Entity

Time filter

Source Type

Florianópolis, Brazil

Saravanan G.,Center for Biological science | Ponmurugan P.,KS Rangasamy College of Technology
International Journal of Endocrinology and Metabolism | Year: 2013

Background: S-allylcysteine, a garlic derivative, could have a protective effect against pathogenesis of diabetes mellitus. Objectives: Sustained free radical generation and oxidative damage to system leads to the final conclusion phase of diabetes and also it coexists with a constant diminution in the antioxidant status.The present study aims to evaluate the therapeutic effects of S-allylcysteine (SAC) against adipocytes hormones and antioxidant defense systems of plasma and erythrocytes of treptozotocin (STZ) induced diabetes in rats. Materials and Methods: Diabetic rats were administered SAC (150 mg/kg b.w) orally for 45 days. At 46th day, the rats were anesthetized, and blood and liver sample were collected for analyzing glucose, plasma insulin, CYP2E1 activity, Thiobarbituric acid reactive substances (TBARS), hydroperoxide, enzymatic and nonenzymatic antioxidants, reduced glutathione (GSH), ceruloplasmin, plasma leptin, and adiponectin. Results: The levels of glucose, CYP2E1 activity, Thiobarbituric acid reactive substances (TBARS), hydroperoxide, and ceruloplasmin were increased significantly; whereas, the levels of plasma insulin, reduced glutathione, enzymatic and nonenzymatic antioxidants, leptin and adiponectin were decreased in experimental diabetic rats. Administration of SAC to diabetic rats led to a decrease in the levels of glucose, CYP2E1 activity, TBARS, and ceruloplasmin. In addition, the levels of plasma insulin, enzymatic and nonenzymatic antioxidants leptin and adiponectin were increased in SAC treated diabetic rats. Gliclazide, a standard drug for diabetes, was used for the comparative purpose. Conclusions: The results of the present investigation suggest that SAC could be used as a food supplement in the treatment of diabetes characterized by provoked antioxidant status, altered blood glucose, and hormones level.


Saravanan G.,Center for Biological science | Ponmurugan P.,KS Rangasamy College of Technology
Journal of Diabetes and its Complications | Year: 2012

Objective: It is considered that diabetes mellitus and thyroid disease are the two common endocrine disorders and also suggested that insulin and thyroid hormones influence each other actions. The present study was designed to investigate the effect of the administration of S-allylcysteine (SAC), a sulfur containing amino acid derived from garlic on blood glucose, insulin, HbA1C, total protein, albumin, Thyroid hormone (T3, T4), TSH, TBARS and circulatory antioxidant levels (SOD, CAT, GSH and GPx) in STZ-induced diabetic rats. Methods: SAC was administered orally for 45 days to control and STZ induced diabetic rats. The effects of SAC on glucose, plasma insulin, HbA1C, total protein, albumin, Thyroid hormone, TSH and circulatory antioxidant levels were studied. Results: The levels of glucose, TBARS, hydroperoxide and HbA1C were increased significantly whereas the levels of plasma insulin, reduced glutathione, superoxide dismutase, catalase, GSH, GPx, total protein, albumin, Thyroid hormone and TSH were decreased in STZ induced diabetic rats. Administration of SAC to diabetic rats showed a decrease in plasma glucose, TBARS, hydroperoxide and HbA1C. In addition, the levels of plasma insulin, SOD, CAT, GPx, GSH, total protein, albumin, Thyroid hormone and TSH were increased in SAC treated diabetic rats. The effect of SAC was compared with gliclazide, a well-known antioxidant and antihyperglycemic drug. Conclusion: From these findings, it is indicated that SAC might be acting through activation in the synthesis and/or secretion of circulating thyroid hormones which in turn stimulate the synthesis of insulin. © 2012 Elsevier Inc. All rights reserved.


Saravanan G.,Center for Biological science | Ponmurugan P.,KS Rangasamy College of Technology | Deepa M.A.,Kristu Jayanthi College | Senthilkumar B.,C Abdul Hakeem College | Senthilkumar B.,Tamil University
Journal of the Science of Food and Agriculture | Year: 2014

Background: Obesity represents a rapidly growing threat to the health of populations and diet intervention has been proposed as one of the strategies for weight loss. Ginger and its constituents have been used for their anti-flatulent, expectorant and appetising properties and they are reported to possess gastro-protective and cholesterol-lowering properties. The present study investigated the effects of gingerol on the changes in body weight, serum glucose, insulin, insulin resistance and lipid profile in plasma and liver as well as on the activity of amylase, lipase and leptin in high-fat diet (HFD)-induced obese rats. Results: HFD-induced obese rats were treated orally with gingerol (25, 50 and 75 mg kg-1) once daily for 30 days. A lorcaserin-treated group(10 mg kg-1)was included for comparison. The levels of bodyweight, glucose, lipid profile and insulin, insulin resistance, leptin, amylase and lipase were increased significantly (P < 0.05) in HFD rats. Rats treated with gingerol and fed a HFD showed significantly (P<0.05) decreased glucose level, bodyweight, leptin, insulin, amylase, lipase plasma and tissue lipids when compared to normal control. The effect at a dose of 75 mg kg-1 of gingerol was more pronounced than that of the dose 25 mg kg-1 and 50mg kg-1. The lorcaserin-treated group also manifested similar effects to those of gingerol. Conclusion: These findings suggested that ginger supplementation suppresses obesity induced by a high fat diet and itmight be a promising adjuvant therapy for the treatment of obesity and its complications. © 2014 Society of Chemical Industry.


Sundar S.K.,M.R.Research | Murugan M.,Center for Biological science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

In this present study, diversity of rhizosphere microbial flora present in the medicinal plant's root soil of Alpinia galanga was studied. The rhizosphere soil was collected from three different places of Kanyakumari District, Tamil Nadu. Nineteen bacteria, five fungal and two actinomycetes species were isolated and identified by cultural, morphological and biochemical studies. Among these Bacillus sp, Aspergillus sp and Streptomyces sp were found higher percentage of general distribution. These results may helpful for researchers who study the diversity of rhizosphere microflora of plants. © 2010 RJPBCS.


Beula Rani K.R.,Alagappa Chettiar College of Engineering And Technology | Sundar S.K.,MR Government Arts College | Murugan M.,Center for Biological science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: The study was undertaken to evaluate the antimicrobial activity and phytochemical constituents of the medicinal plant Alpinia galanga. Methods: The plant samples were collected from the places of Mandaikadu, Kanyakumari District, Tamil Nadu, India. Plant extracts were prepared from the dried leaf powder using different solvents include acetone, chloroform, diethyl ether, ethanol, and distilled water. Initially, antimicrobial activities of the plant extracts were tested by agar well diffusion method against four bacterial, viz., Escherichia coli, Klebsiella pneumonia, Bacillus cereus, and Staphylococcus aureus and two fungal pathogens, viz., Aspergillus niger and Penicillium chrysogenum. Further, the plant extracts were screened for phytochemical constituents by standard protocols. Results: In this study, the entire bacterial pathogens have inhibited by acetone, chloroform, diethyl ether, and ethanol extracts. In phytochemical screening tests, the plant extracts showed positive results for carbohydrates, amino acid, chloride, alkaloids, flavonoids, phenols, and terpenoids. Conclusion: This study reveals the continuation of antimicrobial components in the medicinal plant A. galanga. © 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.

Discover hidden collaborations