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Achour S.,Laboratoire Central dAnalyses Medicales | Achour S.,Université Ibn Tofail | Rhalem N.,Center Antipoison Et Of Pharmacovigilance Du Maroc | Rhalem N.,Université Ibn Tofail | And 6 more authors.
Therapie | Year: 2012

Peganum harmala L. is commonly used in traditional medicine in Morocco for its sedative and emmenagogue properties but expose to the risk of overdose and poisoning. The aim of our study was to analyze a series of 200 cases of poisoning collected in poison control and pharmacovigilance center of Morocco in order to describe the epidemiological, clinical, therapeutic features and outcome of patients and indicate the toxicity of this plant used primarily for therapeutic purposes. Methods. This retrospective study performed over a period of twenty four years from January 1984 to December 2008. Results. The mean age of patients was 24.4±16.8 years with a female predominance (167 women against 33 men). Therapeutic circumstance was found in 32.5%, followed by suicide (28.5%) and abortion (13.5%). The symptomatology was dominated by neurological, gastrointestinal and cardiovascular signs respectively 34.4%, 31.9 % and 15.8%. The evolution has been specified in 114 cases, 7 deaths have been deplored with a fatality rate of 6.2%. © 2012 Société Française de Pharmacologie et de Thérapeutique.


Achour S.,Laboratoire Of Toxicologie | Achour S.,Université Ibn Tofail | Saadi H.,Service de gynecologie obstetrique | Turcant A.,Laboratoire Of Pharmaco Toxicologie | And 4 more authors.
Medecine et sante tropicales | Year: 2012

Peganum harmala L. (wild or Syrian rue) is commonly used as an emmenagogue and abortifacient in traditional medicine in the Middle East and North Africa including Morocco. The purpose of this report is to describe two cases of Peganumharmala L.poisoninginpregnantwomen. Both cases were treated successfully with good maternal-fetal outcome good for mother and child.


Chebat A.,Mohammed V University | Chebat A.,Center Antipoison Et Of Pharmacovigilance Du Maroc | Skalli S.,Center Antipoison Et Of Pharmacovigilance Du Maroc | Benkirane R.,Center Antipoison Et Of Pharmacovigilance Du Maroc | And 3 more authors.
Phytotherapie | Year: 2015

To better assess the prevalence of adverse events (AEs) related to the use of medicinal plants (PM) and inventory the most used in children PM (under 16 years) with hematological diseases and cancer, we conducted a study with 404 patients (or their guardians) for four months at the Pediatric Hematology -Oncology Centre (CHOP) in Rabat. This study was performed using a 10-item questionnaire through which we aim to gather as much information as possible on patients and PM used in hematological diseases and cancer. The survey showed that 14.9% of patients have resorted to the use of PM, all those who have used the PM does not disclose the information to their physician, with a sex ratio of 1.4. Among interviewed patients, using PM, we note that 9.4% had AEs. Analysis of the results showed that tubulo-interstitial nephritis is the most common IE (3.2%), followed by cough and cold (0.5%), diarrhea (0.2 %) and vomiting (0.2%). These results showed that the outcome is favorable in 5% cases. Among the PM used by patients, some of them are involved in adverse reactions, Nigella sativa L. in 5% and Aristolochia longa L. in 2.3%. The resort to medicinal plants as an alternative is a major issue for most of patients, herbals are used in first line in 3.9% of the cases, concomitantly in 85% and as a complementary at the end of the medical therapeutic in 11.1%. The sensitization of patients, families and physicians is of a major importance for an optimal management of patients. © 2014, Springer-Verlag France.


Shaimi S.,Faculte des science de Tetouan | Idrissi M.,Center Antipoison Et Of Pharmacovigilance Du Maroc | Ben Driss E.K.,Faculte des science de Tetouan | Bencheikh Soulaymani R.,Center Antipoison Et Of Pharmacovigilance Du Maroc
Toxicologie Analytique et Clinique | Year: 2014

Objective The present work is aimed to study blood lead level in Casablanca population exposed to lead particles from smelters in Ain Sebaa and Sidi Bernoussi districts and from companies manufacturing batteries in Sidi Bernoussi district. Blood lead level will be also studied in Rabat population not exposed to industrial pollution as control. Method This cross-sectional study exposed/unexposed was conducted in children and adults non-occupationally exposed. The study was based on blood lead level determination and on collecting socio-demographic parameters and lead exposure risk factors in 473 participants. Results Mean blood lead level (53.74 ± 42.08 μg/L) obtained in participants from the exposed area (Casablanca) was significantly higher than mean blood lead level (35.80 ± 34.15 μg/L) obtained in participants from the unexposed area (Rabat). Among the 473 participants in the study, 32 subjects had blood lead level higher than 100 μg/L, 25 cases (78.1%) were from the exposed area. Logistic regression analysis adjusted to the city showed that participants from the exposed area had a significantly higher likelihood to have high blood lead level than participants from unexposed area. Conclusion Increased blood lead levels in participants from Casablanca compared to those from Rabat could be attributed to the exposure to lead particles emitted by smelters in Ain Sebaa and Sidi Bernoussi districts and by companies manufacturing batteries in Sidi Bernoussi district. © 2014 Société Française de Toxicologie Analytique. Published by Elsevier Masson SAS. Allrights reserved.


Achour S.,Laboratoire central danalyses medicales | Achour S.,Laboratoire Of Genetique Et Biomerie | Khattabi A.,Center Antipoison Et Of Pharmacovigilance Du Maroc | Rhalem N.,Center Antipoison Et Of Pharmacovigilance Du Maroc | And 5 more authors.
Sante Publique | Year: 2011

Objective: The purpose of this paper is to describe the epidemiological profile of acute pesticide poisoning in children (APP) treated by the Moroccan Poison Control Center (CAPM) and to analyze death cases in order to determine factors predictive of severity. Method: the study is based on a retrospective study of all cases of APP collected by the CAPM over a period of eighteen years (January 1990 to December 2008). Univariate analysis was performed to identify risk factors. Results: 2,672 cases of childhood poisoning by pesticide were collected. The mean age was 5.6 ± 4.57 years. The sex ratio was 1.12. The cause of poisoning was accidental in 87.1% of cases, followed by attempted suicide (12.1%). Organophosphates were the most frequent poison (50.7%), followed by alpha-chloralose (26.5%). The case fatality rate was 3.3%. Mortality was attributed to organophosphates in 30 cases, followed by inorganic derivatives (7 cases) and carbamates (6 cases). A univariate analysis comparing survivors and groups who died showed that rural origin (p = 0.04), voluntary circumstances (p = 0.001), and the type of chemical class of pesticide (p < 0.001) significantly influence fatal poisoning. Conclusion: Acute pesticide poisoning among children is a reality in Morocco. Preventive measures may be needed.


Lallie H.,Université Ibn Tofail | Hami H.,Université Ibn Tofail | Soulaymani A.,Université Ibn Tofail | Chafiq F.,Center Antipoison Et Of Pharmacovigilance Du Maroc | And 5 more authors.
Bulletin de la Societe de Pathologie Exotique | Year: 2012

The present study aims to determine the main characteristics of ophidian envenomation in the Souss-Massa-Drâa region in Morocco. It consisted of a descriptive retrospective analysis of all snakebite cases recorded by the Moroccan Poison Control and Pharmacovigilance Center, from 1980 to 2008. According to reported data, this region is the most affected in Morocco with 479 cases, that is 27.6% (17 cases/year). The average age of victims was 26.07 ± 18.28 years. The patients developed clinical signs (55%) dominated by disorders of the digestive system (35.5%), cardiovascular diseases (21.4%), and heart rhythm disorders (16.8%). The lethality and sequelae rates were 12% and 1.9%, respectively. © 2012 Société de pathologie exotique et Springer-Verlag France.


Echahbi N.,Université Ibn Tofail | Soulaymani A.,Université Ibn Tofail | Hami H.,Université Ibn Tofail | Benazzouz B.,Université Ibn Tofail | And 7 more authors.
Bulletin de la Societe de Pathologie Exotique | Year: 2013

In Morocco, the Marrakech-Tensift-Al Haouz region is one of the 16 regions most affected by poisoning. The aim of this study was to determine the epidemiological profile of poisoning recorded in the study region. A retrospective study of poisoning cases, declared between 1981 and 2008 in the Morocco Poison Control and Pharmacovigilance Center, was conducted. During the study period, 8517 poisoning cases were collected. The average age of patients was 22 ± 15 years. The male/female sex ratio was 0.85. Food poisoning was the most reported in the region, with 26.6% of cases. Among the 2,779 patients for whom the outcome was known, 65 died, with lethality rate of 23.4‰. The maximum lethality rate was recorded among those poisoned by paraphenylenediamine (170.7‰). © 2012 Springer Verlag France.


Hami H.,Université Ibn Tofail | Soulaymani A.,Université Ibn Tofail | Skalli S.,Center Antipoison Et Of Pharmacovigilance Du Maroc | Mokhtari A.,Université Ibn Tofail | And 3 more authors.
Bulletin de la Societe de Pathologie Exotique | Year: 2011

To assess the extent and severity of poisoning by Atractylis gummifera L. in Morocco, a descriptive retrospective study was conducted on all the poisoning cases listed between 1981 and 2004 to the Morocco Poison Control Center. During this period, 240 people were hospitalized for glue thistle poisoning, 72% of which are children under 16 years. The severity of the poisoning has been affirmed by significant intrahospital lethality. Indeed, among the 182 patients for whom the outcomes were known, 98 died (54%). © Société de pathologie exotique et Springer-Verlag France 2010.


Diallo T.,University des science | Maiga A.,University des science | Sangho H.,University des science | Coulibaly B.,Pharmacie de la Cote | And 4 more authors.
Medecine et Sante Tropicales | Year: 2014

Aims. The aim of this study was to determine the epidemiological characteristics of the cases of fatal poisoning in Mali. Methods. This retrospective study examined the cases of fatal poisoning recorded between 2000 and 2010 in six Health Reference centers, six regional hospitals and three university hospitals in the district of Bamako. Results. During the study period, 146 cases of fatal poisoning were recorded, accounting for 4.6% of all poisoning cases during this period. The average age of patients who died was 24 ± 17.7 years with a female-male ratio of 1.05. Nearly half (43%) were younger than 20 years. The ingestion was intentional in 66.4% of cases, mainly suicide attempts (47%) and therapeutic errors (19%). The median time until arrival at hospital was 8 hours after poisoning with multiple and varied clinical signs. Conclusions. Decreasing the mortality rate from poison ingestion requires increasing public awareness about poisons and improving emergency service equipment and health personnel training.

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