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Hasebe T.,Center for Cancer Control and Information Service | Iwasaki M.,Research Center for Cancer Prevention and Screening | Akashi-Tanaka S.,National Cancer Center Hospital | Hojo T.,National Cancer Center Hospital | And 4 more authors.
Modern Pathology | Year: 2010

The purpose of this study was to determine whether p53 protein expression in tumor-stromal fibroblasts forming fibrotic foci is a significant outcome predictor, similar to p53 protein expression in tumor-stromal fibroblasts not forming fibrotic foci, and whether the combined assessment of p53 expression in tumor-stromal fibroblasts forming and not forming fibrotic foci served as an important outcome predictor among 1039 patients with invasive ductal carcinoma of the breast. We analyzed the outcome predictive power of the Allred score risk classification for p53 in tumor-stromal fibroblasts forming and not forming fibrotic foci using multivariate analyses with well-known clinicopathological factors. The Allred score risk classifications for p53 in tumor-stromal fibroblasts forming and not forming fibrotic foci were superior to the Allred scores for p53 in tumor-stromal fibroblasts not forming fibrotic foci alone for accurately predicting the tumor-related death of patients with invasive ductal carcinoma when examined using multivariate analyses. The Allred score risk classification for p53 in tumor-stromal fibroblasts forming and not forming fibrotic foci significantly increased the hazard rates for tumor recurrence and tumor-related death independent of the UICC pTNM stage in the multivariate analyses. These results indicated that the Allred score risk classification based on the combined assessment of p53 expression in tumor-stromal fibroblasts forming and not forming fibrotic foci is a very useful outcome predictor among patients with invasive ductal carcinoma. © 2010 USCAP, Inc.

Yokoo M.,Research Center for Innovative Oncology | Takayama T.,Center for Cancer Control and Information Service | Karato A.,The Cancer Institute Hospital of Japanese Foundation for Cancer Research | Kikuuchi Y.,Shikoku Cancer Center | And 4 more authors.
Japanese Journal of Clinical Oncology | Year: 2014

Objective: Comprehensive assessment of perceived concerns can be used to guide supportive care appropriate to individual cancer patients. This study sought to determine the prevalence of cancer patients' concerns and the degree to which these concerns contribute to patients' quality of life. Methods: Participants were patients with all types of cancer, who completed an Internet survey questionnaire regarding comprehensive concerns about physical, psychological, psychosocial and economic aspects of having cancer. The questionnaire was based on the newly developed Comprehensive Concerns Assessment Tool and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. Results: We obtained complete data from 807 patients. Factors related to 'self-management' concerns were the most common (61.2%), followed by concerns about 'psychological symptoms' (48.5%), 'medical information' (46.2%), 'daily living' (29.9%), 'pain' (17.6%), 'constipation' (15.6%) and other 'physical symptoms' (15.2%). Multiple regression analysis revealed that all concerns except those about 'medical information' significantly contributed to quality of life. Conclusions: Cancer patients' concerns were shown to be multidimensional and significantly associated with quality of life. Thus, assessment of patients' concerns should be multidimensional in nature, and a multidisciplinary care team should help patients improve their quality of life. © The Author 2014. Published by Oxford University Press. All rights reserved.

Miyazaki Y.,Takasaki University of Health and Welfare | Hayashi K.,Gunma University | Mizunuma H.,Hirosaki University | Lee J.S.,University of Tokyo | And 4 more authors.
Preventive Medicine | Year: 2013

Objective: The purposes of this study were to examine smoking habits in relation to the reproductive events of pregnancy and menopause and clarify the reasons for smoking cessation among ex-smokers. Method: This is a cross-sectional study based on a baseline survey of a prospective cohort study. From 2001 to 2007, a self-administered questionnaire survey was conducted on 49,927 female nurses from all 47 prefectures in Japan. Logistic regression models were used to estimate age-adjusted odds ratios. Results: Of the respondents, 17.2% were current smokers, 11.6% were ex-smokers and 69.8% had never smoked. The prevalence of smoking during pregnancy was 7.8%. Among ex-smokers, 30.3% gave "reproductive events" as their reason for smoking cessation. Current smoking and the number of cigarettes smoked per day before menopause were significantly related to onset of menopause. Conclusion: Women's smoking habits have mutual relationships with reproductive events such as pregnancy and menopause. Although "reproductive events" were an important reason for smoking cessation among women, 7.8% of women still smoked during pregnancy. Smoking was correlated with onset of menopause. Support for smoking cessation is an important healthcare issue throughout women's lifetimes. © 2013 Elsevier Inc.

Ren J.-S.,International Agency for Research on Cancer | Chen W.-Q.,International Agency for Research on Cancer | Chen W.-Q.,Chinese Academy of Sciences | Shin H.-R.,International Agency for Research on Cancer | And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2010

Knowledge of the cancer profile is an important step in planning rational cancer control programs and evaluation of their impact. Due to rapid changes in cancer incidence in China, national surveys may be insufficiently timely to provide adequate descriptions of the national burden. To evaluate the utility of cancer registries in describing the national cancer profile, this study compared two methods of estimating national cancer-specific incidence and mortality in China 2005, based on the Third National Death Survey (method I) as compared with registry material (method II). A total of 2.6 million cancer cases and 1.8 million cancer deaths were estimated by method I, as compared to 2.8 million cancer cases and 1.9 million cancer deaths using method II. The higher level of burden using the latter method in part may be due to a sizable differential in the magnitude of incidence rates across registries for certain cancer sites. Most cancer registries have been located in relatively more developed urban areas, or rural areas associated with higher risk for certain cancers. There are substantial differences in the cancer profile between urban and rural communities in China, and there may be concerns regarding the national representativeness of the data aggregated from this set of cancer registries. Timely and reliable estimation of cancer can only be realized if accurate information is available from cancer registries covering representative samples of the country.

Kumiko S.,Center for Cancer Control and Information Service | Tomotaka S.,Center for Cancer Control and Information Service | Masakazu N.,Center for Cancer Control and Information Service | Akira O.,Center for Cancer Control and Information Service | And 5 more authors.
Cancer Science | Year: 2012

Smoking is a significant contributing factor to disease-related deaths worldwide. Members of the Japanese Cancer Association (JCA) can play a leading role in helping people to live tobacco-free through social action. In 2010, this study assessed smoking prevalence among JCA members and their attitudes toward smoking, smoking cessation, and their responsibilities. Results of the 2010 survey were compared with those of a 2006 survey. Final response rates were 60.8% in the 2006 survey and 47.4% in the 2010 survey, and the current smoking rates were 9.0% and 5.3%, respectively. Regarding concern by current smokers over smoking cessation, the percentage of smokers who were ready to quit smoking within the next month increased from 4.9% to 6.3% between 2006 and 2010. Most JCA members agreed with antismoking actions such as smoking bans in all workplaces, public places, or while walking in the street, regulation restricting the sale and distribution of tobacco to children, tobacco education at school, use of tobacco tax for health, provision of information on tobacco, and smoking cessation support. Approximately 30% of responders disagreed on actions to raise the price of tobacco, regulations restricting the sale of tobacco, health warnings on tobacco packaging, bans on tobacco advertisement, and antismoking campaigns. Barriers to smoking cessation interventions identified were physician's time required to provide interventions, resistance of patients to smoking cessation advice, and lack of education on tobacco control. Not only antismoking actions but also support of smokers by health professionals through adequate education on smoking cessation treatment is needed in the future. © 2012 Japanese Cancer Association.

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