CEM Corporation

Matthews, NC, United States

CEM Corporation

Matthews, NC, United States
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Patent
CEM Corporation | Date: 2017-03-15

A volatile content analysis instrument (20) is disclosed that includes a cavity (25) and a microwave source (33) positioned to produce and direct microwaves into the cavity (25) at frequencies other than infrared frequencies. A balance (44) is included with at least the balance pan (or platform) (30) in the cavity (25). An infrared source (54) is positioned to produce and direct infrared radiation into the cavity (25) at frequencies other than the microwave frequencies produced by the microwave source (33). A lens (32) is positioned between the infrared source (54) and the balance pan (30) for more efficiently directing infrared radiation to a sample on the balance pan (30). The lens (32) has dimensions that preclude microwaves of the frequencies produced by the source (33) and directed into the cavity (25) from leaving the cavity (25).


Patent
CEM Corporation | Date: 2016-12-30

An instrument and method for high pressure microwave assisted chemistry are disclosed. The method includes the steps of applying microwave radiation to a sample in a sealed vessel while measuring the temperature of the sample and measuring the pressure generated inside the vessel and until the measured pressure reaches a designated set point, opening the vessel to release gases until the pressure inside the vessel reaches a lower designated set point, closing the vessel, and repeating the steps of opening the vessel at designated pressure set points and closing the vessel at designated pressure set points to the sample until the sample reaction reaches a designated high temperature. The designated set points can controllably differ from one another as the reaction proceeds. Microwave energy can be applied continuously or intermittently during the opening and closing steps. The apparatus includes a microwave cavity, a microwave transparent pressure resistant reaction vessel in the cavity, a cap on the reaction vessel, a pressure sensor for measuring pressure in the vessel, a temperature sensor, and means for opening and closing the cap at predetermined pressure set points measured by the pressure sensor to release pressure from the vessel.


A precision volumetric liquid dispensing instrument is disclosed that includes two pressure sensors and a fluid passageway with a defined volume portion in communication with the two sensors for receiving and distributing liquid in relatively small volumes. One of the pressure sensors is positioned to measure pressure at one portion of the defined volume portion of the fluid passageway and the other of the gas pressure sensors is positioned to measure gas pressure at a different portion of the defined volume portion of the passageway. At least one valve is in communication with the passageway for moving fluids into or out of the defined volume portion of the fluid passageway, and a processor carries out a step selected from the group consisting of (i) calculating the volume of the liquid based upon the measured pressure and (ii) metering a liquid into the defined volume portion of the fluid passageway until the measured pressure indicates that a desired volume of fluid is in the fluid passageway.


Patent
CEM Corporation | Date: 2016-10-21

An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.


Patent
CEM Corporation | Date: 2015-11-03

A volatile content analysis instrument is disclosed that includes a cavity and a microwave source positioned to produce and direct microwaves into the cavity at frequencies other than infrared frequencies. A balance is included with at least the balance pan (or platform) in the cavity. An infrared source is positioned to produce and direct infrared radiation into the cavity at frequencies other than the microwave frequencies produced by the microwave source. A lens is positioned between the infrared source and the balance pan for more efficiently directing infrared radiation to a sample on the balance pan. The lens has dimensions that preclude microwaves of the frequencies produced by the source and directed into the cavity from leaving the cavity.


A precision volumetric liquid dispensing instrument is disclosed that includes two pressure sensors and a fluid passageway with a defined volume portion in communication with the two sensors for receiving and distributing liquid in relatively small volumes. One of the pressure sensors is positioned to measure pressure at one portion of the defined volume portion of the fluid passageway and the other of the gas pressure sensors is positioned to measure gas pressure at a different portion of the defined volume portion of the passageway. At least one valve is in communication with the passageway for moving fluids into or out of the defined volume portion of the fluid passageway, and a processor carries out a step selected from the group consisting of (i) calculating the volume of the liquid based upon the measured pressure and (ii) metering a liquid into the defined volume portion of the fluid passageway until the measured pressure indicates that a desired volume of fluid is in the fluid passageway.


Patent
CEM Corporation | Date: 2016-03-30

In a method for transferring precise small volumes of liquids (54, 64), the pressure in a defined volume portion (14) of a fluid passageway (12) is measured by means of two pressure sensors in fluid communication with the defined volume portion. A liquid (54, 64) is then added to the defined volume portion of the fluid passageway until the measured pressure indicates that a predetermined volume of liquid has been transferred into the passageway. The measured volume of liquid can then be transferred from the fluid passageway to a reactor (13). The invention has particular utility for chemical reactions carried out using complex manipulations (e.g. combinatorial chemistry) or the synthesis of complex compositions such as peptides. Using solid phase peptide synthesis (SPPS).


A precision volumetric liquid dispensing instrument is disclosed that includes two pressure sensors (10, 11) and a fluid passageway (12) with a defined volume portion (14) in communication with the two sensors for receiving and distributing liquid in relatively small volumes. One of the pressure sensors is positioned to measure pressure at one portion of the defined volume portion of the fluid passageway and the other of the gas pressure sensors is positioned to measure gas pressure at a different portion of the defined volume portion of the passageway. At least one valve (15, 16) is in communication with the passageway for moving fluids into or out of the defined volume portion of the fluid passageway, and a processor (17) carries out a step of:(i) calculating the volume of the liquid based upon the measured pressure and/or(ii) metering a liquid into the defined volume portion of the fluid passageway until the measured pressure indicates that a desired volume of fluid is in the fluid passageway.


Patent
CEM Corporation | Date: 2015-03-18

A method of determining an amount of at least one component of a sample comprises positioning the sample in an NMR instrument having an interior magnetic field, applying at least one sequence of first /2 and second radio-frequency pulses to the sample using the NMR instrument, each respective second pulse being applied before the free induction signal from the first /2 pulse has fully decayed, measuring the amplitude of each first signal produced by the application of each first radio-frequency pulse to determine an FID value, measuring the amplitude of each second signal produced by the application of each second radio-frequency pulse to determine a Spin Echo value and determining the amount of at least one component of the sample by subtracting the Spin Echo value from the FID value.


An improved method for coupling carboxylic acids and amines is disclosed that includes the steps of combining a hyper-acid sensitive linker connecting an amine and a resin, a carboxylic acid, a carbodiimide, an activator additive, and a base; and carrying out the activation and coupling at a temperature greater than 30C.

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