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Ettari R.,University of Milan | Pinto A.,University of Milan | Tamborini L.,University of Milan | Angelo I.C.,Messina University | And 10 more authors.
ChemMedChem | Year: 2014

Novel papain-family cathepsin L-like cysteine protease inhibitors endowed with antitrypanosomal and antimalarial activity were developed, through an optimization study of previously developed inhibitors. In the present work, we studied the structure-activity relationships of these derivatives, with the aim to develop new analogues with a simplified and more synthetically accessible structure and with improved antiparasitic activity. The structure of the model compounds was significantly simplified by modifying or even eliminating the side chain appended at the C3 atom of the benzodiazepine scaffold. In addition, a simple methylene spacer of appropriate length was inserted between the benzodiazepine ring and the 3-bromoisoxazoline moiety. Several rhodesain and falcipain-2 inhibitors displaying single-digit micromolar or sub-micromolar antiparasitic activity against one or both parasites were identified, with activities that were one order of magnitude more potent than the model compounds. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Bertocchi F.,University of Rome Tor Vergata | Nepravishta R.,University of Rome Tor Vergata | Nepravishta R.,Catholic University Our Lady of Good Counsel | Mandaliti W.,University of Rome Tor Vergata | Paci M.,University of Rome Tor Vergata
Applied Magnetic Resonance | Year: 2016

During a penal trial, it was requested to our laboratory to contribute the public minister prosecutor to study with a solid-state technique the effect of the time on a photographic negative and, eventually, to determine if the date of a certain photographic development can be located in a particular time range. It was important the determination of the time when a picture has been developed. Particularly, it was asked to define an estimate, more precisely possible, of the time elapsed from when the picture was taken assuming that it was close to the time of the processing of the negative of the photograph. The 13C cross polarization magic angle spinning nuclear magnetic resonance spectroscopy is known as a technique that is able to characterize the crystallinity of a sample. Among many materials, cellulose matrix is one whose crystallinity is more influenced on time. Assuming that after the wet development of the negative, the transformation of the crystallinity decreases upon time toward the amorphous state, it was possible, with a suitable reference scale, to obtain the approximate date of the development of the picture as required in the trial. This was possible by the preparation of a crystallinity reference scale obtained by photographic negatives developed at precise intervals along time. © 2016 Springer-Verlag Wien Source


La Rosa G.,National Institute of Health | Della Libera S.,National Institute of Health | Iaconelli M.,National Institute of Health | Donia D.,University of Rome Tor Vergata | And 4 more authors.
Journal of Medical Virology | Year: 2016

Human Bocavirus (HBoV) has been recently identified in association with acute viral gastroenteritis (AGE). The objective of this work was to investigate the prevalence of HBoV in children with AGE in Albania. Stool specimens collected from 142 children were analyzed by amplification of partial NP1 and Vp1/Vp2 genes. HBoV was detected in 13 samples (9.1%), 12 HBoV-1 and one HBoV-2. All HBoV-positive patients were co-infected with rotavirus and/or adenovirus, a finding which might indicate that there is no clear causal association of this agent with diarrhea. Further investigation is needed to assess the pathogenic role of HBoV in childhood diarrhea. © 2015 Wiley Periodicals, Inc. Source


Tortelli S.,CNR Institute of Neuroscience | Cavazzini M.,CNR Institute of Neuroscience | Orlandi S.,CNR Institute of Neuroscience | Pozzi G.,CNR Institute of Neuroscience | And 3 more authors.
Journal of Fluorine Chemistry | Year: 2016

Two peripherally octasubstituted zinc phthalocyanines (ZnPcs) bearing six alkoxy residues and two adjacent carboxylic acid anchoring groups were synthesized in order to assess the benefits deriving from the insertion of fluorocarbon domains at the periphery of ZnPc photosensitizers to be used in dye-sensitized solar cells (DSSCs). To this end the alkoxy substituents were terminated with tert-butoxy groups in one case and with perfluoro-tert-butoxy groups in the other. The two ZnPc analogs showed similar light absorption properties and both dyes were able to inject electrons into the conduction band of TiO2 upon photoexcitation. Interestingly, DSSCs based on the fluorous dye exhibited power conversion efficiency almost three times as high as that of its hydrocarbon analog (0.89% vs 0.34%), thus showing that the performance of devices based on ZnPcs can be significantly improved by coating the dye with an outer fluorous layer. © 2016 Elsevier B.V. Source


Nepravishta R.,University of Rome Tor Vergata | Nepravishta R.,Catholic University Our Lady of Good Counsel | Mandaliti W.,University of Rome Tor Vergata | Vallebona P.S.,University of Rome Tor Vergata | And 4 more authors.
Vitamins and Hormones | Year: 2016

Thymosinα1 is a peptidic hormone with pleiotropic activity, which is used in the therapy of several diseases. It is unstructured in water solution and interacts with negative regions of micelles and vesicles assuming two tracts of helical conformation with a structural flexible break in between. The studies of the interaction of Thymosinα1 with micelles of mixed dipalmitoylphosphatidylcholine and sodium dodecylsulfate and vesicles with mixed dipalmitoylphosphatidylcholine/dipalmitoylphosphatidylserine, the latter the negative component of the membranes, by 1H and natural abundance 15N NMR are herewith reported, reviewed, and discussed. The results indicate that the preferred interactions are those where the surface is negatively charged due to sodium dodecylsulfate or due to the presence of dipalmitoylphosphatidylserine exposed on the surface. In fact the unbalance of dipalmitoylphosphatidylserine on the cellular surface is an important phenomenon present in pathological conditions of cells. Moreover, the direct interaction of Thymosinα1 with K562 cells presenting an overexposure of phosphatidylserine as a consequence of resveratrol-induced apoptosis was carried out. © 2016 Elsevier Inc. Source

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