Papaefthymiou M.A.,Center for Adolescent Medicine |
Bakoula C.,Center for Adolescent Medicine |
Sarra A.,Center for Adolescent Medicine |
Papassotiriou I.,Childrens Hospital Aghia Sophia |
And 2 more authors.
Journal of Pediatric Endocrinology and Metabolism
Objective: The aim of this study was to assess possible associations between potential risk factors for fractures and their occurrence in otherwise healthy Greek male adolescents.Subjects: A total of 63 male adolescents participated in the study, 21 males with a history of at least one fracture and 42 healthy male controls.Methods: Each participant was assessed for physical and pubertal status, hormonal profile, bone mineral density, bone turnover indices, and dietary habits.Results: The lower bone mineral density-z scores and increasing testosterone and serum collagen type 1 crosslinked C-telopeptide levels were related to fracture risk, whereas increased insulin-like growth factor-1, soluble receptor activator of nuclear factor kappa-B (factor-êB) ligand, and soluble receptor activator of nuclear factors-êB ligand/osteoprotegerin levels were protective for fractures.Conclusions: The findings indicate a potential 'added value' of hormonal parameters and bone markers to bone mineral density for evaluating fracture risk in healthy male adolescents. Source