OPG biomarkers. Conclusions: Plasma OPG and OPN levels were significantly associated with inflammation and arterial hypertension. They might be useful as additional biomarkers for monitoring endothelial dysfunction and prognosis of cardiovascular diseases. © 2011. Source

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