Catholic University of the Maule
Talca, Chile

Catholic University of Maule is a university in Chile. It is a derivative university part of the Chilean Traditional Universities.This university was created in 1991, in what was the former Talca campus of the Pontifical Catholic University of Chile.Also has a campus in Curico. Wikipedia.

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Castillo-Retamal M.,Catholic University of the Maule
Work (Reading, Mass.) | Year: 2011

To identify methods used to assess physical activity and sedentary behaviour at the workplace and review the validity and reliability of these measures. Databases were searched for relevant published articles including MEDLINE, SPORT Discus, ProQuest and Google Scholar. Keywords used were physical-activity, workplace, sedentary-behaviour, measurement and questionnaire. Studies included were original, written in English, published between 1990 and 2009, and focused on validated physical activity and sedentary behaviour measures at work. Eleven papers were identified in which three used criterion standards, three objective measures, and five subjective measures. The most common method of data collection was through self-report, surveys or questionnaires. Physical activity measured with motion sensors, ranged from 4,422 to 10,334 steps/day (pedometers) and sedentary time ranged from 1.8 to 6 hours/day (h/d) (accelerometers). Self-report measures provided information relevant to the perception of physical activity at work (∼ 0.5 h/d), sitting time (> 3 h/d) and calculated energy expenditure (< 800 kcal/d). Physical activity levels at work were low while sedentary behaviour was high. This was largely a function of occupation (white-collar vs. blue-collar). None of the studies assessed validity or reliability of measures used however, instruments as assessed by others showed moderate to strong validity and reliability values.

Monsalve F.A.,University of Talca | Pyarasani R.D.,University of Talca | Delgado-Lopez F.,Catholic University of the Maule | Moore-Carrasco R.,University of Talca
Mediators of Inflammation | Year: 2013

Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is growing in the adult and pediatric populations. The most widely recognized metabolic risk factors are atherogenic dyslipidemia, elevated blood pressure, and elevated plasma glucose. Individuals with these characteristics commonly manifest a prothrombotic state and a proinflammatory state as well. Peroxisome proliferator-activated receptors (PPARs) may serve as potential therapeutic targets for treating the metabolic syndrome and its related risk factors. The PPARs are transcriptional factors belonging to the ligand-activated nuclear receptor superfamily. So far, three isoforms of PPARs have been identified, namely, PPAR-α, PPAR-β/δ, and PPAR-γ. Various endogenous and exogenous ligands of PPARs have been identified. PPAR-α and PPAR-γ are mainly involved in regulating lipid metabolism, insulin sensitivity, and glucose homeostasis, and their agonists are used in the treatment of hyperlipidemia and T2DM. Whereas PPAR-β/δ function is to regulate lipid metabolism, glucose homeostasis, anti-inflammation, and fatty acid oxidation and its agonists are used in the treatment of metabolic syndrome and cardiovascular diseases. This review mainly focuses on the biological role of PPARs in gene regulation and metabolic diseases, with particular focus on the therapeutic potential of PPAR modulators in the treatment of thrombosis. © 2013 Francisco A. Monsalve et al.

Wernstedt Asterholm I.,Touchstone Diabetes Center | Wernstedt Asterholm I.,Gothenburg University | Tao C.,Touchstone Diabetes Center | Morley T.S.,Touchstone Diabetes Center | And 5 more authors.
Cell Metabolism | Year: 2014

Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a fundamentally negative impact on metabolism, we show that proinflammatory signaling in the adipocyte is in fact required for proper adipose tissue remodeling and expansion. Three mouse models with an adipose tissue-specific reduction in proinflammatory potential were generated that display a reduced capacity for adipogenesis in vivo, while the differentiation potential is unaltered in vitro. Upon high-fat-diet exposure, the expansion of visceral adipose tissue is prominently affected. This is associated with decreased intestinal barrier function, increased hepatic steatosis, and metabolic dysfunction. An impaired local proinflammatory response in the adipocyte leads to increased ectopic lipid accumulation, glucose intolerance, and systemic inflammation. Adipose tissue inflammation is therefore an adaptive response that enables safe storage of excess nutrients and contributes to a visceral depot barrier that effectively filters gut-derived endotoxin. © 2014 Elsevier Inc.

Bravo-Gaete M.,Catholic University of the Maule | Gomez S.,University of Talca | Hassaine M.,University of Talca
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

We first observe that for Lifshitz black holes of which the only charge is the mass, the resulting Smarr relation is a direct consequence of the Lifshitz Cardy formula. From this observation, we propose to extend the Cardy formula to the case of electrically charged Lifshitz black holes satisfying as well a Smarr relation. The expression of our formula depends on the dynamical exponent, the energy and the charge of the ground state which is played by a magnetically charged soliton obtained through a double Wick rotation. The expression also involves a factor multiplying the chemical potentials which varies in function of the electromagnetic theory considered. This factor is precisely the one that appears in the Smarr formula for charged Lifshitz black holes. We test the validity of this Cardy formula in different situations where electrically Lifshitz charged black holes satisfying a Smarr relation are known. We then extend these results to electrically charged black holes with hyperscaling violation. Finally, an example in the charged anti-de Sitter case is also provided. © 2015 American Physical Society.

Misle E.,Catholic University of the Maule
Journal of Plant Nutrition | Year: 2013

A simulation of the accumulation of mineral nutrients in crops by an allometric model dependent on thermal time (non-linear) is proposed as a simple and robust method to calculate and schedule crops fertigation. Crop accumulation of nutrients was calculated by the allometric relation between nutrients and biomass, coupled to a biomass function dependent on a biological age. Thus, a curve for nutrient accumulation can be characterized with six specific parameters, including the allometric exponent. Three data sets were employed to verify simulations. Fit parameters were obtained, being R2 > 0.9 for four of the five main macronutrients. When verifying the simulation ability, RMSE were: nitrogen (N) = 0.1355; phosphorus (P) = 0.1214; potassium (K) = 0.1179; calcium (Ca) = 0.0991 and magnesium (Mg) = 0.0821 (relative data). The proposed allometric method describes the nutrients accumulation with remarkable simplicity and flexibility, while the verification of the model was done on three differing experimental conditions simultaneously. © 2013 Copyright Taylor and Francis Group, LLC.

Rojas A.,Catholic University of the Maule | Delgado-Lopez F.,Catholic University of the Maule | Gonzalez I.,Catholic University of the Maule | Perez-Castro R.,Catholic University of the Maule | And 2 more authors.
Cellular Signalling | Year: 2013

Firstly described in 1992, the receptor for advanced glycation end-products has attracted increasing attention due to its diverse ligand repertoire and involvement in several pathophysiological processes associated with inflammation such as in diabetes, cancer, autoimmune diseases and neurodegenerative diseases.This receptor in addition to its binding capacity for advanced glycation end-products also recognizes some molecules classified as both, pathogen- and damage-associated molecular patterns and thus triggering the transcription of genes encoding inflammatory mediators. Some of these ligands are common for both, the receptor of advanced glycation end-products and members of the Toll-like receptor family, generating shared signaling cascades. Furthermore, these receptors may cooperate as essential partners through the recruitment and assembly of homo- and hetero-oligomers in order to strengthen the inflammatory response. The purpose of this review is to highlight the importance of some particular features of this multiligand receptor, its signaling cascade as well as the cross-talk with some members of the Toll-like receptor family. © 2012 Elsevier Inc.

Romo-Kroger C.M.,Catholic University of the Maule
European Journal of Physics | Year: 2012

Normally, a mechanics laboratory at the undergraduate level includes an experiment to verify compliance with Hooke's law in materials, such as a steel spring and an elastic rubber band. Stressstrain curves are found for these elements. Compression in elastic bands is practically impossible to achieve due to flaccidity. A typical experiment for the complete loadingunloading cycle is to subject a tubular object to torsion. This paper suggests simple experiments for studying properties concerning elasticity and plasticity in elements of common use, subjected to stretching or compression, and also torsion reinforcing. The experiments use plastic binders, rubber bands and metal springs under a moderate load. This paper discusses an experiment with an original device to measure torsion deformations as a function of applied torques, which permitted construction of the hysteresis cycle for a rubber hose and various tubes. Another experiment was designed to define the temporal recovery of a plastic spring with initial stretching. A simple mathematical model was developed to explain this phenomenon. © 2012 IOP Publishing Ltd.

Rojas A.,Catholic University of the Maule | Figueroa H.,Catholic University of the Maule | Morales E.,Catholic University of the Maule
Carcinogenesis | Year: 2010

The receptor for advanced glycation end products (RAGE), firstly described in 1992, is a single-transmembrane and multiligand member of the immunoglobulin protein family. RAGE engagement produces activation of multiple intracellular signaling mechanisms involved in several inflammation-associated clinical entities, such as diabetes, cancer, renal and heart failures, as well as neurodegenerative diseases. Although RAGE expression has been extensively reported in many cancer types, it is now emerging as a relevant element that can continuously fuel an inflammatory milieu at the tumor microenvironment, thus changing our perception of its contribution to cancer biology. In this review, we will discuss the role of multiligand/RAGE axis, particularly at the multicellular cross talk established in the inflammatory tumor microenvironment. A better understanding of its contribution may provide new targets for tumor management and risk assessment. © The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email:

Zamora-Barraza D.,Catholic University of the Maule | Calzada-Perez M.A.,University of Cantabria | Castro-Fresno D.,University of Cantabria | Vega-Zamanillo A.,University of Cantabria
Geotextiles and Geomembranes | Year: 2011

The purpose of this study is to evaluate the durability of anti-reflective cracking systems that have a geosynthetic, geotextile or SAMI layer in the interlayer zone. For this purpose, a dynamic test has been designed that simulates the passing of traffic loads on the road surface. Stresses are applied to a two-layer test piece, which represents the pavement structure, with an anti-crack reflection system between the lower part, which is to be reinforced, and the upper part, which is the new pavement. In the lower layer, a longitudinal groove has been made that simulates an initial crack. All interlayer systems delay crack reflection. The test procedure is sensitive to the kind of interlayer system and helps to determine the optimal dosage of tack coat. Moreover, it has been verified that geogrids show higher resistance to repeated loading cycles, and geogrids with a higher stiffness modulus show better behaviour. © 2010 Elsevier Ltd.

Cordova-Lepe F.,Catholic University of the Maule | Pinto M.,University of Chile | Gonzalez-Olivares E.,Pontifical Catholic University of Valparaíso
Nonlinear Analysis: Real World Applications | Year: 2012

In this paper, a new type of mathematical model to represent certain processes with impulsive dynamic behavior is introduced. The main assumption is that the next impulse time is determined by three fundamental elements: the present impulse time, the state at this moment, and the value to which this state is impelled. We also establish the basic results of existence, uniqueness and continuation of solutions for these new impulsive differential equations. It is observed that the new equations have interesting applications in Bioeconomics, and sometimes they include, the traditional impulsive equations in variable times. © 2012 Elsevier Ltd. All rights reserved.

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