Zamanian-Daryoush M.,Cleveland Clinic |
Zamanian-Daryoush M.,Center for Cardiovascular Diagnostics and Prevention |
Lindner D.,Taussig Cancer Center |
Tallant T.C.,Cleveland Clinic |
And 19 more authors.
Journal of Biological Chemistry
Background: ApoA1, a component of HDL, promotes anti-inflammatory, immunomodulatory, and cardioprotective functions. Results: ApoA1 suppresses tumor growth and metastasis, primarily via modulation of innate and adaptive immune responses. Conclusion: ApoA1 impacts tumor biology at multiple levels, which appear to be linked to immunomodulatory function. Significance: ApoA1 redirects elicited immune cells toward tumor suppression and rejection and may hold benefit as a cancer therapeutic. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Source