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Momcilovic B.,Institute for Research and Development of the Sustainable Eco Systems IRES | Prejac J.,University of Zagreb | Brundic S.,Institute for Research and Development of the Sustainable Eco Systems IRES | Morovic S.,Clinical Hospital Sestre Milosrdnice | And 3 more authors.
Translational Neuroscience | Year: 2010

The recent development of the analytical techniques offers the unprecedented possibility to study simultaneously concentration of dozens of elements in the same biological matrix sample of 0.5 - 1.0 g (multielement profiles). The first part of this essay entitled "Think globally. An outline of trace elements in health and disease" aims to introduce the reader to the fascinating field of elements, there importance to our nutrition, their essentiality, deficiency, toxicity and bioavailability to the body and their overall role in health and disease, including the genetic metabolic impairments. In the second part of the essay entitled " and act locally. The multielement profile of depression" we aimed to show the potential of such a hair multielement profile analysis for the study of human depression in a randomized, double blind, prospective, observational, cross-sectional, clinical, epidemiological, and analytical study. The preliminary results of this ongoing study lead us to put forward the hypothesis that the metabolic origin of depression may be due to some "energostat" failure, probably located in the thalamus, and activated by several essential element deficiencies. © Versita Sp. z o.o.


Prejac J.,University of Zagreb | Visnjevic V.,Institute for Research and Development of the Sustainable Eco Systems | Drmic S.,Neuropsychiatric Hospital Dr. Ivan Barbot | Skalny A.A.,Center for Biotic Medicine | And 2 more authors.
Journal of Trace Elements in Medicine and Biology | Year: 2014

Today, human iodine deficiency is next to iron the most common nutritional deficiency in developed European and underdeveloped third world countries, respectively. A current biological indicator of iodine status is urinary iodine that reflects the very recent iodine exposure, whereas some long term indicator of iodine status remains to be identified. We analyzed hair iodine in a prospective, observational, cross-sectional, and exploratory study involving 870 apparently healthy Croatians (270 men and 600 women). Hair iodine was analyzed with the inductively coupled plasma mass spectrometry (ICP MS). Population (n870) hair iodine (IH) respective median was 0.499μgg-1 (0.482 and 0.508μgg-1) for men and women, respectively, suggesting no sex related difference. We studied the hair iodine uptake by the logistic sigmoid saturation curve of the median derivatives to assess iodine deficiency, adequacy and excess. We estimated the overt iodine deficiency to occur when hair iodine concentration is below 0.15μgg-1. Then there was a saturation range interval of about 0.15-2.0μgg-1 (r2=0.994). Eventually, the sigmoid curve became saturated at about 2.0μgg-1 and upward, suggesting excessive iodine exposure. Hair appears to be a valuable and robust long term biological indicator tissue for assessing the iodine body status. We propose adequate iodine status to correspond with the hair iodine (IH) uptake saturation of 0.565-0.739μgg-1 (55-65%). © 2014 Elsevier GmbH.


Momcilovic B.,Institute za istrazivanje i razvoj odrzivih ekosustava IRES | Prejac J.,Klinicki bolnicki centar Zagreb | Visnjevic V.,Institute za istrazivanje i razvoj odrzivih ekosustava IRES | Brundic S.,Institute za istrazivanje i razvoj odrzivih ekosustava IRES | And 2 more authors.
Journal of Trace Elements in Medicine and Biology | Year: 2016

Lactating mother and her two month old healthy daughter (APGAR 10) gave their scalp hair for a multielement profile analysis; 25 elements were analyzed with the ICP MS. Mother's hair was divided into 5cm long segment proximal to the scull (Young), and the distal segment further up to the hair tip (Old). One centimeter of hair records one month of the metabolic activity of the bioelements in the body. Mother's Young hair and daughters hair have 2.70 and 9.74μgg-1Se, a distinctly higher Se concentrations than the Old hair of 0.87μgg-1. The adequate hair Se concentrations in Croatia women population vary from 0.08 to 0.63μgg-1; values below or above that range indicate deficiency or excess, respectively. Dietary recall revealed that during the last trimester of pregnancy and over a period of a week, the mother has consumed 135g of Brazil nuts (Bertholletia excelsa) (BN); BN is an exceptionally rich Se dietary source. The amount of Se in BN varies and one week consumption of 135g of BN may result in Se daily intake of 367 to 492μgg-1day-1 over a period of seven consecutive days, and what is about or exceeds the Upper Limit of daily selenium intake of 400μg-1g-1. The excessively high infant hair Se mirrored a natural high mother to fetus transplacental transfer of bio elements in the last trimester of pregnancy. The potential toxicological risks of such a high Se transfer remains to be elucidated. © 2015 Elsevier GmbH.


Momcilovic B.,Institute for Research and Development of the Sustainable Eco Systems | Prejac J.,University of Zagreb | Visnjevic V.,Institute for Research and Development of the Sustainable Eco Systems | Mimica N.,University of Zagreb | And 3 more authors.
Toxicological and Environmental Chemistry | Year: 2012

Environmental exposure to silver (Ag) was assessed in occupationally non-exposed adult human population by analyzing Ag in the hair (H · Ag) and whole blood (WB · Ag). H · Ag was analyzed in 311 (123 men, M; 188 women, W); while WB · Ag was determined in 235 of these individuals (90 M, 145 W). Women had more H · Ag than men (M 0.05 vs. W 0.076), whereas WB · Ag concentrations in men and women were not significantly different. A natural distribution of the median derivatives was utilized to generate the dataset to fit the logistic sigmoid curve to assess the current human body burden of environmental Ag population exposure for M and W separately. The H · Ag (μg g-1) below 0.0105 for M and 0.0145 for W, reflects low level of environmental Ag exposure. The adaptive physiological saturation phase followed where H · Ag rose rapidly, first for M and then for W in parallel with biological assay. Both parallel saturation curves converged and plateaued at 0.215 for M and 0.965 for W (μg g-1). The current level of human environmental Ag exposure is low, but cases of high Ag exposure occurred sporadically. In conjunction with the medical histories overt clinical neural toxicity may be expected for H · Ag at 4 μg g-1and higher. There were no significant correlation between the H · Ag and WB · Ag. © 2012 Copyright Taylor and Francis Group, LLC.


Tinkov A.A.,Orenburg State Medical Academy | Ajsuvakova O.P.,Orenburg State Agrarian University | Skalnaya M.G.,Center for Biotic Medicine | Popova E.V.,Orenburg State Medical Academy | And 5 more authors.
BioMetals | Year: 2015

A significant interrelation between heavy metal exposure and metabolic syndrome (MetS) development has been demonstrated earlier. Despite the presence of a number of works aimed at the investigation of the role of Hg in MetS development, the existing data remain contradictory. Therefore, the primary objective of the current work is to review the existing data regarding the influence of mercury on universal mechanisms involved in the pathogenesis of the development of MetS and its components. The brief chemical characterization of mercury is provided. The role of mercury in induction of oxidative stress has been discussed. In particular, Hg-induced oxidative stress may occur due to both prooxidant action of the metal and decrease in antioxidant enzymes. Despite the absence of direct indications, it can be proposed that mercury may induce endoplasmic reticulum stress. As it is seen from both in vivo and in vitro studies, mercury is capable of inducing inflammation. The reviewed data demonstrate that mercury affects universal pathogenetic mechanisms of MetS development. Moreover, multiple investigations have indicated the role of mercury in pathogenesis of MetS components: dyslipidemia, hypertension, insulin resistance, and obesity to a lesser extent. The present state of data regarding the interrelation between mercury and MetS denotes the following perspectives: (1) Further clinic-epidemiologic and experimental studies are required to estimate the association between mercury exposure and the development of MetS components, especially obesity; (2) Additional investigations of the possible effect of organism's mercury content modulation on MetS pathogenesis should be undertaken. © 2015 Springer Science+Business Media New York.

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