Marrakesh, Morocco
Marrakesh, Morocco

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Pagani O.,Oncology Institute of Southern Switzerland IOSI | Pagani O.,Oncology Institute | Ruggeri M.,Oncology Institute | Manunta S.,Oncology Institute of Southern Switzerland IOSI | And 20 more authors.
Breast | Year: 2015

Young patients with breast cancer (BC) are often concerned about treatment-induced infertility and express maternity desire. Conception after BC does not seem to affect outcome, but information in estrogen-receptor positive (ER+) disease is not definitive. From September 2012-March 2013, 212 evaluable patients with ER+ early BC, <37years at diagnosis, from 5 regions (Europe/US/Canada/Middle-East/Australia) answered a survey about fertility concerns, maternity desire and interest in a study of endocrine therapy (ET) interruption to allow pregnancy. Overall, 37% of respondents were interested in the study; younger patients (≤30 years) reported higher interest (57%). Motivation in younger patients treated >30 months was higher (83%) than in older women (14%), interest was independent of age in patients treated for ≤30 months. A prospective study in this patient population seems relevant and feasible. The International-Breast-Cancer-Study-Group (IBCSG), within the Breast-International-Group (BIG) - North-American-Breast-Cancer-Groups (NABCG) collaboration, is launching a study (POSITIVE) addressing ET interruption to allow pregnancy. © 2015 Elsevier Ltd.


PubMed | Breast Unit, Ensemble Hospitalier Of La Cote, University of Washington, Dana-Farber Cancer Institute and 13 more.
Type: Journal Article | Journal: Breast (Edinburgh, Scotland) | Year: 2015

Young patients with breast cancer (BC) are often concerned about treatment-induced infertility and express maternity desire. Conception after BC does not seem to affect outcome, but information in estrogen-receptor positive (ER+) disease is not definitive. From September 2012-March 2013, 212 evaluable patients with ER+ early BC, <37years at diagnosis, from 5 regions (Europe/US/Canada/Middle-East/Australia) answered a survey about fertility concerns, maternity desire and interest in a study of endocrine therapy (ET) interruption to allow pregnancy. Overall, 37% of respondents were interested in the study; younger patients (30 years) reported higher interest (57%). Motivation in younger patients treated >30 months was higher (83%) than in older women (14%), interest was independent of age in patients treated for 30 months. A prospective study in this patient population seems relevant and feasible. The International-Breast-Cancer-Study-Group (IBCSG), within the Breast-International-Group (BIG) - North-American-Breast-Cancer-Groups (NABCG) collaboration, is launching a study (POSITIVE) addressing ET interruption to allow pregnancy.


Moura B.,Departement dOncologie | Migliorin D.,Center dOncologie | Bourhis J.,Departement dOncologie | Daniel R.,CHUV | And 2 more authors.
Revue Medicale Suisse | Year: 2016

Gliomas represent two thirds of all primary brain tumors. Their prognosis depends directly upon their level of differentiation. On MRI, tumoral aggressivity is highlighted by contrast uptake and the infiltrative nature of the lesion. Clinical suspicion must however be confirmed by histology and molecular markers become essential to refine the diagnosis and tailor the treatment. Isocytrate dehydrogenase (IDH) mutations, codeletion of 1p and 19q and the presence of methylation of the MGMT promoter identify a subgroup of gliomas with better prognosis and may help predict response to treatment. Management of patients with primary brain tumors should always be defined in multidisciplinar tumor boards involving neurosurgeons, oncologists, radiation oncologists, neuropathologists and neuroradiologists.


Ismaili N.,Center doncologie | Elmajjaoui S.,Institute National dOncologie | Bensouda Y.,Institute National dOncologie | Belbaraka R.,Center doncologie | And 12 more authors.
Oncology Reviews | Year: 2011

Bladder cancer is the fourth most common cancer for men and the eighth most common cancer for women. Transitional cell carcinoma is the most predominant histological type. Bladder cancer is highly chemosensitive. In metastatic setting the treatment is based on cisplatin chemotherapy regimens type MVAC, MVAC-HD or gemcitabine plus cisplatin. The standard treatment of muscle invasive operable bladder cancer (T2-T4) used widely was radical cystectomy with pelvic lymph nodes dissection; the anatomical extent of pelvic lymphadenectomy has not accurately been defined so far. However, in the last decade, the treatment of tumors was improved by the introduction of chemotherapy as part of the management of the disease. Neoadjuvant chemotherapy should be considered at first, as standard treatment of choice, before local treatment for patients with good performance status (0-1) and good renal function-glomerular filtration rate (GFR) >60 mL/min. For patients treated with primary surgery, adjuvant chemotherapy is a valuable option in the case of lymph nodes involvement. This brief review would provide the evidence of the role of neoadjuvant chemotherapy in the management of operable muscle invasive (T2-T4) bladder cancer. © Springer-Verlag 2011.


Migliorini D.,Center dOncologie | Dietrich P.-Y.,Center dOncologie
Revue Medicale Suisse | Year: 2016

Glioblastomas are highly aggressive tumors. Their prognosis remain poor despite standard therapies combining surgery, radiation and temozolomide based chemotherapy. Among innovating strategies, there is a major interest for immunotherapy. During the past 3 decades, there has been a general scepticism concerning the efficacy of this approach. But the latest achievements, such as immune checkpoint inhibitors in solid tumors, and adoptive cell therapy in hematologic malignancies, have radically changed the face of the field and have already an impact on the daily practice. To which extent these advances have an impact for brain tumors also? This article aims to present the principal clinical applications of the various immune therapies currently under investigation in neurooncology and give an insight on the future perspectives in the field.


Haddad H.,Center doncologie | Sellal N.,Center doncologie | Bourhaleb Z.,Center doncologie
Progres en Urologie | Year: 2014

The prostate is a very rare localization of signet ring cell carcinoma, with few cases reported in the literature. This histological type occurs rather in cancers of the digestive tract (stomach, colon). Authors report a case of a patient aged 63. years. Diagnostic and therapeutic features are discussed. © 2013 Elsevier Masson SAS.


Houjami M.,Center doncologie | Sahraoui S.,Center doncologie | Benchakroun N.,Center doncologie | Jouhadi H.,Center doncologie | And 2 more authors.
Cancer/Radiotherapie | Year: 2011

Purpose: To report the epidemiological, clinical aspects and therapeutic results of intracranial ependymomas in Morocco. Patients and methods: Our retrospective study concerned 16 cases of intracranial ependymomas, treated from January 1995 to December 2002 at the radiotherapy department of Ibn Rochd Hospital of Casablanca, Morocco. Results: The average age was 15 years and complete surgery was possible in two cases. All the patients received cranial radiotherapy, combined with chemotherapy in six cases. Overall survival and progression-free survival at 5. years were respectively 50% and 31%. Eleven patients had local recurrence after an average period of 21 months. Progression-free survival at 5. years was better if complete resection: 100% vs. 28.6% in cases of incomplete resection, and depending on the histological type with 50% for classic ependymomas and 16.6% for anaplastic. Conclusion: Ependymomas are rare tumors and complete resection is the standard treatment followed by postoperative radiotherapy. The place of chemotherapy remains to be defined. © 2010 Société française de radiothérapie oncologique (SFRO).


PubMed | Center doncologie
Type: Case Reports | Journal: Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie | Year: 2014

The prostate is a very rare localization of signet ring cell carcinoma, with few cases reported in the literature. This histological type occurs rather in cancers of the digestive tract (stomach, colon). Authors report a case of a patient aged 63 years. Diagnostic and therapeutic features are discussed.


PubMed | Center dOncologie
Type: Journal Article | Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique | Year: 2011

To report the epidemiological, clinical aspects and therapeutic results of intracranial ependymomas in Morocco.Our retrospective study concerned 16 cases of intracranial ependymomas, treated from January 1995 to December 2002 at the radiotherapy department of Ibn Rochd Hospital of Casablanca, Morocco.The average age was 15 years and complete surgery was possible in two cases. All the patients received cranial radiotherapy, combined with chemotherapy in six cases. Overall survival and progression-free survival at 5 years were respectively 50% and 31%. Eleven patients had local recurrence after an average period of 21 months. Progression-free survival at 5 years was better if complete resection: 100% vs. 28.6% in cases of incomplete resection, and depending on the histological type with 50% for classic ependymomas and 16.6% for anaplastic.Ependymomas are rare tumors and complete resection is the standard treatment followed by postoperative radiotherapy. The place of chemotherapy remains to be defined.

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