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Sainte-Foy-lès-Lyon, France

Allirot X.,Center Europeen Of Nutrition Pour La Sante | Saulais L.,Center Europeen Of Nutrition Pour La Sante | Disse E.,Center Europeen Of Nutrition Pour La Sante | Roth H.,Grenoble University Hospital Center | And 2 more authors.

We assessed the reproducibility of intakes and meal mechanics parameters (cumulative energy intake (CEI), number of bites, bite rate, mean energy content per bite) during a buffet meal designed in a natural setting, and their sensitivity to food deprivation. Fourteen men were invited to three lunch sessions in an experimental restaurant. Subjects ate their regular breakfast before sessions A and B. They skipped breakfast before session FAST. The same ad libitum buffet was offered each time. Energy intakes and meal mechanics were assessed by foods weighing and video recording. Intrasubject reproducibility was evaluated by determining intraclass correlation coefficients (ICC). Mixed-models were used to assess the effects of the sessions on CEI. We found a good reproducibility between A and B for total energy (ICC = 0.82), carbohydrate (ICC = 0.83), lipid (ICC = 0.81) and protein intake (ICC = 0.79) and for meal mechanics parameters. Total energy, lipid and carbohydrate intake were higher in FAST than in A and B. CEI were found sensitive to differences in hunger level while the other meal mechanics parameters were stable between sessions. In conclusion, a buffet meal in a normal eating environment is a valid tool for assessing the effects of interventions on intakes. © 2012 Elsevier Ltd. Source

Allirot X.,Center Europeen Of Nutrition Pour La Sante | Saulais L.,Center Europeen Of Nutrition Pour La Sante | Seyssel K.,Center Europeen Of Nutrition Pour La Sante | Graeppi-Dulac J.,Center Europeen Of Nutrition Pour La Sante | And 11 more authors.
Physiology and Behavior

The effects of increasing eating frequency on human health are unclear. This study used an integrated approach to assess the short-term consequences on appetite and metabolism. Twenty normal-weight men participated in: (i) two sessions consisting of a breakfast consumed in one eating episode at T0 (F1), or in four isocaloric eating episodes at T0, T60, T120, and T180. min (F4), and followed by an ecological ad libitum buffet meal (T240) designed in an experimental restaurant. Intakes were assessed for the whole buffet meal and for each temporal quarter of the meal. (ii) two sessions consisting of the same two breakfasts F1 and F4 in a Clinical Investigation Centre. Blood sampling was performed to study the kinetics of ghrelin, glucagon-like peptide-1 (GLP-1), glucose, insulin, triglycerides and non-esterified fatty acids (NEFA). Substrate oxidation was measured by indirect calorimetry. During each of the 4 sessions, participants rated their appetite throughout the experiment. After F4, at T240. min, GLP-1 concentration was higher (P= 0.006) while ghrelin concentration and hunger ratings were lower (P. <. 0.001). We showed a trend for subjects to consume less energy (-. 88. ±. 61. kcal, P= 0.08) at the buffet after F4, explained by a decrease in lipid intake (P= 0.04). Marked differences in consumption were observed during the last temporal quarter of the meal for total energy and lipid intake (P= 0.03). Mixed models highlighted differences between F1 and F4 for the kinetics of glucose, insulin and NEFA (P. <. 0.001). The area under the curve was lower for insulin (P. <. 0.001) and NEFA in F4 (P= 0.03). Diet induced thermogenesis was reduced in F4 (P. <. 0.05). This study demonstrated the beneficial short-term effect of increasing eating frequency on appetite in lean men considering subjective, physiological and behavioral data. However, the loss of the inter-prandial fast was associated with an inhibition of lipolysis, reflected by NEFA profiles, and a decrease in energy expenditure. © 2013 Elsevier Inc.. Source

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