Time filter

Source Type

Lisbon, Portugal

The Catholic University of Portugal kɐˈtɔlikɐ puɾtuˈɡezɐ]), also referred as Católica or UCP for short, is the only concordatary university of the Catholic Church, in Portugal.Although it is just one university, UCP is organized as an university system, made up of four major regional centres: Lisbon , Beiras , Braga, and Porto. These include 18 faculties, schools and institutes, which are the basic education and research units. Besides the four regional centres in Portugal, UCP also has the University of Saint Joseph in Macau as its affiliate. Wikipedia.

Abecassis-Moedas C.,Catholic University of Portugal
Journal of Product Innovation Management | Year: 2012

This study analyzes why firms use both internal and external design, and attempts to understand the determinants of design architecture choices. It is based on the design literature that analyzes the compared benefits of internal, external, and combined design, and it mobilizes the concept of vertical architecture that designates at the level of the firm the configurations of transactional choices along the firm's value chain. The research methodology follows an exploratory multiple case study of fashion triads (manufacturer, designer, and retailer) theoretically sampled according to the design position (internal, external, or combination) relative to the manufacturer and retailer. Data were collected through face-to-face interviews and archival documents. The 31 triad cases were clustered into five industry architectures (IAs). The IAs are characterized as follows. Designer-led architecture, in which the three players are independent, offers an advantage in terms of branding and creativity. Manufacturer-led architecture, in which design is internal to the manufacturer, is recognized in terms of cost-effectiveness and speed of development process. Retailer-led architecture, in which design is internal to retail, offers advantages in terms of speed of development process and fit with market needs. Finally, the two hybrid architectures-licensing designer and designer retailer cobranding-with a combination of internal and external design are recognized in terms of cobranding and innovation. Through this process, the authors identify three determinants of design architecture choices (efficiency, level of fashion innovativeness, and innovation type) that can be grouped into two main opposing determinants: efficiency and innovativeness. Internal design offers greater efficiency, whereas external design provides increased innovativeness. Efficiency and innovation act in tension, there is no IA that offers both high efficiency and high innovativeness, there is a trade-off effect. But the tension between efficiency and innovativeness can be reconciled by combining internal and external design. Unlike prior literature, this research analyzes vertical choices with regard to choosing among a menu of IAs instead of transactions, and focuses on a distinctly creative activity. External design also offers an "ingredient brand" that end customers may recognize. The authors propose additional research for the generalization of these results. © 2012 Product Development & Management Association. Source

Vale F.F.,Catholic University of Portugal | Vitor J.M.B.,University of Lisbon
International Journal of Food Microbiology | Year: 2010

Helicobacter pylori is a Gram-negative microaerophilic bacterium that has colonized the human gastric mucosa. This infection is very common and affects more than half of the human population. The prevalence is however unbalanced between rural developing areas (more than 80%) and urban developed areas (less than 40%). H. pylori is responsible for several pathologies, such as gastritis, peptic ulcer and gastric cancer but its transmission pathway is still not clear. The risk factors for H. pylori infection include poor social and economic development; poor hygienic practices; absence of hygienic drinking water; and unsanitary prepared food. There is evidence supporting a gastro-oral, oral-oral and faecal-oral transmission, but no predominant mechanism of transmission has been yet identified. Transmission may occur in a vertical mode (e.g. from parents to child) or in a horizontal mode (across individuals or from environmental contamination). In either case, the involvement of water and food cannot be excluded as vehicles or sources of infection. Indirect evidence of presence of H. pylori in water and food, namely the detection of its DNA and survival studies after artificial contamination of food and water has been described. This paper reviews data both favourable and against the role of water and food in the transmission of H. pylori, exploring their role as a potential transmission vehicle for person-to-person and food-chain transmission. The likelihood of the transmission pathway in developing rural and developed urban areas appears to be different. In developed areas, person-to-person transmission within families appears to be dominant, while in the rural developing areas the transmission pathway appears to be more complex. In this later case, the transmission by contaminated food, water, or via intensive contact between infants and non-parental caretakers may have a greater influence than within-family transmission. © 2010 Elsevier B.V. All rights reserved. Source

Leitao A.,Catholic University of Portugal
Ecological Economics | Year: 2010

We investigate how corruption influences the income level at the turning point of the relationship between sulfur emissions and income, using a wide cross-national panel of countries, at different levels of development and with different degrees of corruption. Our results support the Environmental Kuznets Curve hypothesis for sulfur. We find evidence that the higher the country's degree of corruption, the higher the per capita income at the turning point, suggesting different income-pollution paths across countries due to corruption. We build upon a new specification for the EKC developed by Bradford et al. (2005) that avoids using nonlinear transformations of potentially nonstationary regressors in panel estimation. Also, we account for the indirect impact of corruption on emissions through its impact on per capita income. Our main findings remain unchanged when we investigate additional heterogeneity allowing for different income slopes across richer and poorer countries. © 2010 Elsevier B.V. Source

Grosso A.R.,University of Lisbon | De Almeida S.F.,University of Lisbon | Braga J.,Catholic University of Portugal | Carmo-Fonseca M.,University of Lisbon
Genome Research | Year: 2012

Eukaryotic protein-coding genes are transcribed by RNA polymerase II (RNAPII) through a cycle composed of three main phases: initiation, elongation, and termination. Recent studies using chromatin immunoprecipitation coupled to high-throughput sequencing suggest that the density of RNAPII molecules is higher at the 3′-end relative to the gene body. Here we show that this view is biased due to averaging density profiles for "metagene" analysis. Indeed, the majority of genes exhibit little, if any, detectable accumulation of polymerases during transcription termination. Compared with genes with no enrichment, genes that accumulate RNAPII at the 3′-end are shorter, more frequently contain the canonical polyadenylation [poly(A)] signal AATAAA and G-rich motifs in the downstream sequence element, and have higher levels of expression. In 1% to 4% of actively transcribing genes, the RNAPII enriched at the 3′-end is phosphorylated on Ser5, and we provide evidence suggesting that these genes have their promoter and terminator regions juxtaposed. We also found a striking correlation between RNAPII accumulation and nucleosome organization, suggesting that the presence of nucleosomes after the poly(A) site induces pausing of polymerases, leading to their accumulation. Yet we further observe that nucleosome occupancy at the 3′-end of genes is dynamic and correlates with RNAPII density. Taken together, our results provide novel insight to transcription termination, a fundamental process that remains one of the least understood stages of the transcription cycle. Source

Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.71M | Year: 2015

In response to the increasing problem of water shortage, the reuse of treated urban wastewater is considered the most suitable and reliable alternative for sustainable water management and agricultural development. In spite of the benefits associated with this practice, major concerns currently exist, related to the adverse effects regarding chemical and biological contaminants of emerging concern such as antibiotics and mobile antibiotic resistance elements such as antibiotic resistant bacteria and resistance genes. These are now considered as a serious public health problem by various international organizations and the European Commission, because of their spread in the environment, the food chain, drinking water, etc. To tackle these problems, scientists with an interdisciplinary research/training background are urgently needed. This ETN will train a new generation of ESRs to address the risks associated with such contaminants and wastewater reuse. Innovative chemical, microbiological, toxicological and modelling tools, and novel process engineering will form the scientific and training core of their innovative research projects and training. The project will contribute to understanding the fate and transmission of antibiotics and resistance from wastewater to the environment and humans, through soil, ground/surface water and crops. Relevant ELVs will be determined, essential for the development and implementation of regulatory frameworks. This project directly tackles these aspects, by bringing together a multidisciplinary research team, with the private sector, and policy makers and through communication activities towards stakeholders and the wider public.

Discover hidden collaborations