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News Article | May 4, 2017
Site: www.enr.com

An unmanned aerial vehicle (UAV) equipped with light detection and ranging (LiDAR) technology is being tested to document cut-and-fill work on a $74-million interchange in Contra Costa County, Calif. With an equipment cost of about $150,000, the drone’s high-resolution data-capture technology will monitor the movement of 150,000 cu yd of fill, ensuring the estimated $1-million to $2-million worth of earthwork goes as efficiently as possible. “Five years ago, there was no way we could have put LiDAR on a UAV,” says Ed Greutert, principal engineer with Alta Vista Solutions, which proposed testing the technology to the Contra Costa County Transportation Authority (CCTA). “Now, a number of manufacturers are making units that are far more advanced, weighing 4 kilograms [8 lb,13 oz] or less.” A French company, Yellowscan, provides the LiDAR. Weighing 3.5 pounds and consuming 15 watts of power, the device has a precision rate of 4 sq centimeters and boasts 5-sq-cm accuracy. The scans will be used to compare contractor performance versus the plan and identify potential areas of project and performance risk. The data will be used to verify fill-invoice amounts, track materials inventory, and support project scheduling and change-order documentation. It also will be used to monitor stormwater runoff and other environmental conditions, as well as identify potential safety risks and evaluate changes in existing structures that may be introduced during construction. Gathering the unusually high-resolution data initially involved the drone operator repeatedly adjusting to find the optimal height and speed in a trial-and-error process. “I’d say the biggest challenge we had is collecting the data we need to generate a bare-earth digital service model,” says Greutert. “During the first month, the data was not dense enough to use for our purposes.” Another challenge is handling the massive amounts of information. “We collected 100 gigabytes of LiDAR data,” says Greutert. “Moving that around and processing it … can take several hours or overnight. Then, you tweak something and rerun the model.” To be collected over the course of the two-year project in Brentwood, the data are expected not only to maximize efficiency of the earthmoving but also help the public to see each stage of construction, says Randell Iwasaki, executive director at CCTA. “Aerial views are hard to come by. Now, we can get a video of the progress of our project. We can take a look at environmentally sensitive areas. We can show that nobody’s in there—that we are treating those areas as promised. We can ‘fly a job’ after it rains to make sure the [runoff] control systems are working as they should.” Moreover, Iwasaki adds, using the drone means surveyors don’t have to stand in live traffic in harm’s way. “We are always looking for ways to be efficient and safer,” Iwasaki says. “Drones offer a golden opportunity. We can gather enough info from a drone, sensors, etcetera, so we know the taxpayers are getting their money’s worth.” The CCTA last fall awarded the $37-million construction contract to a joint venture of Brosamer & Wall Inc. and Bay Cities Paving & Grading. The project is the concluding chapter of the Highway 4 program, a $1-billion endeavour to improve mobility in the region.


News Article | July 25, 2017
Site: www.businesswire.com

LIVERMORE, Calif.--(BUSINESS WIRE)--Comcast Business today announced it is one of the providers awarded a contract by the state of California’s Department of Technology (CDT) through its CALNET Telecommunications Program to begin contracting with public agencies to support their business requirements. As a result of becoming an authorized CALNET provider, Comcast Business is now able to offer Category 3 Ethernet Services and Category 5 Internet Services to more than 2,000 state and non-state agencies. The CDT is focused on providing services that meet the State’s complex and critical telecommunications and network business needs. The CALNET Telecommunications Program accomplishes this through oversight, statewide policy, and a suite of statewide, competitively bid telecommunications contracts used by both state and local public agencies. The purpose of CALNET is to make it easier for municipalities to work with service providers like Comcast Business that have multi-service offerings. “Being able to offer Comcast Business services to thousands of potential customers who had been hungry for more choices provides a great opportunity for us,” said Mark O’Leary, Vice President of Government and Education for Comcast Business. “We can now leverage our array of specialties including our advanced network, Ethernet and Internet services, and other features to give these agencies the opportunity to future proof their networks with more speed, scalability and efficiency. We look forward to developing new relationships and helping to improve the State’s ability to meet their strategic network goals and to better support their constituents.” With agencies able to contract with Comcast Business and other service providers, there are more services from which higher education institutions, K-12 schools, state agencies, and cities and counties across California can benefit. “Our advocacy for fair, technology neutral, broadband and communication policy in the state reflects our understanding that fiber and broadband services are determinant factors in an organization’s success or failure,” said Carolyn McIntyre, California Cable & Telecommunications Association (CCTA). “With agencies now able to select services from Comcast Business and others to make the best decision for their uniquely-run department, it is a big win for the state of California and ensures state and local agencies have the technological services they need to run optimally.” For more information, please visit https://calnet.b2.app.cloud.comcast.net/Index.html Comcast Business offers Ethernet, Internet, Wi-Fi, Voice, TV and Managed Enterprise Solutions to help organizations of all sizes transform their business. Powered by an advanced network, and backed by 24/7 customer support, Comcast Business is one of the largest contributors to the growth of Comcast Cable. Comcast Business is the nation’s largest cable provider to small and mid-size businesses and has emerged as a force in the Enterprise market; recognized over the last two years by leading industry associations as one of the fastest growing providers of Ethernet services. For more information, call 866-429-3085. Follow on Twitter @ComcastBusiness and on other social media networks at http://business.comcast.com/social. Comcast Cable is one of the nation's largest video, high-speed Internet and phone providers to residential customers under the XFINITY brand and also provides these services to businesses. Comcast has invested in technology to build an advanced network that delivers among the fastest broadband speeds, and brings customers personalized video, communications and home management offerings. Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company. Visit www.comcastcorporation.com for more information.


News Article | July 25, 2017
Site: www.businesswire.com

LIVERMORE, Calif.--(BUSINESS WIRE)--Comcast Business today announced it is one of the providers awarded a contract by the state of California’s Department of Technology (CDT) through its CALNET Telecommunications Program to begin contracting with public agencies to support their business requirements. As a result of becoming an authorized CALNET provider, Comcast Business is now able to offer Category 3 Ethernet Services and Category 5 Internet Services to more than 2,000 state and non-state agencies. The CDT is focused on providing services that meet the State’s complex and critical telecommunications and network business needs. The CALNET Telecommunications Program accomplishes this through oversight, statewide policy, and a suite of statewide, competitively bid telecommunications contracts used by both state and local public agencies. The purpose of CALNET is to make it easier for municipalities to work with service providers like Comcast Business that have multi-service offerings. “Being able to offer Comcast Business services to thousands of potential customers who had been hungry for more choices provides a great opportunity for us,” said Mark O’Leary, Vice President of Government and Education for Comcast Business. “We can now leverage our array of specialties including our advanced network, Ethernet and Internet services, and other features to give these agencies the opportunity to future proof their networks with more speed, scalability and efficiency. We look forward to developing new relationships and helping to improve the State’s ability to meet their strategic network goals and to better support their constituents.” With agencies able to contract with Comcast Business and other service providers, there are more services from which higher education institutions, K-12 schools, state agencies, and cities and counties across California can benefit. “Our advocacy for fair, technology neutral, broadband and communication policy in the state reflects our understanding that fiber and broadband services are determinant factors in an organization’s success or failure,” said Carolyn McIntyre, California Cable & Telecommunications Association (CCTA). “With agencies now able to select services from Comcast Business and others to make the best decision for their uniquely-run department, it is a big win for the state of California and ensures state and local agencies have the technological services they need to run optimally.” For more information, please visit https://calnet.b2.app.cloud.comcast.net/Index.html Comcast Business offers Ethernet, Internet, Wi-Fi, Voice, TV and Managed Enterprise Solutions to help organizations of all sizes transform their business. Powered by an advanced network, and backed by 24/7 customer support, Comcast Business is one of the largest contributors to the growth of Comcast Cable. Comcast Business is the nation’s largest cable provider to small and mid-size businesses and has emerged as a force in the Enterprise market; recognized over the last two years by leading industry associations as one of the fastest growing providers of Ethernet services. For more information, call 866-429-3085. Follow on Twitter @ComcastBusiness and on other social media networks at http://business.comcast.com/social. Comcast Cable is one of the nation's largest video, high-speed Internet and phone providers to residential customers under the XFINITY brand and also provides these services to businesses. Comcast has invested in technology to build an advanced network that delivers among the fastest broadband speeds, and brings customers personalized video, communications and home management offerings. Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company. Visit www.comcastcorporation.com for more information.


News Article | August 2, 2017
Site: www.prweb.com

Pavia Systems, the leading software and technology firm focused exclusively on infrastructure construction, announced today it has entered into a partnership with the Contra Costa County Transportation Authority (CCTA). CCTA will use the HeadLight Project Intelligence platform on a $71.3 million dollar project to place an interchange on a major highway to ease traffic congestion. Pavia Systems’ HeadLight platform enables transportation project inspectors and engineers to collect real-time project data including photo and video capabilities, equipment and personnel tracking, and automatic geolocation and timestamping for quick and comprehensive documentation of project activities to aid communication and risk mitigation. “Pavia Systems’ HeadLight software has transformed the way we manage our infrastructure projects,” said Ivan Ramirez, CCTA manager. “HeadLight helps us stay ahead of issues, keep on schedule and make more effective decisions through accurate data collection. We have already decided to expand our use of  HeadLight on two future CCTA  projects taking place on I-680.” The CCTA interchange project, called the Balfour Project, was started in February 2017 and will add an interchange on SR 4 that will ease traffic congestion for the cities of Brentwood, Antioch and Oakley. The road currently has stop lights which results in traffic congestions and delays. With help from the HeadLight platform, the Balfour Project is currently 20 percent complete and on schedule to be completed by the end of 2018. The California-based transportation authority met with Pavia Systems prior to the project start in hopes of finding ways to improve the way it manages project inspection and contract administration processes. Since implementation of five HeadLight units, CCTA has seen increases in efficiency, due to the ability for one inspector to collect three times more information per day compared to pen and paper methods. The improvement in quality and quantity of information collected is crucial to the overall management of CCTA’s construction projects. “Pavia Systems is proud to partner with proactive and forward-thinking leaders like Contra Costa County,” said Si Katara, President and Co-Founder of Pavia Systems. “CCTA’s proactive use of HeadLight shows its commitment to safer, more efficient work environments. This is precisely the reason we created the HeadLight Project Intelligence Platform.” Pavia Systems collaborated with industry experts to develop the HeadLight platform as a tool for transportation construction teams to increase productivity and prevent losses. The product addresses communication issues critical to the success of infrastructure projects. By increasing collaboration with the contractor and maintaining open dialog with stakeholders from day one, HeadLight helps to minimize risks and save money. About Pavia Systems Inc. Pavia Systems, Inc., founded in 2005, is a technology company delivering Project Intelligence to transportation construction teams through its core platform, HeadLight. The platform helps clients accelerate delivery, reduce risk and increase accountability of construction projects by streamlining and mobilizing project inspections, communications, and documentation. The HeadLight platform has been used on more than $10 billion worth of transportation construction projects nationwide. Customers include large departments of transportation, top-tier consulting engineering firms, contractors, equipment manufacturers, and industry-related materials companies. For more information, please visit http://www.paviasystems.com/.


News Article | July 19, 2017
Site: www.businesswire.com

SAN FRANCISCO & LAUSANNE, Switzerland--(BUSINESS WIRE)--BestMile formalizes its advisory board by appointing two outstanding industry leaders to support its rapid growth, Christopher Choa and Randell Iwasaki. Randell Iwasaki was appointed as the Executive Director of the Contra Costa Transportation Authority (CCTA) in 2010. Prior to working at the CCTA, he worked for the California Department of Transportation for 27 years and his last position was appointed by Governor Schwarzenegger to be Director of the Department. He was recently named one of the top 10 public sector transportation innovators by ENO Transportation. One of the most high profile ventures tributed to Iwasaki is the opening of GoMentum Station, the largest secure proving grounds for autonomous vehicles in the US. In 2013, he was inducted into the ITS America Hall of Fame in recognition of his ability to deliver innovative ITS solutions for California’s transportation system. Christopher Choa, a native New Yorker, leads AECOM’s Cities practice out of London. He works with cities and national governments to develop regional-scale strategies and improve urban performance. A graduate of both Harvard and Yale, Christopher is a Global Trustee of the Urban Land Institute and Chair of Urban Land Institute/UK. He is an appointed advisor to the Mayor of London’s Infrastructure Delivery Board, and an external advisor for the Sustainable Urban Development program at Oxford. “Christopher and Randell are remarkable businessmen with exemplary careers and a broad knowledge of their industry. Their expertises are complementary and reflect the cross-sectoral nature of the autonomous mobility revolution.” explains BestMile’s CEO, Raphael Gindrat. Having ambitious plans to continue improving our technology, it is more important than ever to have individuals of this caliber on board. We are incredibly fortunate to be able to leverage their knowledge to guide the company and provide immediate, long lasting impact on BestMile”. The nomination of an Advisory Board strengthens BestMile’s ability to match the rapid expansion of the autonomous mobility market. The Board will influence BestMile’s long-term strategic growth and product vision as well as actively exchange best practices. The choice of advisors signals the company’s commitment to building the best possible platform for the operation and optimization of autonomous mobility services worldwide with a complete and deep understanding of the industry's needs. “It is a great opportunity to be part of a company that provide technology that truly leverage the potential of autonomous vehicles to transform the way we move in cities. Autonomous mobility will have a drastic impact on sustainable urban development and BestMile will have an instrumental part to play” points out Christopher Choa. “I'm looking forward to serve on BestMile's Advisory Board and share knowledge and experience to help fuel their growth. BestMile is leading the way in empowering existing and new transportation providers to profit from autonomous mobility to expand and transform their businesses.” says Randell Iwasaki. BestMile commercializes the first vehicle agnostic platform allowing for the intelligent operation and optimization of autonomous mobility services, both fixed-route and on-demand. The company allows autonomous vehicles to work together as a coordinated fleet and enables mobility providers to deploy, operate and scale autonomous mobility services.


(PRLEAP.COM) JUNE 15, 2017 - CONCORD, Calif. – First Transit announces that it has signed an agreement as the exclusive transit operator partner at GoMentum Station. The partnership will foster research and innovation in the field of shared autonomous vehicle (SAV) application and technology research.First Transit will join GoMentum Station and use the facility as a test site for innovative transit applications, including a pilot project with EasyMile and the Contra Costa Transportation Authority (CCTA) to deploy the first SAV shuttle on public roads in the United States. This pilot project, which began in late 2016, recently launched the second phase of testing at Bishop Ranch, an office park in San Ramon, California.First Transit is responsible for providing staffing, maintenance and operational support for the two SAV shuttles during the testing and deployment phases of the program."The partnership with GoMentum Station allows us to identify new mobility solutions for our customers using SAV technology," said Brad Thomas, president of First Transit. "We see the broad application of SAV technology as a great first and last mile solution plus countless other transportation challenges."GoMentum Station in Concord, California, is a 5,000-acre test facility where the CCTA and its partners are accelerating the next generation of transportation technologies. Named by the U.S. Department of Transportation as one of ten federally designated automated vehicle proving grounds, GoMentum Station is the largest secure test track of its kind."As a leader in innovative transportation solutions, we are proud to have First Transit as one of our exclusive collaboration partners at GoMentum Station," said Randell Iwasaki, Executive Director of CCTA. "The partnership with First Transit expands the international reach of GoMentum Station, and will provide a unique opportunity for multi-modal testing with a firm that specializes in transit operations. This will enable us to explore how automated vehicles can complement and enhance existing mobility options."About First Transit:First Transit, Inc. has 60 years of experience and is one of the largest private-sector providers of mobility solutions in North America moving more than 350 million passengers annually. First Transit, Inc. provides operation, management and consulting for more than 300 locations in 39 states, Canada, Puerto Rico, Panama and India for transit authorities, state departments of transportation, municipalities, hospitals, universities and private companies. First Transit employs more than 19,500 dedicated transit professionals. For additional information, please visit FirstTransit.com About GoMentum Station:GoMentum Station in Concord, California is where the Contra Costa Transportation Authority leads and facilitates a collaborative partnership among multiple automobile manufacturers; original equipment manufacturers and Tier 1 suppliers; communications suppliers; technology companies; researchers and academia; public agencies and other partners. At GoMentum Station, technology, innovation and commercialization will converge to define the next generation of transportation network infrastructure. More information about GoMentum Station is available at gomentumstation.net About EasyMile:EasyMile is a joint venture between a vehicle manufacturer (Ligier Group) and a high tech company specializing in services robotics (Robosoft). The company provides shared driverless transportation for the last mile that complements mass transportation solutions. This 'green' service addresses short distances that are too long to walk to, from a transport hub to a final destination where cars are either 'off limits' or where parking space is limited or non-existent. It also provides a service for short distances within confined sites. EasyMile autonomous vehicles operate either on demand or follow a set route calling at all stations.About the Contra Costa Transportation Authority:The Contra Costa Transportation Authority (CCTA) is a public agency formed by Contra Costa voters in 1988 to manage the county's transportation sales tax program and oversee countywide transportation planning efforts. CCTA is responsible for planning, funding and delivering critical transportation infrastructure projects and programs that connect our communities, foster a strong economy, increase sustainability, and safely and efficiently get people where they need to go. CCTA also serves as the county's designated Congestion Management Agency, responsible for putting programs in place to keep traffic levels manageable. More information about CCTA is available at ccta.net


News Article | May 12, 2017
Site: www.prweb.com

Mediaplanet today announces the launch of this May’s edition of “Clinical Trials.” This campaign will educate doctors, physicians, nurses, and allied healthcare professionals on the benefits of conducting a clinical trial, while honing in on the proper and most effective ways to improve the process, ultimately leading to an increase in completed trials, treatments, and live saving discoveries. Only around 32% of drugs have a probability into making it to phase 3 trials, and only 1 in 10 drugs actually make it to the market. This means that the time, effort, and dollars that are being spent (800k-1.4B) for clinical trials are not panning out as plan, which causes hesitation in their conduction. There are several factors leading to the incompletion of a clinical trial. Ensuring the clinical trial is planned properly, leads to a higher success rate of the trial.The need for more participants and better planned clinical trials is crucial. The print component of “Clinical Trials” is distributed within today’s edition of USA Today in New York, Boston, Washington/Baltimore, Phoenix, and the Carolinasmarkets, with a circulation of approximately 250,000 copies and an estimated readership of 750,000. The digital component is distributed nationally, through a vast social media strategy, and across a network of top news sites and partner outlets. To explore the digital version of the campaign, click here. Cancer survivor and clinical trial activist T.J. Share graces the cover of the print publication. Through an exclusive interview on the interior, T.J. shares his story on how participating in clinical trials saved his life. T.J. talks about the power of clinical trials and how others can educate themselves on these life-saving studies. T.J. encourages all to consider clinical trials as an option, he says “when it comes down to it, we are all patients at some point, so we should know what all of our options are before making a decisions.” This campaign was made possible with the support of the Center for Information on Clinical Research Participation (CISCRP), Association of Clinical Research Professionals (ACRP), Coalition for Clinical Trials Awareness(CCTA), Clinical Trials Transformation Initiative (CTTI), QST Consultations, TransCelerate BioPharma Inc., Biogen, Merck, Pfizer, Janssen, CureForward, and PerkinElmer. About Mediaplanet  Mediaplanet specializes in the creation of content marketing campaigns covering a variety of industries. We tell meaningful stories that educate our audience and position our clients as solution providers. Our unique ability to pair the right leaders with the right readers, through the right platforms, has made Mediaplanet a global content marketing powerhouse. Our award-winning stories have won the hearts of countless readers while serving as a valuable platform for brands and their missions. Just call us storytellers with a purpose. Please visit http://www.mediaplanet.com for more on who we are and what we do.


REDWOOD CITY, Calif.--(BUSINESS WIRE)--HeartFlow, Inc. today announced that Blue Cross Blue Shield (BCBS) Association’s Evidence Street has issued a positive healthcare evidence review of the Company’s HeartFlow® FFRct. This non-invasive technology is the first to provide insight into both the extent of coronary artery disease (CAD) and the impact the disease has on blood flow to the heart. It combines anatomic information from a coronary CT angiogram and physiology from HeartFlow FFRct to enable clinicians to select an appropriate and personalized treatment for each patient. The Evidence Street review assessed the technical performance, diagnostic accuracy and clinical utility of HeartFlow FFRct and determined that it provides a meaningful improvement in net health outcome when used to guide the care of patients with stable chest pain who are at intermediate risk of CAD and are being considered for invasive coronary angiography. “This marks a major milestone achievement for HeartFlow and our FFRct technology because BCBS’s Evidence Street is among the world’s most rigorous health technology assessments and has significant global reach and influence,” said John H. Stevens, M.D., chief executive officer of HeartFlow. “With BCBS insuring one in three Americans, substantially more patients with suspected CAD in the United States who are part of BCBS plans will be able to access this innovative non-invasive technology. HeartFlow FFRct also could now more rapidly become the standard of care, potentially improving clinical outcomes and saving global healthcare systems billions of dollars annually.” Evidence Street provides healthcare technology evaluations for the BCBS Association, a national federation of 36 independent, community-based and locally operated Blue Cross and Blue Shield companies that collectively provide healthcare coverage for 105 million Americans. Evidence Street’s assessment of HeartFlow FFRct, which is summarized in a 19-page report, concluded that “CCTA (coronary CT angiogram) with a selective FFRct strategy would likely lead to changes in management that would be expected to improve health outcomes by further limiting unnecessary ICA (invasive coronary angiography) testing.” Evidence Street joins a growing number of organizations that support the use of HeartFlow FFRct as part of the diagnostic and treatment pathway for CAD. Several payers, including Aetna, which covers more than 46 million lives, have issued positive coverage decisions. In February, the National Institute for Health and Care Excellence (NICE) of the U.K.’s National Health Service, which covers 59 million lives, issued positive guidance, recommending the technology to help determine the cause of stable chest pain in patients. NICE concluded that HeartFlow FFRct is safe, has a high level of diagnostic accuracy, and may avoid the need for invasive coronary angiography, which is associated with risks. NICE further concluded that, compared to all other tests, use of HeartFlow FFRct is the most cost-effective solution as it avoids unnecessary invasive tests and treatment. Additionally, the American College of Cardiology (ACC) and American Heart Association (AHA) recently released updated Appropriate Use Criteria for Coronary Revascularization in Patients with Stable Ischemic Heart Disease, which include the use of HeartFlow FFRct by healthcare providers in determining the appropriateness of revascularizations in many clinical scenarios. The HeartFlow FFRct process starts with data from a standard, non-invasive coronary CT angiogram from a patient. Leveraging deep learning, an advanced form of artificial intelligence, HeartFlow creates a personalized 3D model of the patient’s arteries. Powerful computer algorithms then solve millions of complex equations to simulate blood flow and assess the impact of blockages in the arteries. With this actionable information, the physician can determine the right course of action for the patient. HeartFlow FFRct has received regulatory approval and is commercially available in the United States, Canada, Europe and Japan. To date, more than 10,000 patients have benefitted from this technology. Coronary artery disease (CAD), also called coronary heart disease, is the leading cause of death for both men and women around the world. CAD develops when the arteries leading to the heart narrow, often because plaque builds up in the vessel walls. Narrowing of the arteries can reduce blood flow to the heart, causing angina (chest pain), myocardial infarction (heart attack) and death. CAD is one of the costliest medical diseases in the world today. HeartFlow, Inc. is a personalized medical technology company seeking to transform the way cardiovascular disease is diagnosed and treated. The company’s HeartFlow FFRct is the first available non-invasive solution that enables a physician to more accurately evaluate whether a patient has significant coronary artery disease (CAD) based on both anatomy (from coronary CT angiogram) and physiology (from HeartFlow FFRct). The solution, which leverages deep learning to create a personalized 3D model of the patient’s arteries, is well positioned to become an integral part of the standard of care for patients who are at risk for CAD because of its potential to improve clinical outcomes, improve the patient experience, and reduce the cost of care. The HeartFlow FFRct is available in the United States, Canada, Europe and Japan. For more information visit www.heartflow.com.


News Article | February 21, 2017
Site: www.eurekalert.org

LOS ANGELES - (Feb. 21, 2017) - A new study suggests testosterone treatments may increase the risk of heart disease in older men. It found a 20% increase in arterial plaque among men aged 65 and older who received testosterone replacement therapy for a year, according to the study published today in the Journal of the American Medical Association (JAMA). The multicenter study followed 138 men enrolled in the Testosterone Trials (TTrials), a National Institutes of Health (NIH) funded clinical research trial to determine if testosterone treatment of men aged 65 and older will help their walking, vitality, sexual function, memory, blood count and cardiovascular risk. The researchers reported that the men who received a placebo had just a 1% rise in plaque volumes, while the men who received the testosterone treatments for a year had a 20% increase in total coronary and noncalcified plaque volumes as measured with coronary computed tomographic arteriography (CCTA). "Heart disease remains the No. 1 cause of death in the U. S., and measuring coronary artery atherosclerosis has become a most effective method for evaluating cardiovascular risk," said Matthew J. Budoff, MD, a cardiologist who is an LA BioMed lead researcher and the primary author of the study. "While physicians are increasingly prescribing testosterone replacement for their older male patients, recent studies had reached conflicting conclusions about the potential cardiovascular risks. This finding of a significant increase in plaque volumes among men undergoing testosterone treatments indicates they may face a potentially increased risk of heart disease. However, longer-term research is needed to determine the actual risk." Dr. Budoff was the principal investigator for the study, and Drs. Ronald Swerdloff and Christina Wang, endocrinologists who are also LA BioMed lead researchers, were also investigators and authors of the study. It is one of four studies published today from the TTrials, a coordinated group of seven trials conducted by a team of researchers from LA BioMed and 12 other medical centers in the U.S., in partnership with the National Institute on Aging. "While our previous research has found some benefits from testosterone treatments, this latest study should provide important guidance for physicians and their patients," said Dr. Budoff. "Men who have underlying coronary artery disease or studies showing elevated arterial plaque levels should discuss carefully with their physicians the benefits and risks of testosterone therapy before initiating it or continuing the therapy." These results indicate the need for a larger and longer trial to determine actual risk of testosterone replacement. The study is one of four studies examining testosterone therapy that were published today in JAMA and JAMA Internal Medicine. In addition to the LA BioMed researchers, the authors of this study are: Susan S. Ellenberg, PhD; Cora E Lewis, MD, MSPH; Emile R Mohler III, MD; Nanette K Wenger, MD, MACC, MACP, FAHA; Shalender Bhasin, MD; Elizabeth Barrett-Connor, MD; Alisa Stephens-Shields, PhD; Jane A Cauley, DrPH; Jill P Crandall, MD; Glenn R Cunningham, MD; Kristine E Ensrud, MD, MPH; Thomas M. Gill, MD; Alvin M Matsumoto, MD; Mark E Molitch, MD; Rine Nakanishi, MD; Negin Nezarat, MD; Suguru Matsumoto, MD; Xiaoling Hou, MS; Shehzad Basaria, MD; Susan J. Diem, MD, MPH; Denise Cifelli, MS, and Peter J. Snyder, MD. Founded in 1952, LA BioMed is one of the country's leading nonprofit independent biomedical research institutes. It has approximately 100 principal researchers conducting studies into improved treatments and therapies for cancer, inherited diseases, infectious diseases, illnesses caused by environmental factors and more. It also educates young scientists and provides community services, including prenatal counseling and childhood nutrition programs. LA BioMed is academically affiliated with the David Geffen School of Medicine at UCLA and located on the campus of Harbor-UCLA Medical Center. For more information, please visit http://www.


News Article | November 30, 2016
Site: www.sciencedaily.com

Researchers using coronary computed tomography angiography (CCTA) have found no association between light to moderate alcohol consumption and coronary artery disease (CAD).

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