Sant'Agostino, Italy

The Università Cattolica del Sacro Cuore , known as UCSC or simply Cattolica, is an Italian private research university founded in 1921. The UCSC is the largest private university in Europe and the largest Catholic University in the world.Its main campus is located in Milan, Italy with satellite campuses in Brescia, Piacenza, Cremona, Rome, and Campobasso.The University is organized into 12 faculties and 7 postgraduate schools. Cattolica provides undergraduate courses , graduate courses and PhD programs . In addition to these, the University runs several double degree programs with other institutions throughout the world. Degrees are offered both in Italian and in English.UCSC has been granted five stars by QS Stars, a global university rating system, in the following fields: employability, teaching, facilities and engagement.Agostino Gemelli University Polyclinic serves as the teaching hospital for the medical school of the Università Cattolica del Sacro Cuore and owes its name to the university founder, the Franciscan friar, physician and psychologist Agostino Gemelli. Wikipedia.

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National Research Council Italy and Catholic University of the Sacred Heart | Date: 2017-04-26

An injectable apatite cement, in which the calcium in the a phase is partially substituted with strontium, and in which tricalcium phosphate in the phase is also present is described. Also described is a method for its preparation and its use in bone regeneration, in particular in vertebroplasty, in kyphoplasty, and in pathologies characterized by a loss of bone substance.

IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of radiation observed at distance from the irradiated metastatic site(s), and the effect of the tumour-specific immunocytokine L19-IL2 (watch our animation explaining the concept at Palliative treatment is the current standard of care for patients with metastatic non small cell lung cancer (NSCLC), unless there is an actionable mutation. By using the concept of limited metastatic disease (10 sites, WHO 0-1: oligo\) we aim to develop a therapy with curative intent. IMMUNOSABR will gather evidence for the clinical efficacy of our bi-modal treatment strategy in a multicentre randomised phase II study ( no. NCT02735850) in patients with limited metastatic NSCLC. IMMUNOSABR is complemented by two strong biomarker work packages which focus on developing an ambitious personalised biomarker strategy, to identify patients who can benefit from the novel treatment strategy. This includes promising non-invasive imaging techniques and state-of-the-art immunological monitoring approaches on tumour tissue and blood. IMMUNOSABR will spur further development of L19-IL2 as a commercial drug and translate the bi-modal treatment strategy towards clinical implementation.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-13-2015 | Award Amount: 6.43M | Year: 2016

MycoKey aims to generate innovative and integrated solutions that will support stakeholders in effective and sustainable mycotoxin management along food and feed chains. The project will contribute to reduce mycotoxin contamination mainly in Europe and China, where frequent and severe mycotoxin contaminations occur in crops, and where international trade of commodities and contaminated batches are increasing. MycoKey will address the major affected crops maize, wheat and barley, their associated toxigenic fungi and related mycotoxins (aflatoxins, deoxynivalenol, zearalenone, ochratoxin A, fumonisins). The project will integrate key information and practical solutions for mycotoxin management into a smart ICT tool (MycoKey App), providing answers to stakeholders, who require rapid, customized forecasting, descriptive information on contamination risk/levels, decision support and practical economically-sound suggestions for intervention. Tools and methodologies will be strategically targeted for cost-effective application in the field and during storage, processing and transportation. Alternative and safe ways to use contaminated batches will be also delivered. The focus of Mycokey will be: i) innovating communications of mycotoxin management by applying ICT, providing input for legislation, enhancing knowledge and networks; ii) selecting and improving a range of tools for mycotoxin monitoring; iii) assessing the use of reliable solutions, sustainable compounds/green technologies in prevention, intervention and remediation. The multi-disciplinary consortium, composed by scientific, industrial and association partners (32), includes 11 Chinese institutions and will conduct the 4 years programme in a framework of international networks.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-07b-2015 | Award Amount: 9.01M | Year: 2016

This aim of IMAGE is to enhance the use of genetic collections and to upgrade animal gene bank management. IMAGE will better exploit DNA information and develop methodologies, biotechnologies, and bioinformatics for rationalising animal genetic resources. It will demonstrate the benefits brought by gene banks to the development of sustainable livestock systems by: enhancing the usefulness of genetic collections to allow the livestock sector to respond to environment and market changes; using latest DNA technology and reproductive physiology for collecting, storing and distributing biological resources; Minimising genetic accidents such as abnormalities or genetic variability tipping points; Developing synergies between ex-situ and in-situ conservation to maximise resources for the future. To this end, the project will involve stakeholders, SME, and academic partners to achieve the following objectives. At the scientific level, the project will: Assess the diversity available in genetic collections; Search for adaptive traits through landscape genetics in local populations; Contribute to elucidate local populations and major genes history; Identify detrimental variants that can contribute to inbreeding depression; Predict cryobank samples reproductive performance; Facilitate the use of collections for genome-assisted breeding. At the technological level, it will develop: Procedures for harmonising gene bank operations and rationalising collections; Conservation and reproductive biotechnologies; A central information system to connect available data on germplasm and genomic collections. At the applied level, it will develop methods and tools for stakeholders to: Restore genetic diversity in livestock populations; Create or reconstruct breeds fitting new environmental constraints and consumer demands; Facilitate cryobanking for local breeds; Define and track breed-based product brands; Implement access and benefit sharing regulations.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-EJD | Phase: MSCA-ITN-2016 | Award Amount: 3.86M | Year: 2017

Expectations play a crucial role in determining the behaviour of many economic decision makers. The recent financial and economic crisis has highlighted the importance of expectation dynamics for economic development, the success of firm strategies and public policies. The Innovative Training Network ExSIDE aims at improving our understanding of the role of expectation formation and social influence for economic dynamics and for the optimal design of economic policy. This agenda will be pursued by combining an interdisciplinary research agenda with an innovative European joint doctoral training programme, which provides Early Stage Researchers with a broad range of expertise and skills needed for a thorough analysis of expectation formation processes and their role in Economics. Both the research projects and the training activities will combine work in Behavioural Economics, Psychoanalysis, Opinion Formation, Network Theory, Agent-based Simulation and Economic Modelling in different areas. The academic training will be complemented by extensive Transferable Skills Training Measures, Inter-Sectoral Training Measures, provided by non-academic partners, and Career Development Training. Interaction with stakeholders, policy makers and the general public will play an important role in pursuing the ExSIDE agenda and disseminating the results. The ExSIDE consortium consists of eight leading European universities and nine non-academic partners. Each Early Stage Researcher will be hosted by two universities, has a secondment with a non-academic partner and will graduate with a joint or double degree. The research and training in ExSIDE will ensure world-wide employability of the ExSIDE graduates inside and outside academia and will also boost the ability of European institutions and companies to develop efficient policies and strategies. ExSIDE will reinforce the establishment and long term sustainability of structured European joint doctoral programmes in Economics.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: DRS-03-2015 | Award Amount: 21.10M | Year: 2016

Effective EU support to a large external crisis requires new approaches. In response to this challenge and to identified user and market needs from previous projects, Reaching Out proposes an innovative multi-disciplinary approach that will optimize the efforts, address a wide spectrum of users and maximize market innovation success. This approach results in five main objectives: to 1. Develop a Collaborative Framework, with distributed platforms of functional services, 2. Implement a flexible and open collaborative innovation process involving users and SMEs, suppliers, operators and research organisations, 3. Develop, upgrade and integrate 78 new connectable and interoperable tools, 4. Conduct 5 large scale demonstrations on the field: o health disaster in Africa (Epidemics in Guinea, with strong social and cultural issues), o natural disaster in a politically complex region and a desert environment (Earthquake in the Jordan Valley, led jointly by Jordan, Israel and Palestine), o three global change disasters in Asia targeted at large evacuation and humanitarian support in Bangladesh (long lasting floods, huge storms and associated epidemics,), EU citizen support and repatriation in Shanghai (floods & storm surge), radiological and industrial disasters impacting EU assets in Taiwan (flash floods, landslides, storm surge and chemical and radiological disasters), supported and co-funded by local authorities, 5. Provide recommendations and evaluations for future legal and policy innovations. The project will be conducted under the supervision of senior end-users. It will be performed with flexible and proven procedures by a balanced consortium of users, industry, innovative SMEs, RTO and academia in the EU and the demonstration regions. The main expected impact is to improve external disaster and crisis management efficiency and cost-benefit and increase the EU visibility whilst enhancing EU industry competitiveness and enlarging the market.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SC1-HCO-06-2016 | Award Amount: 2.04M | Year: 2016

In order to strengthen the sustainability and resilience of health services and systems a unique consortium of governmental and funding organizations plus research institutes, has expressed the ambition to systematically learn from the organisation of care in other settings. Overall objective of TO-REACH is to provide groundwork for an ERA-NET that will contribute to the resilience, effectiveness, equity, accessibility and comprehensiveness of health services and systems. We will do so along two work streams: A) We will develop a research program on cross-border learning from good (or even innovative) models of care and the conditions needed to transfer them to other settings for implementation. It could refer to anywhere in the care chain depending on the priorities as identified in a Strategic Research Agenda (SRA) within this project. Conceptual, methodological and empirical advancement will be achieved through 4 meta-questions that will instruct research under the ERA-NET, linking to what counts as good models of care, what are the conditions required for transferability, what are the conditions for up-scaling, and how do they contribute to the performance of health care organisations and systems. B) We will build a platform for funding organizations that allows for collaboration and coordination in the project and projected ERA-NET. This will synchronize priorities and activities, hence improving the quality and applicability of research with a focus on the topic areas as described under A. TO-REACH will pursue five specific objectives: Mapping health system challenges and priorities by synthesizing different materials and stakeholder inputs; Developing a framework and providing a knowledge synthesis on the above-mentioned meta-questions; Establishing sustainable cooperation of research funding bodies and links with other initiatives; Developing a SRA through agenda setting at European and Member State level; Disseminating the results of TO-REACH.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FCT-16-2015 | Award Amount: 4.46M | Year: 2016

PROTON aims at improving existing knowledge on the processes of recruitment to organised crime and terrorist networks (OCTN) through an innovative integration between social and computational sciences. Moving beyond the state of the art, this integration will support evidence-based policies at the international, national and local level. To achieve its aim, PROTON will complete three specific objectives: 1. Investigate the social, psychological and economic factors leading to OCTN (WP1 and 2), including their connection with cybercrime and the cyberspace (WP3). The factors will be transformed into input (WP4) for PROTONs final outputs, PROTON-S and PROTON Wizard (WP5), designed for helping policy makers to act more effectively against OCTN. 2. Develop PROTON-S, agent-based modelling (ABM) simulations of the effects of different societal and environmental changes on OCTN. PROTON-S will generate virtual societies in a computer laboratory, enabling to test the impact of different scenarios on the evolution of, and particularly individuals recruitment to, OCTN. 3. Develop PROTON Wizard, a user-friendly software tool embedding the results of the ABM simulations. PROTONs impact will improve the quality of prevention policies on OCTN, providing at the same time significant innovations in the social, technological and computational sciences. PROTON-S, based on simulations, will bear no ethical and societal risks, and will create a breakthrough in the understanding of OCTN, enabling better policies and stimulating further innovation. PROTON Wizard will provide the first support tool for policy makers at the international, national and local level, giving easy access to the most advanced scientific research. The participation of different policy makers and potential end-users throughout the whole project will make sure that the final results specifically meet their needs and expectations.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.65M | Year: 2016

The ETN has two aims: to a) train ESRs; b) investigate the The History of Human Freedom and Dignity in Western Civilization. a) The ETN will establish an innovative training programme which allows the ESRs to obtain specialist knowledge of a specific research topic and to obtain transferable skills enabling the students to apply their knowledge in non-academic institutions, e.g. dealing with social welfare, human resources, or legal /political institutes. The training program includes acquiring transferable skills via courses and via secondments in non-academic partner organisations. b) The thesis of the research is that the concept of the ideal modern Western European human being has its roots far back in the history of philosophy and theology. This ideal human being has the right to think, believe, and express itself freely about all matters without fearing retribution, and to be treated as an autonomous and dignified individual. But such a conception is not shared by all and never was. Its long history has been formed through a continuous battle between two theological and philosophical traditions going back to Origen from Alexandria and Augustine of Hippo respectively. Origen saw humans as free, valuable and dignified beings, while Augustine saw them as predestined, sinful and bound to servitude. The network will investigate the reception and use of Origens ideas in order to provide a comprehensive and historically based understanding of these fundamental values, their origins, development and the fights they have gone through. Only then can we argue for their continued place in modern society. Such a project is highly relevant today, since the modern conception of humans is a fundamental pillar of Western democracies which is under pressure from both political and fundamentalist religious groups that question the societal structures building on ideas of humans freedom and dignity, and by global crises and structures that limit the individuals autonomy.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.89M | Year: 2017

Personalized health is a European priority and one of the strategic research areas for Horizon 2020. This project advances the state-of-the-art of personal health technologies for affective disorders, estimated to be the highest ranking cause of disease by 2020. It marks a significant shift from the current wearable technologies capturing emotional responses whose understanding usually requires physicians input, to low-cost self-help technologies for visualizing, exploring and regulating emotions. AFFECTIVA integrates the latest Human-Computer Interaction and Biomedical Engineering findings in designing and developing personal health systems for mental health, with the most influential outcomes and models of emotion regulation from Clinical Psychology. The overall aim is to support self-understanding and successful adoption of adaptive emotion regulation strategies in daily life. AFFECTIVA will contribute towards four significant outcomes: (1) wearable systems for capturing emotion regulation, (2) applications for understanding emotions and their regulatory processes, (3) interactive tools for training adaptive emotion regulation strategies, and (4) theoretical contributions to emotion regulation research in real life. AFFECTIVA builds on exceptional European and North American expertise from both academic and private sector to provide personalized health research with a timely and much needed momentum to address the pressing social challenge of emotional wellbeing and health.

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