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Scott C.T.,Center for Biomedical Ethics | Scott C.T.,University of British Columbia | Caulfield T.,University of Alberta | Borgelt E.,University of British Columbia | Illes J.,University of British Columbia
Nature Biotechnology | Year: 2012

As the healthcare industry moves from a twentieth century approach of providing treatments of last resort to a future of individualized medicine, biobanks will play a pivotal role in this transition. Yet at the cutting edge of biobanking research are new ethical, social and policy challenges beyond those familiar to basic biomedical research. © 2012 Nature America, Inc. All rights reserved. Source

Haimes E.,Northumbria University | Skene L.,University of Melbourne | Ballantyne A.J.,The New School | Caulfield T.,University of Alberta | And 10 more authors.
Cell Stem Cell | Year: 2013

The nature of compensation for women who donate eggs (oocytes) for research remains a contentious issue internationally. This position paper lays out the arguments for, and discusses the arrangements in which, a modest payment might be ethically justifiable. © 2013 Elsevier Inc. Source

Aulisio M.P.,Case Western Reserve University | Aulisio M.P.,Center for Biomedical Ethics | Arora K.S.,Case Western Reserve University | Arora K.S.,MetroHealth Medical Center
HEC Forum | Year: 2014

This paper argues that the type of conscience claims made in last decade's spate of cases involving pharmacists' objections to filling birth control prescriptions and cases such as Ms. Means and Mercy Health Partners of Michigan, and even the Affordable Care Act and the Little Sisters of the Poor, as different as they appear to be from each other, share a common element that ties them together and makes them fundamentally different in kind from traditional claims of conscience about which a practical consensus emerged in the 1980s and 1990s. This difference in kind is profoundly significant; so much so, we contend, that it puts them at odds with the normative basis for protecting conscience claims in United States health care settings in the first place, making them illegitimate. Finally, we argue that, given the illegitimacy of these contemporary claims of conscience, physicians and other health professionals must honor their well-established standing obligations to provide informed consent and refer or transfer care even if the service requested or needed is at odds with their own core moral beliefs - a requirement that is in line with the aforementioned practical consensus on traditional claims of conscience. © 2014 Springer Science+Business Media Dordrecht. Source

Chong S.-A.,Institute of Mental Health | Campbell A.,Center for Biomedical Ethics | Chee M.,National University of Singapore | Liu J.,Genome Institute of Singapore | And 5 more authors.
Early Intervention in Psychiatry | Year: 2011

Aim: This paper describes the rationale, aims and development of the Singapore Translational and Clinical Research in Psychosis, which is a 5-year programme. Methods: The authors provide a selective review of the pertinent findings from the clinical, neuropsychological, genetics and neuroimaging studies on high-risk population and how they were factored in the hypotheses and design of this translational clinical research programme. Results: This programme, which draws upon the previous work of various groups and the experience of the investigators of this consortium, comprises three interlinked studies. The first is a genome-wide association and copy number variation analysis using the diagnostic phenotype of schizophrenia and cognitive phenotypes, and a joint genome-wide analysis performed by combining our data with other datasets to increase the power to detect genetic risk factors. The second is a prospective study of a large group of individuals who are assessed to be at ultra-high risk of psychosis, and the third is a randomized controlled trial to improve neurocognition in patients with schizophrenia. Conclusion: The convergence of various factors including the unique structured characteristics of the Singaporean society, the presence of political will with availability of funding and the established research infrastructure make it possible to accrue the sample size for adequate power to elucidate biomarkers of disease risk and resilience. © 2011 Blackwell Publishing Asia Pty Ltd. Source

Capps B.,Dalhousie University | Bailey M.M.,National University of Singapore | Coker R.,London School of Hygiene and Tropical Medicine | Lederman Z.,Center for Biomedical Ethics | And 3 more authors.
Bioethics | Year: 2015

Pandemic plans recommend phases of response to an emergent infectious disease (EID) outbreak, and are primarily aimed at preventing and mitigating human-to-human transmission. These plans carry presumptive weight and are increasingly being operationalized at the national, regional and international level with the support of the World Health Organization (WHO). The conventional focus of pandemic preparedness for EIDs of zoonotic origin has been on public health and human welfare. However, this focus on human populations has resulted in strategically important disciplinary silos. As the risks of zoonotic diseases have implications that reach across many domains outside traditional public health, including anthropological, environmental, and veterinary fora, a more inclusive ecological perspective is paramount for an effective response to future outbreaks. © 2015 John Wiley & Sons Ltd. Source

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