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Lagnika L.,University Abomey Calavi | Lagnika L.,Center Beninois Of La Recherche Scientifique Et Technique | Anago E.,University Abomey Calavi | Sanni A.,University Abomey Calavi
Journal of Medicinal Plants Research | Year: 2011

Ten extracts from 10 medicinal plants, Acanthospermum hispidium, Argemone mexicana, Byrsocarpus coccineus, Canthium setosum, Croton lobatus, Dichapetalum guineense, Nauclea latifolia, Schrankia leptocarpa, Secamone afzelii, Pterocarpus erinaceus, traditionally used in Benin to treat infectious diseases and were screened for in vitro antibacterial activity towards Staphylococcus aureus, Enteroccocus feacalis, Escherichia coli and Pseudomonas aeruginosa. The 2, 2-diphenylpicrylhydrazyl radical scavenging activity and toxicity assay using Artemia salina were also performed. All extracts were effective against tested microorganisms at different level with MIC ranking from 0.31 to 10 mg/ml. The best inhibition on the growth of tested bacteria was observed with four extracts obtained from D. guineense, N. latifolia, and P. erinaceus (MIC = 0.313 mg/ml). The species S. aureus and E. faecalis were more sensitive than the other test bacteria. All extracts showed good radical scavenging activity range from 1.35 to 3.47 μg/ml. The most effective extract was the methanolic extract of S. leptocarpa, with an EC 50 value of 1.35 μg/ml. The lethality test showed that all tested extracts have low toxicity against the shrimps with LC 50 values ranging from 3.8 to 8.17 mg/ml. The results provide an evidence of the traditional use of same collected plants in the treatment of infective diseases. © 2011 Academic Journals. Source


Anago E.,University Abomey Calavi | Lagnika L.,University Abomey Calavi | Lagnika L.,Center Beninois Of La Recherche Scientifique Et Technique | Gbenou J.,University Abomey Calavi | And 3 more authors.
Pakistan Journal of Biological Sciences | Year: 2011

The ethanol extracts obtained from Psidium guajava, Flacourtia flavescens Boswellia dalzielii, Ficus exasperata, Pavetta corymbosa and Hybanthus enneaspermus, six species traditionally used in Benin to treat several infectious diseases, were evaluated for their in vitro antimicrobial activity against Staphylococcus aureus, Enteroccocus feacalis, Escherichia coli and Pseudomonas aeruginosa. The minimum inhibitory concentration of extracts was determinate using the microplate dilution method. The presence of major phytoconstituents was detected qualitatively. The diphenylpicrylhydrazine radical scavenging activity was also performed. The extracts exhibited antibacterial activities against the tested bacteria. Boswellia dalzielii, Psidium guayava, Pavetta corymbosa and Flacourtia flavescens exibited the lowest minimum inhibitory concentration values (0.313-2.5 mg mL -1). Pseudomonas aeruginosa was the lest sensitive microorganism with MIC values higher than 10 mg inL -1. In antioxidant assay the crude extracts of B. dalzielii and P. corymbosa appeared to be as potent as quercetol with an inhibition percentage of 83 and 75.3% at 10 μg mL -1 which is comparable to 75.9% for quercetol at the same concentration. © 2011 Asian Network for Scientific Information. Source


Guendehou G.H.S.,Center Beninois Of La Recherche Scientifique Et Technique | Guendehou G.H.S.,Finnish Forest Research Institute | Lehtonen A.,Finnish Forest Research Institute | Moudachirou M.,University Abomey Calavi | And 2 more authors.
Southern Forests | Year: 2012

Estimating tree volume and biomass constitutes an essential part of the forest resources assessment and the evaluation of the climate change mitigation potential of forests through biomass accumulation and carbon sequestration. This research article provides stem volume and biomass equations applicable to five tree species, namely Afzelia africana Sm. (Caesalpiniaceae), Anogeissus leiocarpa (DC.) Guill. and Perr. (Combretaceae), Ceiba pentandra (L.) Gaertn. (Bombacaceae), Dialium guineense Willd. (Caesalpiniaceae), Diospyros mespiliformis Hochst. ex A.DC. (Ebenaceae) in natural protected tropical forests and, in addition, Tectona grandis L.f. (Verbenaceae) in plantations. In addition to the tree species specific equations, basic wood density, as well as carbon, nitrogen, organic matter and ash content were determined for these tree species in tropical conditions in West Africa. One hundred and sixty-two sample trees were measured through non-destructive sampling and analysed for volume and biomass. Stem biomass and stem volume were modelled as a function of diameter (at breast height; Dbh) and stem height (height to the crown base). Logarithmic models are presented that utilise Dbh and height data to predict tree component biomass and stem volumes. Alternative models are given that afford prediction based on Dbh data alone, assuming height data to be unavailable. Models that include height are preferred, having better predictive capabilities. Ranges in carbon, nitrogen and ash contents are given as well. The successful development of predictive models through the use of non-destructive methods in this study provide valuable data and tools for use in determining the contribution of these major African rainforest tree species to global carbon stocks, while ensuring the preservation of this valued African resource. This study needs to be expanded to further regions and tree species to complete a full inventory of all tree species, emphasising the relevance of African trees to carbon stocks at a global scale. © 2012 Copyright NISC (Pty) Ltd. Source


Fatondji H.R.,University Abomey Calavi | Kpoviessi S.,University Abomey Calavi | Gbaguidi F.,Center Beninois Of La Recherche Scientifique Et Technique | Bero J.,Catholic University of Louvain | And 5 more authors.
Medicinal Chemistry Research | Year: 2013

To explore the structure-activity relationships of thiosemicarbazones on African trypanosome: Trypanosoma brucei brucei, a series of thirty-five thiosemicarbazones (1-35) have been synthesized and characterized by their 1H NMR, 13C NMR, and FT-IR spectra. All compounds were tested for trypanocidal activity using the method "Lilit alamar blue". The comparison of trypanocidal power of thiosemicarbazones was performed considering their structures. This study that was done using acetophenone thiosemicarbazone (1) as basic model, showed that: (a) the presence of lipophilic substituents in para position on benzene ring, (b) substitution of benzene ring and (c) substitution of hydrogen of thioamide function by a phenyl, strongly influence trypanocidal activity. The various modifications to basic structure (1) allowed the synthesis of 1-(4-chlorophenyl) ethylidene-4-phenyl- thiosemicarbazide (34). With a trypanocidal activity of 3.97 μM, this compound is the most active of the series. © 2012 Springer Science+Business Media, LLC. Source

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