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Parmar A.S.,and Center for Advanced Biotechnology and Medicine | Zahid S.,and Center for Advanced Biotechnology and Medicine | Belure S.V.,and Center for Advanced Biotechnology and Medicine | Young R.,and Center for Advanced Biotechnology and Medicine | And 2 more authors.
Journal of Structural Biology | Year: 2014

Net-negatively-charged heterospecific A:B:C collagen peptide heterotrimers were designed using an automated computational approach. The design algorithm considers both target stability and the energy gap between the target states and misfolded competing states. Structural characterization indicates the net-negative charge balance on the new designs enhances the specificity of the target state at the expense of its stability. © 2013 Elsevier Inc. Source

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