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Mangalore, India

D'Souza B.,Center for Basic science | Vinodchandran M.C.,Kasturba Medical College
Biomedicine (India)

Adult onset Still's disease (AOSD) is a systemic inflammatory disorder characterized by prolonged high grade fever, arthralgia, salmon color rashes. It is often complicated by a fatal condition called hemophagocytic syndrome. Serum Ferritin levels are extremely elevated in AOSD. We are reporting one such case, with ferritin level of more than 1 lac. Source

Vadgaonkar R.,Manipal University India | Rai R.,Center for Basic science | Prabhu L.V.,Manipal University India | Rai A.R.,Manipal University India | And 2 more authors.
Surgical and Radiologic Anatomy

Purpose: Ethmoidal foramina on the medial orbital wall show a higher incidence of variation. Surgeons performing endonasal, anterior cranial fossa and medial orbital wall surgeries must be aware of these variations as they are a source of hemorrhage and also serve as landmark in proximity to the orbital apex. Aim: The present study aims to describe the morphometric distances of various ethmoidal foramina between anterior lacrimal crest to optic canal in south Indian dry human skulls. Materials and method: The study was done on 44 adult dry human skulls. The occurrence of Ethmoidal foramina was noted by direct inspection. The distance of Ethmoidal foramina from anterior lacrimal crest to optic canal was measured with the help of ruler, probe and magnifying glass. Results: The Posterior ethmoidal foramina were found in all 44 skulls bilaterally. Middle ethmoidal foramen was present in 12 and 13 skulls on right and left, respectively. Anterior ethmoidal foramen was found in 38 and 37 skulls on right and left, respectively. The distance between anterior lacrimal crest (ALC) and posterior lacrimal crest (PLC) was in the range of 3–8 mm and that of ALC to anterior ethmoidal foramen was in the range of 24–30 mm. The range of distance between anterior ethmoidal foramen to posterior ethmoidal foramen was 9–17 mm and that between posterior ethmoidal foramen to optic canal was 5–13 mm. Conclusion: These observations would help to predict the anatomical variations in the position of ethmoidal foramina with respect to anterior and posterior lacrimal crest and ensure the safe and precise performance of medial orbital wall surgeries to avoid injuries to the important neurovascular bundles passing through various foramina and fissures. © 2015, Springer-Verlag France. Source

Nayanatara A.K.,Center for Basic science | Tripathi Y.,Santosh Medical College | Nagaraja H.S.,International Medical University | Jeganathan P.S.,Center for Basic science | And 4 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences

The stress response is a natural reaction by the body, against potentially harmful stimuli to enhance the chance for survival. Persistent activation of the chronic stress response can cause changes to homeostatic mechanisms. Immobilization/restraint stress is an easy and convenient method to induce both psychological and physical stress. Wistar strain adult albino rats were divided into two groups as non stressed group (n = 10) and stressed group (n = 10). The stressed groups were exposed to 60 days of chronic immobilization stress. At the end of the sixty day the animals were anaesthetized and blood samples were collected through cardiac puncture. The blood samples of both the groups were analyzed for selected biochemical and lipid parameters. The results were analyzed statistically by using student't test. P < 0.05 was considered as significant. Our present results showed a significant increase in the various organ weights and a significant decrease in the food intake and body weight. All the biochemical parameters [(serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), blood sugar, tissue malondialdehyde (MDA) and serum lipid profile (cholesterol, serum triglyceride (TG), low-density lipoproteins (LDL)] were significantly increased in the stressed group when compared to the non stressed group. The serum high-density lipoproteins (HDL) level did not show any statistically significant changes. The present data indicate that chronic immobilization stress causes the significant alterations in the physiological, biochemical and lipid parameters. Further the study also confirms the shift of oxidants and antioxidant balance during chronic stress. Source

Potu B.K.,Center for Basic science | Rao M.S.,Kuwait University | Nampurath G.K.,Manipal University India | Chamallamudi M.R.,Manipal University India | Thomas H.,Center for Basic science
Chang Gung Medical Journal

Background: The plant Cissus quadrangularis (CQ) is used as an osteoprotective agent in Ayurveda, the Indian system of alternative medicine. The present study was done to validate the anti-osteoporotic role of the petroleum ether extract of CQ on ovariectomy-induced osteoporosis in rats. Methods: Female wistar rats were divided into five groups of six rats each; (1) The Normal control (NC) group (n = 6) received no surgery and no treatment, (2). The Sham control (SHAM) group (n = 6) received sham surgery but no treatment, (3) the Ovariectomized (OVX) group (n = 6) received an ovariectomy and normal saline treatment for 90 days, (4) the Ovariectomized + raloxifene (OVX + RAL) group (n = 6) received an ovariectomy and treatment with raloxifene, a known anti-osteoporotic agent for 90 days commencing from 22nd post ovariectomy day and (5) the Ovariectomy + Cissus quadrangularis (OVX + CQ) group (n = 6) received an ovariectomy, and treatment with the petroleum ether extract of CQ 500 mg/kg body weight daily for 90 days commencing from 22nd post ovariectomy day. At the end of the treatment period, rats in all groups were sacrificed and the right femur was used for biomechanical analysis, and the left femur for histomorphometrical analysis. Results: CQ significantly increased the force required to break the femur (p < 0.001) and significantly increased the thickness of both cortical (p < 0.001) and trabecular bone (p < 0.001). This action of CQ was comparable to the action of raloxifene. Conclusions:The petroleum ether extract of CQ stem seems to possess anti-osteoporotic activity in rats. Source

Rai A.R.,Center for Basic science | Rai R.,Center for Basic science | Vadgaonkar R.,Center for Basic science | Madhyastha S.,Center for Basic science | And 2 more authors.
Journal of Craniofacial Surgery

The aim of the present study was to analyze the anatomical and morphometric variation in shape, frequency of occurrence, direction, and position of accessory infraorbital foramen (AIOF) in relation to infraorbital foramen (IOF) in cadaveric dry skulls to minimize clinical complications and aid in surgical maneuvering in the maxillofacial region and implementing the regional block anesthesia. The IOF is an important anatomical landmark in these surgical manipulations. Because there is limited literature available on AIOF, which transmits accessory branch of the infraorbital nerve, the present study was designed. In the current study, 45 human dry skulls and 20 disarticulated maxillae have been used irrespective of sex. The other parameters included measuring the distance of AIOF from anterior nasal spine, frontomaxillary suture, infraorbital margin, IOF, and zygomaticomaxillary suture. The transverse and vertical diameter of foramen was also noted. All these measurements were taken using a digital caliper. The result of our study reveals that the presence of AIOF is more on the right side compared with the left side. Because the presence of accessory infraorbital nerve needs to be taken care of during maxillofacial surgical interventions, knowledge regarding the presence of AIOF should be taken into consideration for preoperative evaluation. Copyright © 2013 Mutaz B. Habal, MD. Source

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