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Benoit Y.,CBT SA | Sandoz J.-L.,Cbs Therapeutics, Inc. | Gasser J.-D.,CBT SA
WCTE 2016 - World Conference on Timber Engineering | Year: 2016

Non-destructive evaluation of in-field wood poles used in telecom and utilities overhead lines remains as a key issue for network managers. If existing tools all have their own methods to give an estimation of the residual status of individual poles, the goals are usually the same: Security: Keep only safe poles in the networks Costs: Change poles as infrequently as possible Productivity: Inspect as many poles as possible per day For many years, CBT has been working on the topic to achieve these goals. If the tool - called Polux - is considered as the reference on the market, the engineers have developed a newer generation which takes into account complementary parameters to strengthen its performances and ease its practical use in the field (such as improved ergonomics). This paper presents the development of the latest generation of the Polux device including the description of the new parameters taken into account for pole evaluation resulting in improved reliability.


Nourani C.F.,Akdmkrd DAI TU Beriln | Nourani C.F.,Cbs Therapeutics, Inc. | Lauth C.,Copenhagen Business School
Procedia Computer Science | Year: 2015

New optimality principles are put forth based on competitive model business planning. A Generalized MinMax local optimum dynamic programming algorithm is presented and applied to business model computing where predictive techniques can determine local optima. Based on a systems model an enterprise is not viewed as the sum of its component elements, but the product of their interactions. The paper starts with introducing a systems approach to business modeling. A competitive business modeling technique, based on the author's planning techniques is applied. Systemic decisions are based on common organizational goals, and as such business planning and resource assignments should strive to satisfy higher organizational goals. It is critical to understand how different decisions affect and influence one another. Here, a business planning example is presented where systems thinking technique, using Causal Loops, are applied to complex management decisions. Predictive modeling specifics are briefed. A preliminary optimal game modeling technique is presented in brief with applications to innovation and R&D management. Conducting gap and risk analysis can assist with this process. Example application areas to e-commerce with management simulation models are examined. © 2015 The Authors.


Huet T.,University of Strasbourg | Huet T.,Cbs Therapeutics, Inc. | Laverny G.,University of Strasbourg | Ciesielski F.,University of Strasbourg | And 11 more authors.
Cell Reports | Year: 2015

The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand-binding domain with 1,25(OH)2D3 or gemini analogs unveiled the molecular mechanism underlying ligand recognition. On the basis of structure-function correlations, we generated a point-mutated VDR (VDRgem) that isunresponsive to 1,25(OH)2D3, but the activity of which is efficiently induced by the gemini ligands. Moreover, we show that many VDR target genes are repressed by unliganded VDRgem and that mineral ion and bone homeostasis are more impaired in VDRgem mice than in VDR null mice, demonstrating that mutations abolishing VDR ligand binding result in more severe skeletal defects than VDR null mutations. As gemini ligands induce VDRgem transcriptional activity in mice and normalize their serum calcium levels, VDRgem is a powerful tool to further unravel both liganded and unliganded VDR signaling. © 2015 The Authors.


Abstract This study identifies and analyzes the effects of university/college graduates’ personal, household and employment characteristics as well as the relative attributes of their study and work locations on their college-to-work distances. The results illustrate that graduates are drawn to prospering regions with ample job opportunities, supposedly in order to advance their careers. Furthermore, we model and estimate the effect of college-to-work distance on college-to-residence and commuting distances. We find that graduates tend to choose their places of residence so as to balance their commuting distances and the distances to their previous places of study. © 2014, © 2014 Regional Studies Association.


Grant
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase I | Award Amount: 225.00K | Year: 2014

DESCRIPTION (provided by applicant): Recent studies of the applicants support the role of the endogenous gaseous biological mediator hydrogen sulfide (H2S) in colorectal cancer: selective upregulation of cystathionine-b-synthase (CBS) and the subsequent production of H2S in colonic cancer cells serves as a pro-survival factor by stimulating tumor cell bioenergetics, growth, proliferation, migration and invasion. This work identifies CBS as a novel antitumor target. In order to advance the clinical translation of this concept, we will pursue the following two Aims: Aim #1. To conduct screening a composite library of clinical drugs, drug-like compounds and pharmacologically active molecules (gt5,000 compounds) to identify novel pharmacological inhibitors of CBS, with the aim of drug repurposing for cancer therapy. In Aim #2, Inhibitors identified in the cell-based screen will subsequently enter specificity and selectivty screening, followed by bioenergetics studies and studies of tumor cell proliferation in


Rombouts J.V.K.,France Business School | Stentoft L.,Cbs Therapeutics, Inc.
Computational Statistics and Data Analysis | Year: 2014

Option pricing using mixed normal heteroscedasticity models is considered. It is explained how to perform inference and price options in a Bayesian framework. The approach allows to easily compute risk neutral predictive price densities which take into account parameter uncertainty. In an application to the S&P 500 index, classical and Bayesian inference is performed on the mixture model using the available return data. Comparing the ML estimates and posterior moments small differences are found. When pricing a rich sample of options on the index, both methods yield similar pricing errors measured in dollar and implied standard deviation losses, and it turns out that the impact of parameter uncertainty is minor. Therefore, when it comes to option pricing where large amounts of data are available, the choice of the inference method is unimportant. The results are robust to different specifications of the variance dynamics but show however that there might be scope for using Bayesian methods when considerably less data is available for inference. © 2013 Elsevier B.V. All rights reserved.


Hertzum M.,Roskilde University | Clemmensen T.,Cbs Therapeutics, Inc. | Hornbaek K.,Copenhagen University | Kumar J.,Indian Institute of Technology Guwahati | And 2 more authors.
International Journal of Human-Computer Interaction | Year: 2011

Whereas the concept of usability is predominantly defined analytically, people relate to systems through personal usability constructs. Based on 48 repertory-grid interviews, this study investigates how such personal constructs are affected by two factors crucial to the international development and uptake of systems: nationality (Chinese, Danish, or Indian) and stakeholder group (developer or user). We find no significant overall difference across nationalities, but further analyses suggest that conventional usability aspects such as ease of use and simplicity are prominent for Chinese and Danish but not Indian participants and that a distinction between work and leisure-related communication is central to Chinese and Indian but not Danish participants. For stakeholder groups, we find a significant overall difference between developers and users. Unlike developers, users associate ease of use with leisure and, conversely, difficulty in use with work-relatedness. Further, users perceive usefulness as related to frustration and separate from ease of use, whereas developers construe usefulness, fun, and ease of use as related. In construing usability, participants make use of several constructs that are not part of prevailing usability definitions, including usefulness, fun, and security. © Taylor & Francis Group, LLC.


Leander A.,Cbs Therapeutics, Inc.
Environment and Planning D: Society and Space | Year: 2016

This article looks closely at the politics of whitelists in commercial security. It argues that whitelists are essential for the current transformations in regulatory politics in which Codes of Conduct, Best Practices, Benchmarks and Standards are replacing more conventional, legally binding forms of regulation. The article traces how whitelists are tied to these transformations. The account is organized around how the practical, pragmatic and poetic character of lists (Umberto Eco) fashion the work and topological imprint (Manuel DeLanda) of whitelists in commercial security specifically. The article directs attention to the politics of the work and topological imprint of whitelists. This politics is neither hidden nor invisible yet it remains largely unnoted. It is dispersed, mundane and unspectacular. The whitelists are akin to minions whose activities are turning softly regulated commercial security into an infernal alternative (imagery borrowed from Pignarre and Stengers). As minions, whitelists appear insignificant when looked at in isolation. However, by describing their work as a decentralized, disjointed and disorganized group, this article shows their significance for the politics of regulation in commercial security. It advances a conceptualization of this politics and a theorization of its dynamics of relevance for engaging the politics of lists also elsewhere. © 2015, © The Author(s) 2015.


Harbers M.M.,National Institute for Public Health and the Environment | Verschuuren M.,National Institute for Public Health and the Environment | De Bruin A.,Cbs Therapeutics, Inc.
Archives of Public Health | Year: 2015

Background: The European Commission, together with the European Union (EU) Member States, developed a core set of indicators for monitoring public health in the EU, the European Core Health Indicators (ECHI) shortlist. From 2009 to 2012 developmental work on the ECHI indicators continued within the framework of the Joint Action for European Community Health Indicators and Monitoring (ECHIM). In this article, we give the current state of affairs on the availability of data for the ECHI indicators in the Netherlands and show what progress has been made over the past 5 years. The information provided serves as an illustration of the challenges encountered in a European country when working on harmonising national data collections with international data delivery requirements.Methods: To assess data availability, we consulted Dutch data experts and relevant websites and reports on health monitoring activities. We compared the available Dutch data with the definitions, preferred data sources and relevant dimensions as requested by ECHI.Results: The Netherlands can provide data for 66 of the 75 ECHI indicators for which availability could be assessed: for all of the 48 ECHI indicators that can be extracted from international databases and for 18 of the 27 indicators not available from international databases. Breakdowns by socio-economic status and region are not possible for 23 (35%) of the total of 66 indicators for which data are available and for 21 (32%) of these 66 indicators the definition is not exactly the same as requested by ECHIM. Since 2009, better estimates have become available for low birth weight, practising physicians and practising nurses.Moreover, several European initiatives to improve harmonised data collection are expected to have a positive effect on data availability for the Netherlands. Such initiatives should become sustainable in order to provide possibilities for monitoring trends. The scattered data ownership in the Netherlands complicates the coordination work for international data deliveries.Conclusion: Data availability in the Netherlands is good. Since 2009, several Dutch and European developments in harmonising data collection have contributed or will significantly contribute to improvements in the data situation for the ECHI indicators in the Netherlands. © 2015 Harbers et al.


de Goede M.,University of Amsterdam | Leander A.,Cbs Therapeutics, Inc. | Sullivan G.,University of Kent
Environment and Planning D: Society and Space | Year: 2016

This articles introduces the special issue on ‘The Politics of the List.’ We observe that lists proliferate as a technique of governance across multiple domains, including health, security, and commerce. We argue that it is important to take seriously the form and technique of the list itself and engage the knowledge practices, governance effects and ways of ordering the world that the list format enables. In other words, the special issue seeks to ‘remain in the register of the list,’ to unpack its technological arrangements and juridical power. This introduction sets out the key themes of this special issue, through discussing, in turn, the list as a technology of knowledge, the list as a technique of law and governance, the list's complex relation to space and the relation between the list and the digital. We draw on these four elements to characterise what we call the politics of the list in an era of complexity. © 2016, © The Author(s) 2016.

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