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Donia M.,Center for Cancer Immune Therapy | Donia M.,Herlev Hospital | Donia M.,University of Catania | Larsen S.M.,Center for Cancer Immune Therapy | And 4 more authors.
Cytotherapy | Year: 2014

Background aims: The high level of complexity of current Good Manufacturing Practice-compliant methods of manufacturing hampers rapid and broad application of treatment with tumor-infiltrating lymphocytes (TILs). Methods: To ensure higher applicability of TIL production to laboratory routine, a practical and simple protocol of TIL manufacturing with the use of a closed-system bioreactor was developed and implemented at our institution. Results: This protocol enabled significant work load reduction during the most labor-intense step of TIL expansion, and allowed generation of high-quality TIL products, which mediated clinical regression in patients with metastatic melanoma. Conclusions: Implementation of simplified methods of TIL expansion will speed up dissemination of TIL methods worldwide and will increase patient access to this highly effective treatment. © 2014 International Society for Cellular Therapy.

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