Center for Basic science

Mangalore, India

Center for Basic science

Mangalore, India
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Rukmini M.S.,Center for Basic science | Rukmini M.S.,Manipal University India | Rajan M.G.,A J Institute of Medical science | Puneeth A.,Omega Hospitals Pvt. Ltd. | And 2 more authors.
International Journal of Diabetes in Developing Countries | Year: 2017

Alstrom syndrome is a rare autosomal recessive genetic disorder first described in 1959. The syndrome with an estimated prevalence of less than 1 in 1 million has about 700 cases reported worldwide and only about 20 cases have been reported from India. The features of the syndrome include progressive retinal dystrophy and sensorineural deafness with phenotypic similarity to features of metabolic syndrome. Authors report a case of a 9-year-old boy referred to tertiary care hospital for evaluation of elevated blood glucose with polyuria, polydypsia and polyphagia. The child presented with blindness since childhood with delayed motor milestones. The child has normal intellect and noted to have central obesity, hypertension, acanthosis nigricans and micropenis with atrophic testes. Investigations revealed hyperglycemia with glycated haemoglobin of 10 %, hypertriglyceridemia and microalbuminuria. DNA sequence analysis showed a homozygous mutation detected in exon 10 of ALMS1 gene resulting in insertion of ‘T’ between 8150 and 8151 nucleotides of exon 10, thereby resulting in replacement of Ser by Phe at codon 2719 and development of Alstrom’s syndrome. The boy was treated with insulin and metformin for elevated blood glucose and fibrates for hypertriglyceridemia. © 2016, Research Society for Study of Diabetes in India.


Joshua A.M.,Center for Basic science | Karnad S.D.,Center for Basic science | Nayak A.,Center for Basic science | Suresh B.V.,Manipal University India | And 2 more authors.
NeuroRehabilitation | Year: 2017

BACKGROUND & OBJECTIVE: Timed up and go (TUG) test is been used as a screening tool for the assessment of risk of falling in individuals following stroke. Though TUG test is a quick test, it has fair sensitivity compared to other tests. This study was carried out to obtain and compare test scores for different types of foot placements during sit to stand transition in stroke subjects. METHOD: A Cross-sectional study with purposive sampling included 28 post stroke subjects who were able to walk 6 meter with or without assistance. Timed Up and Go test was carried out with four different types of foot placements and scores were recorded. The data were compared using Kruskal-Wallis One way analysis of variance and Wilcoxon signed ranks test. RESULT: There were comparable differences between asymmetric 1 test strategy which involved affected extremity to be placed behind the unaffected and other test strategies (Z = -4.457,-3.848,-4.458; p = 0.000). CONCLUSION: The initial foot placements during sit to stand transition influenced the time taken to complete the test which was significantly higher in asymmetric 1 strategy, Incorporation of the initial foot placement mainly asymmetric 1 strategy into conventional TUG test would help in identifying accurately the subject's functional mobility and postural stability. © 2017 - IOS Press and the authors. All rights reserved.


Potu B.K.,Center for Basic science | Rao M.S.,Kuwait University | Nampurath G.K.,Manipal University India | Chamallamudi M.R.,Manipal University India | Thomas H.,Center for Basic science
Chang Gung Medical Journal | Year: 2010

Background: The plant Cissus quadrangularis (CQ) is used as an osteoprotective agent in Ayurveda, the Indian system of alternative medicine. The present study was done to validate the anti-osteoporotic role of the petroleum ether extract of CQ on ovariectomy-induced osteoporosis in rats. Methods: Female wistar rats were divided into five groups of six rats each; (1) The Normal control (NC) group (n = 6) received no surgery and no treatment, (2). The Sham control (SHAM) group (n = 6) received sham surgery but no treatment, (3) the Ovariectomized (OVX) group (n = 6) received an ovariectomy and normal saline treatment for 90 days, (4) the Ovariectomized + raloxifene (OVX + RAL) group (n = 6) received an ovariectomy and treatment with raloxifene, a known anti-osteoporotic agent for 90 days commencing from 22nd post ovariectomy day and (5) the Ovariectomy + Cissus quadrangularis (OVX + CQ) group (n = 6) received an ovariectomy, and treatment with the petroleum ether extract of CQ 500 mg/kg body weight daily for 90 days commencing from 22nd post ovariectomy day. At the end of the treatment period, rats in all groups were sacrificed and the right femur was used for biomechanical analysis, and the left femur for histomorphometrical analysis. Results: CQ significantly increased the force required to break the femur (p < 0.001) and significantly increased the thickness of both cortical (p < 0.001) and trabecular bone (p < 0.001). This action of CQ was comparable to the action of raloxifene. Conclusions:The petroleum ether extract of CQ stem seems to possess anti-osteoporotic activity in rats.


D'Souza B.,Center for Basic science | Vinodchandran M.C.,Kasturba Medical College
Biomedicine (India) | Year: 2012

Adult onset Still's disease (AOSD) is a systemic inflammatory disorder characterized by prolonged high grade fever, arthralgia, salmon color rashes. It is often complicated by a fatal condition called hemophagocytic syndrome. Serum Ferritin levels are extremely elevated in AOSD. We are reporting one such case, with ferritin level of more than 1 lac.


PubMed | Subbiah Institute of Medical science and Center for Basic science
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2014

Dyslipidemia triggers a sequel of metabolic derangements such as insulin resistance, hyperglycemia and oxidative stress via vicious cycle. Dyslipidemia is characterised by elevation of plasma cholesterol, triglycerides (TGs), or both, or a low level of high-density lipoprotein (HDL) which in turn can progress to atherosclerosis a forerunner for ischemic heart disease (IHD). Dyslipidemia is seen even in subclinical hypothyroid patients.The aim of the study was to look for thyroid & glycemic abnormalities in dyslipidemic patients and compare it with euthyroid, normolipidemic group.Thirty primarily dyslipidemic patients and 30 euthyroid normolipidemic subjects aged 25-55 years were tested for fasting plasma glucose (FPG), fructosamine, lipid profile, thyroid hormones - T3, T4 and thyroid stimulating hormone (TSH). The values were compared with those of age matched euthyroid normolipidemic control group.The dyslipidemic pool showed small but significant decrease in the TSH levels with comparable T3, T4 levels as compared to euthyroid group. The group also had significantly higher FPG, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) levels and lower high density lipoprotein (HDL) levels as compared to the euthyroid normolipidemic group. The plasma fructosamine levels were similar in both the groups. The observed results reflected a picture of subclinical hyperthyroidism in dyslipidemic patients.The observations of the present study preclude a need to assess the thyroid status in patients of primary dyslipidemia as both conditions per se have an increased risk of cardio vascular diseases. A subclinical hyperthyroid state may essentially be helpful in maintaining the lipid metabolism. The prevailing mild hyperthyroid status also makes it important to reconsider the accuracy of long term glycemic indicators like fructosamine and possibly glycated haemoglobin in these patients. Upon establishment of their efficacy and safety, thyromimetics may have a role in the treatment of dyslipidemia.


Kumar A.,Center for Basic science | Rao G.M.,Center for Basic science | Shetty B.V.,Center for Basic science
Indian Journal of Clinical Biochemistry | Year: 2015

Infantile tremor syndrome is seen worldwide more commonly in the developing countries. Although various protein energy malnutrition awareness programme being run in many of these countries including India yet there is persistence of this disease. Here we present a case of 13 month old female child who visited RAPCC paediatrics OPD of Govt. Wenlock Hospital Mangaluru with history of respiratory distress, fever, tremor in limbs and loss of milestones. On examination she had pallor, hyper pigmentation in axilla and toes. Investigatory findings showed megaloblastic erythroid hyperplasia, hemoglobin- 1.6 g % and CT scan of brain showed central atrophic changes. © 2015 Association of Clinical Biochemists of India


Rai A.R.,Center for Basic science | Rai R.,Center for Basic science | Vadgaonkar R.,Center for Basic science | Madhyastha S.,Center for Basic science | And 2 more authors.
Journal of Craniofacial Surgery | Year: 2013

The aim of the present study was to analyze the anatomical and morphometric variation in shape, frequency of occurrence, direction, and position of accessory infraorbital foramen (AIOF) in relation to infraorbital foramen (IOF) in cadaveric dry skulls to minimize clinical complications and aid in surgical maneuvering in the maxillofacial region and implementing the regional block anesthesia. The IOF is an important anatomical landmark in these surgical manipulations. Because there is limited literature available on AIOF, which transmits accessory branch of the infraorbital nerve, the present study was designed. In the current study, 45 human dry skulls and 20 disarticulated maxillae have been used irrespective of sex. The other parameters included measuring the distance of AIOF from anterior nasal spine, frontomaxillary suture, infraorbital margin, IOF, and zygomaticomaxillary suture. The transverse and vertical diameter of foramen was also noted. All these measurements were taken using a digital caliper. The result of our study reveals that the presence of AIOF is more on the right side compared with the left side. Because the presence of accessory infraorbital nerve needs to be taken care of during maxillofacial surgical interventions, knowledge regarding the presence of AIOF should be taken into consideration for preoperative evaluation. Copyright © 2013 Mutaz B. Habal, MD.


PubMed | Center for Basic science
Type: Journal Article | Journal: Indian journal of clinical biochemistry : IJCB | Year: 2012

Susceptibility of Schizophrenic patients to lipid peroxidation relative to healthy control subjects was investigated by measuring the malondialdehyde (MDA) levels in plasma. The main finding was that Schizophrenic patients were more susceptible than control subjects to oxidative damage as evident from increased MDA levels in plasma. Antioxidant levels are also depleted in Schizophrenic patients when compared to normal subjects as evident from decreased levels of vitamins E and C in the plasma. Impaired antioxidant defense and increased lipid peroxidation suggests that treatment with antioxidants (Vitamin E, Vitamin C, beta carotene) at the initial stages of illness may prevent further oxidative injury and deterioration of associated neurological deficits in Schizophrenia.


PubMed | Center for Basic science
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2014

Studies have shown elevated HbA1C in non-diabetic hypothyroid patients. Hypothyroid patients often show anaemia as an associated feature which is an another condition showing falsely elevated A1C. Hence this study is aimed to investigate whether elevated A1C in hypothyroidism can be attributed to anaemia.HbA1C levels of 120 non-diabetic hypothyroid patients (30 microcytic hypochromic anaemia, 30 normocytic normochromic anaemia and 60 non anemic patients) with 120 age, sex, plasma glucose levels and anaemia status matched controls were assessed. Anaemia status was determined by ferritin, Haemoglobin, red cell indices and peripheral smear. Glycemic status was determined by fasting Plasma glucose.HbA1C levels in hypothyroid patients with hypochromic microcytic anaemia and normocytic normochromic anaemia were 6.82 0.71% & 6.32 0.75% against 6.43 0.43% & 5.87 0.46 % of euthyroid anaemia matched controls respectively. While hypothyroid non anemic patients showed A1C levels of 5.91 0.31% against 5.46 0.62% of euthyroid non anemic controls. Hypothyroid Patients with anaemia had a significant odds ratio 3.16 (95% CI 1.426-7.016) for HbA1C > 6.5.Non-diabetic hypothyroid individuals with anaemia shows elevate A1C levels in prediabetes range. Hence care should be excercised while using HbA1C as a diagnostic tool for diabetes in such patients.


Christy A.L.,Center for Basic science | Manjrekar P.,Center for Basic science | Babu R.P.,Center for Basic science | Rukmini M.S.,Center for Basic science | Hegde A.,Center for Basic science
Journal of Clinical and Diagnostic Research | Year: 2013

Aim: Studies have shown elevated HbA1C in non-diabetic hypothyroid patients. Hypothyroid patients often show anaemia as an associated feature which is an another condition showing falsely elevated A1C. Hence this study is aimed to investigate whether elevated A1C in hypothyroidism can be attributed to anaemia. Material and Methods: HbA1C levels of 120 non-diabetic hypothyroid patients (30 microcytic hypochromic anaemia, 30 normocytic normochromic anaemia and 60 non anemic patients) with 120 age, sex, plasma glucose levels and anaemia status matched controls were assessed. Anaemia status was determined by ferritin, Haemoglobin, red cell indices and peripheral smear. Glycemic status was determined by fasting Plasma glucose. Results: HbA1C levels in hypothyroid patients with hypochromic microcytic anaemia and normocytic normochromic anaemia were 6.82 ± 0.71% & 6.32 ± 0.75% against 6.43 ± 0.43% & 5.87 ± 0.46 % of euthyroid anaemia matched controls respectively. While hypothyroid non anemic patients showed A1C levels of 5.91 ± 0.31% against 5.46 ± 0.62% of euthyroid non anemic controls. Hypothyroid Patients with anaemia had a significant odds ratio 3.16 (95% CI 1.426-7.016) for HbA1C > 6.5. Discussion and Conclusion: Non-diabetic hypothyroid individuals with anaemia shows elevate A1C levels in prediabetes range. Hence care should be excercised while using HbA1C as a diagnostic tool for diabetes in such patients.

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