Everett L.J.,700 Clinical Research Building |
Everett L.J.,Penn Center for Bioinformatics |
Jensen S.T.,700 Clinical Research Building |
Jensen S.T.,University of Pennsylvania |
And 3 more authors.
Nucleic Acids Research | Year: 2011
Transcription factor activity is largely regulated through post-translational modification. Here, we report the first integrative model of transcription that includes both interactions between transcription factors and promoters, and between transcription factors and modifying enzymes. Simulations indicate that our method is robust against noise. We validated our tool on a well-studied stress response network in yeast and on a STAT1-mediated regulatory network in human B cells. Our work represents a significant step toward a comprehensive model of gene transcription. © 2011 The Author(s).