Chapel Hill, NC, United States
Chapel Hill, NC, United States
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Powder oral suspension formulations of antibacterial compounds are described herein. In addition, reconstitutable powders of antibacterial compounds and oral suspension formulations thereof are described herein. For many years, there has been a long-felt need for an oral suspension formulation for treating bacterial infections. It is well-understood that pediatric indications rely on such formulations for the effective treatment of bacterial infections in children and infants. In addition, other patients, such a geriatric patients, who cannot or will not swallow tablets or capsules, especially when they are above certain dimensional limits, also rely on such formulations for the effective treatment of bacterial infections.


Powder oral suspension formulations of antibacterial compounds are described herein. In addition, reconstitutable powders of antibacterial compounds and oral suspension formulations thereof are described herein.


Compounds, compositions, and methods are described herein for treating diabetes, fatty liver diseases, fibrotic diseases, such as liver and pulmonary fibrosis, and hepatocellular carcinoma.


Described herein are processes for the preparation of compounds of formula (I): and pharmaceutically acceptable salts, solvates, and hydrates thereof.


The invention described herein pertains to processes for the preparation of macrolide antibacterial agents. In particular, the invention pertains to processes for preparing macrolides and ketolides from erythromycin A.


Compounds, compositions, methods, and uses are described herein for the treatment of respiratory diseases, including cystic fibrosis. Inhalation formulations of macrolide antibiotics are also described herein. The treatment of bacterial infections continues to be an important endeavor of pharmaceutical research and development. The specter of bacterial resistance to currently available antibiotics is ever-present, and accordingly, new and improved compounds, pharmaceuticals formulations, treatment methods, and treatment protocols are needed.


The invention described herein relates to processes for preparing ketolide antibacterial agents. In particular, the invention relates to intermediates and processes for preparing ketolides that include a 1,2,3-triazole substituted side chain.


Patent
Cempra | Date: 2015-09-21

New crystalline forms of macrolide compounds, and pharmaceutical compositions thereof, are described herein. In addition, processes for preparing the crystalline forms are described herein.


Patent
Cempra | Date: 2015-05-29

Use of macrolide and ketolide antibiotics for the treatment of acute exposure and diseases caused by biodefense pathogens is described.


Patent
Cempra | Date: 2016-06-15

Use of macrolide and ketolide antibiotics for the treatment of acute exposure and diseases caused by biodefence pathogens is described.

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