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Manchanda A.,Sri Guru Ram Das Institute of Dental science and Research | Shetty D.-C.,Its Center For Dental Studies And Research
Medicina Oral, Patologia Oral y Cirugia Bucal | Year: 2012

Objective: To assess inter and intra observer variability in grading oral epithelial dysplasia (OED) using Smith and Pindborg grading system, WHO classification system and Brothwell DJ et al. classification system. Study design: In the study 45 histological tissues of dysplasia, 15 each of mild, moderate and severe dysplasia were coded and blindly graded by three observers in three grading systems. Further on the same observers graded 15 slides again of the previous 45 for analyzing the reproducibility in the three grading systems. The individual significance of various indicators of dysplasia among various grades of dysplasia was also assessed. Result: Inter observer agreement was significantly higher in Brothwell system as compared to WHO and Smith and Pindborg system. Intra observer agreement was significantly higher in Smith and Pindborg system, but the predictability and the probability index was distributed over a larger range in this system. Each indicator of dysplasia was also found to be statistically significant (P<0.05) for grading dysplasia. Conclusion: The present study puts forth the inherent intricacies in the grading of oral premalignant lesions. © Medicina Oral S. L. Source


Manchanda A.,Its Center For Dental Studies And Research
Internet Journal of Internal Medicine | Year: 2011

Kikuchi-Fujimoto disease is an enigmatic, benign, and self-limited syndrome characterized by regional lymphadenopathy with tenderness, usually accompanied by mild fever and night sweats. The disease frequently mimics tuberculous lymphadenitis, malignant lymphoma, and some other benign and/or malignant diseases in terms of clinical and laboratory presentation. It is scarcely known in the Western hemisphere. The present case highlights the perplexity in diagnosing KFD which are in close proximity with respect to pathology, behaviour and prognosis with other diseases. © Internet Scientific Publications, LLC. Source


Sharma A.,Its Center For Dental Studies And Research | Deshpande S.,L.E.S.S.
Journal of Indian Society of Pedodontics and Preventive Dentistry | Year: 2011

This study was conducted with the aim to investigate the acidogenic potential of three commonly used pediatric medicines (benadryl syrup, crocin syrup, and novamox dry syrup) upon plaque pH. Materials and Methods: The protocol used in the study followed the guidelines laid down at Scientific Consensus Conferences on methods for assessment of cariogenic potential of food, San Antonio, Texas. Ten young healthy adult volunteers were selected for the study. Subjects were refrained from brushing their teeth for 48 h and did not eat or drink for at least 21/2 h prior to each appointment. pH measurements were taken at baseline to determine resting plaque pH and at time interval of 5, 10, 15, 20, 25, and 30 min following a 1 min rinse with each medication. A pooled sample of plaque was removed from buccal / lingual surfaces, thoroughly mixed with 0.6 ml of double distilled deionized water and plaque pH was determined using a glass combination electrode. Data were compared with plaque pH changes after rinsing with control solution of 10 % sucrose and 10 % sorbitol. Analysis of minimum pH, maximum pH drop, and area under the baseline pH was computed for each medicine and for each case and the test of significance was conducted through the unpaired Student 't' test. Results: There was no significant difference between the benadryl syrup, crocin syrup, and sucrose solution as the medicines behaving essentially same as ten percent sucrose solution with respect to their potential to generate acids. Source


Jain G.,Its Center For Dental Studies And Research | Shetty P.,Ab Shetty Memorial Institute Of Dental Science
Journal of Cytology | Year: 2015

Background: Fine-needle aspiration cytology (FNAC) is not a definitive preoperative diagnostic procedure done for all cases of odontogenic cysts. This is because of the inconsistent results obtained with it. Aims: This study was done to optimize FNAC findings and help in preoperative characterization of odontogenic cysts. Materials and Methods: Cystic fluid was collected and centrifuged from 50 odontogenic cysts that were planned for excision,.Three smears were prepared from the cell sediment obtained after centrifugation and stained. The stained sections were examined for presence and type of epithelial cells, to formulate a preopererative diagnosis. Results: Epithelial cells were detected in 46% cases in smear 1, 48% cases in smear 2, and 52% cases in smear 3. When all three smears from one case were studied, 86% cases showed epithelial cells for evaluation. Conclusion: Cystic aspirate should be centrifuged and the entire cell sediment should be examined by making multiple smears for evaluation of cystic epithelial lining cells. © 2015 Journal of Cytology | Indian Academy of Cytologists | Published by Wolters Kluwer - Medknow. Source


Anand R.,Public-i | Prasad S.,Hospital and Research Institute | Menon I.,Its Center For Dental Studies And Research
Journal of Cancer Research and Therapeutics | Year: 2014

The habit of chewing betel nut has a long history of use. Betel nut and products derived from it are widely used as a masticatory product among various communities and in several countries across the world. Over a long period, several additives have been added to a simple betel nut preparation; thus, creating the betel quid (BQ) and encompassing chewing tobacco in the preparation. Betel nut has deleterious effects on oral soft tissues. Its effects on dental caries and periodontal diseases, two major oral diseases are less well-documented. Betel-induced lichenoid lesions mainly on buccal mucosa have been reported at quid retained sites. In chronic chewers, a condition called betel chewers mucosa is often found where the quid is placed. Betel nut chewing is implicated in oral submucous fibrosis (OSF) and its use along with tobacco can cause leukoplakia, both of which are potentially malignant in the oral cavity. Oral cancer often arises from such precancerous changes. Thus, public health measures to quit betel use are recommended to control disabling conditions such as OSF and oral cancer. Source

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