Leiden, Netherlands

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PubMed | Center for Bone Quality, Leiden University and N Appelman Dijkstra
Type: | Journal: European journal of endocrinology | Year: 2017

Acromegaly is a rare disease caused by excess growth hormone (GH) production by a pituitary adenoma. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of relatively normal Bone Mineral Density (BMD). We aimed to evaluate tissue-level properties of bone using impact microindentation (IMI) in well-controlled patients with acromegaly aged 18 years compared to 44 controls from the outpatient clinic of the Centre for Bone Quality.In this cross-sectional study, Bone Material Strength index (BMSi) was measured in 48 acromegaly patients and 44 controls with impact microindentation using the OsteoprobeOur data indicate that tissue-level properties of cortical bone are significantly altered in patients with controlled acromegaly after reversal of long-term exposure to pathologically high GH and IGF-1 levels. Our findings also suggest that methods other than DXA should be considered to evaluate bone fragility in patients with acromegaly.

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