Leuven, Belgium

The Leuven Faculty of Theology and Religious Studies, was a branch of the Catholic University of Leuven. The faculty traces its history back to its founding in 1432, however it was abolished in 1797 due to the French Revolution. The current faculty was established in 1834, as a part of the Catholic University of Leuven. Following the Belgian Revolution of 1830, which has established the freedom of teaching, this New Catholic University was founded in 1834 in Mechelen by the private initiative of the Belgian bishops. In 1967 the faculty was divided into Flemish and French speaking departments, and they exist today as two separate faculties. Wikipedia.


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Patent
Catholic University of Leuven | Date: 2015-02-27

The present invention relates to improved methods for synthesis of thin film composite membranes by interfacial polymerization. More in particular, the method of the present invention comprises the impregnation of an ultrafiltration porous support membrane with an aqueous solution containing a polyfunctional nucleophilic monomer, and contacting the impregnated support membrane with a second largely water-immiscible solvent containing a polyfunctional epoxide monomer.


Patent
Catholic University of Leuven and Toray Industries Inc | Date: 2014-12-05

A preform includes: (A) a self-reinforced sheet comprising (a-1) a thermoplastic resin and (a-2) a fiber or tape made of a thermoplastic resin which is the same type as the thermoplastic resin (a-1), the self-reinforced sheet (A) being reinforced with the fiber or tape (a-2); and (B) a reinforced sheet comprising (b-1) a randomly-oriented mat of discontinuous carbon fibers and (b-2) a thermoplastic resin. The self-reinforced sheet (A) and the reinforced sheet (B) are laminated one on another. Each thermoplastic resin serves as a matrix resin of the preform.


Patent
Imec and Catholic University of Leuven | Date: 2016-09-09

A solid-state device configured to generate an electric signal indicative of a presence or an absence of a magnetic topological soliton is disclosed. The solid-state device includes a storage element configured to store a magnetic topological soliton. The storage element includes a topological insulator. The storage element also includes a magnetic strip arranged on the topological insulator. The solid-state device also includes a magnetic topological soliton detector configured to generate the electric signal indicative of the presence or the absence of the magnetic topological soliton in a detection region of the storage element. The magnetic topological soliton detector is adapted for detecting a spin-independent difference in tunneling amplitude, a difference in electrical resistance, or a difference in electrical conductivity through the topological insulator in the detection region due to the presence or the absence of the magnetic topological soliton in the detection region.


Patent
Imec and Catholic University of Leuven | Date: 2016-05-09

The disclosure relates to a method for verifying a printed pattern. In an example embodiment, the method includes defining sectors of at least a portion of the features in the reference pattern, determining a contour of the printed pattern, and superimposing the contour of the printed pattern on the reference pattern. The method also includes determining surface areas of sectors of the printed pattern that correspond to the sectors of the reference pattern and calculating one or more parameters as a function of at least one of the surface areas, the parameters being related to a single sector or to multiple sectors. The method additionally includes evaluating the parameters with respect to a reference value.


Patent
Imec and Catholic University of Leuven | Date: 2016-11-15

A device and method for sorting objects immersed in a flowing medium are disclosed. An example device comprises a holographic imaging unit comprising one or more holographic imaging elements, a fluid handling unit comprising one or more microfluidic channels configured to conduct flowing medium along a corresponding holographic imaging element and at least one microfluidic switch arranged downstream of an imaging region in the microfluidic channel configured to direct objects in the flowing medium into a one of a plurality of outlets. The example device also comprises a processor configured to determine real-time characterizations of holographic diffraction images obtained for the moving objects. The processing unit is further configured to control the at least one microfluidic switch in response to the real-time characterizations.


Patent
Imec and Catholic University of Leuven | Date: 2017-01-18

The invention is related to a method for designing a lithographic mask to print a pattern of structural features, wherein an OPC-based methodology may be used for producing one or more simulated patterns as they would be printed through the optimized mask. A real mask is then produced according to the optimized design, and an actual print is made through the mask. To evaluate the printed pattern and the PW on wafer more accurately, experimental contours are extracted from the CD-SEM measurements of the printed pattern. The verification of the mask is based on a comparison between on the one hand the contour obtained from the printed pattern, and on the other hand the intended pattern and/or the simulated contour. A direct comparison can be made between simulation and experiment, without losing all the pieces of info contained in each single CD-SEM picture.


Patent
AC Immune SA and Catholic University of Leuven | Date: 2017-03-01

The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles, in particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimers Disease (AD).


Patent
Imec and Catholic University of Leuven | Date: 2017-02-22

The invention is related to a method for verifying a printed pattern comprising polygon-shaped features (1-7) as printed by a lithographic tool using a lithographic mask, wherein a number of sectors of features of the pattern are first defined, and wherein the surface area of these sectors is used for calculating one or more parameters that express the print quality of the features, said parameters being suitable for determining a process window. The surface area of the sectors is determined on a contour of the printed pattern, obtainable from an CD-SEM image of the printed pattern. According to preferred embodiments, the parameters are ratios of surface area-based values divided by reference values. The reference values may be determined on the basis of the design intent of a pattern or on the basis of a contour extracted from a simulated print of the pattern.


Patent
Vib Vzw and Catholic University of Leuven | Date: 2017-01-18

The present invention relates to antibodies with a specificity for BACE1. More specifically, the invention provides monoclonal antibodies which bind to BACE1 and methods using these antibodies. Said antibodies can be used for research and medical applications.


Patent
Imec and Catholic University of Leuven | Date: 2017-01-04

A sensing device comprising: an output area having an output circuit comprising an integrator adapted to integrate a received current so as to generate an output voltage corresponding to the received current; an electrode area comprising: an electrode comprising an exposed, electrically conductive, surface area and electrode circuitry connected to the exposed surface area, wherein the electrode circuitry comprises a voltage-to-current transducer adapted to produce a wire current corresponding to a voltage present at the exposed surface area; and a connecting wire electrically connecting the electrode circuitry to the output circuit, wherein the current received by the output circuit is the wire current.


Innate immune sensing of dying cells is modulated by several signals. Inflammatory chemokines-guided early recruitment, and pathogen-associated molecular patterns-triggered activation, of major anti-pathogenic innate immune cells like neutrophils distinguishes pathogen-infected stressed/dying cells from sterile dying cells. However, whether certain sterile dying cells stimulate innate immunity by partially mimicking pathogen response-like recruitment/activation of neutrophils remains poorly understood. We reveal that sterile immunogenic dying cancer cells trigger (a cell autonomous) pathogen response-like chemokine (PARC) signature, hallmarked by co-release of CXCL1, CCL2 and CXCL10 (similar to cells infected with bacteria or viruses). This PARC signature recruits preferentially neutrophils as first innate immune responders in vivo (in a cross-species, evolutionarily conserved manner; in mice and zebrafish). Furthermore, key danger signals emanating from these dying cells, that is, surface calreticulin, ATP and nucleic acids stimulate phagocytosis, purinergic receptors and toll-like receptors (TLR) i.e. TLR7/8/9-MyD88 signaling on neutrophil level, respectively. Engagement of purinergic receptors and TLR7/8/9-MyD88 signaling evokes neutrophil activation, which culminates into H2O2 and NO-driven respiratory burst-mediated killing of viable residual cancer cells. Thus sterile immunogenic dying cells perform 'altered-self mimicry' in certain contexts to exploit neutrophils for phagocytic targeting of dead/dying cancer cells and cytotoxic targeting of residual cancer cells.Cell Death and Differentiation advance online publication, 24 February 2017; doi:10.1038/cdd.2017.15. © 2017 Macmillan Publishers Limited, part of Springer Nature.


Gransier R.,Catholic University of Leuven
Ear and Hearing | Year: 2017

OBJECTIVES:: Auditory stimuli modulated by modulation frequencies within the 30 to 50 Hz region evoke auditory steady state responses (ASSRs) with high signal to noise ratios in adults, and can be used to determine the frequency-specific hearing thresholds of adults who are unable to give behavioral feedback reliably. To measure ASSRs as efficiently as possible a multiple stimulus paradigm can be used, stimulating both ears simultaneously. The response strength of 30 to 50Hz ASSRs is, however, affected when both ears are stimulated simultaneously. The aim of the present study is to gain insight in the measurement efficiency of 30 to 50 Hz ASSRs evoked with a 2-ear stimulation paradigm, by systematically investigating the binaural interaction effects of 30 to 50 Hz ASSRs in normal-hearing adults. DESIGN:: ASSRs were obtained with a 64-channel EEG system in 23 normal-hearing adults. All participants participated in one diotic, multiple dichotic, and multiple monaural conditions. Stimuli consisted of a modulated one-octave noise band, centered at 1 kHz, and presented at 70 dB SPL. The diotic condition contained 40 Hz modulated stimuli presented to both ears. In the dichotic conditions, the modulation frequency of the left ear stimulus was kept constant at 40 Hz, while the stimulus at the right ear was either the unmodulated or modulated carrier. In case of the modulated carrier, the modulation frequency varied between 30 and 50 Hz in steps of 2 Hz across conditions. The monaural conditions consisted of all stimuli included in the diotic and dichotic conditions. RESULTS:: Modulation frequencies ≥36 Hz resulted in prominent ASSRs in all participants for the monaural conditions. A significant enhancement effect was observed (average: ~3 dB) in the diotic condition, whereas a significant reduction effect was observed in the dichotic conditions. There was no distinct effect of the temporal characteristics of the stimuli on the amount of reduction. The attenuation was in 33% of the cases >3 dB for ASSRs evoked with modulation frequencies ≥40 Hz and 50% for ASSRs evoked with modulation frequencies ≤36 Hz. CONCLUSIONS:: Binaural interaction effects as observed in the diotic condition are similar to the binaural interaction effects of middle latency responses as reported in the literature, suggesting that these responses share a same underlying mechanism. Our data also indicated that 30 to 50 Hz ASSRs are attenuated when presented dichotically and that this attenuation is independent of the stimulus characteristics as used in the present study. These findings are important as they give insight in how binaural interaction affects the measurement efficiency. The 2-ear stimulation paradigm of the present study was, for the most optimal modulation frequencies (i.e., ≥40 Hz), more efficient than a 1-ear sequential stimulation paradigm in 66% of the cases. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.


Schwalm C.,Catholic University of Leuven
Medicine and Science in Sports and Exercise | Year: 2017

PURPOSE: To determine whether fission and mitophagy are activated by acute endurance exercise in human skeletal muscle and to investigate if this activation is dependent upon the nutritional state. METHODS: Trained athletes (n = 7) cycled for 2 h at 70% VO2 peak in a fed or fasted state. Vastus lateralis muscle biopsies were obtained at baseline, before, immediately after and 1 h after exercise. Protein and mRNA markers for mitophagy, mitochondrial biogenesis, fission and fusion were analyzed using qRT-PCR and Western blot. RESULTS: Fission, assessed by phospho-DRP1 in the mitochondrial fraction, increased post-exercise and 1 h post-ex only in the fed. LC3bII and p62/ SQSTM1 in the mitochondrial fraction were unchanged whereas the LC3bII/LC3bI ratio was decreased only post-exercise in the fasted state (P = 0.019), indicating a reduced mitophagy. Genes implicated in fission and mitophagy like Drp1, Bnip3, and Bnip3L and proteins involved in fission (Fis1) or mitophagy (BNIP3) were all more expressed after exercise in the fed state (P < 0.05). As expected, the mRNA levels of PGC1α, Tfam and HSP60, all markers of mitogenesis, were increased after endurance exercise, but to a larger extent in the fed than in the fasted state. CONCLUSION: The present study provides the very first evidences that mitophagy is not activated during and early after high intensity endurance exercise in human, whatever the nutritional state, despite a selective activation of fission in the fed state. However, when nutrient availability is optimal, muscle cells seems capable to prepare mitochondria for lysosomal degradation. Thus, we may not exclude an activation of mitophagy at a later stage following exercise. © 2017 American College of Sports Medicine


Verhenne S.,Catholic University of Leuven
Arteriosclerosis, Thrombosis, and Vascular Biology | Year: 2017

OBJECTIVE—: Severe deficiency in the von Willebrand factor–cleaving protease ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) because of mutations in the ADAMTS13 gene can lead to acute episodes of congenital thrombotic thrombocytopenic purpura (TTP), requiring prompt treatment. Current treatment consists of therapeutic or prophylactic infusions of fresh frozen plasma. However, lifelong treatment with plasma products is a stressful therapy for TTP patients. Here, we describe the use of the nonviral sleeping beauty (SB) transposon system as a gene therapeutic approach to realize lifelong expression of ADAMTS13 and subsequent protection against congenital TTP. APPROACH AND RESULTS—: We demonstrated that hydrodynamic tail vein injection of the SB100X system expressing murine ADAMTS13 in Adamts13 mice resulted in long-term expression of supraphysiological levels of transgene ADAMTS13 over a period of 25 weeks. Stably expressed ADAMTS13 efficiently removed the prothrombotic ultralarge von Willebrand factor multimers present in the circulation of Adamts13 mice. Moreover, mice stably expressing ADAMTS13 were protected against TTP. The treated mice did not develop severe thrombocytopenia or did organ damage occur when triggered with recombinant von Willebrand factor, and this up to 20 weeks after gene transfer. CONCLUSIONS—: These data demonstrate the feasibility of using SB100X-mediated gene therapy to achieve sustained expression of transgene ADAMTS13 and long-term prophylaxis against TTP in Adamts13 mice. © 2017 American Heart Association, Inc.


The patent describes a one-step liquid biphasic catalytic process for converting a carbohydrate-containing feedstock, preferably lignocellulose, to light naphtha (e.g., hexane, pentane, methyl cyclopentane, cyclohexane, etc.) in presence of an acidic reactive aqueous phase and a redox catalyst in the organic extracting/reaction phase. The process provides a cost-effective route for producing light-naphtha components, in presence or not of deoxygenates. The light naphtha components are useful as feedstock for steam and catalytic cracking to produce value-added platform molecules like ethylene and propylene, as precursor for the synthesis of bioaromatics like benzene and as gasoline fuel feedstock, and as fuel additives, (e.g., the concomitantly formed oxygenates) to improve the biological origin of carbon in the fuel.


News Article | May 8, 2017
Site: www.prnewswire.com

On Thursday, Suárez will tour the local Pediatrics Unit at The University of Kansas Health System, a Children's Miracle Network Hospital, and meet many of the young patients admitted there. While visiting, Suárez and representatives from STANLEY, will present the $100,000 donation to CMN Hospitals on behalf of the Ace Hardware Foundation. The team will also unveil the paint scheme that will run this weekend on the No. 19 STANLEY Toyota. The paint scheme includes names of one child from each state who represents Children's Miracle Network Hospitals, as well as four very special children who will serve as "Honorary Pit Crew Members" of the No. 19 team throughout the weekend. "I've always admired this program," says Suárez. "But I have a whole new level of respect now that I'm partnering with the STANLEY team. I am blown away by the courage and determination of the kids treated at CMN Hospitals and I am more motivated than ever to win this race." This is Suárez's first year racing in the Monster Energy NASCAR Cup Series with Joe Gibbs Racing and the STANLEY race team. The 25-year-old Monterrey, Mexico-native is the first Mexican-born driver to capture a NASCAR national series victory, and the fifth Latino driver to win a NASCAR national series race. Follow Suárez this weekend at #RACINGforMIRACLES. For more information on the "Racing for a Miracle" program, including more ways to support Children's Miracle Network Hospitals, visit http://www.stanleyracing.com Stanley Black & Decker, an S&P 500 and FORTUNE 500 company, is the world's leading provider of tools and storage, the world's second-largest commercial electronic security company, and a leading engineered fastening systems provider, with unique growth platforms in the Oil & Gas and Infrastructure industries. Well-known brands include: STANLEY, BLACK+DECKER, DEWALT, Craftsman, Porter-Cable, Bostitch, Facom, Mac Tools, Proto, Vidmar, Lista, and more. The company's STANLEY Healthcare Solutions division is the North American leader in Infant Security, with its Hugs(TM) Infant Protection System. Learn more at http://www.stanleyblackanddecker.com. Children's Miracle Network Hospitals® raises funds and awareness for 170 member hospitals that provide 32 million treatments each year to kids across the U.S. and Canada. Donations stay local to fund critical treatments and healthcare services, pediatric medical equipment and charitable care. Since 1983, Children's Miracle Network Hospitals has raised more than $5 billion, most of it $1 at a time through the charity's Miracle Balloon icon. Its various fundraising partners and programs support the nonprofit's mission to save and improve the lives of as many children as possible. Find out why children's hospitals need community support, identify your member hospital and learn how you can Put Your Money Where the Miracles Are at CMNHospitals.org and facebook.com/CMNHospitals. As the official charitable division of Ace Hardware Corporation, the Ace Hardware Foundation helps enhance the vision of being the "Helpful Place" in local communities across the country and around the globe through charitable giving. The Ace Hardware Foundation provides support and philanthropic opportunities to its consumers, retail store owners, vendors and team members to give back to local communities through fundraising efforts for Children's Miracle Network Hospitals and American Red Cross Disaster Relief. For more than 90 years, Ace Hardware has been known as the place with the helpful hardware folks in thousands of neighborhoods across America, providing customers with a more personal kind of helpful. With more than 5,000 hardware stores locally owned and operated across the globe, Ace is the largest retailer-owned hardware cooperative in the world. Headquartered in Oak Brook, Ill., Ace and its subsidiaries operate an expansive network of distribution centers in the U.S. and also have distribution capabilities in Ningbo, China; Colon, Panama; and Dubai, United Arab Emirates. Its retailers' stores are located in all 50 states, the District of Columbia and approximately 60 countries. For more information on Ace, visit acehardware.com or the company newsroom at newsroom.acehardware.com. KU Pediatrics, in conjunction with The University of Kansas Medical Center and The University of Kansas Health System, provides the medical care and leading-edge research needed to treat children today and find the treatments for tomorrow.  Since 1985, KU Pediatrics has been partnered with Children's Miracle Network Hospitals to raise funds and provide families with the best care possible.  Through various partners and events, funds raised stay local and are utilized for immediate medical care, equipment and pediatric research initiatives. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/daniel-suarez-and-no-19-stanley-team-race-for-a-miracle-this-weekend-300453174.html


Schmidbaur H.,TU Munich | Schmidbaur H.,King Abdulaziz University | Raubenheimer H.G.,Stellenbosch University | Dobrzanska L.,Catholic University of Leuven
Chemical Society Reviews | Year: 2014

In the first part of this review, the characteristics of Au-H bonds in gold hydrides are reviewed including the data of recently prepared stable organometallic complexes with gold(i) and gold(iii) centers. In the second part, the reports are summarized where authors have tried to provide evidence for hydrogen bonds to gold of the type Au⋯H-X. Such interactions have been proposed for gold atoms in the Au(-i), Au(0), Au(i), and Au(iii) oxidation states as hydrogen bonding acceptors and H-X units with X = O, N, C as donors, based on both experimental and quantum chemistry studies. To complement these findings, the literature was screened for examples with similar molecular geometries, for which such bonding has not yet been considered. In the discussion of the results, the recently issued IUPAC definitions of hydrogen bonding and the currently accepted description of agostic interactions have been used as guidelines to rank the Au⋯H-X interactions in this broad range of weak chemical bonding. From the available data it appears that all the intra- and intermolecular Au⋯H-X contacts are associated with very low binding energies and non-specific directionality. To date, the energetics have not been estimated, because there are no thermochemical and very limited IR/Raman and temperature-dependent NMR data that can be used as reliable references. Where conspicuous structural or spectroscopic effects have been observed, explanations other than hydrogen bonding Au⋯H-X can also be advanced in most cases. Although numerous examples of short Au⋯H-X contacts exist in the literature, it seems, at this stage, that these probably make only very minor contributions to the energy of a given system and have only a marginal influence on molecular conformations which so far have most often attracted researchers to this topic. Further, more dedicated investigations will be necessary before well founded conclusions can be drawn. © 2014 The Royal Society of Chemistry.


Ibanez B.,Hospital Clinico San Carlos | Heusch G.,University of Duisburg - Essen | Ovize M.,Service dExplorations Fonctionnelles Cardiovasculaires | Van De Werf F.,Catholic University of Leuven
Journal of the American College of Cardiology | Year: 2015

The damage inflicted on the myocardium during acute myocardial infarction is the result of 2 processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the last 3 decades, therapies to reduce ischemic injury (mainly reperfusion strategies) have been widely incorporated into clinical practice. The remarkable reduction in death rates achieved with these therapies has resulted in a shift in emphasis from efforts to reduce mortality to a focus on tackling the downstream consequence of survival: post-infarction heart failure. Infarct size is the main determinant of long-term mortality and chronic heart failure, and thus, the possibility of limiting the extent of necrosis during an ST-segment elevation myocardial infarction is of great individual and socioeconomic value. After the great success of therapies to reduce ischemic injury, the time has come to focus efforts on therapies to reduce reperfusion injury, but in the recent few years, few interventions have successfully passed the proof-of-concept stage. In this review, we examine the past, present, and future therapies to reduce ischemia/reperfusion injury. © 2015 American College of Cardiology Foundation.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.98M | Year: 2012

Currently, 180 million people suffer from diabetes worldwide and this number is expected to double until 2030. Diabetes-related healthcare costs may rise to 40% of the total healthcare budget in high incidence countries. Despite these daunting numbers, our knowledge about the pathophysiology of T1D and T2D remains limited and many questions about the relation of the of the beta cell mass, the beta cell function and the metabolism of different tissues remain unanswered. In order to address these urgent questions, great hope has been put on the development of novel tracers, and functional and molecular imaging methods, which only recently have become available for in vivo diabetes imaging. However, it remains difficult to build up top level expertise as few, if any, European institutions are able to offer a profound combined molecular imaging/diabetes training, a shortcoming that continues to hamper the progress of the field. As a consequence, most available molecular imaging techniques are insufficiently characterised for clinical use in diabetes. To address this challenge, we propose a training network (BetaTrain) to connect academic/private sector partners from 5 leading European FP7 consortia with top level expertise in beta cell/diabetes imaging. Like this, BetaTrain will not only provide a unique multidisciplinary intersectoral training opportunity to young scientists in the field, but will also address the urgent challenges in our combat against diabetes. In order to non-invasively characterize beta cells and other relevant tissues in animal models and humans suffering from diabetes, it will be necessary to combine different molecular imaging techniques to provide information complementary to that obtained by other imaging, laboratory, and functional tests. The scientific training program of BetaTrain will therefore characterise, cross-calibrate and map these technologies/tracers in order to create the basis for personalised diagnosis and therapy in diabetes.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.3.3-3 | Award Amount: 3.85M | Year: 2010

Over the last years, large outbreaks of Crimean Congo Hemorrhagic fever virus (CCHFV) in several European countries and neighbouring areas are on the rise. This disease poses a great threat to public health due to its high mortality rate, modes of transmission and geographical distribution. Climate changes and observation of the CCHFV vector in central Europe alarm the European community as we cannot exclude that future outbreaks will take place in non-endemic area of Europe. To date, there is no vaccine available and no selective antiviral drug for the management of the disease. The general knowledge of migration, epidemiology, re-assortment and recombination of the virus is very limited. To fill these gaps, the CCH Fever project proposes to create a multidisciplinary collaborative research environment by bringing together selected competitive advantages such as: operative capacity with appropriate high security research facilities, reference centers and clinical samples from endemic areas and an international network of experienced researchers. This multidisciplinary research consortium will facilitate the progress in several key research areas of the field. This program will mainly focus on (i) developing sensitive and biosafe state-of-art diagnostic tools for CCHFV, (ii) gathering the forces and resources in Europe to build a Biobank of clinical samples, (iii) building a comprehensive database consisting in clinical, laboratory and surveillance data, (iv) taking advantage of unique and state-of art tools to progress towards vaccine candidates and specific antivirals against this bio-threat and (v) disseminating the appropriate knowledge to the health care workers in endemic regions and contributing to capacity building. These achievements will provide tools for local and European public health authorities to prevent or counter future outbreaks and monitor the spread of the disease thanks to the established novel and unique tools and resources.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.3.2 | Award Amount: 13.04M | Year: 2011

Smart systems consist of heterogeneous subsystems and components providing different functionalities; they are normally implemented as Multi-Package on a Board. To fully exploit the potential of current nanoelectronics technologies, as well as to enable the integration of existing/new IPs and More than Moore devices, smart system miniaturization and Multi-Chip in a Package implementation are unavoidable. Such goals are only achievable if a flexible software platform (i.e., the SMAC platform) for smart subsystems/components design and integration is made available to designers and system integrators.\nThe platform must include methodologies and EDA tools enabling multi-disciplinary and multi-scale modeling and design, simulation of multi-domain systems, subsystems and components at all levels of abstraction, system integration and exploration for optimization of specific metrics, such as power, performance, reliability and robustness.\nKey ingredients for the construction of the SMAC platform include: (1) The development of a cosimulation and co-design environment which is aware (and thus considers) the essential features of the basic subsystems and components to be integrated. (2) The development of modeling and design techniques, methods and tools that, when added to the platform, will enable multi-domain simulation and optimization at various levels of abstraction and across different technological domains.\nThe SMAC platform will allow to successfully address the following grand challenges related to the design and manufacturing of miniaturized smart systems: (1) Development of innovative smart subsystems and components demonstrating advanced performance, ultra low power and the capability of operating under special conditions (e.g., high reliability, long lifetime). (2) Design of miniaturized and integrated smart systems with advanced functionality and performance, including nanoscale sensing systems, possibly operating autonomously and in a networked fashion


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 913.50K | Year: 2015

There is an international imperative to improve healthcare through health service research, including nursing research and new innovations. This EU-RISE project Excellent research and expertise of quality of cancer care by internationally trained staff (INEXCA) aims to utilize expertise across the globe to improve research, researcher training and care of cancer patients, family caregivers and patient and public involvement through international and intersectoral collaboration and staff exchange. The ultimate objectives are to create innovative opportunities to improve research and researchers skills and increase knowledge transfer from research to practice and business. The participants in the project representing academic, non-academic and clinical settings as well as information technology industry and health-related business experts from Belgium, Denmark, Finland, Italy, Great Britain and United States of America have enormous and interdisciplinary competences of their specializing areas in research methodology, quality of care, cancer care, patient involvement, family care givers and information technology in academic, non-academic and clinical settings. The participating organizations will bring their best know-how through staffs secondments, workshops, training courses, conferences, publications and other activities. An innovative ICT platform will be developed for sharing information and knowledge. In total, 34 academic and non-academic staff members will be involved in this INEXCA project for 263 months. The participants synergies and complementarities from different disciplines, experiences, methodological advancements as well as clinical practice will be fully in use. The planned secondments will offer the best opportunity to get the best outcomes for patients, families, EU citizens as well as researchers. Descriptors: HEALTH SERVICES, HEALTH CARE RESEARCH


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.4.2-1 | Award Amount: 7.36M | Year: 2010

Assuming an annual birth rate of 10.25 births/1,000 population approximately 25,000 Extremely Low Gestational Age Newborns are born every year in the EU. Conservative figures estimate that approximately half of all these babies will develop low blood pressure and require treatment. However, no uniform criteria exist to define hypotension and the evidence to support our current management strategies is limited. Many of these interventions have been derived from adult literature and have not been validated in the newborn. Dopamine remains the most common inotrope used despite little evidence that it improves outcome. Hypotension is not only associated with mortality of preterm infants but is also associated with brain injury and impaired neurosensory development in ELGAN survivors. Preterm brain injury has far reaching implications for the child, parents, family, health service and society at large. It is therefore essential that we now design and perform the appropriate trials to determine whether the infusion of inotropic agents is associated with improved outcome. We have assembled a consortium with expertise in key areas of neonatal cardiology, neonatology, neurophysiology, basic science and pharmacology with the intention of answering these questions. The objectives of the group are as follows: 1. To perform a multinational, randomized controlled trial to evaluate whether a more restricted approach to the diagnosis and management of hypotension compared to a standard approach, with dopamine as a first line inotrope, affects survival without significant brain injury at 36 weeks gestational age in infants born less than 28 weeks gestation and affects survival without neurodevelopmental disability at 2 years corrected age 2. To perform pharmacokinetic and pharmcodynamic studies of dopamine 3. To develop and adapt a formulation of dopamine suitable for newborns in order to apply for a Paediatric Use Marketing Authorization


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2010.2.3.3-2 | Award Amount: 21.90M | Year: 2010

RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europes and Asias leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design programme. The project aims to identify Small molecule Inhibitor Leads Versus Emerging and neglected RNA viruses (SILVER). It will focus its activities on selected medically important RNA viruses for which the development of drugs is considered essential (Dengue-, entero- and paramyxoviruses), whereas other relatively neglected and/or emerging RNA viruses will be explored to identify the most promising viral protein targets and antiviral compounds. A pipeline strategy has been developed to enable the inclusion in SILVER of viruses at all levels of existing knowledge. Targets for potential drugs include infectious virus, structurally characterised viral enzymes and other proteins. Leads for currently available antiviral drugs have been identified by screening compound libraries in virus-infected cell culture systems and in vitro assays using purified viral enzymes. Selective inhibitors of viral replication have also been (and are being) derived using detailed structural knowledge of viral proteins and structure-based drug design. Hits will be assayed using individual viral protein targets and replicative proteins in complex with viral RNA. The potential protective activity of the most potent inhibitors, that have a favourable (in vitro) ADME-tox profile, will be assessed in relevant infection models in animals. Licenses on promising compounds or compound classes will be presented to the interested pharmaceutical industry. The SILVER consortium will be well placed to play a major role in contributing to the international effort to develop strategies to improve world health.


In this project we aim to investigate the mechanisms involved in memory storage in the brain by a combination of advanced multisite, single unit neural activity monitoring, closed-loop patterned and cell specific activations, and computational techniques, that would allow developing ways to stimulate brain networks in an activity-driven fashion. Combining neuroscience, neuroengineering and computational methods, we intend to create a technological platform for directly interacting with cell assemblies in a two-way dialogue. Using this, we will investigate whether manipulations of cell assembly activities can actually delete or create memories in behavioral experiments. In particular we will concentrate on the hippocampal/cortical interactions in a memory consolidation context as well as on the interactions between two cortical areas, the prefrontal and perirhinal cortex that form a hierarchical representation of memories. The results will provide solid evidence for the role of assemblies in memory processes, and the proof of concept of how these could be manipulated. Eventually these findings should enable radically new research directions for neuro-inspired technologies such as neuromorphic design and cognitive brain-computer interfaces (BCIs) with consequences that we can only begin to imagine.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-33-2015 | Award Amount: 30.12M | Year: 2016

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-07-2014 | Award Amount: 4.19M | Year: 2015

Although cloud computing offers many benefits, security issues such as confidentiality and privacy are still major concerns to those intending to migrate to the cloud. Traditional cloud security has been based on assurance to customers that cloud providers follow sound security practices. As a result, current security mechanisms are commonly located within the cloud platform, hence compelling customers to trust cloud providers. However, customers might be reluctant to outsource sensitive data due to lack of control over data storage and management. To reach its full potential, cloud computing needs solid security mechanisms that enhance trust in cloud computing by allowing cloud customers to have a greater control over the security and privacy of their data. Moreover, it is also necessary to consider countermeasures to ensure that vulnerabilities or attacks do not have a negative impact on cloud security and that applications continue to operate and provide a good level of service even during an attack. The main objective of CLARUS is to enhance trust in cloud computing services by developing a secure framework for the storage and processing of data outsourced to the cloud that allows end users to monitor, audit and retain control of the stored data without impairing the functionality and cost-saving benefits of cloud services. The CLARUS solution will provide the end user with a dedicated proxy located in a trusted domain implementing security and privacy features towards the cloud provider. The proxy is intended to be deployed within the client computer, in a server within the users domain, in an edge device (e.g. a router), or in any other location trusted by the user. CLARUS will also provide a set of security auditing services enabling the user to supervise the security operations performed by the CLARUS framework as well as other trust-enhancing features.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: DRS-09-2015 | Award Amount: 8.81M | Year: 2016

Recent studies from the IPCC indicate that Europe is particularly prone to increased risks of river and coastal floods, droughts resulting in water restrictions and damages from extreme weather such as heat events and wildfires. Evaluations also show a huge potential to reduce these risks with novel adaptation strategies. Researchers, innovators and incubators develop innovative products and services to reduce the increased climate change risks. Many of these innovations however hardly arrive at the markets. BRIGAID BRIdges the GAp for Innovations in Disaster resilience. BRIGAIDs approach is supported by three pillars. (1) At first BRIGAID takes into account the geographical variability of climate-related hazards and their interaction with socio-economic changes, (2) BRIGAID establishes structural, on-going support for innovations that are ready for validation in field tests and real life demonstrations and (3) BRIGAID develops a framework that enables an independent, scientific judgement of the socio-technological effectiveness of an innovation. BRIGAIDs objective is ambitious but achievable with strong consortium partners in EU, two Associated Countries and support from Overseas Territories. BRIGAID (a) brings actively together innovators and end-users in Communities of Innovation, resulting in increased opportunities for market-uptake; (b) contributes to the development of a technological and performance standards for adaptation options by providing a Test and Implementation Framework (TIF) and test facilities throughout Europe; (c) Improves innovation capacity and the integration of new knowledge by establishing an innovators network and (d) strengthens the competitiveness and growth of companies with the support of a dedicated business team. Finally BRIGAID develops a business models and market outreach to launch innovations to the market and secure investments in innovations beyond BRIGAIDs lifetime.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: BES-13-2015 | Award Amount: 1.50M | Year: 2016

Political conflicts have long since gone beyond national borders and peace building has become central to the self-conception of the European Union as a foreign policy actor. Current challenges in Conflict Prevention and Peace Building (CPPB) trainings are that many programmes on offer are both too general/narrow, they are not applicable enough, weak on concrete skills enlargement and moreover training alone is not sufficient. Overcoming these challenges requires novel CPPB training curricula and linked activities. PeaceTraining.eu aims to analyse these issues with strong involvement of all relevant stakeholders to take into account current practices and provide new training methods for CPPB personnel. In order to meet these challenges and to investigate this complex field of research a multidimensional modeling approach is used. The resulting, proprietary PeaceTraining.eu Cube Model describes curricula structures including stakeholders, new methods, course structures, techniques as well as further aspects, e-approaches, tools and entities. The PeaceTraining.eu Web Platform (www.peacetraining.eu) features a knowledge base, stakeholder maps, expert navigators, infographics, best practice libraries, and digital guidebooks to strengthen the information transfer among all project developments and future implementations. Additional Training Curricula Setup Utilities and Search Tools four training centres and trainers are provided through the project. Thus, PeaceTraining.eu increases awareness on the topic and also attracts secondary target groups including training course provider, educational institutions and trainers because of its sustainable strategy with long-term mobilisation and engagement activities including an International PeaceTraining.eu Symposium. On a European scale, PeaceTraining.eu will deliver new CPPB training methods and curricula and serve as a one-stop resource to increase efficiency and reduce costs.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.3.2-3 | Award Amount: 17.07M | Year: 2010

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of resistance. The proposal includes development of both slow release and gel formulations, pharmacokinetic and challenge experiments in macaques as well as human studies including a collaborative study with an EDCTP-funded project to use multiplex and proteomic technologies as well as culture-independent DNA-based analysis of mucosal microbiota to investigate biomarkers and establish a baseline signature from which perturbations can be recognised. This is a large consortium comprising 30 partners from 8 EU countries and from Switzerland, Ukraine, South Africa and the United States.Partners include microbicide developers, IPM and Particle Sciences, and producers, Gilead, Tibotec and Virco. Two SMEs will also participate in RTD aspects. The consortium is multidisciplinary with scientists engaged in basic discovery working with new targets and developing novel chemistry to produce compounds with improved safety and efficacy profiles as well as altered patterns of resistance.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-26-2014 | Award Amount: 5.09M | Year: 2015

Cystic Fibrosis (CF) is a genetic disease with the higher incidence in Europe showing c.a. 5% mortality in childhood. The majority of patients suffer from lifelong pancreatic insufficiency leading to maldigestion of food and malabsorption and consequently with malnutrition and growth stunting. An accurate enzyme replacement arises as an early nutritional intervention able to provide better nutritional status and patients welfare from early stages avoiding complications associated to the development of the disease. By means of our innovative and portable ICT tool we will improve the socio-economic impact of the disease, promoting healthy lifestyle, intertwining patient empowerment, education and training with self-management and prevention of secondary CF-complications. The multidisciplinary and complementary approach of this co-developed integrative PROJECT guarantees the patients adherence to the treatment and the best outcome of the nutritional intervention mainly in childhood. The beneficiaries of the application comprise patients, care-givers, families and health professionals as well as health monitoring authorities. MyCyFAPP is tailored designed and will be clinically validated for CF self-management and monitoring becoming a competitive market product in Europe. This APP will have a key role as decision support system, boosting the growth and competitiveness of the participating SMEs in Europe which will ensure the commercial exploitation of the results, the market uptake and the MyCyFAPP distribution for the benefit of the patient.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: HEALTH.2013.4.1-4 | Award Amount: 553.89K | Year: 2013

The landscape of genetic testing is rapidly changing. Soon, whole genome sequence analysis (3Gb-testing) will be an effective and financially viable alternative to targeted gene analysis. New technologies that allow efficient sequencing of a whole human genome in a diagnostic setting will have an enormous impact on diagnostic centres replacing many existing molecular and cytogenetic tests. Patients deserve to benefit from our vastly growing knowledge on functional genomics. 3Gb-testing is the ideal method to bring these benefits to the public. However, it is critical to avoid mistakes with respect to ethics, quality, over or mis-interpretation of data. It is essential that our society is prepared for the change once it is implemented. Hence, current gaps in our knowledge have to be identified and research has to be initiated to bridge these gaps. The 3Gb-TEST project will bring stakeholders together and ensure they are informed with respect to the desirable and undesirable developments. The clinical utility and cost effectiveness of whole genome sequencing needs to be determined as part of a robust health technology assessment process (HTA). Interpretation of sequence data in terms of clinical relevance will pose a challenge to both laboratory and clinical geneticists. Substantial investments may be required and the logistic restructuring of genetic services will need to be addressed. This project aims to prepare Europe for innovations in molecular testing. Quality assessment schemes, HTA and guidelines have to be in place. Healthcare professionals must be aware of the impending change and potential impact on practice. The Consortium will inform the healthcare community and make recommendations to the European Commission, the European Society of Human Genetics, and national organizations relevant to this field. A key output will be a validated roadmap for the implementation of diagnostic genome sequencing in Europe.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.4.2 | Award Amount: 12.53M | Year: 2010

iTEC is a large-scale pilot involving up to 1,000 classrooms focused on Learning in the 21st Century and the design of the future classroom. Partners include 15 Ministries of Education, leading ICT vendors, innovative SMEs, TEL researchers, teacher educators and experts in school validations and pedagogical evaluation. The key aim is to develop engaging scenarios for learning in the future classroom that can be validated in large-scale pilots and subsequently taken to scale.\n\niTEC produces meaningful pedagogical scenarios (assisted by semantic web technology) for the future classroom and, from these, derives learning activities and new approaches to assessment that engage teachers, learners and stakeholders outside the school. These are then tested and evaluated in the largest pan-European validation with schools yet undertaken.\n\nThe iTEC technology approach will make the technical components, (people, tools, services and content) required by the scenarios, interoperable and discoverable, so that teachers can more easily select and combine relevant components tailored to the future classroom scenario of their choice. This is in line with current trends in which teachers can choose from a wide variety of loosely coupled tools and where interactive whiteboards and other interactive, multi-touch technologies may be acting as a gateway for teachers to start exploring the further use of digital technologies in their classrooms.\n\nCombined with this, iTEC will research the skills and competences needed by teachers in the future classroom and equip teachers, both within and beyond the project, with the pedagogical knowledge and skills needed to implement project scenarios.\n\nHaving identified scenarios with the maximum potential to have a transformative effect on the design of the future classroom, the project will implement a mainstreaming strategy designed to ensure that work carried out in the large-scale pilots contribute to the educational reform process.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2009-2.5-1 | Award Amount: 6.94M | Year: 2010

Mutation of transport industry to carbon fibre reinforced polymer (CFRC) is now ineluctable in order to reduce our mobility environmental imprint. This sector is at a turn of its conversion from metal to composite, which should impose a radical rethinking of the whole supply chain. Combined developments of materials and matched processes is the main strategy of IMS&CPS project, only such a concerted effort may favor best synergies in the final part within a cost-effective process. The Main challenges for definitive conversion of transport sector to CFRC remains: (1) improvement of mechanical properties (mainly impact properties and interlaminar failure) (2) development of cost-effective manufacturing processes. IMS&CPS will address both challenges: - by positioning of CNT at specific locations (in the reinforcing fibre, at the fibre surface and/or in the matrix) and with specific orientations (random or 1D, 2D-orientated) as predicted by advanced engineering and innovative modeling tools for optimized properties. - by manufacturing CFRC by closed mould technologies : adapted RTM, SQRTM(RTM with prepreg) and Quickset processes, the today most competitive processing alternatives to autoclaves. Cheap and/or automated 3D-preform will be also developed for offering highest and easiest part integration in order to reduce at maximum assembly costs, which counts for one third of a CFRC part costs. CNT offers other opportunities to the designers: electrical, thermal conductivities, fire- and wear-resistance as well as sensing capabilities. Such performance improvements will be studied in IMS&CPS. A special effort will be focused on CFRC electrical conductivity enhancement by CNT insertions for lightning degradation prevention, for EMI shielding, which are today aerospace important issues. Sensing properties offered by CNT insertion will be also investigated. One highly-integrated part will be finally elected in order to demonstrate all IMS&CPS achievements.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-1.4-1 | Award Amount: 15.92M | Year: 2010

Type 1 diabetes is a serious chronic disease with major health risks and heavy burden on patients and society. It is caused by massive immune-mediated loss of insulin-producing beta cells in the pancreas that can so far not be locally corrected. A cellular allotransplant in the liver can install a new beta cell mass but the size is insufficient and the procedure faces limitations of donor shortage, inaccessibility of the implants, risks of associated immunosuppression. Our consortium of research, clinical and bioindustry teams is focused on overcoming these obstacles and implementing a roadmap for translation to preclinical models and clinical trials. We will pursue three interacting tracks. First, our ability to induce beta cell progenitors and stimulate beta cell proliferation in vivo should lead us to cells and compounds that activate this process in a diabetic pancreas, thus activating endogenous beta cell regeneration. Second, we will produce human beta (progenitor) cells in vitro by derivation from stem cells as well as from reprogrammed autologous cells; their therapeutic potential will be compared to that of primary human beta cells following implantation in rodents using a site that is accessible to modulation and monitoring. Third, we will design an antibody-based therapy for inducing immune tolerance to regenerated beta cells and to a beta cell implant. Efficacy, safety and regulatory criteria will be determined for clinical implementation. Clinical protocols will be prepared by adjusting associated therapy and by adopting an accessible and controlled implant site. Clinical trials will benefit from state-of-the art biologic markers for comparative analysis of the developed forms of beta cell therapy. This program should provide proof of principle for strategies that make beta cell transplantation and beta cell regeneration realistic for large numbers of type 1 diabetic patients, and probably also for some categories of type 2 diabetes.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-1.4-3 | Award Amount: 14.94M | Year: 2010

Ischemic Heart Disease (IHD) is the biggest single cause of death in Europe and in the developed world. Angioplasty and stents are successful in re-establishing perfusion of ischemic myocardium and have helped to reduce early mortality after acute myocardial infarction (AMI). However damaged tissue is not recovered and, therefore, this is always followed by cardiac remodelling and Chronic Heart Failure (CHF). CHF is a terminal disease with an annual mortality rate of ~18% with no cure besides heart transplantation, only available to a minority of patients. Autologous cell therapy has been proposed as a solution and clinically tested but has proven marginally effective at best. Its cost and the complexity of clinical procedures make it unsuitable for treating the large number of patients that need affordable and readily available products to treat the acute phase of the disease. Moreover, most of these approaches are predicated on the outmoded concept that the adult human myocardium lacks regenerative capacity. Recent findings show that adult myocardium harbours a population of resident pluripotent cells with the characteristics of true cardiac stem cells (CSC) able to regenerate contractile myocardium. This opens novel therapeutic avenues capable of producing real anatomical and functional regeneration. The CARE-MI proposal addresses the clinical implementation of this recent paradigmatic change. We will clinically test and further develop myocardial regenerative therapies based on the in situ activation, multiplication and differentiation of the endogenous CSCs with the aim to provide therapies that are: a)Affordable, in terms of the production costs of the medicinal product b)Readily and widely available, implying that the product may be easily stored and readied for application at all times at minimum cost. c)Easy to apply and compatible with current clinical standard of care for AMI, including the widespread use of PTCA interventions


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-32-2014 | Award Amount: 3.96M | Year: 2015

Online banking, e-commerce, telemedicine, mobile communication, and cloud computing depend fundamentally on the security of the underlying cryptographic algorithms. Public-key algorithms are particularly crucial since they provide digital signatures and establish secure communication without requiring in-person meetings. Essentially all applications today are based on RSA or on the discrete-logarithm problem in finite fields or on elliptic curves. Cryptographers optimize parameter choices and implementation details for these systems and build protocols on top of these systems; cryptanalysts fine-tune attacks and establish exact security levels for these systems. Alternative systems are far less visible in research and unheard of in practice. It might seem that having three systems offers enough variation, but these systems are all broken as soon as large quantum computers are built. The EU and governments around the world are investing heavily in building quantum computers; society needs to be prepared for the consequences, including cryptanalytic attacks accelerated by these computers. Long-term confidential documents such as patient health-care records and state secrets have to guarantee security for many years, but information encrypted today using RSA or elliptic curves and stored until quantum computers are available will then be as easy to decipher as Enigma-encrypted messages are today. PQCRYPTO will allow users to switch to post-quantum cryptography: cryptographic systems that are not merely secure for today but that will also remain secure long-term against attacks by quantum computers. PQCRYPTO will design a portfolio of high-security post-quantum public-key systems, and will improve the speed of these systems, adapting to the different performance challenges of mobile devices, the cloud, and the Internet of Things. PQCRYPTO will provide efficient implementations of high-security post-quantum cryptography for a broad spectrum of real-world applications.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.5.2 | Award Amount: 4.55M | Year: 2013

Regional anaesthesia (RA) has been used increasingly during the past four decades. This is addressed to the perceived advantages of reduced postoperative pain, earlier mobility, shorter hospital stay, and significantly lower costs. The performance of regional anaesthesia necessitates blocking the peripheral nerves by local injection of anaesthetic. Clinically this is achieved by the insertion of the injection needle close to the peripheral nerve, which is visualized with ultrasound and the proximity of the needle to the nerve is assessed with an electric nerve stimulator. However, it is a subtle technique and requires good theoretical, practical, and non-cognitive skills to allow trainees to achieve confidence in performing regional anaesthesia and to keep complications to a minimum. Current training methods for regional anaesthesia include cadavers, video teaching, ultrasound guidance, and simple virtual patient modelling. These techniques have limited capabilities and do not consider individual anatomy. The Virtual Physiological Human (VPH) creates the possibility to generate patient-specific computer models and apply them to RA procedures. The goal of this project is to increase the application, the effectiveness and the success rates of RA and furthermore the diffusion of the method into a broader clinical use through the developmentof patient-specific VPH models for anaesthesia. We aim at developing two independent but complementary systems, one system for training and one for guidance: a patient-specific Regional Anaesthesia Simulator (RASim) enhanced with ultrasound guidance and a Regional Anaesthesia Assistant (RAAs), which will assist the physicians to localize the nerve during the actual procedure. The RASimAs project will combine both, offering the possibility of training in the regional anaesthesia technique during the training phase of the physician and providing assistance during the clinical application of regional anaesthesia at later stages.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.9 | Award Amount: 3.75M | Year: 2010

Actuators based on electroactive polymer (EAP) hydrogels constitute a very attractive yet poorly explored technology. EAP hydrogels can expand and contract by several times their original volume by application of a small voltage. They can be engineered to be either porous or non-porous and the pore density and distribution can also be controlled. Their inherent limitations of very low actuation speed and need to operate in an aqueous medium constitute no impediment and in fact make them particularly suitable to a host of medical applications, some of them with high economic and societal relevance.\n\nThe Heart-e-Gel project utilises a microsystem concept based on electrode activation to change the volume of EAP hydrogels designed for operation in the cardiovascular system. Given the soft and aqueous nature of these gels and considering the need to accommodate for large volume changes, integrating these materials into complete microsystems poses unique challenges in terms of heterogeneous integration.\n\nHeart-e-Gel proposes to target specific medical applications and will require modelling of the microsystem-medical interface as well as assessing the potential of different material, actuation, volume sensing, and system delivery options. Three types of systems of immediate interest in cardiovascular surgery have been selected: a generic occluder for vascular repair, a system for improving endografts/stents for the treatment of abdominal aortic aneurysms, and an adaptable band around the pulmonary artery for patients with congenital heart diseases, or with arteriovenous fistulas.\n\nWhile carrying out the systematic study of EAP hydrogel integration into microsystems, substantial information on processing and characterisation will be gathered and will ultimately lead to a technology library that can enable microsystem designers to address an even wider range of applications.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EE-03-2014 | Award Amount: 5.33M | Year: 2015

RIBuild will strengthen the knowledge on how and under what conditions internal thermal insulation is to be implemented in historic buildings, without compromising their architectural and cultural values, with an acceptable safety level against deterioration and collapse of heavy external wall structures. The general objective of RIBuild is to develop effective, comprehensive decision guidelines to optimise the design and implementation of internal thermal insulation in historic buildings across the EU. RIBuild focuses on heavy external walls made of stone, brick and timber framing, as most historic buildings are made of these materials. The general objective is achieved through three main activities To obtain a thorough knowledge level to characterise the eligibility of the building for a deep internal thermal insulation renovation. This knowledge is obtained through screening of historic buildings, investigation of material properties and threshold values for failure To determine the conditions under which different internal insulation measures are reliable and affordable measures based on probabilistic modelling of the hygrothermal performance, the environmental impact and the cost/benefit To develop a set of comprehensive decision guidelines, which are demonstrated in a number of buildings. RIBuild addresses the most difficult retrofitting measure of historic buildings: internal thermal insulation. The adaption of knowledge developed by RIBuild contributes to sustainable historic buildings with improved energy efficiency implying an easier conversion of energy supply from inefficient fossil fuels to efficient renewable energy sources. RIBuild also assesses the hygrothermal performance of the building construction, thus no collateral damage occurs; in case of failure an easy roll back of the measures is possible. The guidelines developed in RIBuild strongly support the deep and holistic retrofitting approach which historic buildings face in the coming years.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.72M | Year: 2014

To tackle its (critical) raw material dependency, Europe needs comprehensive strategies based on sustainable primary mining, substitution and recycling. Freshly produced flows and stocks of landfilled industrial residues such as mine tailings, non-ferrous slag and bauxite residue (BR) can provide major amounts of critical metals and, concurrently, minerals for low-carbon building materials. The European Training Network for Zero-Waste Valorisation of Bauxite Residue (REDMUD) therefore targets the vast streams of new and stockpiled BR in the EU-28. BR contains several critical metals, is associated with a substantial management cost, whereas spills have led to major environmental incidents, including the Ajka disaster in Hungary. To date, zero-waste valorisation of BR is not occurring yet. The creation of a zero-waste BR valorisation industry in Europe urgently requires skilled scientists and engineers, who can tackle the barriers to develop fully closed-loop environmentally-friendly recovery flow sheets. REDMUD trains 15 researchers in the S/T of bauxite residue valorisation, with emphasis on the recovery of Fe, Al, Ti and rare earths (incl. Sc) while valorising the residuals into building materials. An intersectoral and interdisciplinary collaboration of EU-leading institutes and scientists has been established, which covers the full value chain, from BR to recovered metals and new building materials. Research challenges include the development of efficient extraction of Fe, Al, Ti and rare earths (incl. Sc) from distinct (NORM classified) BRs and the preparation of new building materials with higher than usual Fe content. By training the researchers in pyro-, hydro- and ionometallurgy, electrolysis, rare-earth extraction and separation technology, inorganic polymer and cement chemistry, Life Cycle Assessment (LCA), NORM aspects and characterisation, they become the much needed scientists and engineers for the growing European critical raw materials industry.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2009-3-2-01 | Award Amount: 7.90M | Year: 2010

Biodiversity in the seas is only partly explored, although marine organisms are excellent sources for many industrial products. Through close co-operation between industrial and academic partners, the MAREX project will collect, isolate and classify marine organisms, such as micro- and macroalgae, cyanobacteria, sea anemones, tunicates and fish from the Atlantic, Pacific and Indian Oceans as well as from the Mediterranean, Baltic and Arabian Seas. Extracts and purified compounds of these organisms will be studied for several therapeutically and industrially significant biological activities, including anticancer, anti-inflammatory, antiviral and anticoagulant activities by applying a wide variety of screening tools, as well as for ion channel/receptor modulation and plant growth regulation. Chromatographic isolation of bioactive compounds will be followed by structural determination. Sustainable cultivation methods for promising organisms, and biotechnological processes for selected compounds will be developed, as well as biosensors for monitoring the target compounds. The work will entail sustainable organic synthesis of selected active compounds and new derivatives, and development of selected hits to lead compounds. The project will expand marine compound libraries. MAREX innovations will be targeted for industrial product development in order to improve the growth and productivity of European marine biotechnology. MAREX aims at a better understanding of environmentally conscious sourcing of marine biotechnology products and increased public awareness of marine biodiversity and potential. Finally, MAREX is expected to offer novel marine-based lead compounds for European industries and strengthen their product portfolios related to pharmaceutical, nutraceutical, cosmetic, agrochemical, food processing, material and biosensor applications.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.1 | Award Amount: 2.54M | Year: 2012

The MUSE project will introduce a new way of exploring and understanding information by bringing text to life through 3D interactive storytelling. Taking as input natural language text like childrens stories or medical patient education materials, MUSE will process the natural language, translate it into formal knowledge that represents the actions, actors, plots and surrounding world, and then render these as virtual 3D worlds in which the user can explore the text through interaction, re-enactment and guided game play.\nTo enable such a system, MUSE will make targeted advances in natural language processing that enable the translation of natural language text to the necessary knowledge representations, as well as targeted advances in the action representation and story planning necessary for interactive storytelling. In natural language processing, MUSE will develop new techniques for finding explicit action structures in text and combining them with implicit action structures inferred from the context based on probabilistic models of translation and automatic methods for acquiring world knowledge from large corpora. In interactive storytelling, MUSE will develop action and object representations that bridge the gap between natural language and virtual worlds, and will create advanced techniques for planning virtual world stories given inconsistent and incomplete information.\nThe proposed methodology will be evaluated and showcased on two scenarios: one for creating immersive childrens stories from text and one for allowing medical patients to interact with patient education materials. Comparable to the invention of symbolic writing systems several millennia ago, MUSE contributes to a novel symbolic system communicating natural language utterances.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.6.6 | Award Amount: 3.11M | Year: 2011

Transport congestion problems contribute ~70% of pollutants to urban environments. The transport sector by itself consumes up to ~30% of the total energy in the EU. These figures suggest that if Europe is to reduce its CO2 emissions by making an efficient use of energy while improving the quality of life in European cities, novel approaches for the optimal management of urban transport complexity must be developed and adopted in the transport sector.\n\nMODUM addresses the environmental footprint in the transport sector by aiming to develop a new approach for pro-active demand-responsive management of traffic to enable energy-efficient multi-modal transport choices accommodating dynamic variations, minimising the environmental impact and improving the quality of life in urban environments. Moreover, MODUM will consider commuters, in combinations of both private and public transport, facing dynamic conditions such as unexpected disturbances typical of urban environments.\n\nIn particular, MODUM focuses on the comparison and then the potential synthesis of two approaches: 1) a traffic flow self-organising mechanism based on ant-like agent technology and 2) a reverse route planning based on software agent technology; using real-time data and declared destinations. Both mechanisms have proven successful in other application domains and have the potential of utilising vehicles computational power and networking capabilities for achieving their active participation in the demand-response management of urban traffic.\n\nThe metrics for the comparison will be extracted from real needs of traffic control centres and from transport users in our selected cities. Once the metrics are defined, a series of simulation experiments of realistic complexity will be constructed using real-time data feeds available from transport sensing infrastructure. Results from these will profile the two approaches against certain scenarios of traffic disturbances causing rapid changes in conditions. A synthesis of the two approaches will then be developed by the academic partners.\n\nSoftware implementation of the synthesised approach will then be embarked upon, focusing on the telecommunication challenges of a realistic demonstrator. The developed prototype will be validated on the initial scenarios by staging real-life experiments, which the relevant traffic management structures within the traffic control centres will evaluate. Such experiments will include historical data and simulations in combination with real-time data feeds from existing infrastructure and vehicles going through a section of a city in a number of congestion profiles. Analogous experiments will include people moving in a city by different means of transport.\n\nThe prototype will provide an implementation of an optimisation approach to traffic management capable of dynamically adapting the overall flows of traffic to unexpected disturbances to minimise carbon emissions within an urban complex environment. Fina


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.12M | Year: 2012

In everyday life, people listen to speech under a wide range of conditions that are non-optimal relative to the controlled conditions in laboratory experiments. Classical research methods can only deal with the effects of individual adverse conditions. This has contributed to the fragmentation of speech communication research in numerous sub-disciplines that have little interaction. While each type of adversity can have important consequences on its own, it is often the combination of conditions that conspire to create serious communication problems especially for elderly and hearing impaired persons. The long-term objective of Investigating Speech Processing in Realistic Environments (INSPIRE) is creating a community of researchers who can exploit synergies between the sub-disciplines that investigate individual aspects of speech communication, resulting in a new curriculum: Real-world speech communication. We will develop novel research methods that take advantage of the massive amounts of experimental data that are becoming available and allow for the analysis of communication behaviours in real-world situations characterised by simultaneous presence of multiple adverse conditions. Computational models will be developed that allow to predict speech intelligibility for normal-hearing and hearing-impaired listeners under realistic conditions. INSPIRE will create a permanent collection of measurement data and tools that are accessible for external researchers for testing and comparing speech intelligibility models, thus enabling a breakthrough improvement in hearing instrument tuning. INSPIRE will achieve its objectives by bringing together E(S)Rs with leading academic scientists from the core disciplines in speech communication, R&D personnel from leading companies in acoustics and hearing instruments and ENT specialists from hospitals that treat people with hearing impairments. All research projects in the network will address multiple adverse conditions.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.12.1 | Award Amount: 10.02M | Year: 2013

The proposed project DEEP-ER (DEEP-Extended Reach) addresses two significant Exascale challenges: the growing gap between I/O bandwidth and compute speed, and the need to significantly improve system resiliency. DEEP-ER will extend the Cluster-Booster architecture of the Dynamical Exascale Entry Platform (DEEP) project by a highly scalable I/O system and will implement an efficient mechanism to recover application tasks that fail due to hardware errors. The project will leverage new memory technology to provide increased performance and power efficiency. As a result, I/O parts of HPC codes will run faster and scale up better HPC applications will be able to profit from checkpointing and task restart on large systems reducing overhead seen today. Systems that use the DEEP-ER results can run more applications increasing scientific throughput, and the loss of computational work through system failures will be substantially reduced.\nDEEP-ER will build a prototype with the second generation Intel Xeon Phi processor, a uniform high-speed interconnect across Cluster and Booster, non-volatile memory on the compute nodes, and network attached memory providing high-speed shared memory access. A highly scalable and efficient I/O system based on the Fraunhofer file system will support I/O intensive applications, using optimised I/O middleware SIONlib and EIOW. A multi-level checkpoint scheme will exploit scalable I/O and fast, non-volatile memory close to the nodes to reduce the overhead of saving state for long-running tasks. The OmpSs based DEEP programming model will govern the creation of checkpoints and restart failed tasks from the beginning or recover saved state depending on their granularity.\nSeven important HPC applications will be optimised demonstrating the usability, performance and resiliency of the DEEP-ER Prototype. The applications come from different scientific and engineering areas and represent requirements of simulation-based and data-intensive HPC codes.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.3.1-1 | Award Amount: 7.75M | Year: 2014

Transition to adulthood is the period of onset of most of the serious mental disorders that disable or kill in adult life. Current service configuration of distinct Child and Adolescent Mental Health (CAMHS) and Adult Mental Health (AMHS) Services is considered the weakest link where the care pathway should be most robust. Transition-related discontinuity of care is a major socioeconomic and societal challenge for the EU. The MILESTONE project is an EU-wide study determining care gaps in current services across diverse healthcare systems and robustly evaluating an innovative transitional care model. In ten high-quality work packages we will map current services and transitional policies across EU; develop and validate transition-specific outcomes measures; conduct a longitudinal cohort study of transition process and outcomes across eight EU countries; develop and test, in a cluster-randomised trial, the clinical and cost-effectiveness of an innovative transitional care model; create clinical, organisational, policy and ethics guidelines for improving care and outcomes for transition age youth; and develop and implement training packages for clinicians across EU. The project will provide robust evidence for the most cost-effective way to meet the as-yet-unmet need of young people who fall through the CAMHS-AMHS divide; facilitate the development of integrated models of care and function; improve health care outcomes and system efficiencies; and ensure take-up of best practice. The project has active and intensive participation of young people, carers, advocacy groups and key stakeholders and involves two SMEs, Concentris and HealthTracker. Findings from the project will transform mental health care in EU for young people. Our results will assist policy makers in making informed and evidence-based decisions for improving health systems, enhancing patient outcomes, quality of life, service satisfaction, and improving health status at individual and population levels.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SEC-2013.1.1-2 | Award Amount: 4.75M | Year: 2014

The increase of the identity theft phenomenon across Europe and its related human and economical impacts is a major concern for all M.S. Several EU initiatives are ongoing to try to curb this concern. Todays identity can take various forms, either in the real world, as a primary identity delivered by a M.S. (passport, ID card, driving license...) but more and more in the 2.0 world (secondary identity for banking, administration, professional and commercial activities...). Similarly identity theft can take various forms, from stealing citizens paper documents, or simply by using digital means. Privacy is at the center of all concerns, as any solution must protect citizens identity and privacy, whilst not being worse than the problem itself. The major objective of EKSISTENZ is to protect EU citizens identities from all current threats but also to foresee what the future threats would be. The project will study in deep the identity theft phenomenon in Europe, revealing the flaws in the different paper-based procedures but also in the new dematerialized processes, assess the threat for the citizen and consequently, will develop technological components, backward compatible with different existing M.S. frameworks. EKSISTENZ will also focus on an identity-as-a-service approach, to allow M.S. interoperability, leading to a more global system to provide secure and strong identity for all M.S. To achieve this, the consortium will bring together different types of users involved in the identity chain (authorities, industrials, stakeholders, businesses), specialized technology providers and of course, data protection and privacy experts. EKSISTENZ will recommend updates to EU regulations in order to clearly inform, protect, propose responses and increase its resilience following an attempt. Knowing this, identity theft will become, if not impossible, much harder to carry out.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.5 | Award Amount: 1.71M | Year: 2011

Guardian Angels (GA) are future zero-power, intelligent, autonomous systems-of-systems featuring sensing, computation, and communication beyond human aptitudes. GA will assist humans from their infancy to old age in complex life situations and environments. Zero-power reflects system-of-systems ability to scavenge energy in dynamic environments by disruptive harvesting techniques. The project prepares zero-power technologies based on future energy-efficient technologies, heterogeneous design, and disruptive energy scavengers.\nThree zero-power generations of GAs are foreseen: Physical Guardian Angels are zero-power, on-body networks or implantable devices that monitor vital health signals and take appropriate actions to preserve human health. Environmental Guardian Angels extend monitoring to dynamic environments, using disruptive scavengers, personalized data communication, and first thinking algorithms. They are personal assistants that protect their wearers from environment dangers. Emotional Guardian Angels are intelligent personal companions with disruptive zero-power, manmachine interfaces deployed at large scale. They sense and communicate using non-verbal languages playing an important role in health, education, and security worldwide. This project addresses the following scientific challenges for energy-efficient visionary Guardian Angel autonomous systems: (i) energy-efficient computing (down to E=10-100kT), (ii) and communication (approaching the limit of 1pJ/bit), (iii) low-power sensing, (iv) disruptive scavenging (bio-inspired, thermoelectric, etc, targeting energy densities of tens of mW/cm2), and (v) zero-power man-machine interfaces. A selection of emerging technologies based on energy efficiency is proposed. We will also develop design tools that integrate electrical, mechanical, optical, thermal, and chemical simulation tools over length and time scales currently not achievable.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.69M | Year: 2014

Neurogastroenterology is a new and emerging medical/scientific subspecialty that currently has no formal training opportunities in medicine and related disciplines. It includes basic science aspects (neurophysiology, neurobiology, neuropsychology, psychophysiology) and clinical aspects (gastroenterology, neurology, internal medicine, surgery, psychology, psychosomatic medicine) of the neural control of intestinal functions (motility, secretion, absorption, immunity, sensitivity) in health and disease. Functional disorders of the gastrointestinal tract are among the most frequent disorders in the general population, are associated with high psychiatric (depression, anxiety, chronic fatigue) and somatic comorbidities (back pain, headache), and account for substantial direct and indirect health care costs occurring throughout Europe. Functional disorders of the gastrointestinal tract are thought to be due to disorganized gut-brain interaction of either afferent or efferent or both pathways in control of intestinal functions. In addition, low-grade inflammation, nutritional challenges of the local immune system, and/or post-infectious neuroplastic changes of the enteric nervous system of the gut are believed to be common pathogenetic mechanisms. Genetic contributions have been established, and psychological modulators of its clinical expression have been shown to be effective; both contribute to the efficacy of therapeutic interventions. The standards of diagnosis of functional bowel disorders are still a matter of debate, and only a few effective treatment strategies are available. The NeuroGut network, consisting of experienced academic and industrial partners organized in the European Neurogastroenterology and Motility Society (ESNM), is therefore aimed at offering young researchers excellent training opportunities in neurogastroenterology and in complementary skills in order to generate a new generation of scientists dedicated to resolving open questions.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.57M | Year: 2011

BioTiNet ITN is an inter-disciplinary, inter-sectoral and multinational initiative, which has the primary goal of training researchers who will help to improve the overall efficiency of metallic implants in orthopedic treatment by minimizing the stress shielding effect, and promote technical, biological and clinical developments at a pan-European level, for the benefit of all European inhabitants. BioTiNet ITN brings together 12 leading European research groups which possess state of the art expertise and excellent research infrastructures to provide opportunities for 18 young scientists to receive exceptional, high-level training in biomedical materials, with special emphasis on the development of novel low-rigidity Titanium-based structures for orthopaedic use. The project will screen and explore a wide structural spectrum with specific characteristics, balancing the advantages of a reduced Youngs modulus and the best resistance to deformation, which will help relieve problems with stress shielding. The novel Titanium-base structures will meet the end-user/customer requirements of biomechanical and biochemical functionality and also the material producers requirement of processing. The research program comprises four complementary research work packages, designed to deliver to the young researchers the most relevant state of the art knowledge and expertise in the biomaterials research field for a career development in line with the scientific, industrial and societal needs and challenges. Network-wide and local research training activities, training in complementary skills dedicated to biomaterials field (entrepreneurship, ethics, communication, innovation, IPR, project management etc.) and the cooperation with industrial partners will guarantee the complete training in this scientific field of a new generation of scientists, thus allowing them to become European professionals with excellent career perspectives.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: FoF.NMP.2012-5 | Award Amount: 5.19M | Year: 2012

The Hi-Micro project intends to realise an innovative approach for the design, manufacturing and quality control of tool inserts to achieve significant breakthrough in mass production of precision 3D micro-parts, through further developing both enabling manufacturing technologies, including additive manufacturing (AM), micro electrical discharge machining (micro-EDM), micro electro-chemical machining (micro-ECM) and micro-milling, and unique metrology and quality control methods such as computer-tomography (CT) metrology and digital holography. Together with industrial technology providers, the Hi-Micro project will further bolster the performance of industrial equipment for mass production of precision 3D micro-parts, through modular design of tool insert units with improved thermal management capability, development of on-machine handling system and in-line quality control device. Activities will run over the entire value chain of mass production of precision 3D micro-parts, from product and tool insert design, manufacturing of tool inserts, micro injection moulding processes, to the production equipment and quality control in the whole production chain. In order to tackle the identified challenges and critical problems, the Hi-Micro project will provide radical innovations and major breakthroughs as follows: Development of design and tolerance guidelines for advanced micro manufacturing of components (nominal size <1mm) Reliable capability of manufacturing tool inserts with complex internal features for conformal thermal management in micro-injection moulding (IM) and micro powder injection moulding (PIM) Processing technologies and equipment for manufacturing of 3D micro-parts with increased precision and accuracy to ensure smaller tolerances for the products, Metrology methods for complex internal structure and high-speed inline quality control with improved measurement efficiency and without loss of resolution or accuracy.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.3.2-1 | Award Amount: 3.62M | Year: 2012

Integrated delivery systems of care, e.g. networks of health organizations and professionals who work together to coordinate services to meet their patients needs, are an important way of linking fragmented services and maximizing system efficiency and seamlessness of patient transition. Research increasingly shows that patients with advanced cancer and advanced chronic disease are treated well by integrated palliative care pathways, with comparable quality of care at lower costs. Palliative care involves the multidisciplinary care for patients in the last phase of life-threatening disease and is expected to largely grow due to the ageing of the European population. However, palliative care in Europe is still mostly organized across institutional lines: hospital, home care, hospice. This project aims at the identification of best practices in integrated palliative care with regard to quality of life and quality of care. Mixed methods will be used to identify models for integrated palliative care in Europe and to assess patient/caregiver experiences and perceptions within these pathways at the one hand and organizational, managerial, financial and regulatory aspects of these integrated pathways at the other hand. The project will evaluate existing initiatives for patients with cancer, COPD and CHF, and will deliver recommendations on (requirements for) best practices in integrated palliative care. This will also include recommendations on (changes in) skill mix of health professionals. Results will be disseminated via conferences, articles, and an interactive website including an e-learning module. This project will contribute vastly to the improvement of the (organization of) care for patients with advanced cancer and chronic disease and can be extrapolated to other patients with complex care needs.


Grant
Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.11.3 | Award Amount: 13.23M | Year: 2013

Cloud for Europe (C4E) addresses the objectives of the European Cloud Partnership program. It gives a clear view on the public sector requirements and usage scenarios for Cloud Computing in Europe. The main objectives of C4E are to remove the obstacles for Cloud adoption and to harmonize the requirements from different public organisations beyond national borders. Stakeholders from industry, purchasers, government users and citizens are involved in this process. This analysis phase will be followed by a pre-commercial procurement (PCP) for services that are identified as missing or need to be adopted for Governments use. To overcome legal issues, C4E will spend efforts to accomplish suitable contractual terms and conditions for future Cloud procurements.\n\nThe C4E consortium brings together a fine range of experts and demonstrates a sound balance between legal, procurement and technology experience. By performing market and requirements analysis on current technologies and legal issues, gaps will be identified and documented. Continuous dialog with stakeholders is essential from the beginning of the project. This will stimulate industry, especially small and medium enterprises (SMEs) to participate in the PCP and to develop solutions needed by the public sector. Eight Consortium partners are indicating their conditional intent to invest in the PCP phase. How the costs, risks and benefits of the PCP phase will be distributed among all partners will be determined in negotiation with the European Commission and the partners. Each partner will do the investment in the PCP phase as stated in a contract between the partners that is to be established. Lessons learned and the developed Cloud services will be published for future re-use of the PCP instrument in other R&D projects. C4E will build trust in Cloud Computing by applying PCP as an instrument for industry innovation and simultaneously enhance cloud adoption in the public sector.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: FCT-06-2015 | Award Amount: 6.20M | Year: 2016

Money underpins all terrorist activities (without money propaganda, training, recruitment, and support are less effective or null). The disruption of terrorist financing activity is a key element in any fight against terrorism. DANTE will deliver effective, efficient and automated data mining, analytics solutions and an integrated system to detect, retrieve, and analyse huge amounts of heterogeneous and complex multimedia and multi-language (in five languages) terrorist-related contents from both the Surface and the Deep Web, including the Dark Nets. The ultimate goal is to discover (by connecting the dots), analyse and monitor potential terrorist-related activities and people, with focus on online fund raising activities, but also considering propaganda, training and disinformation. The challenging results of DANTE are achievable by exploiting, improving and integrating several existing data mining and analysis tools (mostly provided and owned by the partners; some already with high TRL). These tools and services will be further evolved and enhanced to be put at the service of the requirements provided by LEA partners (Guardia Civil, Policia Judiciaria, Home Office, Carabinieri). Thus, starting from lab and pre-prototype tools and methods, a market ready product with higher TRL will be the major outcome of DANTE. The presence of end user partners in the consortium will allow the validation/optimisation of the solution and boost of its adoption in their operational circumstances. The DANTE system will be validated and demonstrated in three pilots under the direct responsibility of the involved LEAs in their operational environments with the aim of detecting, analysing and monitoring terrorist-related contents for (i) propaganda (including recruitment, incitement, radicalization and disinformation), (ii) training and (iii) fund raising. DANTE surpasses the needs of the call for ensuring TRL6 of the projects results, by including components that will reach TRL7.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: LCE-05-2015 | Award Amount: 51.69M | Year: 2016

In order to unlock the full potential of Europes offshore resources, network infrastructure is urgently required, linking off-shore wind parks and on-shore grids in different countries. HVDC technology is envisaged but the deployment of meshed HVDC offshore grids is currently hindered by the high cost of converter technology, lack of experience with protection systems and fault clearance components and immature international regulations and financial instruments. PROMOTioN will overcome these barriers by development and demonstration of three key technologies, a regulatory and financial framework and an offshore grid deployment plan for 2020 and beyond. A first key technology is presented by Diode Rectifier offshore converter. This concept is ground breaking as it challenges the need for complex, bulky and expensive converters, reducing significantly investment and maintenance cost and increasing availability. A fully rated compact diode rectifier converter will be connected to an existing wind farm. The second key technology is an HVDC grid protection system which will be developed and demonstrated utilising multi-vendor methods within the full scale Multi-Terminal Test Environment. The multi-vendor approach will allow DC grid protection to become a plug-and-play solution. The third technology pathway will first time demonstrate performance of existing HVDC circuit breaker prototypes to provide confidence and demonstrate technology readiness of this crucial network component. The additional pathway will develop the international regulatory and financial framework, essential for funding, deployment and operation of meshed offshore HVDC grids. With 35 partners PROMOTioN is ambitious in its scope and advances crucial HVDC grid technologies from medium to high TRL. Consortium includes all major HVDC and wind turbine manufacturers, TSOs linked to the North Sea, offshore wind developers, leading academia and consulting companies.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-18-2015 | Award Amount: 6.31M | Year: 2016

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe. Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal intensive care, 45-50% of affected children die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective interventions, beside hypothermia, are warranted to further improve their outcome. Allopurinol is a xanthine oxidase inhibitor and reduces the production of oxygen radicals and brain damage in experimental, animal, and early human studies of ischemia and reperfusion. This project aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to near-term infants with HIE in addition to hypothermic treatment. Beyond this primary objective, the project will provide information on the effect of hypothermia on pharmacokinetics of drugs with a similar metabolism as allopurinol in neonates. Furthermore it will give the opportunity to further develop and validate biomarkers for neonatal brain injury using advanced magnetic resonance imaging, biochemistry, and electroencephalogramms, which will then be available for future studies testing neuroprotective interventions. Finally, this trial will extend our knowledge about incidence of and risk factors for perinatal asphyxia and HIE possibly enabling generation of more preventive strategies for the future.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-EJD | Phase: MSCA-ITN-2014-EJD | Award Amount: 3.79M | Year: 2015

Theoretical Chemistry and Computational Modelling (TCCM) is emerging as a powerful tool to help in the rational design of new products and materials for pharmaceutical, chemical, energy, computer, and new-materials industries. To achieve this goal, it is necessary to go beyond the traditional electronic structure studies, and merge complementary techniques that are normally not available at a single research group. The research programme of the TCCM-EJD aims at applying computational modelling to problems demanded by the industry and with high societal relevance, namely Materials with special properties, Biomolecules for new therapies and Energy storage. The objective of the Joint Doctorate is to prepare future research leaders, able to develop and use multidisciplinary computational techniques (methods and software), with solid communication skills, with many contacts established through the intensive relationship with worldwide leading researchers of 12 European universities and 14 additional partners, including 7 industrial and spin-off companies. A Joint Doctorate in TCCM is already operative since 2011, based on a fully participative scientific discussion and assessment of all research projects with a clear interdisciplinary character and the direct participation of the non-academic sector. The training programme puts the emphasis in common training, including 3 annual International Workshops, 3 schools on High Performance Computing and 3 tutorials in new computer codes. Career development opportunities are enhanced with regular inter-sectoral activities, transferable skill education and career coaching.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-39-2015 | Award Amount: 3.93M | Year: 2016

its4land delivers an innovative suite of land tenure recording tools that responds to sub Saharan Africas immense challenge to rapidly and cheaply map millions of unrecognized land rights in the region. ICT innovation will play a key role. Existing approaches have failed: disputes abound, investment is impeded, and the communitys poorest lose out. its4land reinforces strategic collaboration between the EU and East Africa via a scalable and transferrable ICT solution. Established local, national, and international partnerships drive the project results beyond R&D into the commercial realm. its4land combines an innovation process with emerging geospatial technologies, including smart sketchmaps, UAVs, automated feature extraction, and geocloud services, to deliver land recording services that are end-user responsive, market driven, and fit-for-purpose. The transdisciplinary work also develops supportive models for governance, capacity development, and business capitalization. Gender sensitive analysis and design is also incorporated. Set in the East African development hotbeds of Rwanda, Kenya, and Ethiopia, its4land falls within TRL 5-7: 3 major phases host 8 work packages that enable contextualization, design, and eventual land sector transformation. In line with Living Labs thinking, localized pilots and demonstrations are embedded in the design process. The experienced consortium is multi-sectorial, multi-national, and multidisciplinary. It includes SMEs and researchers from 3 EU countries and 3 East African countries: the necessary complementary skills and expertise is delivered. Responses to the range of barriers are prepared: strong networks across East Africa are key in mitigation. The tailored project management plan ensures clear milestones and deliverables, and supports result dissemination and exploitation: specific work packages and roles focus on the latter.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-1-2014 | Award Amount: 2.40M | Year: 2015

The making of policies coping with Global Systems is a process that necessarily involves stakeholders from diverse disciplines, each with their own interests, constraints and objectives. People play a central role in such collective decision making and the quest for solutions to a problem generally intertwines its very specification. Simulators can assist in this process provided they employ adequate high-level modelling to separate the political question from the underlying scientific details. Domain-specific Languages (DSL) embedded in Functional Programming (FP) languages offer a promising way to implement scalable and verifiable simulators. But the use of simulators is essentially a trial-and-error process too tedious for execution in a group session. A paradigm shift is needed towards active problem solving where stakeholders objectives can be taken along from the very beginning. Constraint Programming (CP) has demonstrated to enable such a shift for e.g. managed physical systems like water and power networks. This project lays the base for a DSL aimed at building scalable Rapid Assessment Tools for collective policy making in global systems. This can be achieved through foundational scientific work at different levels: from the high-level, political modelling, adapting the social discipline of Group Model Building (as used in business organizations), through visual forms of CP as well as gamification aspects, down to the needs for a host language, combining CP and FP. Special emphasis is put on domain-specific constraints, constraint composition, and composable solvers and heuristics. Results are applied and validated for the problem case of Climate-Resilient Urban Design, but the ambition is a general framework applicable to many other systems. The case study is assessed by an external multi-disciplinary Advisory Board of Stakeholders that guides the specification process and evaluates needs and usability of the tools.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.88M | Year: 2015

The European Brain Council (EBC) has recommended the disorders of the brain to be prioritised for funding. The purpose of this ChildBrain ETN is 1) to train young scientists, Early Stage Researchers (ESRs), to utilise evidence-based neuroscientific knowledge for helping children, especially those at high risk for dropout due to neurocognitive disorders, to meet future educational and societal demands. The network aims 2) to develop new, innovative brain imaging-based tools through research and industry to be applied by researchers and clinical sector end users for 3) increasing understanding and improving diagnosis and treatment of neurocognitive disorders, as well as enhancing targeted educational programs. To accomplish these goals, we aim 4) to form a cross-disciplinary and trans-sectorial European network of experts. Three research and two training work packages (WPs) are planned to reach these goals. The Childhood neurodevelopmental disorders WP comprises new research and training on the neural underpinnings of dyslexia, ADHD, epilepsy, and hearing loss and creates links to healthcare industry and special education. The Brain development WP will focus on understanding the systems-level brain development at the level of the individual child. The Brain research methods WP will develop new multi-modal data analysis methodologies that are essential for children and will also further brain research in adults. The academic, industrial and private sector partners will work across these themes, offering the ESRs project-specific collaboration, secondments, workshops, summer school and courses on scientific, transferable and entrepreneurial skills, as well as supervision. The ChildBrain ETN will produce a new generation of scientists with the theoretical, technological, and entrepreneurial skills necessary for making breakthroughs in the understanding of brain development and childhood neurocognitive disorders.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.00M | Year: 2015

The height of conventional wind turbines is limited by the enormous stresses on the structure. The idea of the Airborne Wind Energy (AWE) is to replace the most efficient part of a conventional wind turbine, the tip of the turbine blade, with a fast flying high efficiency kite, and to replace the rest of the structure by a tether which anchors the kite to the ground. Power is generated either by periodically pulling a ground based generator via a winch, or by small wind turbines mounted on the kite that exploit its fast cross wind motion. While the concept is highly promising, major academic and industrial research is still needed to achieve the performance required for industrial deployment. This can best be done by innovative junior researchers in a closely cooperating consortium of academic and industrial partners. The ITN AWESCO combines six interdisciplinary academic and four industrial network partners with seven associated partners, all selected on the basis of excellence and complementarity. All partners work already intensively on AWE systems, several with prototypes, and they are committed to create synergies via the cooperation in AWESCO. The main task is to train fourteen Early Stage Researchers (ESRs) in training-by-research and to create a closely connected new generation of leading European scientists that are ready to push the frontiers of airborne wind energy. AWESCO is the first major cooperation effort of the most important European actors in the field and will help Europe to gain a leading role in a possibly huge emerging renewable energy market, and to meet its ambitious CO2 targets. In addition, the AWESCO early stage researchers will be trained in cutting-edge simulation, design, sensing, and control technologies that are needed in many branches of engineering.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.1. | Award Amount: 6.45M | Year: 2013

Referring to the increasingly challenging EU2020-ambition of Inclusive Growth, the objectives of the InGRID project are to integrate and to innovate existing, but distributed European social sciences research infrastructures on poverty and living conditions and working conditions and vulnerability by improving the transnational data access, organising mutual knowledge exchange and improving methods and tools for comparative research. This integration will provide the related European scientific community with new and better opportunities to fulfil its key role in the development of evidence-based European policies for Inclusive Growth. In this regard specific attention is paid to a better measurement of related state policies, to high-performance statistical quality management, and to dissemination/outreach activities with the broader stakeholder community-of-interest, including European politics, civil society and statistical system. For this purpose key actors of the related European Research Area are coupled in the InGRID consortium, representing specific data infrastructures and cumulated know-how. Pan-European optimisation of the infrastructure is created by organising an open, harmonised high-performance on-site access with an extensive visiting grant system. Joint research activities are conducted for the innovation and optimisation of the infrastructure. Key issues tackled in this respect include: the multidimensionality as a standard for poverty research; the problem of hard-to-identify and hard-to-reach vulnerable groups in data collection; the improvement of longitudinal and regional poverty mapping; the survey technology for linking vulnerability in working conditions with economic change and employers behaviour; the harmonisation of classifying jobs and skills; improving tools to generate comparative policy indicators; optimising the micro-simulation of policy impacts; and statistical quality management.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2011.2.1-1 | Award Amount: 10.36M | Year: 2012

One of the biggest challenges facing global society today is the widespread and growing presence of hunger and food insecurity. Given that the lead time for some social and technological solutions is long, a long-term framework on global food and nutrition security (FNS) is required. FoodSecure aims at improving the resilience of the food system, by providing a means to mitigate risks and uncertainties in the world food system caused by economic and climatic shocks while providing for sustainable economic growth. The project provides an analytical toolbox to experiment, analyse, and coordinate the effects of short and medium term policies, thereby allowing for the execution of consistent, coherent, long-term strategies with desirable consequences. The FoodSecure collaboration responds to the challenge of food shortages and volatility by providing stakeholders, in the EU and beyond, with the capacity to assess and address the short term and long term challenges of food and nutrition security both effectively and sustainably. The project draws on an expert, multi-disciplinary, science team to provide a complete set of knowledge to inform and guide decision makers and other stakeholders in formulating strategies to alleviate food shortages. The food system is analysed in relationship to the ecosystem, energy, and financial markets, all of which are potential sources of shocks that can disrupt the food system. In addition, it is examined in light of fundamental societal trends and changing attitudes towards food consumption and production. The project emphasises the diversity of challenges of FNS in countries and regions. The project delivers new empirical evidence on the drivers of global FNS, and classifies regions and livelihood systems in typologies . A harmonised data system and modelling toolbox are developed for forecasts (on short term) and forward looking (towards 2050) on future hunger. A support for effective and sustainable actions will include the identification of the critical pathways for technological and institutional change and for EU policies in the areas of development aid, climate change, trade, common agricultural policy and renewable energy, including sustainability criteria.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 2.85M | Year: 2016

MarPipe is a consortium of 11 partners (IBP-CNR, SZN, UiT, UNIABDN, GEOMAR, KULeuven, UCC, eCOAST, MEDINA, MicroDish, Italbiotec) based in 8 countries (I, N, UK, D, B, IRL, E, NL), including 3 from the non-academic sector. We will train 11 ESRs in marine drug-discovery, providing these researchers with unique skills toward becoming world leaders in this research field and to advance their careers in academia or industry. MarPipe PhDs will be trained in a programme including training-by-research, joint courses of technical, scientific and transferrable skills, active participation to public scientific events, and an intense inter-sectoral networking exchange plan. Marine organisms have the capacity to produce a variety of biologically potent natural products, including antibiotic and anticancer compounds. MarPipe aims at further development of antimicrobial and anticancer lead compounds originating from a previous EU project (PharmaSea), and will also explore the bioactivity of deep-sea samples (5000m) collected during the recent Eurofleet-2 project in the sub-Antarctic. The PhD students will thus be involved in all phases of the drug discovery pipeline, from isolation of new microbial strains to pre-clinical development of lead compounds. Importantly, they will also be trained to overcome existing bottlenecks in the field, e.g. low yields and low chemodiversity, isolation of known compounds, toxicity of compounds. The discovery rates of new bioactive antimicrobial and anticancer molecules will be enhanced through 11 PhD projects that cover all phases of the biodiscovery pipeline. As a final outcome of the project, we envisage the creation of a marine biodiscovery start-up company, which will include most of the MarPipe partners. The scientists of the future will be trained to become conscious about the socio-economic and policy context of their work, since several specific MarPipe PhD projects focus on legal, policy, innovation and entrepreneurship themes.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.83M | Year: 2016

The European chemical industry faces some very serious challenges if it is to retain its competitive position in the global economy. The new industries setting up in Asia and the Near East are based on novel process-intensification concepts, leaving Europe desperately searching for a competitive edge. The transition from batch to continuous micro- and milliflow processing is essential to ensure a future for the European fine-chemicals and pharmaceuticals industries. However, despite the huge interest shown by both academia and industrial R&D, many challenges remain, such as the problems of reaction activation, channel clogging due to solids formation and the scaling up of these technologies to match the required throughput. COSMIC, the European Training Network for Continuous Sonication and Microwave Reactors, takes on these challenges by developing material- and energy-efficient continuous chemical processes for the synthesis of organic molecules and nanoparticles. The intersectoral and interdisciplinary COSMIC training network consists of leading universities and industry participants and trains 15 ESRs in the areas of flow technology, millifluidics and external energy fields (ultrasound and microwaves). These energy fields can be applied in structured, continuous milli-reactors for producing high-value-added chemicals with excellent yield efficiencies in terms of throughput, waste minimization and product quality that simply cannot be achieved with traditional batch-type chemical reactors. The chemical processes that are at the heart of COSMICs game-changing research are catalytic reactions and solids-forming reactions. COSMICs success, which is based on integrating chemistry, physics and process technology, will re-establish European leadership in this crucial field and provide it with highly trained young experts ready for dynamic careers in the European chemical industry.


Grant
Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.94M | Year: 2016

Additive Manufacturing (AM) is a fastgrowing sector with the ability to evoke a revolution in manufacturing due to its almost unlimited design freedom and its capability to produce personalised parts locally and with efficient material use. AM companies however still face technological challenges such as limited precision due to shrinkage and buildin stresses and limited process stability and robustness. Moreover often postprocessing is needed due to the high roughness and remaining porosity. In addition qualified, trained personnel is hard to find. This ITN project will address both the technological and people challenges. To quality assure the parts produced, PAM will, through a close collaboration between industry and academia, address each of the various process stages of AM with a view to implementing good precision engineering practice. To ensure the availability of trained personnel, ESRs will, next to their individual research and complementary skills training, be immersed in the whole AM production chain through handson workshops where they will design, model, fabricate, measure and assess a specific product. The expected impact of PAM thus is: 1. The availability of intersectoral and interdisciplinary trained professionals in an industrial field thats very important for the future of Europe, both enhancing the ESR future career perspectives and advancing European industry. 2. The availability of high precision AM processes through improved layout rules with better use of AM possibilities, better modelling tools for firsttime right processing, possibility for insitu quality control ensuring process stability and, if still needed, optimised postprocessing routes 3. As a result of 1: an increased market acceptance and penetration of AM. 4. Through the early involvement of European industry: a growing importance of the European industrial players in this fastgrowing field. This will help Europe reach its target of 20% manufacturing share of GDP.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.89M | Year: 2017

Reliability and radiation damage issues have a long and important history in the domain of satellites and space missions. Qualification standards were established and expertise was built up in space agencies (ESA), supporting institutes and organizations (CNES, DLR, etc.) as well as universities and specialized companies. During recent years, radiation concerns are gaining attention also in aviation, automotive, medical and other industrial sectors due to the growing ubiquity and complexity of electronic systems and their increased radiation sensitivity owing to technology scaling. This raises the demand for dedicated design and qualification guidelines, as well as associated technical expertise. Addressing open questions linked to respective qualification requirements, the proposed training network RADiation and Reliability Challenges for Electronics used in Space, Aviation, Ground and Accelerators (RADSAGA) will for the first time bring together industry, universities, laboratories and test-facilities in order to innovate and train young scientists and engineers in all aspects related to electronics exposed to radiation. The expertise of the space and avionics sectors will be complemented with new and unique test facilities, design and qualification methodologies of the accelerator sector, promising for other application areas. Driven by the industrial needs, the students will be trained by established specialists in all required skills, and acquire expertise through innovative scientific projects, allowing to: (i) push the scientific frontier in design, testing and qualification of complex electronic systems for mixed field radiation environments (ii) establish related courses to train future engineers/physicists; and (iii) issue design and test guidelines to support industry in the field, protecting European competitiveness when radiation effects become as important as thermal or mechanical constraints for the aviation, automotive and other industrial sectors.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.86M | Year: 2017

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The project aims to accelerate the realisation of animal-free safety assessment and to graduate 15 PhD students with the ideal skill sets to carry out the strategy designed in in3 in the near future.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.1.3-1 | Award Amount: 3.07M | Year: 2013

RASTANEWS intends to enhance knowledge base, at both theoretical and an applied level, on many aspects of the future of macro-economic and monetary integration in Europe thus paving the way to a revised governance of the EMU, and the EU as a whole, in the wake of the debt crisis. We see three key issues about the working of the EU macro-economy that deserve deeper investigation. The first is the issue of incomplete and informationally inefficient financial markets, the Achilles heel of the consensus DSGE models. The second, related issue, is the heterogeneity in expectations, which should play a fundamental role in explaining the behaviour of asset prices. The third issue is the need to overcome the traditional dichotomy between Keynesian (short run) and neoclassical (long run) policy prescriptions. Taking these issues seriously has important implications for the conduct of EU monetary and fiscal policies and for EU governance system. In addition, to facilitate the timely identification of macro risks, we propose a new system of early warning indicators, to be implemented within the EMU surveillance mechanism. This proposal is consistent with our theoretical framework and is based on an empirical macro-finance approach.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2011.6.4-1 | Award Amount: 3.66M | Year: 2012

The objective of SIMPATIC is to provide policy makers with a comprehensive and operational tool box allowing for a better assessment of the impact of research and innovation policies in Europe. SIMPATIC represents a unique bottom-up project proposal, bringing together micro and macro researchers with expertise in evidence-based policy analysis and impact assessment of research and innovation policies, thus allowing European innovation policy makers to better address EU2020 challenges. Insights from micro-analysis and micro-evidence, including SIMPATICs own frontier pushing ex-post policy impact analysis of R&D subsidies and tax credits, will be used as input in SIMPATICs sectoral EU macro models, DEMETER and GEM-G3. These models have already regularly served in the assessment of innovation and environmental policies in Europe, and have thus proven their strength as support tools for ex ante and ex post assessments of EU policies. With SIMPATICs proposal, these models will be upgraded to include the latest insights from micro models in order to better respond to the new, grand challenges of RTD policies, including environment and social inclusion; SIMPATIC will thus develop and use the best possible evidence and methodologies to simulate the impact of a number of research and innovation policy alternatives, providing new insights into the potential impact of various policy alternatives, thus contributing to advancing impact assessment and evidence based innovation policy design in Europe.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.00M | Year: 2016

ENSAR2 is the integrating activity for European nuclear scientists who are performing research in three of the major subfields defined by NuPECC: Nuclear Structure and Dynamics, Nuclear Astrophysics and Nuclear Physics Tools and Applications. It proposes an optimised ensemble of Networking (NAs), Joint Research (JRAs) and Transnational Access Activities (TAs), which will ensure qualitative and quantitative improvement of the access provided by the current ten infrastructures, which are at the core of this proposal. The novel and innovative developments that will be achieved by the RTD activities will also assure state-of-the-art technology needed for the new large-scale projects. Our community of nuclear scientists profits from the diverse range of world-class research infrastructures all over Europe that can supply different ion beams and energies and, with ELI-NP, high-intensity gamma-ray beams up to 20 MeV. We have made great effort to make the most efficient use of these facilities by developing the most advanced and novel equipment needed to pursue their excellent scientific programmes and applying state-of-the-art developments to other fields and to benefit humanity (e.g. archaeology, medical imaging). Together with multidisciplinary and application-oriented research at the facilities, these activities ensure a high-level socio-economic impact. To enhance the access to these facilities, the community has defined a number of JRAs, using as main criterion scientific and technical promise. These activities deal with novel and innovative technologies to improve the operation of the facilities. The NAs of ENSAR2 have been set-up with specific actions to strengthen the communities coherence around certain resarch topics and to ensure a broad dissemination of results and stimulate multidisciplinary, application-oriented research and innovation at the Research Infrastructures.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.98M | Year: 2011

Virus infections remain a major cause of disease, with dramatic costs in mortality, morbidity, and economic loss worldwide. There is an unmet need for potent antiviral drugs, in particular against viruses with a (\)RNA genome which include many important pathogens of humans and animals. Antiviral drug development requires a detailed understanding of virus replication and effective translation of this knowledge into drug discovery. Europe needs well-trained experts with multidisciplinary skills to advance this field. However, few, if any, European training institutes have the broad know-how required to provide such a comprehensive training programme. The EUVIRNA partnership aims to fill this gap with the proposed EUVIRNA training programme. The EUVIRNA partnership consists of six outstanding European academic partners and four industrial partners (one pharmaceutical R&D company and three SMEs), and an associated partner (SME specialized in education). All EUVIRNA partners are recognized leaders in their field, ensuring state-of-the-art training possibilities, and their skills are highly complementary. Three Visiting Researchers will complement the expertise of the partners. EUVIRNA aims to introduce 18 ESRs and 2 ERs to state-of-the-art knowledge and technology applied in molecular virology and antiviral therapy, with both local and network-wide training activities. Individual research projects, research training workshops and intersectoral secondments will be supplemented with complementary skills courses to improve career development and perspectives. The industrial partners are actively involved in the entire programme, and will furthermore organize a 1-week industry-oriented conference aimed at further bridging the gap between academia and industry. Thus, EUVIRNA offers talented researchers a multidisciplinary and intersectoral training programme and prepares them for a future leading role in European molecular virology research and antiviral dru


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.27 | Award Amount: 12.01M | Year: 2010

The overall aim of NERA is to achieve a measurable improvement and a long-term impact in the assessment and reduction of the vulnerability of constructions and citizens to earthquakes. NERA will integrate the key research infrastructures in Europe to monitor earthquakes and assess their hazard and risk, and will combine expertise in observational and strong-motion seismology, modeling, geotechnical and earthquake engineering to develop activities to improve the use of infrastructures and facilitate the access to data. NERA will ensure the provision of high-quality services, including access to earthquake data and parameters and to hazard and risk products and tools. NERA will coordinate with other EC projects (SHARE, SYNER-G) a comprehensive dissemination effort. NERA will contribute to the OECD GEM program and to the EPOS ESFRI infrastructure.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.2-01 | Award Amount: 13.29M | Year: 2012

The PharmaSea project focuses on obstacles in marine biodiscovery research, development and commercialization and brings together a broad interdisciplinary team of academic and industry researchers and specialists to address and overcome these. The partners are ideally placed to demonstrate how to widen the bottlenecks and increase the flow of ideas and products derived from the marine microbiome towards a greater number of successes in a larger number of application areas. Despite the tremendous potential of marine biodiscovery, exploitation, particularly at a commercial scale, has been hampered by a number of constraints. These relate to access (physical and legal), genetics of the organisms, compound isolation, structure elucidation, early reliable validation of biological activity and best mechanisms of flow-through into exploitation. PharmaSea will solve these chronic bottlenecks by developing essential actions beyond the state of the art and linking them with best practice and appropriate pragmatic approaches. The robust pipeline structure established within PharmaSea will process a wide genetic basis including marine microbial strain collections held by partners and new strain collections from extreme environments (deep, cold and hot vent habitats) to produce new products with desirable characteristics for development by the SME partners in three accessible market sectors, health (infection, inflammation, CNS diseases), personal care and nutrition. The global aim of PharmaSea is to produce two compounds at larger scale and advance them to pre-clinical evaluation. To address relevant challenges in marine biodiscovery related to policy and legal issues, PharmaSea will bring together practitioners, legal experts, policy advisors/makers and other stakeholders, focusing on the feasibility of harmonising, aligning and complementing current legal frameworks with recommendations and ready to use solutions tailored to marine biodiscovery.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.2.2-1 | Award Amount: 7.48M | Year: 2012

Falls are a major public health concern that directly affects millions of elderly Europeans, the healthcare system, and the adult children and caregivers of older people. The V-TIME approach combines cutting edge technology with emerging concepts from gerontology, neuroscience and rehabilitation to reduce fall risk in a unique way. The V-TIME multi-modal intervention consists of treadmill training (TT) that promotes walking abilities and physical fitness. A key novel addition is the simultaneous use of a virtual reality (VR) environment that challenges, implicitly teaches and enhances cognitive skills that facilitate the safe execution of many activities of daily living: visual scanning, planning, dual tasking abilities, and obstacle negotiation. Exciting pilot studies support the idea that TT augmented with VR (TT\VR) addresses the limitations of existing fall prevention interventions. Via TT\VR, V-TIME offers task-specific training in a motivating and safe environment that can readily be reproduced and standardized. The major goal of the current proposal is to establish the beneficial effects of V-TIME training in a large (n=300) and diverse group of elderly via a multi-centre, prospective randomized controlled trial. Outcomes include post-training 6 month fall incidence rates (the primary outcome), gait, physical activity (e.g., steps walked in 7 days), cognitive function, quality of life, and neuroimaging measures (fNIRS, fMRI). The effects of dosing and an extension phase will be examined (n=60). The consortium brings together world leaders in ageing, neuroscience, rehabilitation and VR technology to test a new therapy that may dramatically reduce the negative costs of falls, financial and other. The RCT is designed to show that V-TIME offers a significant and clinically relevant greater benefit compared to current clinical management; to probe brain plasticity; and to establish efficacy on fall risk, mobility, cognitive function, and functional independence.


IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of radiation observed at distance from the irradiated metastatic site(s), and the effect of the tumour-specific immunocytokine L19-IL2 (watch our animation explaining the concept at https://youtu.be/6wDE6RkrikA). Palliative treatment is the current standard of care for patients with metastatic non small cell lung cancer (NSCLC), unless there is an actionable mutation. By using the concept of limited metastatic disease (10 sites, WHO 0-1: oligo\) we aim to develop a therapy with curative intent. IMMUNOSABR will gather evidence for the clinical efficacy of our bi-modal treatment strategy in a multicentre randomised phase II study (clinicaltrials.gov no. NCT02735850) in patients with limited metastatic NSCLC. IMMUNOSABR is complemented by two strong biomarker work packages which focus on developing an ambitious personalised biomarker strategy, to identify patients who can benefit from the novel treatment strategy. This includes promising non-invasive imaging techniques and state-of-the-art immunological monitoring approaches on tumour tissue and blood. IMMUNOSABR will spur further development of L19-IL2 as a commercial drug and translate the bi-modal treatment strategy towards clinical implementation.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-01-2016 | Award Amount: 15.04M | Year: 2017

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations. MultipleMS will therefore develop, validate, and exploit methods for patient stratification in Multiple Sclerosis, a chronic inflammatory disease and a leading causes of non-traumatic disability in young adults, with an estimated cost of 37 000 per patient per year over a duration of 30 years. Here we benefit from several large clinical cohorts with multiple data types, including genetic and lifestyle information. This in combination with publically available multi-omics maps enables us to identify biomarkers of the clinical course and the response to existing therapies in a real-world setting, and to gain in-depth knowledge of distinct pathogenic pathways setting the stage for development of new interventions. To create strategic global synergies, MultipleMS includes 21 partners and covers not only the necessary clinical, biological, and computational expertise, but also includes six industry partners ensuring dissemination and exploitation of the methods and clinical decision support system. Moreover, the pharmaceutical industry partners provide expertise to ensure optimal selection and validation of clinically relevant biomarkers and new targets. Our conceptual personalized approach can readily be adapted to other immune-mediated diseases with a complex gene-lifestyle background and broad clinical spectrum with heterogeneity in treatment response. MultipleMS therefore goes significantly beyond current state-of-the-art thereby broadly affecting European policies, healthcare systems, innovation in translating big data and basic research into evidence-based personalized clinical applications.


Patent
University College Cork and Catholic University of Leuven | Date: 2013-11-20

A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, wherein the groups are as defined in the claims. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula (I), and the use of compounds of formula (I) in the preparation of a medicament for treating a viral disorder.


Bariwal J.,Catholic University of Leuven | Van Der Eycken E.,Catholic University of Leuven
Chemical Society Reviews | Year: 2013

Nitrogen containing compounds are of great importance because of their interesting and diverse biological activities. The construction of the C-N bond is of significant importance as it opens avenues for the introduction of nitrogen in organic molecules. Despite significant advancements in this field, the construction of the C-N bond is still a major challenge for organic chemists, due to the involvement of harsh reaction conditions or the use of expensive catalysts in many cases. Thus, it is a challenge to develop alternative, milder and cheaper methodologies for the construction of C-N bonds. Herein, we have selected some prime literature reports that may serve this purpose. © 2013 The Royal Society of Chemistry.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2012.2.5-03 | Award Amount: 3.70M | Year: 2013

General objective of the project is to integrate advancement in scientific knowledge about the impact of food chains with application of knowledge to practice to increase food chains sustainability through public policies and private strategies. This general objective will be pursued through the following specific objectives: To develop and validate a performance criteria matrix for assessment and comparison of food chains operating at a range of geographical scales through analysis of how food chain impacts are communicated in different spheres of society. To build a database of quantifiable indicators of impact and a set of 20 case studies aimed at understanding how impacts are generated within specific food chains. To advance knowledge on methodological problems and trade-offs arising when measuring and comparing the impact of food chains within and between sectors. To assess how performance is perceived by stakeholders in different national contexts through participatory assessment and multicriteria analysis of the different typologies of food chains. To assess the actual and potential role of public and private policies addressing food chains and to turn assessment into policy recommendations. To build a network that turns the advancement of scientific knowledge into decision making tools for domestic and public consumers, producers, citizens, scientists, policy makers, civil society organizations. The project will be developed around the following assumptions: Costs and benefits analysis needs methodological update: for this reason the broader concept of performance is used The performance of food chains has multiple dimensions (economic, social, environmental, health, ethical) To turn knowledge into practice a demand-driven approach is necessary, focusing on how food choice affects the five dimensions of impact The complexity of impacts of food chains requires plurality of methods and transdisciplinarity


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.3.1-1 | Award Amount: 3.90M | Year: 2011

New knowledge is not necessarily readily applied in medicine, even when there is evidence of its effectiveness. As a result of the gap between knowing and doing, policy makers, professional care providers, patients and their families have benefited too little from new developments. Implementation research has developed models for stepwise implementation but it is still unclear which strategies are effective for whom and which factors influence the effectiveness of implementation strategies. From the point of view of implementation sciences changing palliative care is a major challenge, since adequate organization of palliative care requires collaboration between a range of different professionals and healthcare organizations. Besides, as a consequence of the ageing population, the number of people in need for cancer and dementia palliative care will rise. Therefore we will focus on implementation strategies in palliative care. The overall aim of this project is to develop optimal implementation strategies for using quality indicators to improve the organization of palliative cancer and dementia care in Europe and to study factors influencing the effectiveness of the strategies. We will focus on the implementation process and concentrate the work packages on: the organization of palliative care, the development of a set of setting-specific implementation strategies including an interactive website and instruction by consultants, the evaluation of the use of selected strategies to improve the organization of palliative care and factors influencing the effectiveness of the implementation strategies. This information will be used to build a conceptual model that should be applicable across diverse healthcare settings and that allows rigorous assessment of the effectiveness of implementation strategies. Dissemination of the results will be enhanced by involving stakeholders, including two European networks related to the subject of this implementation process study.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2011.2.2.1-2 | Award Amount: 24.91M | Year: 2012

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are: (i) to identify novel mechanisms of regulation and function of microglia under various conditions (inflammatory stimuli; neurodegenerative and -regenerative model systems); (ii) to identify and implement new targets for activated microglia, which may serve for diagnostic (imaging) and therapeutic purposes; (iii) to design new molecular probes (tracers) for these novel targets and to implement and validate them in in vivo model systems and patients; (iv) to image and quantify modulated microglia activity in patients undergoing immune therapy for cognitive impairment and relate findings to clinical outcome. Within INMiND we bring together a group of excellent scientists with a proven background in efficiently accomplishing common scientific goals (FP6 project DiMI, www.dimi.eu), who belong to highly complementary fields of research (from genome-oriented to imaging scientists and clinicians), and who are dedicated to formulate novel image-guided therapeutic strategies for neuroinflammation related neurodegenerative diseases. The strength of this proposal is that, across Europe, it will coordinate research and training activities related to neuroinflammation, neurodegeneration/-regeneration and imaging with special emphasis on translating basic mechanisms into clinical applications that will provide health benefits for our aging population. With its intellectual excellence and its crucial mass the INMiND consortium will play a major role in the European Research Area and will gain European leadership in the creation of new image-guided therapy paradigms in patients with neurodegenerative diseases.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2010.4.2-9-2 | Award Amount: 9.40M | Year: 2011

The goal of HeMiBio is to develop a hepatic microfluidic bioreactor from human iPSC-derived hepatocytes, hepatic sinusoidal endothelial cells (HSEC) and stellate cells (HSC), suitable for inclusion in a repeated dose toxicity testing strategy of pharmaceuticals/cosmetic ingredients. The successful creation of such a liver-device requires (a) homotypic and heterotypic interactions between the three cell types to induce and maintain their functional, differentiated state, and (b) optimisation of the matrix, oxygenation conditions, nutrient transport and physiological shear forces. The objectives are (1) to engineer the cellular components incorporated in the bioreactor to enable specific and spatially defined enrichment of the different cells from iPSC progeny, and, by gene editing, to allow non-invasive monitoring of the cellular state (differentiation and damage). (2) Aside from the molecular sensors, an array of electro-chemical sensors will be embedded in the reactors to assess liver-specific function and cellular health under repeated dose toxicity conditions, dynamically and in a high-throughput way. Cells and sensors will be built into (3) bioreactors that will be sequentially upgraded from 2D to 3D microfluidic reactors to ultimately allow full maintenance of mature functional hepatocytes, HSC and HSEC for >28 days. (4) As the ultimate goal is to use the device as a human-based alternative to rodent long-term hepatotoxicity studies, it will be of utmost importance to provide proof of concept that the 3D-devices reveal the hepatotoxicity of prototypical hepatotoxic compounds in vivo (5). -Omics and cell functionality studies will provide evidence that liver-like cells are present, exposed and affected by the selected toxic compounds. These ambitious objectives will be achieved by the excellent project team, composed of academic/industrial partners with unique and complementary biology, physiology, toxicology and technical skills from 7 EU Member States.


Grant
Agency: European Commission | Branch: FP7 | Program: ERC-SG | Phase: ERC-SG-PE5 | Award Amount: 1.50M | Year: 2011

Many critical photochemical and photophysical processes, from photosynthesis in plants, to photocatalytic reactions, and to generation of electricity in solar cells, depend on an efficient light-matter interaction. In order to increase, for example, the efficiency of photocatalysis, the interaction of the photocatalyst with light has to be increased. This project will pursue two lines of investigation in order to achieve this. Firstly, the concept of light-harvesting will be exploited. Light energy can be harvested by collecting, directing and concentrating it at a reaction center, in a fashion that mimics that used by plants. Secondly, for specific types of catalysis such as noble metal nano-particle (NP) based catalysis, the plasmon light field at the metal NPs can potentially be used to enable a more efficient light-matter interaction. The applicant proposes to combine both approaches, to create a plasmonic antenna to funnel light to a reaction center, whilst at the same time using the plasmons generated as an efficient reaction field in catalysis. The outcome will make it possible to drastically increase activities of (photo)catalysts, enabling their efficient operation under sunlight or even in weak room light conditions. For this, the project firstly adevelops novel photo-induced synthesis for metal NPs, both in solution and at surfaces, as well as at arranging the NPs in effective antennae. Secondly, microscopy modes will be developed/implemented that allow monitoring the growth of the NPs in situ, that allow checking the quality of the arrays and that allow in situ monitoring of catalytic test reactions. These knowledge will be applied to real world (photo)catalysts (gold NP catalysis and TiO2, respectively). This project will thus result in new light-induced synthesis and fabrication methods of NPs; in new and/or improved microscopy modes and spectroscopic schemes in order to study the relationship between plasmonic properties and chemical reactions.


Grant
Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 72.73M | Year: 2013

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the FET Flagship Programme, is to translate this vision into reality, using ICT as a catalyst for a global collaborative effort to understand the human brain and its diseases and ultimately to emulate its computational capabilities. The Human Brain Project will last ten years and will consist of a ramp-up phase (from month 1 to month 36) and subsequent operational phases.\nThis Grant Agreement covers the ramp-up phase. During this phase the strategic goals of the project will be to design, develop and deploy the first versions of six ICT platforms dedicated to Neuroinformatics, Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technological capabilities required by future versions of the platforms, implement a policy of Responsible Innovation, and a programme of transdisciplinary education, and develop a framework for collaboration that links the partners under strong scientific leadership and professional project management, providing a coherent European approach and ensuring effective alignment of regional, national and European research and programmes. The project work plan is organized in the form of thirteen subprojects, each dedicated to a specific area of activity.\nA significant part of the budget will be used for competitive calls to complement the collective skills of the Consortium with additional expertise.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.01M | Year: 2013

The ADAPT-r ITN aims to significantly increase European research capacity through a unique and ground-breaking research model: at its core is the development of a robust and sustainable ITN in an emergent Supra-Disciplinary field of research across a range of design and arts disciplines creative practice research. ADAPT-r will train new researchers, increase supervisory capacity, partner with private sector SMEs in research projects providing substantial opportunity for real world testing of the research and real world training, and introduce creative practice research methodologies to a new generation. The unique model proposed will enable ADAPT-r to substantially leverage the number of doctoral candidates within the ITN budget model maximising higher degree training opportunities. The research that is produced through the ADAPT-r ITN will contribute to a wider research effort to increase knowledge, understanding and quality of research in creative disciplines and its methods. The Marie Curie ITN funding will enable an existing bi-lateral research training relationship to be expanded to include multiple partners from across Europe to create a greatly enhanced international research training network with a long-term future. The ADAPT-r ITN will address identified deficits in EU research training for creative disciplines. Through training creative practice researchers in the explication and dissemination of tacit knowledges and latent cognitive resources the ADAPT-r ITN will make a substantive contribution to meeting EU 2020 priorities by building a new generation of creative practice researchers and research lead practitioners able to meet the complex and often competing demands of contemporary Europe. Implementation of the ADAPT-r ITN will result in 32 Fellowships, 8 training conferences, a major research conference, a major exhibition, three key books, and a web site providing public access to research and events.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2011.7.2-1 | Award Amount: 19.44M | Year: 2012

6 Transmission System Operators (Belgium, France, Greece, Norway, Portugal and United Kingdom) and CORESO, a TSO coordination centre, together with 13 RTD performers propose a 4 year R&D project to develop and to validate an open interoperable toolbox which will bring support, by 2015, to future operations of the pan-European electricity transmission network, thus favouring increased coordination/harmonisation of operating procedures among network operators. Under the coordination of RTE, new concepts, methods and tools are developed to define security limits of the pan European system and to quantify the distance between an operating point and its nearest security boundary: this requires building its most likely description and developing a risk based security assessment accounting for its dynamic behaviour. The chain of resulting tools meets 3 overarching functional goals: i) to provide a risk based security assessment accounting for uncertainties around the most likely state, for probabilities of contingencies and for corresponding preventive and corrective actions. ii) to construct more realistic states of any system (taking into account its dynamics) over different time frames (real-time, intraday, day ahead, etc.). iii) to assess system security using time domain simulations (with less approximation than when implementing current standard methods/tools). The prototype tool box is validated according to use cases of increasing complexity: static risk-based security approach at control zone level, dynamic security margins accounting for new power technologies (HVDC, PST, FACTS), use of data coming from off-line security screening rules into on-line security assessment, and finally security maps at pan European level. Dissemination is based on periodic workshops for a permanent user group of network operators invited to use modules to meet their own control zone needs and the ones of present or future coordination centres.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2010.1.1-01 | Award Amount: 10.25M | Year: 2011

Fruit Breedomics has as its strategic goal to improve the efficiency of fruit breeding by bridging the gap between scientific genetics research and application in breeding. Fruit Breedomics takes a multidisciplinary approach, including genetics, genomics, ecophysiology and bioinformatics, to improve the efficiency apple and peach breeding programmes by: i) developing new and adapted tools, ii) studying a wide range of traits to enlarge the coverage of selection criteria, iii) analysing and exploiting the wide genetic diversity available, iv) making the research outputs (valuable traits, genetic markers and genes, innovative tools and methodologies, new plant material) directly applicable for the breeders, v) establishing a stakeholder network. Fruit Breedomics will provide the European fruit tree sector with cutting-edge breeding tools to improve selection efficiency as well as superior pre-breeding material to meet grower and consumer demands for healthy cultivars of high quality that can be grown in sustainable agriculture systems in the context of climate change. The project will develop tailored molecular and bioinformatics tools to extensively exploit the diversity present in European germplasm collections and breeding populations. This will lead to the selection of desired favourable genes needed for improvement of main horticultural traits. The collected data will provide precious genetic information on the pool of genitors and founders to be used in future breeding programmes. The project will focus primarily on apple and peach, two major fruits in Europe, but many tools and much knowledge gained will also be of benefit to other species of the Rosaceae family via the strong ancestral relatedness among these species.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SiS.2013.1.2-1 | Award Amount: 4.38M | Year: 2014

The proposal responds to the Horizon 2020 challenge called Climate action, resource efficiency and raw materials. In addition, it addresses the second specific challenge of the Mobilising and Mutual Learning Action Plans (MMLAP) topics, listed in the Science in Society call for proposals of the Capacities Work Programme 2013, namely Assessment of sustainable innovation. The projects main objective will be to develop a methodological framework for assessing sustainable innovation and managing multi-disciplinary solutions through public engagement in the RTDI system by ensuring the commitment of a broad spectrum of societal stakeholders into its implementation, including industry, policy-makers, research organisations and academia, civil society organisations and the general public. In achievement to the overall objective of the proposed action, the specific objectives include the development of: - a working definition of sustainable innovation, building on common definitions, academic literature as well as expert advice internal and external to the project consortium; - ways to include general public concerns in assessing the social impact of these innovations on society in consultation workshops. Issues such as participation in the development of innovation, inclusiveness, ethics, gender and open access will be considered in these sessions; - a common understanding of best practices in sustainable innovation management; - a framework for assessment and management of sustainable innovations; - specific policy recommendations on how to improve innovation management and how sustainability considerations can be incorporated into it based on the findings of the assessment framework and public consultations. CASI mobilises 19 partners from 12 EU Member States. Through a network of country correspondents CASI will cover the whole of Europe. The work is structured in 11 work packages, and the mandatory work packages as outlined in the call are included.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SEC-2011.5.1-1 | Award Amount: 4.74M | Year: 2012

Identity management using Biometrics is deployed in a growing number of applications ranging from identification platforms (e.g. biometric passports) to access control systems for border checks or banking transactions. Unfortunately, the reliability of these technologies remains difficult to compare. There are no european-wide standards for evaluating their accuracy, their robustness to attacks or their privacy preservation strength. BEAT will fill this gap by building an online and open platform to transparently evaluate biometric systems, designing protocols and tools for vulnerability analysis and developing standardization documents for Common Criteria evaluations. The planned impact is three-fold: the reliability of biometric systems becomes standardized and comparable, potentially leading to a meaningful increase in their performance; technology transfer from research to companies becomes easier with the use of an interoperable framework; authorities and decision-makers become more informed about the progress made in biometrics as results impact standards.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.3.2-3 | Award Amount: 3.17M | Year: 2013

The LIPSE project (Learning from Innovation in Public Sector Environments) identifies drivers and barriers to successful social innovation in the public sector. Through studying social innovation and co-creation practices and processes in 11 European countries and 7 policy sectors, LIPSE will create and disseminate essential knowledge about public innovation. The LIPSE consortium consists of leading institutions in 11 European countries. Seven empirical cross-national work packages will collect new insights on five building blocks of social innovation in the public sector: 1. Innovation environments 2. Innovation inputs 3. Innovation tools and processes 4. Innovation outcomes, diffusion and upscaling 5. Feedback loops in innovative systems The project will firstly map institutional environments to study the role of social capital, innovation champions and leadership, using survey research and social network analysis. The project will then look at citizens inputs into public innovation processes through participation, complaints and co-creation. This will be achieved by a) analysing secondary administrative datasets from ombudsmen and national audit offices b) case studies in social and welfare services and urban and rural regeneration and c) large scale survey research. It will then examine the use of risk management in innovation processes. A work package on innovation diffusion and adoption will assess what factors contribute to the successful upscaling of ICT-driven social innovations, with a focus on teleworking (as a new way of working) and e-procurement. Finally, the project will develop a comprehensive set of public sector social innovation indicators and explore future trends in social innovation through scenario-mapping with academic and practitioner experts. The dissemination of knowledge will be widespread, using websites, articles, books, road shows and conferences across Europe.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2012.6.4-1 | Award Amount: 6.77M | Year: 2012

Urban regions in the EU face increasing but uncertain flood risks due to urbanization and the effects of climate change. In European (a.o. the Flood Risk Directive) and in national and regional policies, attempts are made to diversify and align different Flood Risk Strategies (FRSs). In our proposal, five such strategies are distinguished: risk prevention; flood defense; mitigation; preparation; and recovery. We assume that vulnerable urban agglomerations will be more resilient if multiple FRSs are applied simultaneously, linked together and aligned. At the same time, the application of a diverse cluster of FRSs has to be appropriate, i.e. attuned to the physical and social context. The latter asks for innovative Flood Risk Governance Arrangements (FRGAs). In the proposed program, insights from governance and legal scholars will be integrated and combined, leading to policy design principles for FRGAs as well as concrete recommendations for policy and law at the level of the EU, its member states, regional authorities, and public-private partnerships. Across different EU countries and regions, we expect to identify different mixes of FRSs. We will analyze, explain and evaluate the emergence and dominance of the FRGAs through which these FRSs are institutionally embedded. For this, a comparative analysis of FRGAs in six EU member states will be carried out. This analysis will reveal good practices, provide understanding of the resilience of FRSs as well as their appropriateness in different physical, social and legal contexts. The design principles thus derived, will be brought together in a design-oriented framework for ex-ante evaluation of FRGAs. As part of the program, various target group specific knowledge dissemination activities will be carried out, aimed at regional stakeholders, high level policymakers and EU officers. To this end, Grontmij, a consultancy company, and CEPRI (The European centre for flood risk prevention) have been included in the consortium, apart from universities in the six EU member states.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2012.2.1.1-1-B | Award Amount: 15.82M | Year: 2012

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts assembled to date (collectively >10,000 patients) with detailed phenotypic information and comprehensive biorepositories containing DNA, blood, urine, amniotic fluid and kidney tissue. The project aims to (1) identify the genetic and epigenetic causes and modifiers of disease and their molecular pathways; (2) define a novel mechanistic disease ontology beyond phenotypical or morphological description; (3) develop innovative technologies allowing rapid diagnostic testing; (4) discover and validate biomarkers of disease activity, prognosis and treatment responses; and (5) develop in vitro and in vivo disease models and apply high-throughput compound library screening. For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (functiomics) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic intervention. These efforts will converge in the development of innovative diagnostic tools and biomarkers and efficient screening strategies for novel therapeutic agents.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.56M | Year: 2012

Soft nanotechnology is generally considered as a field that will have a major impact on technological developments in near future. However, the fundamental understanding of the wealth of new structures lacks far behind, despite supporting activity from material science. Such an understanding is indispensable for sustainable growth of this important research domain and its applications. A physics-oriented interdisciplinary education is urgently needed to guide young researchers to the point where they can tackle the relevant fundamental questions. SOMATAI is set up to provide just such training by combining two distinct scientific fields: Soft matter science is a well established interdisciplinary field for the bulk investigation of polymers, colloids, and liquid crystals with response amplitude and time to external stimuli as a function of soft matter structure being of special interest. The second highly relevant field is interface science, since nano-structured materials contain a huge area of internal interfaces which have an essential impact on material properties. The application of the soft matter approach to interfaces promises new and deeper understanding of interfacial phenomena. Interfaces of a water phase to a solid, liquid or gaseous second phase are of special interest and a focal point of SOMATAI. Such interfaces are highly relevant to products from European industry (food, cosmetics, paints) and processes (washing, coating, water purification). They have an outstanding importance from a scientific point of view due to specific interactions at such interfaces. This carefully planned teaching and research programme in a network of 10 leading academic partners, 1 large scale companies, 2 SMEs, and 4 top-level associated partners from Germany, Taiwan and the USA will ensure that young researchers are given an excellent training in a pioneering research domain of high scientific and technological relevance, where Europe can take a leading position.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.11M | Year: 2013

The DREAMS Initial Training Network will investigate the problem of modeling, controlling, removing, and synthesizing acoustic reverberation with the aim of enhancing the quality and intelligibility of audio, music, and speech signals. The proposed research and training program builds upon four disciplines that are equally important in understanding and tackling the (de-)reverberation problem: room acoustics, signal processing, psychoacoustics, and speech and audio processing. The strong commitment of the private sector in the proposed ITN consortium, consisting of 4 academic and 8 industrial partners, illustrates the timeliness and importance of the (de-)reverberation problem in a wide variety of applications. However, carrying application-driven solutions is not the only objective of the DREAMS research program. Indeed, the aim is also to take a significant step forward and make fundamental scientific contributions in each of the four disciplines mentioned earlier. To this end, the envisaged ITN will host 12 early stage researchers and 4 experienced researchers, each performing an individual research project around one of four themes that reflect the most challenging open problems in the area of (de-)reverberation. The DREAMS ITN will be implemented such as to maximize the international and intersectoral experience of the research fellows, by defining relevant secondments in academia and industry, both in the host country and abroad. Moreover, experienced researchers will be expected to take on a supervisory role in coordinating one of the four research themes, with the aim of developing solid skills in leadership and research management. Finally, a training program of extremely high quality is proposed, with local as well as network-wide training, which relies on the scientific excellence of the involved partners and of invited external researchers, and which heavily depends on the input of the private sector.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: GC.NMP.2012-2 | Award Amount: 13.08M | Year: 2012

By bringing together 21 partners including 7 major carmakers, 7 major suppliers, 2 SMEs and 5 academia / research centres, ALIVE will develop directly exploitable knowledge on materials and design concepts which offer a high potential for significantly reducing the weight of vehicles for affordable application to high productions volumes, focusing on next generation Electric Vehicles (EVs). Specifically ALIVE has set a target of achieving a 30% \ 20% weight reduction for the untrimmed vehicle body together with a 25-30% weight reduction of the hang-on parts, chassis and main interior sub-systems. ALIVE strives to generate substantial, tangible innovation in terms of vehicle design, materials, forming & joining technologies, simulation & testing and includes an exceptionally ambitious physical validation activity that will not only deliver a full structural demonstrator of all modules addressed but which will also include destructive crash and durability testing executed on the assembled modules including the entire body. The objective of the car manufacturers and the supply chain within the ALIVE consortium is to accelerate the take up of these innovative technologies, enabling their application in high volume EV production some 5 years earlier than would have been the case otherwise. Importantly the aim is to jointly exploit the potential economies of scale which can only be achieved via pre-competitive collaborative research by identifying and applying common solutions in terms of materials and their respective process technologies. ALIVE is directly linked to a network of recently concluded, on-going and planned parallel activities and as such offers a coordinated platform within the context of the Green Car program for achieving an unprecedented level of impact with respect to increasing EU competitiveness through the development and uptake of real innovation.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2012.1.3-2 | Award Amount: 1.39M | Year: 2013

MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational Modelling Assay Platform (MAP) which can be used as a Risk Indicator tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype on a shortlist of MeNPs - which can be further developed to screen the toxicity of a large number ENPs. Based on the concept of Integrating Testing Strategies (ITS), the proposed generic MAP combines two main and complimentary paradigms: (1) a novel Computational Modelling Package (CMP) based on structural, mechanistic, as well as kinetic modelling tools and (2) an innovative high content screening (HCS) strategy that allows performing multiplexed streamlined assays for calibration, refinement and validation of the computed models. First a series of classification algorithms will be applied to identify MeNPs with similar toxicity patterns, then computational modelling tools will be developed to establish a more rational relationship between MeNPs descriptors and their toxicity in a dynamic and quantitative way. An in-vitro/in-vivo HCS paradigm will be developed as a scalable assessment tool to calibrate and validate the predictive power of the CMP using subsets of the training set or independent set of MeNPs (validation set) respectively.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 1.69M | Year: 2013

TRADERS focuses on developing and testing a framework of methodologies on which art and design (A&D) researchers can rely when working on public space projects in participatory ways. This framework is transferable and aims to enhance the potentials in A&D practices to contribute creatively in processes of urban and branch-related change. The framework will inform and will be informed by a toolkit. For coherence in the training, Hasselt-Genk will be the anchor case area on which the ESR researchers work together. TRADERS will cooperate with Z-OUT: a centre of expertise on art, design and architecture in relation to public space. To assure the adequacy of an A&D research project, five complementary research foci are covered that correspond to the methodological framework and entail innovative research topics on participation for public space: Intervention (KHLIM (research group Social Spaces, Media, Arts & Design Faculty i.c.w. LUCA)), Play (UGOT), Multiple Performative Mapping (DAE), Data-mining (RCA) and Modeling in dialogue (CHALMERS). A sixth focus will be on the development of a meta-framework allowing these research foci to communicate and collaborate (KU Leuven). To bundle the strengths of different disciplines to commonly approach other non-A&D disciplines and sectors, every participant will work in a partnership with a public or private organization, offering a research and training environment to the researcher and ensuring that his/her research project has a practical and use-oriented focus. TRADERS contains a training program consisting of, a.o.: supervised involvement in six research/training projects at the host organizations with shared activities in Training-through-Research Synergy weeks, collaboration for the research/training with stakeholders and branches that represent future employers, collaboration with various researchers and enterprises from different countries, network-wide research training and Complementary Skills Training at Summer Schools, conference and secondments to associated partners.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.8.1 | Award Amount: 3.74M | Year: 2012

weSPOT aims at propagating scientific inquiry as the approach for science learning and teaching in combination with todays curricula and teaching practices. It lowers the threshold for linking everyday life with science teaching in schools by technology. weSPOT supports the meaningful contextualization of scientific concepts by relating them to personal curiosity, experiences, and reasoning. weSPOT addresses several challenges in the area of science learning and technology support for building personal conceptual knowledge. The project focuses on inquiry-based learning with a theoretically sound and technology supported personal inquiry approach. In inquiry based-learning learners take the role of an explorer and scientist and are motivated by their personal curiosity, guided by self-reflection, and develop knowledge personal and collaborative sense-making and reasoning. weSPOT will work on a meta-inquiry level in that it will (a) define a reference model for inquiry-based learning skills, (b) create a diagnostic instrument for measuring inquiry skills, and (c) implement a working environment that allows the easy linking of inquiry activities with school curricula and legacy systems. The foreseen weSPOT Toolkit gives smart support for personal scientific inquiry to address a lack of scientific inquiry skills in an age group of 12-25. Furthermore, weSPOT will unleash support of triggering and leveraging curiosity that is missing in todays learning technology. weSPOT will develop (1) an open source service framework for inquiry workflows, (2) tools for mobile data collection and personal experience sampling. Additionally, it will develop (3) learning analytics tools for collaborative and personal reflection, and (4) a badge system for linking formal and informal learning activities via social media. These products will be customized and evaluated in at least 8 primary test-beds in a European wide approach in 8 European member states.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2009-2-3-01 | Award Amount: 8.17M | Year: 2010

The objective of the FRISBEE (Food Refrigeration Innovations for Safety, consumers Benefit, Environmental impact and Energy optimisation along the cold chain in Europe) project is to provide new tools, concepts and solutions for improving refrigeration technologies along the European food cold chain. At all stages the needs of consumer and European industry will be considered. The project will develop new innovative mathematical modelling tools that combine food quality and safety together with energy, environmental and economic aspects to predict and control food quality and safety in the cold chain. The FRISBEE partners will develop new and emerging refrigeration technologies providing energy efficient and sustainable alternatives to current technologies. The project is constructed around 8 work packages. Management is covered in work package 1. Work package 2 will develop innovative databases of current technologies to enable later comparison between new and current technologies. Work package 3 will develop Quality and Energy/Environment Assessment Tools (QEEAT). In work packages 4 and 5 the team will develop new and emerging refrigeration technologies for representative cold chains selected for applicability to the European food industry. Work from work packages 4 and 5 will be further developed and demonstrated in work packages 6 and 7. Work from the project will be disseminated widely in work package 8. The project involves 26 partners from 12 EU member, associated and candidate countries. Within the consortium, 13 of the partners are companies, 2 are NGOs or represent other companies (mainly SMEs) and the remainder are research based partners. The consortium includes 6 SME partners. The international expertise and synergy of the 26 FRISBEE partners enables the work to be exploited on a European level. Therefore it is expected that the European food industry, related cold chain actors and consumers will all benefit from the FRISBEE project.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.4-1 | Award Amount: 7.84M | Year: 2010

Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare diseases, particularly those of genetic origin, are associated with the requirement for solid organ transplantation as the disease progresses. At Opsona Therapeutics we have developed a novel antibody (OPN-305) which has received OMP designation (EU/3/09/638) for use in the prevention of DGF. The scientific basis of this development is the inhibition of Toll-like receptor 2 (TLR2)-mediated ischaemic reperfusion injury which has a pivotal role in the pathogenesis of DGF and its sequelae. The MABSOT project is designed to progress the development of this OMP through Phase I and II clinical trial. The successful completion of the programme will allow the continued development of OPN-305 as an OMP for the treatment of DGF in a range of solid organ transplant situations. OPN-305 development will have significant benefit to these patients and health care providers in reducing the prolonged hospitalisation of these individuals, providing greater longevity associated with the transplanted organ and enhanced quality of life for these individuals.


Grant
Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.86M | Year: 2013

The development of new production processes and innovative sintering technologies, i.e. firing processes during which the conversion of a powder compact into a fully dense bulk compound is realized, as well as the improvement of the current processes and technologies, would permit to enhance the use of ceramics in industrial applications by increased product development and high added value products. This will reinforce the position of the European companies against their competitors in Asia and America. Nowadays, non-conventional machining processes allow cost effective processing of ceramics introducing the possibility to obtain complex 3D shapes. Processes such as vibration assisted and electrical discharge machining solve the limitations of conventional processes like grinding, introducing more flexible and cost effective machining capabilities. The HYMaCER project, driven by 4 dedicated Hi-Tech SMEs, aims at developing a complete supply chain for large size technical ceramic blanks in order to fulfill their need for economically produced, innovative and difficult to densify technical ceramics, all three parameters which are currently limiting the SMEs market expansion. The SMEs will join their knowledge on spark plasma sintering (NANOKER & FCT) and machining of ceramics (Ceratec, ARTOOLING & FCT) to produce innovative technical ceramics with an already proven market potential for dedicated niche markets. In order to realise this, the SMEs will be supported by 3 RTD centres with a long standing expertise in ceramic material development (K.U.Leuven & CSIC), spark plasma sintering (CSIC & K.U. Leuven) and non-conventional machining (K.U.Leuven & IK4-TEKNIKER). The research will be focused on the fabrication of electrically conductive technical ceramics, combining an oxide matrix with a secondary, electrically conductive phase, by means of the largest world-wide hybrid spark plasma sintering equipment, with pressing force up to 400 tons and component capacity up to 400 mm in diameter, of FCT origin, and recently installed at NANOKER.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.1-6 | Award Amount: 4.07M | Year: 2011

Lung cancer is the most common cancer fatality in Europe (335000 deaths/yr). Non-small cell lung cancer (NSCLC) consists 85% of the cases, with 5 yr survival <15%. Hence, this proposal focuses on the urgent need for better NSCLC therapies. This is a European problem at societal and scientific level: better therapies are needed to keep the spiralling costs of European health systems under control, and the required expertise (basic science, clinical, biotech, experimental therapeutics) is scattered over the EU. Because of the diversity of the NSCLC problem (and the small/medium size of the project) we are focusing on two particular problems: 1) to find solutions for the currently clinically observed resistance problems with epidermal growth factor receptor (EGFR) targeting therapies (10% of NSCLC patients), and 2) to find a solution for the clinically unmet need for NSCLC patients with KRAS mutations (30% of NSCLC), for whom there virtually is no cure (besides very modest effects of platinum based therapies). Based on this focus, we assembled an EU wide consortium which joins excellent expertise at both the basic science (EGFR family, KRAS), clinical (involvement of several clinical study leaders) and biotech level (involvement of academic and SME biotech component). We aim: 1) To identify novel drug targets for the improvement of EGFR targeting therapies and for the development of therapies for K-Ras mutant patients (via genome wide RNAi screening and kinome/secretome profiling). 2) To validate these targets in innovative mouse models that replicate the clinical problem, and in patient materials (tissue and serum) 3) To develop novel therapeutics based on the unique expertise of our partners: anti-receptor DARPins (designed ankyrin repeat proteins), monoclonals or soluble receptors targeting the BROADER EGFR family (to block compensatory signalling), and protein kinase inhibitors The results will have important basic scientific, clinical and economic impact


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2013.7.2.1 | Award Amount: 10.86M | Year: 2013

Power system reliability management means to take decisions under increasing uncertainty (for instance, related to renewable generation). It aims to maintain power system performance at a desired level, while minimizing the socio-economic costs of keeping the power system at that performance level. Seven TSOs (Belgium, Bulgaria, Czech Republic, Denmark, France, Iceland, Norway), together with eleven RTD performers, propose the four year GARPUR research project. GARPUR designs, develops, assesses and evaluates new system reliability criteria and management while maximizing social welfare as they are progressively implemented over the next decades at a pan-European level. The new management methodologies encompass multiple business activities (system development, asset management, power system operation) that, in turn, ensure coherent decision-making at the respective time horizons. These methodologies also involve mathematical and computational models to predict the location, duration and amount of power supply interruptions. Five alternatives to improve reliability management of the pan-European power system are studied. After practical validation by the TSOs, these alternatives are analysed with the help of a quantification platform. Pilot tests of the new proposed reliability criteria are performed by individual TSOs or (when appropriate) a group of TSOs using this quantification platform, either in a given control zone or (where appropriate) throughout the pan-European system. Reliability criteria are compared and presented to the TSO community and regulatory authorities who establish the robustness of the results. Dissemination activities of the new reliability criteria are supported by a Reference Group of TSOs and address all the key electricity market stakeholders. An implementation roadmap is delivered for the deployment of the resulting technical and regulatory solutions to keep the pan-European system reliability at optimal socio-economic levels.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.3.3-1 | Award Amount: 7.78M | Year: 2013

Concept and aim: 20 million fans attend top division football games each week and many more watch on TV. Our social innovation is to attract people to lifestyle change through the personal connection and loyalty to the club they support. Our aim is to use this social innovation to change physical activity and sedentary behaviour, specially targeting low-SES groups, and men as well as women. EuroFIT is supported by UEFA and top football clubs. Workplan: End-users and policy-makers are involved throughout. We will: a) produce a device (SitFIT) that provides real-time feedback on objectively measured sedentary time and physical activity; b) deploy and evaluate smartphone games to drive activity through social interaction (MatchFIT); c) integrate these with state-of-the-art evidence on behavioural change and its maintenance in a web-supported lifestyle programme delivered by top EU football clubs (EuroFIT)). We will evaluate EuroFIT in a multi-centre randomised controlled trial to assess impact on physical activity and sedentary behaviour, physical and mental health and weight. We will investigate the correlates of long-term changes and impact on participants families. Finally we will develop a robust strategy for replication of EuroFIT Impact: We will generate excellent research evidence on the use of social innovation for health. Social impact will include reductions in health risk, improvements in well-being and the decreased inequalities as more men, especially those in low SES groups, are attracted to lifestyle change. Research impact will be achieved through new understanding of the how health indicators respond to change in sedentary behaviour and physical activity and through new knowledge of longterm maintenance of lifestyle changes. Policy impact will result from the production of clear implementation strategies and involvement of policy makers and opinion leaders from the outset, supported by a targeted communication strategy.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.80M | Year: 2015

Hybrid and Full Electric Vehicles ((H)EVs) are essential for the transition towards sustainable e-mobility. The permanent magnets in motors/generators of (H)EVs are either NdFeB or SmCo magnets, which contain large quantities of rare earths, which are critical metals with the highest supply risk for Europe. As highlighted by the European Rare Earths Competency Network, recycling of rare-earth magnets from (H)EVs should receive top priority. Reclaiming of rare-earth magnet motors/generators used in (H)EVs is a major challenge because the magnets are difficult to remove from the assemblies. The conventional hydrometallurgical routes for the recovery of rare earths from End-of-Life permanent magnets have a high environmental impact due to inefficient use of chemicals, whereas the conventional pyrometallurgical routes for the production of magnet master alloys are energy-inefficient. DEMETER, the European Training Network for the Design and Recycling of Rare-Earth Permanent Magnet Motors and Generators in Hybrid and Full Electric Vehicles, concurrently develops (1) innovative, environmentally-friendly direct and indirect recycling strategies for the permanent magnets in the motors and generators of (H)EVs that are currently already on the market and (2) design-for-reuse solutions for motors and generators in the (H)EVs of the future. An intersectoral and interdisciplinary consortium of leading EU universities, research institutes and manufacturers from the automotive and magnet sector trains 15 Early Stage Researchers (ESRs). The research challenges include the development of hydrogen-based grain-refinement technologies to produce nanograin magnets directly from scrap magnets, the recovery of rare earths from SmCo and NdFeB magnets of motors/generators by ionometallurgical methods, and the design of motors/generators with reusable magnets, where the designs are based on 2D and 3D flux paths as well as non-traditional materials.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SPIRE-05-2015 | Award Amount: 6.00M | Year: 2015

In ADREM, leading industries and university groups in process intensification, catalytic reactor engineering and process control team up to address the domain of resource- and energy-efficient valorisation of variable methane feedstocks to C2\ hydrocarbons. The development of new and intensified adaptable catalytic reactor systems for flexible and decentralized production at high process performance is in focus, able to operate with changing feedstock composition and deliver on-demand the required product distribution by switching selected operational/control parameters and/or changing modular catalyst cartridges. In the long term, we expect the reactors to operate energy- and emission-lean using green electricity as the direct, primary energy source. In order to converge to the optimal design, the project will utilize the unique integral, four-domain process intensification (PI) methodology, pioneered by the consortium. This is the only approach able to deliver a fully intensified equipment/process. The key feature is the systematic, simultaneous addressing of the four domains: spatial, thermodynamic, functional and temporal. ADREM will provide: highly innovative, economic and environmentally friendly processes and equipment for efficient transformation of methane into useful chemicals and liquid fuels, for which monetary savings of more than 10% are expected. process technologies applying flexible modular one-step process with high selectivity for valorisation of methane from various sources. modular (and containerized and mobile) reactors permitting flexible adaptation of the plant size to demand and also utilizing smaller or temporary sources of methane or other feeds. The project will employ emerging reactor technologies coupled to especially designed catalytic systems to address a variety of scenarios embodying methane valorisation. The concepts developed can be later readily extrapolated on other types of catalytic processes of similar sizes.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.4 | Award Amount: 14.52M | Year: 2012

The FutureID project builds a comprehensive, flexible, privacy-aware and ubiquitously usable identity management infrastructure for Europe, which integrates existing eID technology and trust infrastructures, emerging federated identity management services and modern credential technologies to provide a user-centric system for the trustworthy and accountable management of identity claims.\nThe FutureID infrastructure will provide great benefits to all stakeholders involved in the eID value chain. Users will benefit from the availability of a ubiquitously usable open source eID client that is capable of running on arbitrary desktop PCs, tablets and modern smart phones.\nFutureID will allow application and service providers to easily integrate their existing services with the FutureID infrastructure, providing them with the benefits from the strong security offered by eIDs without requiring them to make substantial investments. This will enable service providers to offer this technology to users as an alternative to username/password based systems, providing them with a choice for a more trustworthy, usable and innovative technology. For existing and emerging trust service providers and card issuers FutureID will provide an integrative framework, which eases using their authentication and signature related products across Europe and beyond. To demonstrate the applicability of the developed technologies and the feasibility of the overall approach FutureID will develop two pilot applications and is open for additional application services who want to use the innovative FutureID technology.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: DS-06-2014 | Award Amount: 5.82M | Year: 2015

The advent of Social Networks has made both companies and public bodies tremendously exposed to the so-called Social Engineering 2.0, and thus prone to targeted cyber-attacks. Unfortunately, there is currently no solution available on the market that allows neither the comprehensive assessment of Social Vulnerabilities nor the management and reduction of the associated risk. DOGANA aims to fill this gap by developing a framework that delivers aDvanced sOcial enGineering And vulNerability Assessment. The underlying concept of DOGANA is that Social Vulnerabilities Assessments (SVAs), when regularly performed with the help of an efficient framework, help deploy effective mitigation strategies and lead to reducing the risk created by modern Social Engineering 2.0 attack techniques. Two relevant features of the proposed framework are: i) the presence of the awareness component within the framework as the cornerstone of the mitigation activities; ii) the legal compliance by design of the whole framework, that will be ensured by a partner and a work package explicitly devoted to this task. Moreover, the outcomes of the project are also expected to provide a solid basis to revise the insurance models for cyber-attacks related risks, thanks to the involvement of 2 strong DOGANA partners in this area of activity. The project will be implemented by a consortium of 18 partners, from 11 different countries, including users, technology providers of whom 3 are major world-wide cyber-security solutions market leaders as well as legal and psychological expertise. An extensive field trial plan enables the testing of the DOGANA platform with six users (4 partners and 2 supporting users) operating in the critical areas of energy, finance, transport, utilities, and public authorities. DOGANA has also created a unique consortium with a world-wide scope.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.86M | Year: 2016

European societies face rapid social changes, challenges and benefits, which can be studied with traditional tools of analysis, but with serious limitations. This rapid transformation covers changes in family forms, fertility, the decline of mortality and increase of longevity, and periods of economic and social instability. Owing to population ageing across Europe, countries are now the experiencing the impact of these rapid changes on the sustainability of their welfare systems. At the same time, the use of the space and residential mobility has become a key topic, with migrations within the EU countries and from outside Europe being at the center of the political agenda. Over the past decade research teams across Europe have been involved in the development and construction of longitudinal population registers and large research databases, while opening up avenues for new linkages between different data sources (ie administrative and health data) making possible to gain an understanding of these fast societal transformations. However, in order to work with these types of datasets requires advanced skills in both data management and statistical techniques. LONGPOP aims to create network to utilize these different research teams to share experiences, construct joint research, create a training track for specialist in the field and increase the number of users of these large possibly underused - databases, making more scientists and stakeholders aware of the richness in the databases.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-02-2016 | Award Amount: 7.43M | Year: 2017

Power electronics is the key technology to control the flow of electrical energy between source and load for a wide variety of applications from the GWs in energy transmission lines, the MWs in datacenters that power the internet to the mWs in mobile phones. Wide band gap semiconductors such as GaN use their capability to operate at higher voltages, temperatures, and switching frequencies with greater efficiencies. The GaNonCMOS project aims to bring GaN power electronic materials, devices and systems to the next level of maturity by providing the most densely integrated materials to date. This development will drive a new generation of densely integrated power electronics and pave the way toward low cost, highly reliable systems for energy intensive applications. This will be realized by integrating GaN power switches with CMOS drivers densely together using different integration schemes from the package level up to the chip level including wafer bonding between GaN on Si(111) and CMOS on Si (100) wafers. This requires the optimization of the GaN materials stack and device layout to enable fabrication of normally-off devices for such low temperature integration processes (max 400oC). In addition, new soft magnetic core materials reaching switching frequencies up to 200 Mhz with ultralow power losses will be developed. This will be assembled with new materials and methods for miniaturised packages to allow GaN devices, modules and systems to operate under maximum speed and energy efficiency. A special focus is on the long term reliability improvements over the full value chain of materials, devices, modules and systems. This is enabled by the choice of consortium partners that cover the entire value chain from universities, research centers, SMEs, large industries and vendors that incorporate the developed technology into practical systems such as datacenters, automotive, aviation and e-mobility bikes


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-22-2016 | Award Amount: 15.59M | Year: 2016

ZIKAlliance is a multidisciplinary project with a global One Health approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2013.1.2-1 | Award Amount: 4.43M | Year: 2013

Gastroenteritis, caused by the airborne Norovirus, is the third most deadly infectious disease worldwide, infecting ~4% of the population annually, worldwide, and has related costs measured in billions annually in the EU alone. Today, detection of airborne viruses can only be done in retrospect in the laboratory, which severely limits the ability to rapidly react and limit the spread of an outbreak. The NOROSENSOR consortium will address this problem by developing the first of its kind, real-time sensor for airborne viruses, with particular focus on the NoV. Because the virus concentration in air can be very low, and because rapid and efficient virus trapping and concentration methods have been missing, no solution exists today. The NOROSENSOR project will fill this important need by integrating a number of recently developed, highly powerful technologies: Novel nanobiotechnology: nanobead enhanced rolling circle amplification (nano-RCA), engineered synthetic DNA aptamers, and proximity ligation assays (PLA) First ever airborne nanoparticle manipulation: capturing, filtering and up-concentration of viruses using acoustophoresis and electrostatic precipitation. with beyond state-of-the-art: Ultra-sensitive QCM mass-sensitive transducers and electronics. Novel Off-stoichiometry Thiol-Ene-Epoxies (OSTE) polymers for cartridge and reagent storage on-chip. The consortium consist of six of the highest ranked European Universities, each experts in their research area, two SMEs providing a unique expertise in their core business areas, and a large multinational industry in infection control technology.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.3.1-2 | Award Amount: 7.84M | Year: 2013

Antimicrobial resistance is arguably the most significant challenge facing the EU health care system. The unnecessary use of antibiotics is a key driver in the development of antibiotic resistance. Cystic Fibrosis (CF) represents a unique disease model to study bacterial resistance and to explore therapeutic strategies for same, as chronic lung infection overlaps with acute lung exacerbations caused by a multitude of organisms that traditionally evolve various mechanisms of resistance. With time, chronic polymicrobial infection develops, with the most dominant infecting organism being Pseudomonas aeruginosa, which is also important in other infections including wounds, burns and patients with medical devices, making it an important clinical target for the EU. In CF infections, empiric intravenous antibiotics are usually given for two weeks. Recurrent infections and treatments result in increasing antimicrobial resistance, and alterations in pathogen host interactions in the lung and gut flora. Next-generation DNA sequencing technology now offers DNA-based personalised diagnostics and treatment strategies. Enhancing our knowledge of the microbiome allows the use of stratified targeted antibacterial therapy that can be compared with standard empirical antibacterial therapy currently used. We believe this will reduce antibiotic usage, optimize dosage and duration startegies as the therapy will be tailored to the actual individual patient needs. Cystic Fibrosis Microbiome-determined Antimicrobial Therapy Trial in Exacerbations: Results Stratified (CF MATTERS) will provide a randomized multi-centre controlled trial of microbiome-derived antimicrobial treatments versus current empirical therapy. Simultaneously parallel human host-pathogen interaction studies in sputa, human gut microflora analysis and evaluation of murine exacerbation models will be performed. This will improve prescription practice and decrease antimicrobial usage and resistance.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-22-2016 | Award Amount: 12.56M | Year: 2016

The ZikaPLAN initiative combines the strengths of 25 partners in Latin America, North America, Africa, Asia, and various centres in Europe to address the urgent research gaps (WP 1-8) in Zika, identifying short-and long term solutions (WP 9-10) and building a sustainable Latin-American EID Preparedness and Response capacity (WP 11-12). We will conduct clinical studies to further refine the full spectrum and risk factors of congenital Zika syndrome (including neurodevelopmental milestones in the first 3 years of life), and delineate neurological complications associated with Zika due to direct neuroinvasion and immune-mediated responses. Laboratory based research to unravel neurotropism, investigate the role of sexual transmission, determinants of severe disease, and viral fitness will envelop the clinical studies. Burden of disease and modelling studies will assemble a wealth of data including a longitudinal cohort study of 17,000 subjects aged 2-59 in 14 different geographic locations in Brazil over 3 years. Data driven vector control and vaccine modelling as well as risk assessments on geographic spread of Zika will form the foundation for evidence-informed policies. The Platform for Diagnostics Innovation and Evaluation will develop novel ZIKV diagnostic tests in accordance with WHO Target Product Profiles. Our global network of laboratory and clinical sites with well-characterized specimens is set out to accelerate the evaluation of the performance of such tests. Based on qualitative research, we will develop supportive, actionable messages to affected communities, and develop novel personal protective measures. Our final objective is for the Zika outbreak response effort to grow into a sustainable Latin-American network for emerging infectious diseases research preparedness. To this end we will engage in capacity building in laboratory and clinical research, collaborate with existing networks to share knowledge and tackle regulatory and other bottlenecks.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.3.1-5 | Award Amount: 3.89M | Year: 2012

The aim of the SME-driven COATIM consortium is to tackle the increasing problem of infections due to biofilms, groups of microorganisms that stick together on different surfaces within the human body and escape conventional antibiotic treatment. Biofilms are typically found on medical devices like implants. The most recent generation of implants with open porosity enable fast osseointegration, but also present an increased risk of microbial biofilm-associated infection. Biofilm-associated infections are responsible for 15-25% of implant failure, and necessitate burdensome and costly revision surgery. The latter is estimated to represent a supplementary medical cost of 800m/year in Europe without taking into account the pain and distress of the patients, indicating that any significant reduction of this type of implant failure is highly recommended. Until now, biocidal implant coatings have been developed that are based on either the release of silver ions, which are toxic upon accumulation, or on conventional antibiotics that have poor activity against microorganisms in biofilms. Therefore, COATIM aims to develop the next generation of implant coatings containing novel potent proprietary antibiofilm molecules (ABMs) with inhibitory activity against microbial biofilms. In COATIM, these ABMs are grafted or deposited on small titanium implant substrates, as a model for dental and orthopaedic implants. Next, the ABM-coated implants are evaluated for in vitro and in vivo activity in resisting microbial infection without compromising osseointegration. Finally, the ABM-coating is applied on complex orthopaedic and dental implants, allowing the exploitation of the results by industry. In parallel, the antibiofilm mode of action of the ABMs is unraveled. COATIM contributes to a dynamic and competitive knowledge-based economy, sustainable development, and serves the needs of the SME-intensive medical technology products market in Europe.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-18-2016 | Award Amount: 4.53M | Year: 2016

The MIDAS consortium is a partnership involving health authorities in five EU countries and the U.S. and technical big data experts from research institutions, MNCs and SMEs. Managing big data for health in all is a monumental challenge for policy makers. MIDAS is addressing this challenge by developing and delivering an integrated solution which will liberate knowledge from data silos and unify heterogeneous big data sources to provide evidence-based actionable information and transform the way care is provided. Despite the urgent need and opportunity, the level of e-health deployment, to share medical data is very low. Indeed 52% of the hospitals do not share any medical information with external GPs electronically. MIDAS will map, acquire, manage, model, process and exploit this heterogeneous health care, governmental and open data to provide an innovative world leading beyond state of the art solution which will inform risk stratification and long term policy-making decisions, demonstrating a positive impact across the EU and beyond. MIDAS will: Provide a data mapping solution Use open, social media and citizen data for high level policy analysis Use technology to exploit the value of big data for actionable information Disseminate best practice on privacy by design, ethics and governance Make Europe a leader in e-health platforms Policy makers, patients and citizens will be co-creators of the solutions, ensuring that these are user validated, feedback is integrated, results are actionable and knowledge created to show benefit across a range of epidemiology challenges. Major health challenges which will be addressed include: ageing population, obesity and mental health. Stakeholders will work together to make Europe a leader in e-health solutions, stimulating new opportunities for industry in this innovative field.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.2.2-1 | Award Amount: 5.92M | Year: 2013

BIP-UPy addresses the need for biomedical implants which can be easily fine-tuned in their properties in regards to bioactivity, biodegradability, and mechanical performance, and thereby be optimized for their targeted clinical application. This project will develop a library comprising of a selection of synthetic polymers and specific bioactivities which can be used to provide the required properties for a targeted biomedical implant. The polymeric materials that will be addressed are supramolecular UPy-modified polymers for uses in urologic implants and embolic implants, benefitting large population groups: bio-degradable meshes with improved in-situ tissue regeneration in pelvic floor repair and endovascular embolic implants with a reduced aneurysm recurrence risk. A mix-and-match approach will be used to bioactivate these supramolecular base materials. The supramolecular nature of the materials allows for mild processing conditions. Main objective is to develop a methodology for obtaining implantable polymers with specifically designed bioactivity for in-situ Tissue Engineering, in which the medical implant is obtained in one step by co-processing of the peptide molecules with the neat polymeric material. Key deliverables are protocols for processable biocompatible UPy-based polymers synthesis and manufacturing scale-up; protocols for UPy-based polymers bioactivity tailoring; procedures for processing the UPy-based polymers preserving the bioactivity efficiency; sterilisation protocols for bioactive medical implants; bioactive implants prototypes with tailored bioactivities; material and implant biocompatibility and bioactivity tests data; new predictive in-vitro tests and drafts of regulatory docs. BIP-UPy consortium comprises 9 partners from 5 European countries: 3 RTD performing institutions and 2 Hospitals, 3 SMEs and 1 LE representing the strong industrial involvement. Forth SME (CHEMPILOTS-DK) has whithdrawn from project on 31/12/2014.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2009-3.4-1 | Award Amount: 10.23M | Year: 2010

CROPS will develop scientific know-how for a highly configurable, modular and clever carrier platform that includes modular parallel manipulators and intelligent tools (sensors, algorithms, sprayers, grippers) that can be easily installed onto the carrier and are capable of adapting to new tasks and conditions. Several technological demonstrators will be developed for high value crops like greenhouse vegetables, fruits in orchards, and grapes for premium wines. The CROPS robotic platform will be capable of site-specific spraying (targets spray only towards foliage and selective targets) and selective harvesting of fruit (detects the fruit, determines its ripeness, moves towards the fruit, grasps it and softly detaches it). Another objective of CROPS is to develop techniques for reliable detection and classification of obstacles and other objects to enable successful autonomous navigation and operation in plantations and forests. The agricultural and forestry applications share many research areas, primarily regarding sensing and learning capabilities.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.1 | Award Amount: 6.72M | Year: 2010

ESS-DACE aims to secure the continuation and consolidation of the European Social Survey (ESS) as a key data source for measuring and understanding long-term changes in public attitudes across Europe. This will be achieved by strengthening the links between the 7 institutions responsible for the central design and coordination of the ESS infrastructure, as well as between the ESS and its funders, data users, national teams and a distinguished network of advisers. The objectives of the ESS infrastructure are: to chart and explain changes in Europes social, political and moral climate (WP2, WP4); to achieve and spread improved standards of rigour in cross-national social measurement, and simultaneously to raise the threshold standards of national surveys (WP3, WP5, WP7, WP12); to introduce and encourage the use of soundly-based attitudinal indicators of national progress, based on citizens judgments of key aspects of their societies (WP6); to undertake and facilitate the training of European researchers in comparative quantitative measurement and analysis (WP9); to provide enhanced access remotely to the users of and participants in the infrastructure (WP8); to improve the visibility and outreach of quantitative data on social change to academics, policy makers and the wider public (WP5, WP10, WP11); to maintain and update a specially-created contextual data repository to help isolate the independent effect of background political and social developments on shifts in attitudes and values (WP13) and to refine the financial, operational and organisational arrangements of the ESS infrastructure to suit its longer term perspectives and commitments (WP3). This application is to ensure not just the survival of the ESS time series, but also to consolidate its achievements by creating a transparent, accessible and increasingly valued mechanism for unpicking the relationship between Europes changing institutions and the shifting values of its people.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-01-2016 | Award Amount: 7.59M | Year: 2017

Objectives The H-CCAT project designs, upscales and shapes hybrid catalysts for the C-H functionalization of aromatic compounds. These solid catalysts will possess better recoverability, higher turnover numbers and better selectivity than current homogeneous catalysts for these reactions. The solid catalysts are applied at demonstration scale in the step-economical production of arylated or alkenylated aromatics, yielding motifs of active pharmaceutical ingredients. Methodology We will design heterogeneous hybrid catalysts featuring deactivation-resistant active sites, based on N-heterocyclic carbenes (NHCs) or diimine ligands and active metal ions. Via efficient, one-step protocols based on self-assembly, these sites will be embedded in robust porous hybrid materials like hybrid silica or metal-organic frameworks. Deactivation or metal aggregation will be prevented by site isolation or by efficient metal reoxidation (for the oxidative alkenylations). Metal leaching is precluded by using strong bonds between metals and embedded ligands like NHCs. Flow protocols will be designed to maximize the turnover numbers. Catalyst synthesis will be scaled up to kg scale, using efficient one-step protocols, minimizing use of solvents or waste formation. Soft shaping methods, e.g. spray drying, will preserve porosity and activity of the hybrid solids. A demonstration is conducted at minipilot scale at the J&J site (Belgium), allowing LCA analysis, techno-economic assessment and elaboration of the business plan. Relevance to work program The catalysts feature new, deactivation resistant active sites; their TOF/TON is maximized by an appropriate porous structure which even can be swelling. Catalysts are produced using innovative one-step protocols to form porous hybrid catalysts as powders or even immediately as shaped objects. The molecules targeted have strong biological and pharmaceutical relevance; they target diseases like influenza, cancer or HIV (case study: Rilpivirine).


Grant
Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2013.3.2 | Award Amount: 4.65M | Year: 2013

The aim of SSL-erate is to accelerate the uptake of high-quality SSL technology in Europe by means of open innovation with and by bringing validated information to all relevant stakeholders. A coordinated European effort is required to address the European societal challenges (in particular health & quality of life in an ageing society, energy consumption and resource efficiency), to resolve the specific challenges of the Lighting industry as noted in the results of the Green Paper Lighting the Future consultation (notably: poor SSL quality, lack of information and awareness among citizens) and to enable lighting solutions with a societal and environmental sustainability perspective, leading to a future in which Europe evolves to the global leadership in SSL systems and solutions. The lighting industry is highly fragmented. As a consequence of this the innovation speed and success rate have been too low and the benefits that we all expect from better lighting solutions, do not sufficiently materialize. To overcome this fragmentation, a collaborative way-of-working, using open-innovation and smart specialization principles, will be taken as the guiding approach. The active involvement of various stakeholders will be realized through workshops, but also through the creation of a web-based SSL-erate Innovation platform, which is planned to continue beyond the duration of this project. Relevant (lighting and non-lighting) companies, but also other stakeholders (like e.g. public authorities, property owners, research institutes, (lead) users/citizens, entrepreneurs, architects, installers) will become active contributors to this accelerated innovation process by applying validated insights on green business development and lighting effects on health & well-being in SSL business experiments.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.83M | Year: 2011

Renal disease is a global public health problem, with the incidence of end stage renal disease (ESRD) rising annually. Current treatment options for ESRD are dialysis or renal transplantation, which have significant drawbacks in terms of increased morbidity and mortality, besides placing an increasing economic burden on society. The development of interventions aimed at preventing ESRD, including drug- and cellular-based therapies, is made difficult by the lack of availability of primary human renal cells for in vitro drug testing and by our inability to accurately assess the effectiveness of cellular-based therapies in appropriate animal models. However, due to recent advances in the fields of stem cell science, biomaterials and bioelectronics, we have unprecedented opportunities to generate the following tools that will facilitate important breakthroughs in renal medicine: (i) human kidney-derived stem/progenitor cells (KSPCs) for drug discovery and cellular therapy; (ii) biomaterials for regulating the differentiation of the KSPCs in vitro for use in drug development programmes; (iii) electronic devices capable of measuring renal function, enabling the effectiveness of stem cell-based therapies to be properly evaluated. The overarching goal of the NephroTools ITN is to provide state-of-the-art multidisciplinary training for a cohort of 15 young researchers in order to equip them with the skills required to make a significant impact in renal medicine and the wider field of stem cell biotechnology. To achieve this goal, the training of each researcher will be based around a specific research project, coupled with placement periods, within a multidisciplinary and cross-sectoral Network that aims to evaluate the potential of human kidney stem/progenitor cells for use in drug discovery and regenerative therapy programmes.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.2-1 | Award Amount: 7.98M | Year: 2010

According to the European Society of Cardiology there has been an increase in the life expectancy at the age of 65 of the European population from 15.0 to 17.0 years in the years since 1980. In the elderly, up to 50% of deaths are caused by cardiovascular diseases, the majority accounted for by coronary artery disease. The most effective treatment for obstructive coronary disease is percutaneous intervention with coronary stenting and fuelled by the increasing disease burden there has been a rapid increase in the number of percutaneous coronary intervention procedures in Europe from 184,000 in 1992 to 885,000 in 2004. If the rate of progression remains constant, the projected number of coronary intervention procedures per annum will be about 1.5 million by 2010, with a stenting rate of close to 100%. The principal safety issue with current coronary stenting procedures is late stent thrombosis which, with a case mortality rate approaching 50%, makes this problem a very significant European health issue. The PRESTIGE project will result in significant improvement in prediction and prevention of late stent thrombosis by providing novel strategies that causally impede incident events without increasing the overall risk of bleeding. These goals will be achieved by a multidisciplinary consortium formed by world-leading EU-based specialists covering the requisite scientific skills and experience. Since the first drug-eluting stent was introduced in 2002 the growth of this sector has been explosive. Forecasts predicted the potential for this market segment to exceed 4.6 billion by 2009. The economic impact of this very ambitious project will be to provide the European health industries with novel stent products and new imaging technologies to identify patients at-risk, as well as amended European treatment guidelines. The social impact will be, amongst others, a tremendous cost reduction for the public and private health insurance systems all over Europe.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SEC-2012.6.1-2 | Award Amount: 4.77M | Year: 2013

PARIS will define and demonstrate a methodological approach for the development of surveillance infrastructure which enforces the right of citizens for privacy, justice and freedom and takes into account the evolving nature of such rights, e.g. aspects that are acceptable today might not be acceptable in the future, and the social and anthropological nature of such rights, e.g. perception of such rights varies. The methodological approach will be based on two pillars, first a theoretical framework for balancing surveillance and privacy/data protection which fully integrates the concept of accountability, and secondly an associated process for the design of surveillance systems which takes from the start privacy (i.e. privacy-by-design) and accountability (i.e. accountability-by-design). The theoretical framework will first be defined in a generic way and guidelines will be provided to define specialized conceptual frameworks (e.g. for a given country), further called SALT frameworks (Social/Anthropological/Legal/Technological) Examples of SALT frameworks will be provided. The case of SALT frameworks interplay (i.e. exchanging surveillance data) will be analysed. A framework management tool will be developed (1) to allow for the creation and edition of a conceptual framework and (2) to subsequently act as a reference to surveillance system designers. A SALT compliant design process will then be defined, i.e. surveillance and privacy balance according to the specialized framework will be ensured through the process. Two use case will be demonstrated, one based on video search technology which focuses on the archived data, and one based on biometrics technology which focuses on embedded systems sensor like data. The two use cases will used different SALT frameworks. The resulting methodology will be promoted through associations and standardization bodies. The project is 36-months long and includes 8 partners.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.32 | Award Amount: 11.03M | Year: 2010

ENSAR is the Integrating Activity of Nuclear Scientists from almost all European countries performing research in three of the major subfields of Nuclear Physics: Nuclear Structure, Nuclear Astrophysics and Applications of Nuclear Science. It proposes an optimised ensemble of Networking (NAs), Transnational Access and Joint Research Activities (JRAs), which will ensure qualitative and quantitative improvement of the access provided by the current seven infrastructures, which are at the core of this proposal. The novel and innovative developments that will be achieved by the RTD activities will also assure state-of-the-art technology needed for the new large-scale projects. Our community of nuclear scientists profits from the diverse range of world-class research infrastructures in Europe that can supply different ion beams and energies. We have made great efforts to make the most efficient use of these facilities by developing the most advanced and novel equipment needed to pursue their excellent scientific programmes and applying state-of-the-art developments in nuclear instrumentation to other research fields and to benefit humanity (e.g. archaeology, medical imaging). Together with multidisciplinary and application-oriented research at the facilities these activities ensure a high-level socioeconomic impact. To enhance the access to these facilities, the community has defined a number of JRAs, using as main criterion scientific and technical promise. These activities deal with novel and innovative technologies to improve the operation of the facilities. In addition, a key JRA aims at integrating the laboratories in Central and South-Eastern European countries with those elsewhere in Europe. The NAs of ENSAR have been set-up with specific actions to strengthen the communities coherence around certain research topics and to ensure a broad dissemination of results and stimulate multidisciplinary and application-oriented research at the Research Infrastructures.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.1.1-02 | Award Amount: 7.98M | Year: 2012

The objective of the EU-PLF project is to deliver a validated Blueprint for an animal and farm-centric approach to innovative livestock farming in Europe proven through extensive field studies. This blueprint represents a manual for farmers and their surrounding industry including high tech SMEs and other stakeholders. It is a reference tool offering pragmatic guidance on how Precision Livestock Farming (PLF) systems can be applied to farm level in order to create value for the farmer and other stakeholders. EU-PLF is based on the PLF concept that represents the continuously automated measurements directly on the animal or in its environment. Beyond the use of the PLF data (body movements or sounds, etc.) for monitoring and management, the data can be translated into key indicators on animal welfare, animal health, productivity and environmental impact. Highly experienced European teams from different disciplines with a proven track record in animal and PLF-related fields - animal scientists, veterinarians, ethologists, bio-engineers, engineers, social scientists and economists, leading industrial market players in the livestock industry and high tech SMEs have joined to deliver a useful PLF Blueprint. Most of the academic partners are leading previous research projects funded by the EU in animal and PLF related fields. To ensure that the Blueprint assists the European livestock industry beyond the duration of the project, 50 SMEs or potential starters will be identified all over Europe to play a key role in the EU-PLF project. With a competition for SMEs and starters, the best ideas get funding to design a PLF-prototype with their high tech innovative solutions. In collaboration with a leading industrial PLF-partner, they use the Blueprint to bring their prototype to farm level. This allows developing business models and linking high tech SMEs to European industry players to create new PLF-products with global impact.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.25M | Year: 2011

Gaia is the ESA cornerstone mission set to revolutionise our understanding of the Milky Way. This proposal will shape a critical mass of new expertise with the fundamental skills required to power the scientific exploitation of Gaia over the coming decade and beyond. The GREAT-ITN research theme is Unravelling the Milky Way focused on four fundamental problems: unravelling the origin and history of our home galaxy; tracing the birth place and understanding the astrophysical properties of the stellar constituents of our galaxy; deepening the understanding of planetary systems by linking the study of exoplanets to the origins of the solar system; take up the grand challenges offered by Gaia in the domains of the distance scale and the transient sky. The GREAT-ITN will deliver a training programme structured around these research themes to a core of new researchers, equipping them with the skills and expertise to become future leaders in astronomy or enter industry. These skills are relevant across many of the key challenges facing us now from climate change to energy security. These require well trained people, people which this GREAT-ITN will deliver. The 12 GREAT-ITN partners in Europe, and 1 in China, each have world leading expertise. 19 additional associate partners provide access to complementary expertise and facilities. The network includes three associates from the Information Technology industry: Microsoft, InterSystems and The Server Labs, each driving the new global on-line agenda. The European Space Agency provides the vital interface to the Gaia project, and exposure to the Space industry. This powerful combination of expertise, from industry and academia, will lead to a new cluster of expertise in the area of Galactic astronomy, deliver powerful and effective training to a large pool of Early Stage Researchers, and cement a sustainable research community adding impact to Europes leadership in this fundamental area of astrophysics.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.1-6 | Award Amount: 4.16M | Year: 2011

Lung and pancreatic cancers still have a mortality rate over 85% at 5 years of diagnosis, a clear demonstration of the actual treatment failure and the need for improved clinical management. This involves better tools for diagnosis, prognosis, and selection of sensitive and resistant patients to current conventional therapies or improved innovative treatments as well as the development of novel therapeutic strategies. The major objective of this proposal is to improve management of patients with either lung or pancreatic tumors by studying the clinical applications of still not investigated metabolic and signalling pathways with the following aims: -development of new tools for early diagnosis -identification of novel tumour markers for early diagnosis and prognosis -prediction of response to conventional treatments -identification of the molecular mechanisms of generation of resistance -development of improved treatments based on the identification of novel molecular targets -design of novel anticancer strategies. -achieve a better understanding of how combinatorial treatments using current standard clinical procedures with novel treatments under development may improve patient outcome. The proposed consortium is composed of four experimental research groups with a profound knowledge on molecular and cellular biology of cancer, and ample experience in the design of targeted and personalized cancer therapies along with translational research, complemented with three clinical groups with an extensive experience in the clinical management of lung and pancreatic cancer patients, guaranteeing a clinical proof-of principle and applicability, integrating basic-clinical European scientific excellence. Furthermore, the consortium has incorporated one company with direct involvement in critical areas that will make feasible to translate to the clinic the results generated in the project.


CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives: 1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic therapy, real-time & follow-up therapy monitoring of atherosclerotic coronary artery disease (CAD), 2) nonclinically evaluate this system, 3) clinically validate the system after regulatory approval, & 4) reduce in the long-term CAD deaths and morbidity by up to 40%, resulting in a significant decrease of the European and global healthcare costs for CAD, increasing the income of the European healthcare industry from CAD market which is the global largest. The CosmoPHOS-nano consortium has a five year history of successful collaboration between the industrial and academic partners, and its funding would underpin a team devoted to delivering a novel powerful & affordable healthcare solution against the leading cause of death, without the need for heavy and expensive medical equipment. The CosmoPHOS system consists of two interacting components: a) targeted theranostic near-infrared photoactivatable biocompatible nanomedicines, and b) medical devices. After systemic administration, the nanomedicines targeted accumulate in coronary atherosclerotic plaques, followed by endocoronary photoactivation and detection by the medical devices, enabling molecular imaging, targeted therapy, real-time & follow-up therapy monitoring of CAD. Preliminary in vitro & in vivo successful experimental results, as well as parts of the CosmoPHOS system are already available from the prior five year collaboration. The project plan includes: A) nonclinical R&D (30 months); B) nonclinical validation & regulatory approval (18 months); C) first-in-man phase-I clinical trial in 20 CAD patients (12 months).


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.3.6-02 | Award Amount: 11.33M | Year: 2013

STREPSYNTH aims to set-up a Streptomyces-based new industrial production platform (SNIP) for high value added biomolecules. Streptomyces lividans was chosen as a bacterial host cell because it has been already shown to be highly efficient for the extracellular production of a number of heterologous molecules that vary chemically, has a robust tradition of industrial fermentation and is fully accessible to genetic intervention. To develop SNIP our strategy has two components: first, we will construct a collection of reduced-genome S. lividans strains. This will metabolically streamline the cell and rid it of agents (e.g. proteases) of potential harm to the heterologous polypeptides. Second, we will engineer synthetic parts and cassettes, i.e. reshuffled, rewired and repurposed genetic elements either indigenous to S. lividans or heterologous genes organized in artificial operon clusters. These elements will serve three aims: transcriptional and translational optimization, sophisticated on-demand transcriptional regulation that will provide unique fermentation control and metabolic engineering of complete cellular pathways channeling biomolecules to profuse extracellular secretion. Synthetic parts and cassettes will be either directly incorporated into the genome or be hosted in the form of plasmids. Systems biology tools will guide fine-tuning rounds of cell factory engineering and fermentation optimization. To set up SNIP we chose two classes of biomolecules with obvious immediate industrial value and application: heterologous proteins (industrial enzymes, biopharmaceuticals, biofuel enzymes, diagnostics) and small molecules (lantipeptides and indolocarbozoles) useful for multiple industrial purposes (biopharmaceuticals, additives, food technology, bioenergy). These biomolecules are of immediate interest to SMEs that participate and guide the industrial relevance of STREPSYNTH. SNIP is a modular platform that can be repurposed for diverse future applications.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.45M | Year: 2013

In vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging (MRS(I)) are unique, indispensable techniques for non-invasive metabolic imaging. Important areas where MRS(I) can make a difference are oncology and neurology, where metabolic changes due to, e.g., tumour formation, can be detected earlier and more sensitively than with morphological imaging modalities alone. Despite its huge proven potential, MRS(I) is not yet a routine clinical tool operated solely by clinicians. This requires reliable automation of complex procedures, strengthening standardisation and quality control. This in turn requires significant research progress and training of a new generation of scientists. Specifically, TRANSACT aims at: - Training 13 young scientists as future leaders in the field of MRS(I), capable of contributing with essential new developments such as spectral quality assurance criteria and standards, and optimal exploitation of complementarities between multi-modal magnetic resonance imaging modalities. - Pursuing research advances in theoretical and practical aspects of MRS, in particular experimental design by quantum mechanical simulation, data acquisition, data processing, data fusion and biomedical applications in oncology and neurology. - Establishing Europe as leader in the field within three sectors: academia, industry, clinic. TRANSACT links 10 academic and 4 industrial partners with complementary expertise in basic science, clinical research and information technology. Through a detailed training programme consisting of individual research projects, well-targeted secondments, scientific network-wide workshops, transferable skills courses, and individualized progress follow-up, TRANSACT will ensure a successful outcome in terms of career perspectives for the recruited researchers, continued collaboration between the partners and a more structured doctoral training in this field.


Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.42M | Year: 2011

Engineering for future mobility must be inspired by ecology and economy to enable green and silent vehicles. Current university based education is focusing on classical fields like mechanical engineering on one side with some aspects of Noise, Vibration & Harshness (NVH) and Light Weight Design (LWD) or like electrical engineering covering aspects of Electrification & Hybridisation on the other side. The proposed GRESIMO project (Best Training for Green and Silent Mobility) aims to bring together early stage researchers and experienced specialists from across industry and academia in Europe covering NVH, LWD and H/E disciplines to form a broad range of professional background. Recent research underlines the strong interaction and shows the often conflicting demands of these 3 topics. Consequently, an optimum for future vehicle development requires an interdisciplinary education in this triangle of topics. GRESIMO focus is to motivate and encourage early stage researchers for scientific work in the new interdisciplinary research fields NVH\LWD, LDW\H/E and H/E\NVH. The fellows will be trained and supported in their phase of doctoral thesis to find innovative PhD topics as well as to receive specific education in theoretical and practical trainings. The education will comprise existing lectures in the partner network as well as training specifically developed for the interdisciplinary needs. GRESIMO is formed by a group of participating hosts, combining leading education and research institutions as well as industrial enterprises in 6 countries of the EC. Thus the engineers will participate in both the scientific research work and the practical application of new methods of testing and simulation. They will profit from extended international knowledge after their academic education when starting to work in the industry. Furthermore, the industry will gain from the specific training of the young researchers for the requirements to develop green and silent vehicle.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.72M | Year: 2013

Cultural Heritage (CH) is an integral element of Europe and vital for the creation of a common European identity and one of the greatest assets for steering Europes social, economic development and job creation. However, the current research training activities in CH are fragmented and mostly design to be of a single-discipline, failing to cover the whole lifecycle of Digital Cultural Heritage (DCH) research, which is by nature a multi-disciplinary and inter-sectoral research agenda. ITN-DCH aims for the first time worldwide that top universities, research centers, industries and CH stakeholders, end-users and standardized bodies will collaborate to train the next generation of researchers in DCH. The project aims to analyze, design, research, develop and validate an innovative multi-disciplinary and inter-sectoral research training framework that covers the whole lifecycle of digital CH research for a costeffective preservation, documentation, protection and presentation of CH. ITN-DCH targets innovations that covers all aspects of CH ranging from tangible (books, newspapers, images, drawings, manuscripts, uniforms, maps, artefacts, archaeological sites, monuments) to intangible content (e.g., music, performing arts, folklore, theatrical performances) and their inter-relationships. The project aims to boost the added value of CH assets by re-using them in real application environments (protection of CH, education, tourism industry, advertising, fashion, films, music, publishing, video games and TV) through research on (i) new personalized, interactive, mixed and augmented reality enabled e-services, (ii) new recommendations in data acquisition, (iii) new forms of representations (3D/4D) of both tangible /intangible assets and (iv) interoperable metadata forms that allow easy data exchange and archiving.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 4.09M | Year: 2014

Improving Childrens Auditory REhabilitation (iCARE) Communication through language is vital to develop and maintain everything around us. By 15 years of age, about 5 out of 1000 children suffer from a moderate, severe or profound hearing impairment that can potentially affect communication, learning, psychosocial development and academic achievement if not appropriately handled. The EU promotes the active inclusion and full participation of disabled people in society. However, full active inclusion in an oral society can only be achieved through cooperation and involvement across disciplines (language, psychology, audiology, engineering, special education,). It is therefore of fundamental importance to approach the inclusion of children with hearing impairment in an interdisciplinary manner, and to train future experts to adopt such principles in their research and practice. The objectives of improving Childrens Auditory REhabilitation (iCARE) are twofold: 1) to provide training create a new generation of researchers capable of exploiting the synergies between different disciplines to optimize spoken communication in children with hearing impairment, and 2) to combine research across disciplines to develop novel methods, training skills and procedures for improving auditory rehabilitation. iCARE is an international and interdisciplinary consortium from academia, industry and socio-economic agencies. The proposed training consortium is unique because the partners are specialized in a variety of disciplines, both technical and non-technical, all of utmost importance to the core issue: optimizing inclusion of children with hearing impairment in an oral society through evidence-based research. The consortium will provide comprehensive training of fellows to become communication experts, and enable the development of novel methods, tools and evaluation material that will suit the evolving needs of children with hearing impairment in a holistic manner.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.4.2-3 | Award Amount: 3.93M | Year: 2010

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children, affecting approximately 5% children in Europe. Methylphenidate (MPH) is the most-commonly prescribed medication for ADHD children; it is also increasingly used in ADHD adults. In 2007, the European Commission requested a referral to the Committee for Medicinal Products for Human Use (CHMP) under Article 31 of Directive 2001/83/EC, as amended, for MPH because of safety concerns. The CHMP concluded that study of the long-term effects of MPH on growth, sexual development, neurological system, psychiatric states and cardiovascular system is needed. In response to the CHMPs concerns, the ADDUCE (Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects) research team has been formed by a consortium of experts in the fields of ADHD, drug safety, neuropsychopharmacology and cardiovascular research. The ADDUCE project aims to investigate the long-term adverse effects of MPH on growth, neurological system, psychiatric states and cardiovascular system in children and adults. The ADDUCE team will use multiple pharmacoepidemiological research methods to achieve its aim: (1) Retrospective analysis of existing databases. (2) 2-year prospective cohort study recruiting 800 MPH-treated children and adolescents and 800 controls. (3) Cross-sectional study (600 MPH-treated patients and 600 controls) in late adolescents and young adults. Furthermore the ADDUCE team will develop research tools for the evaluation of adverse effects of MPH on cognition and motivation. The ADDUCE consortium comprises 12 academic partners, 1 SME and 1 EU professional network. The ADDUCE team will directly interact with the European Medicines Agency to assist them in making regulatory decisions on the safety of MPH in children and adults. The ADDUCE team will adopt an open-access policy to ensure the information and results have the maximum public health impact.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.4.1-1 | Award Amount: 13.78M | Year: 2013

With numerous European industries heavily depended on imported REE raw materials, there is a need for EU to secure a viable supply of REE minerals as well as develop from the ground up the currently non-existent European REE extraction and processing industry. The goal of the EURARE project will be (i) to characterize the potential REE resources in Europe; and (ii) to research, develop, optimize and demonstrate technologies for the efficient and economically viable exploitation of currently available European REE deposits with minimum consequences to the environment. In the EURARE project, the mineral processing technologies currently used for the REEs minerals will be investigated for representative European REE ores, with a tendency for improvement by adopting new approaches for the complete ore utilization and minimal environmental consequences, establishing integrated mineral processing systems, with zero or close to zero tailings. The current state-of-the-art processes for REE extraction follows complicated, energy and resource intensive technologies. The EURARE project aims in developing novel cost-effective and resource-efficient REE extraction process, tailored specifically for European REE ore deposits as well as for European health, safety and environmental protection standards. As an added value to the work already described, EURARE will seek to demonstrate new sources for REE exploitation from industrial metallurgical waste which will not only be financial lucrative but will minimize the overall environmental footprint of the primary European metallurgical industry. Special attention in all cases will be given in health, safety and social issues, in light of naturally occurring radioactive elements. At the end of the EURARE project it is expected that a novel sustainable exploitation schema for Europes REE deposits will have been established


Grant
Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: HEALTH.2010.1.2-3 | Award Amount: 2.25M | Year: 2011

EuroGentest is an FP6 European network for the harmonization of genetic testing and for the further improvement of quality in genetic services across Europe. This proposal is to support EuroGentest2, a Coordination Action that will cover the different aspects of quality assurance of genetic practice and has all the ingredients to fulfil the needs. EuroGentest2 will be concerned with setting the targets for laboratory and health professional accreditation, by contributing to guidelines and standards, and actively interacting with the professional organizations and the policy makers. EuroGentest2 will also assist the diagnostic and clinical community and the individual laboratories and counselling units in reaching those aims by providing tools for quality management and by coordinating training activities. EuroGentest2 will extend its activities from postnatal diagnostic and predictive testing to prenatal testing, thereby building on the achievements of the FP6 SAFE network, and to direct to consumer testing. A major aim of the Coordination Action will be the creation of a European association of genetic diagnostic centres that will guarantee the future of the network. The Coordination Action will lead to the further harmonization and quality assurance of genetic practice. The patients will benefit by the improvement of the analytical and clinical quality and validity of the testing, and from improved trans-border services and information. The European diagnostics industry will benefit through a faster access of innovations to the market through the validation for diagnostic use. It will enable countries and regions with less developed health care infrastructure to develop standards for best practice of provision of clinical genetic service. The Coordination Action will also identify research needs and have the capacity to set a research agenda that corresponds to the needs of the human genetics community


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SEC-2012.4.2-2 | Award Amount: 13.14M | Year: 2013

The dynamic capture of situational awareness concerning crowds in specific mass gathering venues and its intelligent enablement into emergency management information systems, using smart communication devices and spaces is critical for achieving rapid, timely guidance and safe evacuation of people out of dangerous areas. Humans could be overwhelmed by fast changes of potentially dangerous incidents occurring at confined environments with mass-gathering. They could fail to make objective decisions to find their way to safety. This condition may lead to mass panic and make emergency management more challenging. In eVACUATE, the intelligent fusion of sensors, geospatial and contextual information, with advanced multi-scale crowd behaviour detection and recognition will be developed. The structured fusion of sensing information with dynamic estimated uncertainties on behaviour predictions will advance eVACUATE crowd dynamic models; and virtual reality simulations of crowds in confined environments. A service oriented Decision-Support System shall be developed to dynamically distribute on-demand evacuation information to emergency management actors as the crisis unfolds. Decision-makers at the command posts, first responders, front-line stewards and volunteers receive real-time situation aware information of updated evacuation strategies using robust and resilient eVACUATE information and communication infrastructure. Smart spaces of electronic, audio and other mobile devices shall be connected to the integrated system to provide safer evacuation routings for people. The eVACUATE system performance and scalability will be validated in five distinct scenarios involving incidents with large crowd at various venues with the requirements of evacuation time reductions and increases of safety and security. These are: 1) Underground stations in Bilbao and 2) Marseille; 3) Real Sociedad Footbal Stadium in San Sebastian, 4) Athens International Airport and 5) a STX Cruiseship.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2013.1.3-2 | Award Amount: 3.34M | Year: 2014

During the global financial crisis and ensuing Great Recession, economists at policy-making institutions had little choice but to augment macroeconomic models with ad-hoc assumptions and adjustments in order to provide analysis and advice for policy makers. Our consortiums proposal aims to move policy-focused macroeconomic modelling beyond this approach to the endogenous modelling of the dynamics resulting from financial risks and related decision making in banks, households, firms and public institutions. We bring together four broad lines of research to systematically develop new behavioural and institutional building blocks, integrating them in policy-focused macroeconomic models and using these models in a new framework for policy evaluation. In terms of building blocks, one line of research moves beyond the assumption of representative and homo-oeconomicus-type agents to incorporate micro-behavioural realism in decision making, while a second line of research advances the modelling of financial institutions, their fragility and the dynamics of systemic risk. The third line of research integrates these new building blocks (including a selection of those developed by researchers outside the consortium) in a new generation of policy-focused macroeconomic models. In parallel, in the fourth line of research new policy evaluation tools are developed, with a focus on robust tools aimed at containing financial contagion and boom-bust cycles, maintaining fiscal sustainability and coordinating monetary, fiscal and regulatory policies in normal and crisis regimes. The consortium comprises researchers with a strong track record in advancing the frontier on behavioural and institutional modelling, highly influential macroeconomic modellers as well as seasoned veterans of model-based monetary, fiscal, and regulatory policy evaluation and design. Consortium members have strong academic backgrounds as well as substantive practical experience at policy-making institutions.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2010.2.1.4-1 | Award Amount: 9.23M | Year: 2010

FunDivEUROPE (FUNctional significance of forest bioDIVersity in EUROPE) proposes to quantify the effects of forest biodiversity on ecosystem function and services in major European forest types in the main bioclimatic regions of Europe. FunDivEUROPE will be based on four scientific platforms and seven cross-cutting Work Packages. The project will combine a global network of tree diversity experiments (Experimental Platform) with a newly designed network of observational plots in six focal regions within Europe (Exploratory Platform). Additionally, the project will integrate an in-depth analysis of inventory-based datasets of existing forest monitoring networks to extend the scope to larger spatial and temporal scales (Inventory Platform). FunDivEUROPE will thus combine the strengths of various scientific approaches to explore and quantify the significance of forest biodiversity for a very large range of ecosystem processes and ecosystem services. Using modeling and state-of-the-art techniques for quantitative synthesis, the project will integrate information gained from the different platforms to assess the performance of pure and mixed species stands under changing climate. In addition to the three research platforms, FunDivEUROPE will set up a Knowledge Transfer Platform in order to foster communication, aggregation and synthesis of individual findings in the Work Packages and communication with stakeholders, policy makers and the wider public. The information gained should thus enable forest owners, forest managers and forest policy makers to adapt policies and management for sustainable use of forest ecosystems in a changing environment, capitalizing on the potential effects of biodiversity for ecosystem functioning. The experiences gained within FunDivEUROPE will finally allow contributing to the development of the European Long-Term Ecosystem Research Network, complementing existing forest observation and monitoring networks.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.30 | Award Amount: 9.70M | Year: 2011

The central objective of this ESMI proposal is to create a top-level interdisciplinary research infrastructure available to a broad European materials research community. This is of crucial importance to the EU in view of the European strategy for nanosciences and nanotechnology and its implementation report that identifies a lack of leading interdisciplinary infrastructures. ESMI offers the most important experimental and synthesis techniques and combines world-class infrastructures with cutting edge scientific expertise through a sophisticated networking programme. The anticipated JRA will further improve the existing infrastructure. Computer simulations being of increasing importance for the understanding and prediction of complex materials, ESMI offers access to simulation groups and their advanced tools. The availability of such an infrastructure will provide soft matter scientists with a broad choice of techniques to address their scientific objectives. It will result in a quantum leap in research opportunities and assure that European scientists have a world-class collaborative capability for their frontier research. ESMI will strongly contribute to a fundamental understanding, allowing the development of new, tailored smart materials. ESMI follows the FP6 experience of the NoE SoftComp. A key feature developed within SoftComp is the highly successful Research Platforms offered to its members, anticipating the spirit of the EU Integrated Infrastructure Initiative. ESMI will promote the SoftComp experience to the European materials community, reflecting the EU recommendations that FP6 collaborative projects may well lead to new European infrastructures. Together with a platform for disseminating the results and educating a new generation of young soft matter scientists, ESMI represents an important added value to the European Research Area in nanoscience, nanotechnology and materials science


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SEC-2013-1.6-4 | Award Amount: 16.64M | Year: 2014

The purpose of Project VALCRI is to create a Visual Analytics-based sense-making capability for criminal intelligence analysis by developing and integrating a number of technologies into a coherent working environment for the analyst we call the Reasoning Workspace. Conceptually, the Reasoning Workspace comprises three areas: (i) a Data Space which will enable an analyst to see what data and themes exist, (ii) an Analysis Space to which data can be brought into to carry out various computational analyses including statistical and text analysis, and (iii) a Hypothesis Space that will enable the analysts to assemble their evidence into coherent arguments that lead to meaningful and valid conclusions. The user interface will be rooted in the concepts of Visual Analytics the emerging science of analytical reasoning facilitated by visual interactive interfaces (Thomas and Cook, 2004), and specially designed to support the interactive dynamics (Heer and Shneiderman, 2012) required to enable real-time analytic interaction with data. The design of the user interface will move away from the traditional windows and list of lists views for presenting data, and instead to create information objects that may be directly manipulated and freely organised visuo-spatially by the analysts so that location and spatial groupings have meaning and can be manipulated directly by selection and dragging; or we can initiate Boolean operations on the content of the two or more clusters by dragging one cluster onto another. In addition, the presentation of multiple views of the information objects, in the form of network graphs, timelines, geo-spatial etc. can lead to further insight, especially when interactivity is enabled. This tight coupling between visualisation and computation is crucial for developing and maintaining cognitive momentum, the train of thought that enables creativity and sense-making.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2011.1.4-5 | Award Amount: 1.98M | Year: 2011

The goal of this project is to develop multiscale theoretical models of biocompatible metallic nanomaterials and apply them for the analysis, design and optimization of the materials. Two groups of titanium based nanomaterials are considered (while the methods developed should be applicable to other metallic materials as well): nanostructured commercially pure titanium and shape memory NiTi alloy. The multiscale model of nanostructured titanium (nTi) includes atomistic molecular dynamics (MD) discrete dislocation dynamic model (DDD) of the nucleation, interaction and movement of dislocations, crystal plasticity models mechanical behavior of Ti nano-grains, coupled texture and substructure evolution model for severe plastic deformation of polycrystalline Ti, micromechanical analysis of the grain sizes and microstructures on the mechanical properties. The atomistic and micromechechanical modeling of martensitic transformation (or reorientation) lattice strain of NiTi alloys is carried out. The biocompatibility of these two groups of materials (MD modeling of the interactions between metallic nanoparticles and biological molecules) is studied theoretically. The theoretical studies and recommendations are validated experimentally and in practice.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SEC-2012.3.4-6 | Award Amount: 15.61M | Year: 2013

FastPass will establish and demonstrate a harmonized, modular approach for Automated Border Control (ABC) gates. FastPass brings together key players of the entire ABC value chain - system and component producers, research institutions, governmental authorities and end-users. The development of a harmonized ABC gate will be accomplished with continuous end-user involvement. The entire innovation process, from components development to the final design of the user interface, will continuously be evaluated by the two end user groups, travellers and border guards. Border control is a major challenge for security and mobility within the EU. Travellers request a minimum delay and a speedy border crossing, while Border Guards must fulfil their obligation to secure the EUs borders against illegal immigration and other threats. Fastpass will serve both demands at the same time to keep security at the highest level while increasing the speed and the comfort for all legitimate travellers at all border control points. The FastPass ABC process will be designed to address both requirements with equal emphasis. One aspect of a speedy border crossing by legitimate travellers is a harmonised user interface. This will allow frequent travellers from Europe and third country states to pass through an ABC with minimum delay, using the full potential of ID documents. Improved traveller identification technologies, such as new biometric modules will increase the security of the ABC process and minimise spoofing. A demonstration and evaluation at all types of border (air, land and sea) will be implemented in at least three different member states. Compliance with European societal values and citizens rights is central to the acceptance of the developed technologies, and will accompany the development and end-user interaction throughout the project. FastPass will develop a reference architecture for ABC gates, and will pursue a European initiative for a global standard in ABC technology.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2009-2.5-1 | Award Amount: 6.98M | Year: 2010

The M-RECT project aims to create multiscale-reinforced semi-crystalline thermoplastics (PEEK and PPS), which will outperform all reinforced polymers in terms of strength, stiffness, creep and mainly damping by upscaling and further developing state of the art production methods, within cost-efficient manufacturing routes. The envisaged multiscale reinforcement will comprise of dispersed straightened and aligned to polymer molecules multi-walled carbon nanotubes (CNTs) and also fully impregnated, long carbon fibres (CF). In order to achieve this objective a number of novel technological achievements including CNT functionalization techniques, fluid-assisted CNT alignment, microwave and induction heating of composites, out of autoclave manufacturing including bagging techniques, DIRIS sandwich panel production, fluoropolymer radiation-absorbing coatings and polymer optical fibre technology will be further developed and used. The CNT or multi-scale reinforced PEEK or PPS sheets and the resulting sandwich panels will be used as raw material for manufacturing laminated complex prototypes covering a wide range of industrial applications such as automotive, railroad, aeronautical, space, civil engineering and biomedical. Optimized design of these structures will be based on suitably developed numerical modelling and optimization tools within the proposed project and which will be validated through extensive testing at nano, meso and macro-scale. The anticipated impacts of the development of the envisaged top-performance lightweight thermoplastic composites and their manufacturing routes will extend to an international level by decreasing energy and fuel consumption, decreasing waste production and improving recyclability, creating profitable spin-off activities, promoting safety and improving the urban environment.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2009.7.1.1 | Award Amount: 56.70M | Year: 2010

A group of 6 Transmission System Operators (Belgium, Denmark, France, Germany The Netherlands and Spain) with 2 generator companies, 5 manufacturers and research organisations, propose 6 demonstration projects to remove, in 3 years, several barriers which prevent the electric system from welcoming more wind electricity, and wind electricity from contributing more to the electric system. The full scale demonstrations aim at proving the benefits of novel technologies (most of them available from manufacturers) coupled with innovative system management approaches. The contribution of wind energy to the system will show how aggregated wind farms can provide system services (voltage and frequency control) in Spain. The aggregation of wind farms with flexible generation and loads will be demonstrated in Denmark using a scalable IT platform developed by a generator. Increasing the flexibility of transmission networks will be tested in Belgium (existing sensors and coordinated power flow control devices avoiding possible large scale instabilities induced by wind farms in the CWE region) and in Spain (dynamic wind power evacuation capacity using real-time computations based on short-term generation forecasts and use of a mobile Overload Line Controller). Off-shore wind farms are addressed from a security viewpoint. Secure HVDC meshed networks will be validated in France using simulations and full scale experiments of two different HVDC circuit breaker technologies. Off-shore wind farm shut downs under stormy conditions will be demonstrated in Denmark using the world largest off-shore wind farm with balancing power provided by the Norwegian hydro capacities through a HVDC link. The experimental results will be integrated into European impact analyses to show the scalability of the solutions: routes for replication will be provided with benefits for the pan European transmission network and the European electricity market as soon as 2014, in line with the SET plan objectives.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: KBBE.2012.2.3-05 | Award Amount: 3.84M | Year: 2013

Food security is a global challenge. Within the overall increased demand for food, and particularly meat production, there is also an urgent need to increase supply of protein from sustainable sources. The principle objective of the international and multidisciplinary PROteINSECT consortium is to facilitate the exploitation of insects as an alternative protein source for animal and human nutrition. Advances have been made in rearing of insects for incorporation in animal feed in countries including China and Mali. The consortium brings together expertise in these countries together with European insect breeders and feed production companies in order to optimise systems and set up pilot scale production facilities in the EU. The project will demonstrate the feasibility of the use of insect-derived proteins in animal feed through trials with fish, poultry and pigs. Quality and safety along the food chain from insect protein itself, to incorporation in feed and ultimately human consumption of insect-protein reared livestock, will be evaluated. The use of waste streams that focus on animal rather than plant material for insect rearing will be examined. To optimise the economic viability of the use of insect proteins, uses for the residual flows from the production system will be determined. Life cycle analyses will enable the design of optimised and sustainable production systems suitable for adoption in both ICPC and European countries. Key to uptake is ensuring that a regulatory framework is in place and this will be encouraged by the preparation of a White Paper following consultation with key stakeholders, experts and consumers. PROteINSECT will build a pro-insect platform in Europe to encourage adoption of sustainable protein production technologies in order to reduce the reliance of the feed industry on plant/fish derived proteins in the short term, and promote the acceptance of insect protein as a direct component of human food in the longer term.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.4.1-2 | Award Amount: 3.96M | Year: 2012

About 75% of advanced epithelial ovarian cancer (EOC) patients respond to first-line surgery and chemotherapy but most relapse and ultimately acquire platinum resistance which soon leads to death. Relapsed high grade serous ovarian cancer (HGSOC) is the single main cause of EOC-related morbidity and mortality (despite the fact that HGSOC is highly chemosensitive). We hypothesize that the primary tumour includes a small population of resistant cells that are ultimately responsible for relapse and that by targeting this population front-line we may prolong disease-free survival or even achieve cure. OCTIPS will use unique retrospective and novel prospective paired tumour samples collected at the time of diagnosis and relapse to identify and validate molecules and pathways responsible for relapse. This identification will employ cutting edge high throughput multiplatform analyses such as next generation sequencing, mRNA and miRNA expression arrays and SNP array. Known and newly defined molecules or pathways will be evaluated in innovative integrated cancer model systems, utilising cell lines and avian egg and murine xenografts. New therapies to target these molecules and pathways will be developed and validated in these model systems. In order to translate these findings into patient benefit, agents that target the relapsing cell population will be tested for tolerability, efficacy, ability to combine with first line chemotherapy and then in randomised first line trials by the OCTIPS consortium. By translating the clinical observation of treatment failures into innovative cancer models that mimic relapsed ovarian cancer, we will validate improved front-line therapeutic strategies to help prolong patient survival. The impact of this application is that it defines a highly rigorous approach to integrate the bedside to bench to bedside paradigm, leading to novel prognosis-changing strategies for the treatment of ovarian cancer patients.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-2.3.1 | Award Amount: 8.65M | Year: 2013

The European Energy Research Alliance, set-up under the European Strategic Energy Technology Plan, has launched an initiative for a Joint Programme on Nuclear Materials (JPNM). The JPNM aims at establishing key priorities in the area of advanced nuclear materials, identifying funding opportunities and harmonizing this scientific & technical domain at the European level by maximizing complementarities and synergies with the major actors of the field. The JPNM partners propose, through MatISSE, a combination of Collaborative Projects and Coordination and Support Actions to face the challenge of implementing a pan-European integrated research programme with common research activities establishing, at the same time, appropriate strategy and governance structure. Focusing on cross-cutting activities related to materials used in fuel and structural elements of safe and sustainable advanced nuclear systems, the project aims at covering the key priorities identified in the JPNM: pre-normative research in support of ESNII systems, Oxide Dispersed Strengthened steels, refractory composites for the high temperature applications, development of predictive capacities. MatISSE will foster the link between the respective national research programmes through networking and integrating activities on material innovations for advanced nuclear systems, sharing partners best practices and setting-up efficient communication tools. It is expected that, through MatISSE, a real boost toward Joint Programming among the Member States, the European Commission and the main European research actors, will be achieved.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2013.5.2-1 | Award Amount: 6.39M | Year: 2014

Using an innovative interdisciplinary approach, MIME will generate an organised body of policy-relevant propositions addressing the full range of questions raised in the call. Our aim is to identify the language policies and strategies that best combine mobility and inclusion. MIME emphasises complementarity between disciplines, and brings together researchers from sociolinguistics, political science, sociology, history, geography, economics, education, translation studies, psychology, and law, who all have longstanding experience in the application of their discipline to language issues. The diverse concepts and methods are combined in an analytical framework designed to ensure their practice-oriented integration. MIME identifies, assesses and recommends measures for the management of trade-offs between the potentially conflicting goals of mobility and inclusion in a multilingual Europe. Rather than taking existing trade-offs as a given, we think that they can be modified, both in symbolic and in material/financial terms, and we argue that this objective can best be achieved through carefully designed public policies and the intelligent use of dynamics in civil society. Several partners have been involved in successful FP6 research, and key advances achieved there will guide the MIME project: languages are viewed as fluid realities in a context of high mobility of people, goods, services, and knowledge, influencing the way in which skills and identities are used and constantly re-shaped. The project integrates these micro-level insights into a macro-level approach to multilingual Europe. MIME results will be made widely available through a creative approach to dissemination, including training modules and the MIME Stakeholder Forum, allowing for sustained dialogue between academics, professional associations and local/regional authorities. The project culminates in a consensus conference where recommendations based on the project findings are adopted.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SST.2010.1.1-3. | Award Amount: 8.16M | Year: 2011

Ground vibration, effected by rail services, is an important environmental concern, affecting European citizens nearby any rail infrastructure. Surveys show that many Europeans are subjected to annoying levels of feelable vibration and vibration-induced noise. Although solutions are available for track in tunnels, tracks at grade are a much more extensive problem even for vibration-induced noise. However, solutions for tracks at grade are lacking: for some problems currently no feasible solutions at reasonable cost are available. A group of railway operators, infrastructure managers, infrastructure and rolling stock manufacturers, and construction companies, end users of vibration mitigation technology, have gathered, to propose a major project for Railway Induced Vibration Abatement Solutions (RIVAS). They aim at providing tools and methods to reduce vibration below the threshold of annoynace and induced noise below background levels by 2013. The group includes the expertise of research organisations and universities with specialist laboratory and theoretical modelling facilities. The issues are treated in a holistic way with the focus on reducing the annoyance to lineside residents. The project examines all vibration effects and aspects of the system: vehicle, track, propagation, freight and high-speed rail services. WP1 establishes the test procedures to monitor and control the performance of vibration mitigation measures under realistic conditions WP2 develops and evaluates mitigation measures based on reducing the excitation of vibration at the vehicletrack interface by improved maintenance WP3 develops and evaluates mitigation measures for ballasted and slab tracks WP4 will develop and evaluate mitigation measures based on sub-grade improvement and ground barriers within the railway infrastructure WP5 addresses the impact of the vehicle Each of the solutions is to be validated with field tests on the major European rail networks represented in RIVAS


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.1.2-1 | Award Amount: 13.84M | Year: 2010

Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the worlds population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-4.2-1 | Award Amount: 7.36M | Year: 2010

Second-generation antipsychotics are increasingly being prescribed to children and adolescents. Their use, however, is mostly off-label, and adequate and sufficient data about efficacy and particular safety are lacking. This proposal focuses on two indications, the use of risperidone in children and adolescents with conduct disorder who are not mentally retarded, and the use of risperidone in adolescents with schizophrenia. The objectives are to 1) perform a series of clinical studies that will provide sufficient information for a Paediatric Use Marketing Authorisation to be obtained for these indications; 2) address scientific questions about the moderating and/or mediating factors of the efficacy and safety of risperidone in children and adolescents, and 3) disseminate the knowledge acquired by the proposed studies to medical and mental health professionals, to patients and their families and society in general.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2013.1.5 | Award Amount: 1.31M | Year: 2013

The mission of PRIPARE is twofold: facilitate the application of a privacy and security -by-design methodology that will contribute to the advent of unhindered usage of Internet against disruptions, censorship and surveillance, support its practice by the ICT research community to prepare for industry practice; foster risk management culture through educational material targeted to a diversity of stakeholders. To this end PRIPARE will\n\tspecify a privacy and security-by-design software and systems engineering methodology, using the combined expertise of the research community and taking into account multiple viewpoints (advocacy, legal, engineering, business),\n\tprepare best practices material (guidelines, patterns, success stories) for the development and implementation of products and services of ICT-based systems and use-cases in the area of cloud computing, mobile services and the management of cyber incidents, \n\tsupport FP7 and Horizon 2020 research projects through training workshops and practical support in applying PRIPARE best practices in their environment.\n\tprovide educational material on approaches for risk management of privacy and create awareness on the need for risk management culture among users. Material consistent with PRIPARE methodology will be structured in a modular way in order to fit to different targets (policy makers, users, ICT students and professional). \n\tidentify gaps and provide recommendations on privacy and security-by-design practices, support of unhindered usage of Internet and on the creation of a risk management culture. A research agenda will be proposed.\nPRIPARE consists of a consortium of 11 partners with strong links with the privacy community (data protection authorities/policy makers, privacy advocacy organisations, technology, engineering). In order to prepare for the longer term adoption by the industry, a representative advisory board will be set up. The support action duration is 24 months.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2012.4.2-1 | Award Amount: 8.27M | Year: 2013

FRAME, a 4-year multidisciplinary project, represents a consortium of 19 internationally recognized and globally networked human rights institutes from across Europe and strategic regions around the world. Through FRAME, more than 100 leading researchers and practitioners - with a strong gender balance - aim to provide the necessary building blocks for a coherent EU human rights policy comprised of: (i) a sound knowledge base taking account of the factors, concepts, institutions and instruments underlying human rights protection; (ii) appraisal of the EUs full potential to contribute to global human rights governance through its relationship with multiple actors and its manifold policies; and (iii) a set of indicators, tools and policy proposals geared to strengthen human rights implementation in EU policy-making. Through 4 research clusters, FRAME offers creative solutions to enhance the coherence and effectiveness of EU human rights policy. Cluster 1: Factors examines the key factors facilitating or hindering human rights protection, the concepts of human rights, democracy and the rule of law and the human rights protection institutions and instruments at global, regional and national level. Cluster 2: Actors addresses the EUs human rights engagement with the UN, regional multilateral organizations, regional and strategic partnerships with third countries and non-state actors, as well as the relationship between EU institutions and the Member States. Cluster 3: Policies hones the fostering of human rights in EU policies on development and trade, human rights violations in conflicts, freedom, security and justice and external human rights and democratization action. Cluster 4: Tools develops indicators, tools and policy proposals, including policy benchmarking, to monitor and improve the effectiveness of EU human rights policy. FRAMEs vital impact on human rights research, education and policy innovation will continue beyond the projects lifetime.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.54M | Year: 2013

SPRITE is a multi-disciplinary European training network which brings together Europes premier research institutes in technology and applications of ion beams. Those involved are already actively collaborating, for example in the recently very favourably reviewed EC Infrastructure project SPIRIT. SPRITE addresses the urgent European need - identified in a recent Foresight Review - to train the next generation of researchers in this multi- and supra- disciplinary emerging field. Through its Internship Mobility Partnerships (IMPs) SPRITE offers an innovative training package, providing the researchers with the opportunity to gain real world experience and business facing skills in the private and public sectors. In addition, ELVEs (European Laboratory Visit Exchanges) are an integral part of the training program. In combination with the IMPs, every ER and ESR will thus spend up to 30% of its time outside its host laboratory, part of this time in another EC country. Collaboration with the IAEA opens up a further dimension to SPRITE, enabling the researchers to put their research into a global context and to interact with scientists from all over the world. Despite the numerous participants SPRITE is able to offer a personalized training program. For this purpose the Action Planner, a web-based training needs analysis tool, developed at the University of Surrey will be used. This maps on to the Researcher Development Framework, currently being trialled by the European Science Foundation. Action Planner allows the training for each researcher to be tailored to their individual needs and aspirations. In addition to individualized training, SPRITE organizes network wide training events, encompassing amongst others technical training and business facing skills. In this way SPRITE researchers will leave not only as a brilliant and experienced researcher but also as a skilled manager, able to lead their own group.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.5 | Award Amount: 5.36M | Year: 2011

TOSCA-MP aims to develop user-centric content annotation and search tools for professionals in networked media production and archiving (television, radio, online), addressing their specific use cases and workflow requirements. This will be achieved by scalable and distributed content processing methods performing advanced multimodal information extraction and semantic enrichment. Other key technology areas will include search methods across heterogeneous networked content repositories and novel user interfaces. An open standards based service oriented framework integrates the components of the system.\nTOSCA-MP will enable professionals in media production and archiving to seamlessly access content and indexes from distributed heterogeneous repositories in the network. This will be achieved by providing technologies that allow instant access to a large network of distributed multimedia databases, including beyond state-of-the-art metadata linking and alignment. The distributed repositories can be accessed through a single user interface that provides novel methods for result presentation, semi-automatic annotation and means of providing implicit user feedback.\nTOSCA-MP enables content holders to leverage scalable distributed processing in the network. The networked approach enables the use of in-house or external service models. Thus, content holders can use these services without giving content out of their hands. Advanced genre-adaptive indexing methods provide multilingual speech processing, object detection, quality analysis, semantic enrichment based on visual and speech analysis, enrichment from external sources and multimodal content clustering.\nThe project will develop models of key user tasks in the audiovisual media production workflow. These models are used to adapt the components of the system to the specific and dynamic requirements of real user tasks in the media production domain, and to evaluate the tools in a cost-effective way.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2013.2.2-4 | Award Amount: 6.10M | Year: 2013

Energy harvesting at low frequency has proven to be difficult to achieve in the past because of the properties of the materials that the devices are fabricated from. In particular the stiffness of conventional silicon and all piezoelectric materials makes it exceedingly difficult to make a system that can operate below 100Hz. There are many sources of low frequency vibrations e.g. human motion, the motion of ships, and traffic; so an Energy Harvester that can operate in this frequency range would have a large commercial potential and extensive opportunities for future exploitation. This multi disciplinary project proposal addresses the lack of durable energy harvesting systems in this frequency range. With primary objectives of the project being the development of materials and devices for; Low frequency tunable energy harvesting device and High energy density compact supercapacitors for energy storage with secondary objectives being: - The necessary electronics to connect them and make them work efficiently - Packaging technologies that will integrate the full system and make it biocompatible - A study of component reliability and models that can project their lifetime - An end of life study and an environmental impact assessment Perpetually self powered electronic systems that can be implanted into the human body is the application area that we have targeted for demonstration of this technology, because there are a clear set of requirements which will motivate the design, fabrication and test of the system under consideration. The two primary objectives present a range of novel and substantial materials challenges in both making the components, achieving a reliable unattended operational extended lifetime and ensuring that the devices are not toxic to the host that they are implanted into. While the secondary ones will facilitate an appropriate demonstration of the technology and ensure its usefulness after the project has been completed.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2011.2.3.3-1 | Award Amount: 15.16M | Year: 2011

The capacity of zoonotic RNA viruses to emerge as major agents of human disease can appear limitless. Current intervention strategies have demonstrated limited success. Rapid, innovative and effective solutions are needed to reduce the apparently accelerating process of zoonotic disease emergence. We will study the following zoonotic viruses with epidemic potential in Europe: influenza virus, hepatitis E virus, viruses of the Japanese encephalitis serocomplex and lyssaviruses. These diverse viruses arise from the main reservoirs and vectors of potentially emerging viral diseases and use the three major routes of transmission: respiratory, faecal-oral and vector borne. Inter-disciplinary studies will generate valuable data on patterns of crossing the species barrier, transmission and disease emergence, including ecological and anthropological factors which determine virus availability and opportunities for exposure and infection. We will unravel the complex biological interactions between the virus and the recipient hosts that drive the viral adaptation and elucidate the factors determining the ability of the viruses to spread to and between humans (including pandemic spread). Furthermore, immune mechanisms of protection and novel prevention strategies will be investigated. Data will be compiled in a unique and freely accessible data-sharing platform to build a framework for analysing the drivers of pathogen emergence. Modelling, building on the analysis of key data, will focus on the extent to which pathogen trajectories are predictable and will identify high-risk situations and environments. This will allow improvement of disease surveillance, control, preparedness and intervention. Training in leading European Universities, as well as exchanges of approaches and data sharing with national and international health organizations will strengthen European position in this global challenge.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: Fission-2013-5.1.1 | Award Amount: 1.86M | Year: 2013

Medical exposures for radiological examinations represent the highest and fastest growing contribution to manmade radiation exposure in the EU underlying the need for medical physics experts (MPEs), regulators and scientists in industry to bring in new research results and expertise and to deploy resources in addressing this important issue. The EC recognized the urgency and the EU tender European guidelines for the Medical Physics Expert (MPE) (TREN/H4/1672009) was issued to develop and update the role of MPEs in Europe. The final report has been approved by the EC and includes an agreed mission statement and key activities for MPEs. The new qualification framework defines the MPE as an MP who, through planned advanced training and CPD, achieves the highest level possible (i.e., European Qualifications Level 8) in her/his specialty. However, it is recognized that few Member States have the expertise and facilities to provide the necessary training. A preliminary survey among National Organisations of MP and medical device companies showed that a dedicated training scheme has become a necessity. Three end-users were identified: the hospital MPE, the scientist in industry and regulators assessing exposures in Diagnostic and Interventional Radiology. The EUTEMPE-RX consortium will develop, put into practice and evaluate a new pilot EFTS for the MPE in Diagnostic and Interventional Radiology, which includes both face-to-face and on-line teaching. The aim is to ensure that candidates become knowledgeable about all current issues in radiation safety culture in hospitals and to make the MPE a radiation protection advocate for patients. The course will address the themes identified in the MELODI strategic research agenda, DoreMi and EMAN projects. A business plan will be developed for the sustainability of the network, which would provide a template for the development of similar programmes in the other specialties of medical physics.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.3.5-01 | Award Amount: 3.95M | Year: 2011

BIOTREAT brings together six research institutions and four SMEs to develop much-needed water treatment biotechnologies for removing pesticides, pharmaceuticals and other organic micropollutants from contaminated drinking water resources. These biotechnologies will be developed into prototype biofilter systems ready for subsequent commercialisation. The biofilters will contain non-pathogenic pollutant-degrading bacteria, with the bacteria being immobilised on specific carriers to ensure their prolonged survival and sustained degradative activity. Through beyond state-of-the-art research, BIOTREAT will ensure that these novel water treatment biotechnologies are highly transparent, reliable and predictable. Two complementary biotreatment strategies will be followed, one based on metabolic processes whereby the bacteria completely mineralise specific micropollutants and the other based on cometabolic degradation utilising the ability of methane- and ammonium-oxidising bacteria to unspecifically degrade a range of micropollutants for which specific degraders are not yet available. The biofilter systems will be carefully validated through cost-benefit analysis and environmental life cycle assessment. A road map will be drawn up for post-project exploitation, including individual SME business plans. Effective dissemination of the BIOTREAT results will be ensured by close collaboration with an End-user Board comprised of representatives from waterworks, water authorities, industry, etc. In addition to bringing considerable advances to water treatment biotechnology, the main outcome of BIOTREAT will thus be prototype biofilter systems (metabolic and cometabolic) ready for commercialisation in a number of highly relevant water treatment scenarios, including existing sand filters at waterworks, mobile biofilters placed close to groundwater abstraction wells, sand barriers between surface waters and abstraction wells, and protective barriers in aquifers.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.2.1-3 | Award Amount: 14.90M | Year: 2010

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project will lead to evidence that is directly applicable to treatment guidelines, will explore the development of novel treatments and will identify potential mechanisms for new drug development. To achieve these goals we have assembled a European team of experts that is second to none in the world. Together we will pursue the following objectives: -To use MRI to optimise treatment outcome and to facilitate prediction of response to treatment; - To provide a rational basis for antipsychotic choices in the treatment of first episode schizophrenia or schizophreniform disorder; - To improve functional outcome and reduce drug discontinuation by means of psychosocial interventions. - To explore the potential of cannabidiol CBD, a modulator of endocannabinoid functioning, as an alternative to D2 based antipsychotics - To validate a new approach to improve cognitive performance in patients with cognitive deficits on the basis of their genetic make up; - To use theoretically driven neurochemical imaging (MRS) and empirically driven genetic/genomic markers as predictors of response to treatment.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.1 | Award Amount: 2.38M | Year: 2012

In industry, society and science advanced software is used for solving planning, scheduling and resource allocation problems, collectively known as constraint satisfaction or optimization problems. At the same time, one continuously gathers vast amounts of data about these problems. This project starts from the observation that current software typically does not exploit such data to update schedules, resources and plans. It aims at developing a new approach in which gathered data is analysed systematically in order to dynamically revise and adapt constraints and optimization criteria. Ultimately, this could create a new ICT paradigm, called Inductive Constraint Programming, that bridges the gap between the areas of data mining and machine learning on the one hand, and constraint programming on the other hand. If successful, this would change the face of data mining as well as constraint programming technology. It would not only allow one to use data mining techniques in constraint programming to improve the formulation and solution of constraint satisfaction problems, but also to employ declarative constraint programming principles in data mining and machine learning.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-3.1.1 | Award Amount: 10.26M | Year: 2013

Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioecology, nuclear emergency management) scientific issues would continue to be hosted by the sister associations, Alliance and NERIS, these associations are encouraged to join MELODI to establish an umbrella structure as equal partners. OPERRA will exploit the synergies of EURATOM and other EC programmes considering the most relevant joint program areas and mechanisms for funding joint activities. The project will also strengthen the links with national funding programs as well as the European education and training structures. Also, it will take steps towards a greater involvement of those new Member States who could benefit from increased participation in the radiation research programmes. Finally, OPERRA will take steps to further integrate the joint use of infrastructures in European countries, and to develop and facilitate an easier access to research infrastructures. The final objective of this project is to build up an umbrella coordination structure that has the capacity in a legal and logistical sense to administer future calls for research in radiation protection as a whole (including low-dose risk, radioecology, nuclear emergency management, and also research activities related to the medical uses of ionizing radiation) on behalf of the European Commission. OPERRA will prepare the organisation for a first competitive call by the end of 2013 for projects in low-dose risk research and a second competitive call in 2014 for broader projects in radiation protection research, subject to the approval of EC services, with the support of Go-between administrator operator and an external advisory entity.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.93M | Year: 2014

TEMPO addresses the needs of European companies and society for embedded control technology, through training on cutting edge research in the rapidly emerging inter-disciplinary field of embedded predictive control and optimization. The key objectives are: - to expand the scientific and technical knowledge platform for Embedded Predictive Control and Optimization in Europe; - to exploit this platform to train a new generation of world class researchers and professionals that are highly attractive for employment by the European industry; - to establish structures for long-term cooperation and strengthen the relations among the leading universities and industry in Europe in this field, to continuously develop the research training platform that European industry relies on. To achieve the objectives listed above, the main tasks of TEMPO are: - to attract and train 14 Early Stage Researchers in embedded MPC and optimization via a joint academic/industrial program of cutting edge training-by-research, high quality supervision, complementary and transferable skills training, inter-network secondments, and workshops; - to create a closely connected group of leading European scientists that are highly sought after by European industry, and ready to push forward embedded MPC and optimization into new innovative products, industries and services; - to build a solid foundation for long-term European excellence in this field by disseminating the research and training outcomes and best practice of TEMPO into the doctoral schools of the partners, and by fostering long-term partnerships and collaboration mechanisms that will outlast the ITN; - to disseminate the know-how of the participants to each other and to external groups via networking activities, inter-sectoral exposure, secondments, workshops, demonstrations, sharing of learning material, public engagement and outreach activities, and open source public domain software outcomes.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.1.4-1 | Award Amount: 8.01M | Year: 2013

In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient treatment, quality of life and long-term graft survival. Also, there is an unmet need for better understanding of the immune and non-immune mechanisms of interstitial fibrosis /tubular atrophy and graft loss. Combining all the skills required to build upon previous findings, BIOMARGIN will offer such opportunities in renal transplantation by integrating several omics approaches (mRNA, miRNA, peptides, proteins, lipids and metabolites) in blood, graft tissue and urine, in a well thought out, multistage discovery-to-validation translational programme, following the highest European ethics and regulatory requirements, as well as quality controls and quality assessments at all clinical and analytical steps. It is probably one of the first programmes to pursue such an integrated and systematic research approach. BIOMARGIN aims to: (i) discover, select and validate blood and/or urine biomarkers of renal allograft lesions in adult and pediatric kidney transplant recipients; (ii) provide renal transplant physicians with non-invasive, robust diagnostic tests and interpretation algorithms enabling closer, more accurate, more predictive and/or less invasive monitoring of transplanted patients; (iii) help to avoid or diminish the use of biopsies and improve patient treatment, quality of life and long-term graft survival; (iv) help understand the mechanisms involved in the allograft injury processes which, combined with mass spectrometry imaging should offer pathologists new molecular targets and tools for renal graft biopsy analysis.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2012.3.2-1 | Award Amount: 8.36M | Year: 2013

The main objectives of this project are to investigate the diversity of family forms, relationships, and life courses in Europe; to assess the compatibility of existing policies with these changes; and to contribute to evidence-based policy-making. The project will extend our knowledge on how policies promote well-being, inclusion and sustainable societal development among families. Our approach relies on three key premises. First, family life courses are becoming more diverse and complex. Second, individual lives are interdependent, linked within and across generations. Third, social contexts and policies shape individual and family life courses. Building upon these premises we a) explore the growing complexity of family configurations and transitions, b) examine their implications for men, women and children with respect to inequalities in life chances, intergenerational relations and care arrangements, c) investigate how policies address family diversity, d) develop short- and longer-term projections, and e) identify future policy needs. Transversal dimensions that are integrated into the project are gender, culture, socioeconomic resources and life stages. Our approach is multidisciplinary combining a wide range of expertise in social sciences, law and the humanities represented in the consortium of 25 research partners from 15 European countries, old and new member states, and three transnational civil society actors. We will conduct comparative analyses applying advanced quantitative methods to high quality register and survey data, and qualitative studies. The project will also develop a database of the legal content of family forms available in European countries, suitable for comparative analyses. Together with various stakeholders, government agencies, national and local policy-makers, non-governmental organizations and additional members of the scientific community across Europe, we will identify and disseminate innovation and best policy practices.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2011.1.2-1 | Award Amount: 10.37M | Year: 2012

The objective of this 4-year project is to provide the analytical basis for a socio-ecological transition in Europe: the change to a new growth path with smart, sustainable and inclusive growth as is envisaged in the EU 2020 strategy. In order to support the transition, we analyse the need, the feasibility and best practice for change, specifying the institutional changes needed at all policy levels to implement these options. The old and new challenges Europe is facing define the starting point: globalisation, new technologies and postindustrialisation, demographic change and ecology in the context of welfare systems that have come under stress due to high public deficits. The vision is that Europe will become a role model for a high road growth path which actively incorporates social and ecological goals, employment, gender and cultural aspects in an ambitious, forward looking way while continuing to be competitive in a globalised world. To achieve these objectives, the consortium will carry out and synthesise robust research in research areas covering the challenges to the welfare system, the biophysical dimension of socio-economic development, the identification of drivers towards socio-ecological transition, the role of governance and institutions on the European as well as the regional level. The consortium will benefit from ongoing dialogue with international experts in the form of expert panels and sounding boards, taking into account their views on the direction and feasibility for this new growth path. The project will be carried out by a consortium of 34 partners from universities and research institutes with international and interdisciplinary expertise. It represents 12 member states. High level Scientific and Policy Boards will monitor the analysis and the policy conclusions to guarantee the impact and dissemination of the results.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-28-2015 | Award Amount: 3.33M | Year: 2016

12% of the developed world suffers from congestive heart failure (CHF), which is the most frequent cause of hospitalization in people aged over 65. CHF management involves medications, monitoring of fluid intake and weight, exercise and lifestyle modifications. Since most patients are elderly and suffer from co-morbidities, they have difficulty adhering to the management guidelines, which often leads to poor outcomes. The HeartMan project will develop a personal health system to help CHF patients manage their disease. Its core will be a decision support system that will provide personalised advice to the patients. Its first key feature will be evidence-based predictive models: a short-term model developed in the European project Chiron, and long-term models adapted to focus on modifiable parameters that can improve the patients predicted outcomes. Its second key feature will be the delivery of the advice through a cognitive behavioural therapy based on cognitive dissonance. This is a proven approach that exploits the dissonance between healthy attitudes and unhealthy behaviours to improve the behaviours. It will be augmented by mindfulness exercises, which are expected to make the patients more receptive to the HeartMans advice. The system will also feature advanced health devices and monitoring methods to understand the patients physical and psychological state, and standard-based data management for wide interoperability. In developing the HeartMan system, a human-centred approach will be used. The resulting system will be validated in two trials, which will test its medical effectiveness and usability. The project will also have strong dissemination and exploitation. To ensure industry-standard robustness, the industrial partners will have key role in developing the prototypes, and the documentation necessary for certification as a medical device will be prepared. All the consortium will be involved in IPR management and the building of business models.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2012.7.2.1 | Award Amount: 13.05M | Year: 2012

Eight Transmission System Operators (BE, CZ, FR, DE, IT, PT, CH, PL) and ENTSO-E, together with 4 associations of technology manufacturers, and 16 RTD performers propose a 3-year R&D project to develop and to apply a methodology for the long-term development of the Pan-European transmission network. The project aims at delivering a top-down methodology to support the planning from 2020 to 2050. First, it implements a set of future power scenarios, including generation units, the possible use of electricity storage and demand-side management solutions: scenarios for power localization are proposed with assumptions on the energy mix in each of the connected clusters covering the ENTSO-E area. Network studies are performed to detect the weak points when implementing the scenarios for 2050. Grid architectures options and a modular development plan are then proposed, including electricity highways, on the basis of power flow calculations, network stability analysis, socio-economic, network governance considerations, and with remarks from the consultation of European stakeholders. In parallel, an advanced planning methodology is designed, developed and tested with academic laboratories to address a few critical aspects of the above planning methodology, which may impact the robustness of the resulting architectures. This enhanced approach takes into account the correlated uncertainties in renewable generation and consumption, potential voltage and stability issues, and black-out risks including the feasibility of defence plans to avoid uncontrolled cascading failures of the candidate architectures. It includes the use of non-linear detailed models of power grids and stochastic optimization techniques. The dissemination is coordinated by ENTSO-E to reach the widest audience and to prepare the exploitation of the results. Standardization and complementary research efforts are pointed out for the future investment optimization with the support of the manufacturing industry.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.1.2-12 | Award Amount: 3.93M | Year: 2012

The genetic changes associated with domestication in aquaculture pose an increasing threat to the integrity of native fish gene pools. Consequently, there is a bourgeoning need for the development of molecular tools to assess and monitor the genetic impact of escaped or released farmed fish. In addition, exploration of basic links between genetic differences among farmed and wild fish and differences in important life-history traits with fitness consequences are crucial prerequisites for designing biologically informed management strategies. The project AquaTrace will establish an overview of current knowledge on aquaculture breeding, genomic resources and previous research projects for the marine species seabass, seabream and turbot. The project will apply cutting-edge genomic methods for the development of high-powered, cost-efficient, forensically validated and transferable DNA based tools for identifying and tracing the impact of farmed fish in the wild. Controlled experiments with wild and farmed fish and their hybrids will be conducted with salmon and brown trout as model organisms using advanced common garden facilities. These experiments will elucidate the fundamental consequences of introgression by pinpointing and assessing the effects on fitness of specific genomic regions. Generated insights will form the basis of a risk assessment and management recommendations including suggestions for mitigation and associated costs. This information and the developed molecular tools will be available as open-access support to project participants and external stakeholders including the aquaculture industry. The project is expected to facilitate technology transfer to the aquaculture sector by promoting better tailored breeding practices and traceability throughout production chain. Overall this initiative will support the development of sustainable European aquaculture and provide Good Environmental Status in line with the Marine Strategy Framework Directive.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: ENERGY.2011.7.3-1 | Award Amount: 3.88M | Year: 2011

The present project provides the necessary support to the EEGI Team gathering, in a structured and organised way, a team of top level players (research centres, SMEs, universities, in close coordination with ENTSO-e and EDSO for SG) to design in a coordinated way with both TSOs and DSOs a set of accompanying activities to make sure that the EEGI will pass through the critical 2012-2014 period (preparation of FP8, initial operation of ACER, increased specification duties of the network operators) when dealing with the most complex electricity system in the world and to address the five remaining critical issues (costs, benefits, KPIs, knowledge sharing and financing) in involving all the stakeholders, to ensure the rational, fluid and stable EEGI workflow, as to reach safely the 2020 European goals.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: KBBE-2009-3-7-01 | Award Amount: 20.52M | Year: 2010

BIOCORE will create and demonstrate create a lignocellulosic biorefinery for sustainable processing of agricultural residues (wheat and rice straws), SRC wood (poplar) and hardwood forestry residues, into 2G biofuels, bulk chemicals, polymers, speciality molecules, heat and power. To reach this overall objective, BIOCORE will: 1) Describe how a mixed lignocellulosic feedstock-based biorefinery can be supplied with biomass, taking into account biomass handling, feedstock variability and seasonality. Biomass provisioning scenarios will be described for several different local contexts (Europe and Asia) 2) Adapt and streamline a patented organosolv technology for targeted biorefining of BIOCORE feedstocks and develop all necessary processing steps (including enzymatic hydrolysis and physico-chemical operations) to produce high quality cellulose, polymeric and oligomeric hemicellulose-derivatives, high quality lignins, heat and power from process residues 3) Develop multiple product manufacturing pipelines using a combination of advanced biotechnologies, chemical catalysis and thermochemical processes for the production of building block chemicals and polymers for bulk markets from sugars and lignins 4) Design a complete biorefinery concept that will describe the alternative product manufacturing pathways. This will be achieved by developing integrated flowsheets and process designs that include all of the operational units, supply chain models, and economic factors 5) Demonstrate the performance of the biorefinery through an integrated approach, producing industrial scale pilots for the biorefinery complexes that are closer to the market 6) Assess the environmental, economic and social sustainability of the biorefinery concept considering the entire value chain 7) Ensure efficient technology transfer to the energy sector, chemical and biotech industries, agro and forestry sectors, and the general public and policy makers


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.6 | Award Amount: 6.87M | Year: 2011

Offering collective and participative experiences to real-world and online communities is at the heart of the Future Media Internet (FMI) and will form an essential part of entertainment, education, collaborative working, product and service innovation and advertising. Communities involved potentially include hundreds of professionals, tens of thousands at live public events and millions online. Current FIRE testbeds fail to meet needs of FMI researchers in terms of testbed resources, let alone support such experimentation in the real-world where insights into the behaviour of Future Internet systems are closer to reality. Extensive research into testbeds is needed to support the R&D of large-scale social and networked media systems as well as to understand and manage complex communities and ecosystems.\nEXPERIMEDIA will develop and operate a unique facility that offers researchers what they need for large-scale FMI experiments. Testbed technologies will include user-generated high quality content management and delivery, a 3D Internet platform and tools for 3D reconstruction from live events, augmented reality platform, tools for integration of social networks, access technologies and a range of network connectivity options. Testbed management services will provision, control and monitor resources according to SLAs thus offering QoS guarantees.\nExperiments will be conducted in the real-world at live events and to diverse communities to accelerate the adoption of FMI. Testbeds include the Schladming Ski Resort, the Multi-Sport High Performance Centre of Catalonia, historical sites provided by the Foundation for the Hellenic World and the 3D Innovation Living Lab. Experiments will explore new forms of social interaction and rich media experiences considering the demands of online and real-world communities. The variety of testbeds will ensure the generality of our approach. A Future Media Internet Competence Centre will promote sustainable access to venues for FMI experiments and engagement with the wider community.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2013.2.2 | Award Amount: 3.22M | Year: 2013

The European robotics community has grown significantly over the last few years. At the same time public funding enabled the community to become more organised on both the research (EURON) and the industrial (EUROP) side and to develop the currently valid Strategic Research Agenda (SRA).Very recently EURON and EUROP decided to combine their portfolio of activities and member base within a new non-profit organisation, euRobotics AISBL, which intends to engage in a contractual Public-Private Partnership (PPP) with the European Commission (EC). The main players behind this success story have joined in this project to address the most important challenges for the coming three to five years:\n- Professional coordination of technology roadmapping and implementation of innovation activities\n- Fostering collaboration among all stakeholders of European robotics\n- Promoting European robotics\nThis projects ambition is to create sustainable solutions for these challenges, building on the successful instruments the robotics community has already experimented with. These instruments have not yet fully achieved the required goals, partly because of a lack of dedicated, professional support and partly because the challenges have changed as a consequence of the higher ambitions and the larger set of stakeholders to be involved. This will change with the recent founding of euRobotics AISBL and the commitment of both industrial and academic stakeholders to more closely and formally cooperate, but especially through the PPP with the EC. The following activities are planned engaging the whole community:\n- Robotics roadmap coordination\n- Robotics PPP preparation and ramp-up\n- Facilitating robotics innovation\n- Robotics networking\n- Dissemination and outreach\nThese core activities will defragment the community and construct a European robotics industry with sufficient identity and presence to create world leadership in terms of both strategic capability and economic impact.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.5.2 | Award Amount: 16.43M | Year: 2013

MD-Paedigree is a clinically-led VPH project that addresses both the first and the second actions of part B of Objective ICT-2011.5.2:\n1. it enhances existing disease models stemming from former EC-funded research (Health-e-Child and Sim-e-Child) and from industry and academia, by developing robust and reusable multi-scale models for more predictive, individualised, effective and safer healthcare in several disease areas;\n2. it builds on the eHealth platform already developed for Health-e-Child and Sim-e-Child to establish a worldwide advanced paediatric digital repository.\nIntegrating the point of care through state-of-the-art and fast response interfaces, MD-Paedigree services a broad range of off-the-shelf models and simulations to support physicians and clinical researchers in their daily work. MD-Paedigree vertically integrates data, information and knowledge of incoming patients, in participating hospitals from across Europe and the USA, and provides innovative tools to define new workflows of models towards personalised predictive medicine. Conceived of as a part of the VPH Infostructure described in the ARGOS, MD-Paedigree encompasses a set of services for storage, sharing, similarity search, outcome analysis, risk stratification, and personalised decision support in paediatrics within its innovative model-driven data and workflow-based digital repository. As a specific implementation of the VPH-Share project, MD-Paedigree fully interoperates with it. It has the ambition to be the dominant tool within its purview. MD-Paedigree integrates methodological approaches from the targeted specialties and consequently analyzes biomedical data derived from a multiplicity of heterogeneous sources (from clinical, genetic and metagenomic analysis, to MRI and US image analytics, to haemodynamics, to real-time processing of musculoskeletal parameters and fibres biomechanical data, and others), as well as specialised biomechanical and imaging VPH simulation models.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC5-13-2016-2017 | Award Amount: 6.99M | Year: 2016

The PLATIRUS project aims at reducing the European deficit of Platinum Group Metals (PGMs), by upscaling to industrial relevant levels a novel cost-efficient and miniaturised PGMs recovery and raw material production process. The targeted secondary raw materials will be autocatalysts, electronic waste (WEEE) and tailings and slags from nickel and copper smelters, opening-up an important range of alternative sources of these critical raw materials, with the potential to substitute a large amount of primary raw materials which are becoming more and more scarce in Europe. For the first time five of the major research centres in Europe will collaborate in developing and fine tuning the most advanced recovery processes for PGMs. This joint effort will lead to a unique exchange of know-how and best practices between researchers all over Europe, aiming at the selection of the recycling process and the preparation of the Blueprint Process Design that will set the basis for a new PGM supply chain in the EU. Two primary and secondary material producers with a consolidated business model will carry out validation of the innovative recovery processes in an industrially relevant environment by installing and testing them in an industrially relevant environment and benchmarking with the currently adopted recovery processes. A recycling company will provide a link to market introduction by manufacturing autocatalysts with second-life PGMs obtained via the PLATIRUS technology. Two large automotive companies will validate the material produced through the new recovery process, and ensure end-user industry driven value chains for recovered PGM materials. LCA, economic and environment assessment of the whole process will be led by a specialized consultancy company. Finally, the PLATIRUS project will be linked to European and extra-European relevant stakeholders, research activities and industries, with a solid dissemination, communication and exploitation plan.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: AAT.2011.4.4-3. | Award Amount: 50.74M | Year: 2011

The project proposal concerns the challenges posed by the physical integration of smart intelligent structural concepts. It addresses aircraft weight and operational cost reductions as well as an improvement in the flight profile specific aerodynamic performance. This concerns material concepts enabling a conformal, controlled distortion of aerodynamically important surfaces, material concepts enabling an active or passive status assessment of specific airframe areas with respect to shape and potential damages and material concepts enabling further functionalities which to date have been unrealizable. Past research has shown the economic feasibility and system maturity of aerodynamic morphing. However, few projects concerned themselves with the challenges arising from the structural integration on commercial aircraft. In particular the skin material and its bonding to the substructure is challenging. It is the aim of this project proposal to demonstrate the structural realizability of individual morphing concepts concerning the leading edge, the trailing edge and the winglet on a full-size external wing by aerodynamic and structural testing. Operational requirements on morphing surfaces necessitate the implementation of an independent, integrated shape sensing system to ensure not only an optimal control of the aerodynamic surface but also failure tolerance and robustness. Developments made for structural health monitoring will be adapted to this task. Similar systems optimized for rapid in-service damage assessment have progressed to a maturity which allows their inclusion in the next generation of aircraft. However, the time consuming application of these sensor systems has to be further improved by integration at the component manufacturing level. The additional benefit of a utilization of these adapted systems for part manufacture process and quality control shall be assessed in SARISTU. Addressing the Nanotechnology aspect of the call, benefits regarding significant damage tolerance and electrical conductivity improvements shall be realized at sub-assembly level.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: Fission-2010-2.3.1 | Award Amount: 4.95M | Year: 2011

The present FP-7 proposal MAX is subsequent to the recommendations of the Strategic Research Agenda of SNETP for ADS development in Europe. Its aim is to pursue the R&D required for a high power proton accelerator as specified by the MYRRHA project. There is especially a strong focus on all the aspects that pertain to the reliability and availability of this accelerator. This R&D effort builds on the large body of results and the clear conclusions that have been obtained during the consecutive FP5 project PDS-XADS and FP6 project EUROTRANS. MAX will further investigate the key issues of redundancy and fault-tolerance by real-world experience in making maximum use of already existing or to-be-built dedicated prototypes, both on the injector side and on the main superconducting linac side. At the end of the MAX project, it will be possible to generate an updated consolidated reference layout of the accelerator for MYRRHA with sufficient detail and adequate level of confidence in order to initiate its engineering design and subsequent construction phase.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-2.4.4-1 | Award Amount: 8.05M | Year: 2010

The Collaborative Project on Mendelian Forms of Parkinsons Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinsons disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years it has become increasingly clear that progress in the understanding of the molecular basis of PD, the second most common neurodegenerative disorder, and hence the chance to develop effective disease-modifying treatments, will most likely be brought about by focusing on the rare variants of the disease with known genetic defects. The groups forming the MEFOPA-consortium will therefore analyze the molecular pathways underlying inherited forms of PD with autosomal-dominant and autosomal-recessive inheritance in an integrative way, using cellular and animal models and cutting-edge technology. These two subprojects will provide targets for novel, disease-modifying treatment strategies. In a third subproject, a European registry and biobank for patients with rare Mendelian forms of PD will be established. Body fluids will be collected and systematically analyzed by unbiased proteomic techniques as well as by focussed analysis of candidate proteins, and ex vivo cellular models will be generated, in order to allow validation of disease-related alterations detected in the models analyzed in subprojects 1 and 2. Through this integrated, translational approach combining basic and clinical research groups, the project aims to achieve measurable progress in defining the relevant targets and readouts for disease-modifying therapies and will set the stage for rationally designed drug trials in carefully selected groups of patients and even presymptomatic mutation carriers.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.93M | Year: 2013

A DC grid based on multi-terminal voltage-source converter is a newly emerging technology, which is particularly suitable for the connection of offshore wind farms. Multi-terminal DC grids will be the key technology for the European offshore SuperGrid. In this proposal, DC power flow, DC relaying protection, steady state operation, dynamic stability, fault-ride through capability, and impacts of DC grids on the operation of AC grids and power market will be studied. Systematic comparison of DC grid topologies and stability control strategies will be carried out. DC grids for offshore wind power transmission and onshore AC grid interconnection will be investigated. Operation and control will be evaluated using various simulation platforms and experimental test rigs. The achievements from the project will greatly contribute to integrating offshore wind power into the onshore AC grids in European countries and for the European Super Grid. The MEDOW consortium involves 11 partners (5 universities and 6 industrial organisations). Each institution in the consortium contributes various expertise on the manufacturing, design, operation, and control of multi-terminal DC grids. Three visiting scientists of outstanding international stature will be appointed to further strengthen the training capacity and quality of MEDOW. This project will recruit 12 early-stage researchers (ESRs) and 5 experienced researchers (ERs). These researchers will receive interdisciplinary and intersectoral trainings in different countries to improve career opportunities. Research results will be disseminated through publications, intellectual properties, and direct application in the industries. MEDOW offers a development path to researchers across Europe in the area of DC grids, in addition to fostering greater ties between industry and academia in this key development area.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.13 | Award Amount: 16.30M | Year: 2011

DEEP proposes to develop a novel, Exascale-enabling supercomputing platform along with the optimisation of a set of grand-challenge codes simulating applications highly relevant for Europes science, industry and society. The DEEP System will realise a Cluster Booster Architecture that can cope with the limitations purported by Amdahls Law. It will serve as proof-of-concept for a next-generation 100 Petaflop/s PRACE production system, striving for independent provision of HPC technology, in particular general purpose Exascale performance supercomputers in Europe. The DEEP concept is based on the duality of an advanced multi-core Cluster system with InfiniBand interconnect complemented by a Booster of Intel many-core MIC processors connected through a Terabit EXTOLL network. A novel open source system software stack along with Cluster Booster adapted programming models, libraries, and performance tools will achieve high productivity and will enable unprecedented scalability on millions of cores. The DEEP hardware and software technology is developed in Europe while the new many-core processor is an essential component of international cooperation. The DEEP concept has the potential to improve the power efficiency of HPC systems by an order of magnitude. Its innovative cooling concept will allow approaching power usage effectiveness values very close to 1. Representative HPC codes from Health and Biology, Climatology, Seismic Imaging, Industrial Design, Space Weather, and Superconductivity will be optimised on DEEP and the extrapolation to millions of cores will be demonstrated. The pan-European DEEP consortium has proven competence to meet the projects massive technological and scientific challenges. DEEP aims at disseminating knowledge amongst major European industrial stakeholders and the entire PRACE consortium through its technical advisory group STRATOS and will contribute to the vision of the PROSPECT association for a European HPC technology platform.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.75M | Year: 2011

The FlowAirS proposal is collaborative training research network. It will be focused on the generation, propagation and reduction of sound in flow ducts for transport, buildings and power generation. There is a real need for a European-wide training in this field: the FlowAirS general objective is to train by research a new generation of young researchers with multi-disciplinary skills and able to make research careers more attractive and will enhance their own career opportunities. To achieve this goal, a partnership has been established between seven academic research centres of excellence, five industrial world leaders in their respective sectors, one innovative SME and four private research institutes or consulting engineering company: the collaboration between academia and private sector representatives is a key element of the FlowAirs training research programme. The work programme is divided in 8 Work Packages (WPs). The first 2 WPs deal with sound sources mechanisms. WP3 will be focused on innovative solutions for noise reduction. Three other WPs are concerned by the different numerical procedures and system identifications that are used in flow duct systems. One of the WP deals with the dissemination of the results to European citizens, researchers and industries. The last WP is on management and training. Training activities will be organized along three main axes: 1) training through research; 2)formal training giving all the important skills needed by researchers in the field of sound in flow duct systems and 3)training through practical experience on industrial sites. By participating to FlowAirS young researchers will gain a multi-disciplinary and appropriate background in generation, propagation andreduction of sound in flow ducts. The FlowAirS project will bring to European citizens innovative solutions to reduce the noise pollutionwhich is one of the key solutions for enhancing people quality of life and health in the European Union.


Patent
Imec, Atlas Neuroengineering Bvba, Vib and Catholic University of Leuven | Date: 2012-06-28

A kit of parts for electrical stimulation and/or recording of activity of excitable cells in a tissue is described. The kit of parts comprises on the one hand a probe guiding means comprising a plurality of accommodation channels, each channel being adapted for accommodating a probe device having a plurality of stimulation means and/or recording means located on a die. At least one of the plurality of accommodation channels has a curved shape. The kit of parts also comprises at least one probe device for electrical stimulation and/or recording of activity of excitable cells in a tissue, the probe device comprising a plurality of stimulation means and/or recording means located on a die having a thinned and etched surface for providing flexibility to the probe device.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2012.2.1.1-2 | Award Amount: 17.67M | Year: 2013

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing HF before the onset of symptoms and ii. subsets of patients who are more likely to respond to specifically targeted therapies (personalized medicine). In available cohorts, we will identify the most promising omics-based BM profiles for the pre-symptomatic diagnosis and future prediction of HF in patients at risk. The predictive value of the BMs for other co-morbidities commonly associated with HF and ageing will also be investigated. Furthermore, in a prospective trial, we will investigate the potential for targeting preventive therapy at patients with the greatest likelihood of response and the lowest risk of adverse effects. Our selection of innovative omics-based BMs is based on knowledge of biological pathways of the disease, which may facilitate identification of Biotargets for future therapies. On the economic side, HOMAGE will act as an economic catalyst for European SMEs in the field of cardiovascular and ageing BMs, estimated to peak annual turnovers of up to 800 M.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SPA.2012.2.1-01 | Award Amount: 3.22M | Year: 2013

Observations of oscillations on the solar and stellar surfaces have emerged as a unique and extremely powerful tool to gain information on, and understanding of, the processes in the Sun and stars, and the origin of the variability in the solar and stellar output. Through helio- and asteroseismology detailed inferences of the internal structure and rotation of the Sun, and extensive information on the properties of a broad range of stars can be obtained. Space-based observations play a leading role in helio- and asteroseismology, in close synergy with ground-based observations as well as theoretical modelling. Long observing sequences are essential for measuring the oscillation frequencies with the precision required, and to extract the lowest mode frequencies involved. The enormous value of long-term space-based observations has been demonstrated in the solar case by the joint ESA/NASA SOHO mission (Solar and Heliospheric Observatory. This is now being followed by instruments on the NASA Solar Dynamics Observatory (SDO) mission.Large volumes of exquisite data on stellar oscillations of stars with a broad range of masses and ages are being collected by the CNES space mission CoRoT (Convection, Rotation and Transit) and the NASA Kepler mission. Extensive Earth-based observations of solar oscillations have been undertaken with the GONG network (Global Oscillations Network Group) and the Birmingham Oscillation Network (BiSON) to ensure continuous monitoring. A asteroseismic network, SONG (Stellar Observations Network Group) is being established under Danish leadership. Equally important for asteroseismology is the availability of supplementary data on the stars from more traditional observations, to determine their surface temperature, composition, radius, etc. Only through a coordinated use of the space- and ground-based data can the full potential of helio- and asteroseismology be realized.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: ENV.2013.6.5-2 | Award Amount: 1.20M | Year: 2013

SEFIRA has the objective of creating a European coordination of transdisciplinary scientific and socio-economic resources in order to support the review and implementation of air quality legislation by the European Commission (EC) led by DG Environment. The EC has now given increased attention to the socio-economic dimension of air quality policies in order to improve their effectiveness and acceptability. SEFIRA will coordinate some of the best scientific and socio-economic resources and will review air quality policies and legislation at the interface between environmental, economic and social sciences in order to achieve a deeper understanding of these complex issues. Individual behaviours and choices will be analysed in a socio-economic context ranging from the local to the European level. The main fields involved in the action will be atmospheric sciences, environmental and legal sociology, anthropology, geography and economics. The integration of disciplines, the relationship with the most relevant stakeholders and an effective coordination between the SEFIRA consortium and other European projects in the same field will be a priority. The project strategy will support the development of a new European appraisal of problems and resources in the field, will deploy a pilot survey and a test of policy implementation by innovative models of individual choices analysis and ecosystem services valuation. Stakeholders will be involved from the beginning of the project in a process of dialogue and cooperative problem solving in order to ensure relevance and robustness as the work progresses from local to European level.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.81M | Year: 2012

Adaptive interactions with the environment depend on sophisticated brain plasticity mechanisms at multiple levels: from single neurons to large-scale brain networks. Traditionally, the study of plasticity has been fragmented into sensory, motor or decision-related circuits. However, translating brain plasticity findings to brain repair requires an understanding of the interactions between these circuits. Our aim is to integrate this study of learning and plasticity to promote wellbeing and advance healthcare interventions. We take a multidisciplinary approach, synthesising methods from physiology, cellular neurobiology, pharmacology, brain imaging, behavioural science and computational modelling to reveal plasticity at multiple scales (cellular, structural and functional). We will test how learning modifies sensory representations, perceptual decisions and motor outputs. Further, we will examine brain reorganisation and long-term plasticity in cases of congenital or acquired sensory and motor deficits. Our approach requires the coordinated efforts of international research leaders who work in top Universities and market-leading companies. This research training environment will deliver a cohort of young researchers experienced in transcending traditional disciplinary boundaries to deliver deeper insight into brain plasticity. Further, ABCs approach of cementing interactions between sectors into the training programme means that our ESRs will have the skills necessary to move between sectors and can maximise the translation of their findings for human health and wellbeing. The work has impact in assistive technology, education and rehabilitation and expert recognition systems. The involvement of private sector companies, and a pronounced focus on translational aspects within the networks activities (i.e. at all training events), will enhance European capacities for brain plasticity research and its applications.


Patent
AC Immune SA, Catholic University of Leuven and Genentech | Date: 2013-03-15

The present invention provides, methods end composites for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the Invention relates to humanized antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers to methods and compositions involving antibodies for the therapeutic and diagnostic use In the treatment of tauopathies including Alzheimers Disease (AD).


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-07-2016-2017 | Award Amount: 4.95M | Year: 2016

According to the Integrated Roadmap of the Set-plan, and to reach the new EU target of 27% of renewable energies in 2030, there is the need to rapidly expand the use of all renewable energy sources in Europe to accelerate the fight against global climate change. This requires the acceleration of development of new options that are emerging today, particularly, technologies that solve the key issue of energy storage. The next-CSP Project is a response to this need and addresses significant improvements in all three elements targeted by the LCE-07-2016 call related to concentrated solar power: heat transfer fluids, which can be used for direct thermal energy storage; the solar field; and high temperature receivers allowing for new cycles. The proposed fluidized particle-in-tube concept is a breakthrough innovation that opens the route to the development of a new generation of CSP plants allowing high efficiency new cycles (50% and more) and 20% improvement of CSP plant efficiency. The Next-CSP technology that cumulates the know-how acquired during the CSP2 FP7 EU project on the particle-in-tube technology can be rapidly cost-competitive and introduced in the market. A cost reduction by 38% is expected with respect to current CSP electricity cost. The project will demonstrate at industrial pilot scale (TRL5) the validity of the particle-in-tube concept atop the Themis facility solar tower. A 4-MWth tubular solar receiver able to heat particles up to 800C will be constructed and tested as well as the rest of the loop: a two-tank particle heat storage and a particle-to-pressurized air heat exchanger coupled to a 1.2 MWel gas turbine. A commercial scale power plant (150 MWel) will also be designed on the basis of experimental and simulation results and associated costs assessed. The consortium includes 6 companies that will lead the development of the first worldwide demonstration of this innovative technology and pave the way for future commercial exploitation.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.1.3-2 | Award Amount: 3.09M | Year: 2013

The INSPIRES project aims to contribute to resilient and inclusive labour markets in Europe. It comparatively assesses the resilience and inclusiveness of labour markets in European countries, it identifies innovative policies that have contributed to resilience and inclusiveness and it analyzes strategies of policy learning that facilitate the development and transfer of these innovations within and across European nation states. In order to do so, it analyzes in-depth the evolution of labour markets policies, employment policies and social policies. Moreover, it qualitatively and quantitatively assesses the labour market position of vulnerable groups from 2000 onwards. INSPIRES covers eleven countries from all European welfare traditions: Mediterranean, Eastern-European, Anglo-Saxon, Scandinavian and the continental regimes. The consortium consists of a multidisciplinary team of leading European scholars that focus on the labour market, employment issues and social policies. The INSPIRES project aims to accumulate practice-oriented knowledge on the factors that positively and negatively affect resilience and inclusiveness. It seeks to explain differences within and between countries, and within and between the labour market positions of different vulnerable groups on the labour market. INSPIRES intends to isolate the impact of national policies from the structural demographic, social and economic characteristics on labour market resilience. Building upon this analysis, it tries to identify processes of policy learning and innovation that occur in the interactions between policy makers, politicians, non-profit organizations, trade unions, business associations and other stakeholders at the European, national and regional level. The outcomes of INSPIRES contribute to facilitating policy learning and innovation processes across territorial and sectoral boundaries and to the creation of inclusive and resilient labour markets in European countries.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2011.3.1 | Award Amount: 357.31K | Year: 2013

This proposal is submitted to support and ensure continuation of the EURO-DOTS initiative, that was launched as a Support Action in response to the FP7-Call 5 and that has successfully realized all the objectives resulting in the installation of a virtual platform to serve the Doctoral Schools in Europe in micro/nano-electronics. When the present 2-year EURO-DOTS project ends on 30 April 2012, it will not only have a fully operational platform and system in place, but it will also have realized the build-up of a course portfolio of nearly 50 PhD course titles, offered and organized by universities all over Europe. The major objective of EURO-DOTS was to improve the offering and quality of training provided to European PhD students in the micro/nano-electronics area based on the comprehensive analysis of university offering and industrial needs. One week intensive courses help them fulfilling the requirements for ECTS credits imposed by European universities for obtaining the PhD degree in Engineering. Essential in this endeavor are the scholarships that PhD students can apply for. This boosts the mobility of students but most importantly, it allows them to attend the right course at the right place, where the expertise on the treated subject is guaranteed.The major objective of this EURO-DOTS-2 follow-up project with a 2 year duration, is to ensure the continuation and continuity of the present successful action. This implies maintaining and improving operation of the platform, managing course portfolio and planning, stimulating development and submission of new courses in response to the needs of industry and researchers, managing and attributing of scholarships for PhD students and promotion of platform service and course offering. The present partnership, installed committees and organization will be basically retained. This continuity can be realized with a limited but indispensable budget of which half will be used for the scholarships.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.9.1 | Award Amount: 2.00M | Year: 2013

The project is aimed at developing a new ICT paradigm, which considers multiple heterogeneous devices that cooperate in multiple signal processing tasks. This is radically different from current ICT paradigms, in which stand-alone devices merely focus on individual tasks or multiple devices perform one joint task, e.g., in a wireless sensor network (WSN). Examples of the heterogeneous devices considered are tablets, smartphones, handheld cameras, active headsets and hearing aids. Each device is equipped with one or several sensors, e.g., microphones and cameras, as well as with computing and wireless communication facilities, and has its own signal processing task, e.g., a local signal enhancement task. The aim is to achieve superior performance in these tasks through cooperation amongst the devices, which then effectively act as nodes in a WSN type set-up, where each node contributes to the other nodes tasks.The main objective is to develop distributed, cooperative and adaptive signal processing algorithms for the acquisition, coding, processing, and in-network fusion of multimedia signals, in particular for the enhancement of audio and video signals. The algorithms are operated in a heterogeneous, ad-hoc and dynamic network, where each node has its own signal processing task as well as its own specific mode of operation. Furthermore, the algorithms should be scalable and require minimal communication bandwidth and power. As the network nodes may be selfish or opportunistic, general operating principles will be designed that provide incentives for cooperation. A general bottom-up design strategy will be adopted, rather than the usual top-down approach used in WSNs.The project will yield new theoretical frameworks for distributed detection, classification, estimation, coding, topology inference and cooperation strategies. In addition, two use cases are proposed in the context of audio and video enhancement, which will eventually serve as a proof of concept.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.4.2-2 | Award Amount: 8.11M | Year: 2011

EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existing diagnostic and predictive algorithms. For this purpose a large number of cohorts from different European regions, both patient and population cohorts, that have been accurately assessed for cardiovascular phenotypes are readily available to the consortium. Access to clinical samples and to standardised cardiovascular phenotypes will be granted by a strong clinical platform as one of the key work packages of EU-MASCARA. Both cross-sectional and prospective analyses will be performed that will result in the development of improved risk prediction scores. The consortium is heavily supported by contributions of SMEs in key areas of the proposed research: biomarker testing, data handling and analysis, assay development and project management. EU-MASCARA is further characterised by a strong integrative approach both within and across work packages, with results from one task informing strategies of research in other tasks. With a dedicated bioinformatics and health economic platform the most robust biomarkers will be selected and analysed for their benefit in clinical practice. EU-MASCARA will rigorously validate biomarkers that have been proposed to be associated with cardiovascular disease and risk across different disease entities and also in independent general population samples. The most robust biomarkers will be implemented in novel biochip based assays for clinical use.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2012-IAPP | Award Amount: 2.66M | Year: 2013

Infertility is a serious medical concern preventing the parenthood in 10% of couples. Infertility treatment using assisted reproduction techniques (ART) is popular in Europe with up to 5% of children born thanks to medical help. Despite many technological improvements the overall pregnancy rate after infertility treatment using the most commonly practiced in vitro fertilization (IVF) remains only 30% per single cycle. The specific features of human reproduction include the high prevalence of diverse chromosomal pathologies in oocytes and early embryos, and significant dysregulation in gene expression in embryo and endometrial tissue, both being the risk factors for implantation failure and decreased pregnancy rate after IVF. Hence, the intrinsic motivation for the current SARM project stems from the perceived need to contribute to future IVF improvements and benefit from the recent breakthroughs in technological innovations. Our primary research objective is to unravel the molecular nature of human preimplantation embryo development and endometrial maturation. This ambitious goal will be achieved by exploiting highly sophisticated single-cell genomics tools, such as fine-resolution mapping of DNA copy-number changes by using SNP-arrays and sequencing platforms, and characterizing single-cell transcriptional landscape by RNA-sequencing. These studies are likely to propose novel embryonal and endometrial biomarkers useful for selecting the most competent embryos for transfer or identifying the causes of female infertility of endometrial origin. The SARM consortium consists of 2 industrial (IVIOMICS, Paterna/Spain and Competence Centre on Reproductive Medicine, Tartu/Estonia) and 3 academic (Karolinska Institute, Stockholm/Sweden; Katholieke Universiteit Leuven, Belgium and University of Tartu/Estonia) partners, forming a strong, stimulating and coherent research environment ensuring the pooling of complementary scientific skills in reproductive genetics and medicine.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.4 | Award Amount: 4.67M | Year: 2012

The overall purpose of MUSES is to foster corporate security by reducing the risks introduced by user behaviour.Data security and privacy are of fundamental importance to organizations, where they are defined and managed via Security Policies. Most security incidents are caused by organization insiders, either by their lack of knowledge or inadequate or malicious behaviour.Nowadays, information is highly distributed amongst corporate servers, the cloud and multiple per-sonal devices like PDAs, tablets and smart phones. These are not only information holders but also user interfaces to access corporate information. Besides, the Bring Your Own Device practice is becoming more common in large organisations, posing new security threats and blurring the limits between corporate and personal use.In this situation enforcement of Security Policies is increasingly difficult, as any strategy with a chance to succeed must take into account several changing factors: information delocalisation, access from heterogeneous devices and mixing of personal and professional activities. Besides, any mechanism or control must be user friendly and provide non-intrusive, clear feedback on the risk being incurred at any time.MUSES will provide a device independent, user-centric and self-adaptive corporate security system, able to cope with the concept of seamless working experience on different devices, in which a user may start a session on a device and location and follow up the process on different devices and locations, without corporate digital asset loss.During project development, metrics of usability, context risk evaluation, user current trust situation and device exposure level will be defined and several guidelines for design of secure applications, company policies and context-based security requirements will be produced. A real-time trust and risk analysis engine will also be developed with security mechanisms hard to compromise once installed on the target platforms


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.4 | Award Amount: 4.51M | Year: 2010

There is enormous economic potential for the application of embedded optimization technologies in embedded systems design. Recent advances in the performance of embedded hardware platforms, in combination with fundamental improvements in optimization theory and algorithms, have opened the door to widespread applications over the next decade. Embedded optimization will enable huge energy and resource savings, increased safety, and improved fault detection across a wide a range of industrial applications in the mechatronic, automotive, process control and aerospace sectors. In order to realize the full potential of optimization in embedded systems, their design must also be supported by a focussed set of tools enabling the rapid transfer of novel high-performance algorithms to practical applications.\n\nThe EMBOCON consortium will enable widespread application of real-time optimization in embedded systems through:\n\n: Tailoring of customized numerical algorithms to increase their robustness and efficiency on embedded systems\n: Enabling real-time optimization on cheap industry-standard hardware platforms\n: Defining a common user interface for optimization technologies to facilitate technology transfer to industry, and\n: Performing challenging case studies in cooperation with industrial partners to demonstrate technological maturity.\n\nThe EMBOCON consortium will strengthen a network of world-leading academic and industrial partners with complementary expertise in control, optimization and embedded systems in a range of industrial applications. Particular emphasis is placed on close collaboration between mathematical algorithm developers, control theorists, hardware specialists and industrial application engineers. The network will consolidate and extend Europes position as the world research leader in these areas and foster strong collaborative links between European academia and industry.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.81M | Year: 2013

The BATWOMAN ITN aims at structuring research training in basic and advanced acoustics and setting up a work program on methodologies for acoustics for skills development in a highly diverse research field offering multiple career options. The consortium consists of renowned public and private partners from musical acoustics, room acoustics and automotive acoustics who will merge their existing knowledge, extend it jointly and complement it with insights of recent sound perception research. This will exploit existing synergies and overcome obvious fragmentation in research, methodology and basic as well as advanced acoustics training. Providing interdisciplinary training and joining or exchanging methodology in research, is expected to have a strong impact on the skills of trained researchers as far as sound design capabilities, modelling accuracy, efficiency and applicable frequency range is concerned. Adding the understanding of human auditory perception will help to tackle the hard problem of sound quality parameters and to better understand stimulating effects on well-being and cognition of people exposed to sound, but also harmful effects, like annoyance or even deteriorating cognitive performance. The ITN will provide interdisciplinary and intersectoral research training for excellence. It will structure existing PhD-level training in acoustics setting up European curricula with compatible and recognised courses offered by Universities and private enterprises. Simultaneously it will push the state of the art in vibro-acoustic modelling and in interdisciplinary design optimisation by initiating a joint research effort increasing critical mass. The complementary structure of the network will make it not to break apart after the ITN project period. It is rather expected that the methodologies used to analyse, design and optimise transport vehicles, rooms and musical instruments will grow together and will be further developed in an interdisciplinary joint effort.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-06-2016 | Award Amount: 4.11M | Year: 2017

Rabies is the deadliest disease on earth (99.9% fatality rate). Annually, ~58.000 people die from rabies, more than half of them are children. Many remain unvaccinated because of the high costs and the need for a cold-chain. Likewise, despite the existence of an excellent yellow fever (YF) vaccine, yearly ~30.000 people die of YF. The 80-year old low-tech production process does not allow to produce sufficient doses. There is now a real danger that major YF-outbreaks become uncontrollable. We aim at developing an efficient, safe, cheap, thermostable and easy-to-produce vaccine that can be needle-free administered, that protects against both rabies and YF, and that can be implemented in routine prophylactic paediatric vaccination. For this, we will employ our (P01a) proprietary infectious DNA (iDNA) vaccine technology. Simple, even needle-free injection of a low dose (1-10g) of this easy-to-produce naked plasmid in mice and hamsters launches the YF vaccine virus and protects hamsters as efficiently as the commercial vaccine against lethal YF challenge. The iDNA YF vaccine will be used as vector to express relevant protective rabies antigens. Dual protection of such chimeric iDNA rabies/YF vaccine will be demonstrated against lethal rabies and YFV challenge in small animal models. Likewise, chimeric rabies/Japanese encephalitis and rabies/Zika virus iDNA vaccine candidates will be generated using this versatile platform. Next, induction of protective immunity will be demonstrated in rhesus macaques. The iDNA vaccines combine the benefits of both the YF live-attenuated vaccine (highly efficient life-long induction of immunity) and the thermo-stability, ease-of-production and the potential to customize (in response to emerging medical needs) of classical DNA vaccines. A path towards advanced pre-clinical and clinical development of such novel vaccines will be developed in compliance with European regulatory and WHO prequalification requirements.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 2.83M | Year: 2015

Pure accelerated radioisotope beams have been used for 50 years in fundamental physics R&D, e.g. for nuclear structure studies (pear shaped exotic nuclei, Nature 2013); CERN-ISOLDE plays a central role in developing accelerator technologies and fostering collaborative approaches to advance this field of isotope mass separation online. Our most recent contribution was the use of nanomaterial targets for more intense and reliable beam production, and laser ion sources for their purification (discovery of yet unknown 233Francium). Radioisotopes are widely used for functional imaging in medicine, based on 99mTechnetium or on 18Fluorine. This field is expected to rapidly expand, when coupling imaging with new cancer treatments, with isotopes emitting different type of radioactivity, e.g. alpha particles. This is shown with the recently introduced 223Radium chloride (Xofigo) used as a treatment drug in advanced bone cancers. However, either shortage in the supply of 99mTechnetium or lack of access to new radioisotope with adequate properties is a severe treat to develop personalized treatment that combine functional imaging and therapy. Ovarian cancers have poor prognosis, are the second most frequent cancer for women and one of the deadliest. They are difficult to treat, because of possible presence of metastasis, and because this region is difficult to irradiate without collateral damages. MEDICIS-PROMED will train a new generation of scientists to develop systems for personalized Medicine combining functional imaging and treatments based on radioactive ion beam mass-separation. This will be done across a coherent intersectorial multidisciplinary network with world-leading scientists in their field. Subsystems for the development of new radiopharmaceuticals, of isotope mass separators at medical cyclotrons, and of mass separated 11Carbon for PET-aided hadron therapy will be specifically developed to treat the ovarian cancer.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: FoF.NMP.2013-7 | Award Amount: 11.42M | Year: 2013

Factory-in-a-Day aims at improving the competitiveness of European manufacturing SMEs by removing the primary obstacle for robot automation; installation time and installation cost. The high costs result in payback periods, making the investment in robotized automation economically unattractive. Factory-in-a-Day will reduce the installation time (and the related cost) from months to one single day. The project follows the steps of such an installation day. (1) New standardized arms, mobile platforms, and hands are combined with 3D printed custom parts to be designed in a matter of hours from novel design templates. (2) Robots are placed in an unaltered production location, where new self-calibration routines and a novel software framework allow effortless interconnection of robot components and existing machinery. (3) For selected application domains (e.g. mould finishing and assembly) a set of novel learnable skills (cf. Apps) allow rapid teaching of the production tasks. (4) The robots collaborate safely with humans in a shared un-fenced workspace due to safe robot arms with dynamic obstacle avoidance, made possible by novel proximity-sensing skin and online path re-planning algorithms. Augmented reality lets the robots project their intended motion plans to inform the workers. (5) Finally, Factory-in-a-Day also innovates the organizational aspects of robot installation. The project is driven by Europes top robotics researchers (e.g. TUD, KUL, TUM, Fraunhofer) and industry players (Philips, Universal Robotics, Siemens, Materialise). The second-largest temp agency Randstad and its participating client SMEs will test hybrid human-robot teams performing short-batch production work. Together with novel certification procedures proposed in Factory-in-a-Day and strong , Europe-wide dissemination targeted at manufacturing industry, the technological and organizational innovations are poised to radically change the robot automation sector.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.2.1-2 | Award Amount: 15.03M | Year: 2010

The aim of EU-GEI is to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order to identify these interactive determinants, EU-GEI will employ family-based, multidisciplinary research paradigms, which allow for the efficient assessment of gene-environment interactions. In order to go beyond old findings from historical convenience cohorts with crude measures of environmental factors and clinical outcomes, the focus in EU-GEI will be on recruitment of new, family-based clinical samples with state-of-the-art assessments of environmental, clinical and genetic determinants as well as their underlying neural and behavioural mechanisms. New statistical tools will be developed to combine the latest multilevel epidemiological with the latest genome-wide genetic approaches to analysis. Translation of results to clinical practice will be facilitated by additional experimental research and risk assessment bioinformatics approaches. This will result in the identification of modifiable biological and cognitive mechanisms underlying gene-environment interactions and the construction of Risk Assessment Charts and Momentary Assessment Technology tools which can be used for (i) early prediction of transition to psychotic disorder in help-seeking individuals with an at-risk mental state and (ii) early prediction of course and outcome after illness onset. In order to reach these goals, EU-GEI has assembled a multidisciplinary team of top schizophrenia researchers who have the range of skills required to deliver a program of research that meets all the calls requirements and who have access to / will collect a number of unique European samples. The partners in EU-GEI represent the nationally funded schizophrenia / mental health networks of the UK, Netherlands, France, Spain, Turkey and Germany as well as other partners.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INSO-4-2015 | Award Amount: 2.85M | Year: 2016

Science2Society creates, pilots and shares good practices, guidelines and training materials that improve awareness and practical performance in seven concrete university-industry-society interfacing schemes especially affected by Science 2.0 and open innovation. It covers a very wide range of interfacing / co-creation approaches (and the synergy between them) and advances far beyond the traditional role of the interface as a facilitator of knowledge transfer from university to business. Sound methodological frameworks will be combined with real life experience from practitioners in science and industry, making the transition from promising blueprints to actual change within some 3000 actors in Europe by 2020. Science2Society does not only collect knowledge and models; it deeply and innovatively analyses how these can be improved (using advanced methods pioneered in business practice such as process re-engineering, design thinking and change management) and runs substantial experiments to validate the created optimized interfacing schemes. A complete package of dissemination activities will ensure that these results measurably impact the performance of European universities (and other stakeholders) in this area. Our project brings together both practitioners as well as method and system experts; it brings together universities, industries, research & technology organizations and SMEs. The project is endorsed by large (EU-level) networks of peers and ecosystem partners, allowing the project to actually engage in direct dialogue during project execution with hundreds of actors far beyond the consortium itself. Moreover, by building and establishing a Community of Practice type Learning and Implementation Alliance, we will ensure that a self-sustained cross-sector community on the subject of Science 2.0-enabled innovation ecosystems (and the key role of universities interfacing with their ecosystem partners) will be in place and operational by the end of our project.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SEC-2013.2.5-3 | Award Amount: 13.20M | Year: 2014

The protection of critical infrastructures increasingly demands solutions which support incident detection and management at the levels of individual CI, across CIs which are depending on each other, and across borders. An approach is required which really integrates functionalities across all these levels. Cooperation of privately operated CIs and public bodies (governments and EU) is difficult but mandatory. After about 10 years of analysis and research on partial effects in CIP and for individual infrastructure sectors, ECOSSIAN is supposed to be the first attempt to develop this holistic system in the sense portrayed above. A prototype system will be developed which facilitates preventive functions like threat monitoring, early indicator and real threat detection, alerting, support of threat mitigation and disaster management. In the technical architecture with an operations centre and the interfaces to legacy systems (e.g., SCADA), advanced technologies need to be integrated, including fast data aggregation and fusion, visualization of the situation, planning and decision support, and flexible networks for information sharing and coordination support, and the connection of local operations centres. This system will only be successful, if the technical solutions will be complemented by an effective and agreed organizational concept and the implementation of novel rules and regulations. And finally, the large spectrum of economically intangible factors will have significant influence on the quality and acceptance of the system. These factors of societal perception and appreciation, the existing and required legal framework, questions of information security and implications on privacy will be analyzed, assessed and regarded in the concept. The system will be tested, demonstrated and evaluated in realistic use cases. They will be developed with the community of stakeholders and cover the sectors energy, transportation and finance, and the ubiquitous sector of ICT.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.4. | Award Amount: 12.42M | Year: 2013

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to: Develop a series of mutant alleles for every gene in the mouse genome Determine the phenotypic consequences of each mutation Identify mouse models for the complete disease spectrum in humans To further develop and exploit the emerging mouse mutant resource, mouse models must be preserved and made available to the European biomedical research community. To this effect, the Infrafrontier-I3 project brings together the leading European centers for systemic phenotyping of mouse mutants and the European Mouse Mutant Archive network. The Infafrontier-I3 partners aim to meet the future challenges presented by phenotyping, archiving and disseminating mouse models in the ERA as follows: Contribute to resource development by archiving of 1215 new mouse mutant lines Provide free of charge Transnational Access to mouse production and 1st line phenotyping capacities Offer a specialized axenic service to produce, maintain and to distribute germ-free mice Provide user friendly accession of Infrafrontier services, extensive manual data curation and cross referencing with other mouse database Improve user services by developing novel phenotyping and cryopreservation SOPs and by refining innovative research instrumentation Engage with the user community using a wide range of PR activities, a dedicated user meeting and an industry liaison workshop Offer state of the art cryopreservation and phenotyping training courses Benchmark Infrafrontier services with other major repositories The comprehensive physical and data resources that will be generated by Infrafrontier-I3 will contribute to link basic biomedical research to medical applications and thereby drive innovation and support the Europe 2020 Strategy.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SEC-2011.3.4-1 | Award Amount: 18.18M | Year: 2012

Significant efforts have been invested to strengthen border ID checks with biometrics Travel Documents embedding electronic chips (ePassport). However, problems appeared regarding fraud in the ePassport issuing process, citizen losing control on their personal data, difficulties in certificates management, and shortcomings in convenience, speed, and efficiency of ID checks, including the access to various remote data bases. FIDELITY is a multi-disciplinary initiative which will analyse shortcomings and vulnerabilities in the whole ePassports life cycle and develop technical solutions and recommendations to overcome them. FIDELITY will demonstrate privacy enhanced solutions to: -Secure issuing processes: authentication of documents, preventing impersonation fraud -Improve ePassport security and usability: authentication processes, ID check speed, accuracy of biometrics, management of certificates, access to remote data bases, convenience of biometric sensors and inspection devices -Better manage lost and stolen passports -Strengthen privacy: privacy-by-design applied to all phases of the ePassport life cycle, systematic anomysation of data and separation of data streams, using novel privacy-enhancing-technologies FIDELITY will strengthen trust and confidence of stakeholders and citizens in ePassports, provide more reliable ID checks, hence hinder criminal movements, and ease implementation of E/E records providing better analysis of migration flows. FIDELITY solutions will be designed for backwards compatibility to be deployed progressively in the existing infrastructure. The FIDELITY consortium is composed of market-leading companies, innovative SME, renowned academia, ethical-sociological-legal experts, and end-users, which will help to define requirements and recommendations and assess results. They will, with the other partners actively promote the project results towards stakeholders and international working groups that elaborate future ePassport standards.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2013-IAPP | Award Amount: 2.73M | Year: 2014

ISSFLOW aims at developing fundamental understanding of complex fluids to allow for the design of smart and functional gels and fluids via the development of novel rheology modifiers. A consortium of 5 partners (1 large industry, 1 SME and 3 academics) has been set up to exchange knowledge in the areas of rheology, sustainable synthesis and scale-up of novel molecules, modeling, characterization of complex fluids (including high viscous fluids and gels) via scattering, NMR and microscopy techniques, and production of finished products in a broad number of applications ranging from detergents and pharmaceuticals to restoration of paintings and lubricants. The overall generated knowledge will be integrated in an overarching model that will be able to predict the best rheology modifier for a specific application, taking into account final rheology properties required, performance, process and aesthetics, facilitating the launch of improved or new products to the market.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2012.2.1.1 | Award Amount: 4.21M | Year: 2012

For a continued decrease of levelised costs of energy from photovoltaics (PV), the prices of PV system components have to be further decreased while performance, functionality, reliability and lifetime on the component and system level need to be increased. In an integrated view, PV system performance emerges from, but is not limited to the performance of the components. The Performance Plus project focuses on the PV system rather than on the component level. The main idea of the project is to optimise the system as a whole rather than the separate components. The aim is to develop a collection of tools for modelling, monitoring and control of PV systems. All R&D results and models will be validated with empirical data. The realisations will be demonstrated. In order to ensure economic impact, possible pathways for exploitation will be explored jointly by the partners during the project execution. The tools will serve to optimize and enhance the performance, reliability and lifetime of commercial PV systems beyond the state of the art. Means for a better integration of PV-generated electricity into the power system shall be provided by methods for short-term forecasting, integrated energy management and storage control, PV system monitoring and control. Specific objectives are: - Robust system design modelling for diligent design and bankability - Robust operational modelling for optimising the system output - Integrated energy management and storage control - Real time monitoring and control: sensors communication and feedback - Hardware and software tools for testing - Validation, demonstration and target control Performance Plus will bring scientific knowledge far beyond the state of the art for each of the objectives listed. The project is scheduled for 36 months.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2010-4.0-1 | Award Amount: 13.81M | Year: 2011

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or therapeutic application as defined by their active agent compositions. For diagnostics, superior tracers will be developed for molecular MR/PET and gamma camera imaging, enabling efficient diagnosis and guided surgery respectively. Novel functionalized nano-core systems will be conjugated with semi-confluent active shell layer. Three types of shell layers will be design: (1) novel iron oxide nanoparticles as advanced MRI contrast agents and/or (2) DOTA complexes for MRI (with Gd3\), or PET (with Ga-68), or gamma camera (with Ga-69); (3) Integrating within one tracer both iron oxide nanoparticles and DOTA-Ga-68 complexes for a sequential or simultaneous MR/PET imaging. For therapeutics, active nanosystems will be developed to deliver (1) therapeutic siRNAs or (2) anti-MP-inhibitory-scFVs. These non-classic anti-tumor drugs will be designed based on an extensive tumor degradome analysis for combining blockage of selective matrix MPs, thus preventing basic invasive and metastasis steps, with siRNA based neutralization of secondary molecular effects induced by the specific protease inhibition. Individualized degradome analysis will be developed for potential profiling of anti-MP and siRNAs based therapy per patient. To facilitate the above diagnostics and therapeutic effects, advanced tumor targeting and penetration active agents will be linked to nano-core functionalized groups, including a biocompatible PEG layer linked to tumor selective MMP substrate molecules and highly safe and potent novel somatostatin analogue peptides targeting SSTR overexpression.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-02b-2015 | Award Amount: 7.63M | Year: 2016

European crop production is to remain competitive while reducing environmental impacts, requiring development and uptake of effective soil improving cropping systems. The overall aim of SOILCARE is to identify and evaluate promising soil-improving cropping systems and agronomic techniques increasing profitability and sustainability across scales in Europe. A trans-disciplinary approach will be used to evaluate benefits and drawbacks of a new generation of soil improving cropping systems, incorporating all relevant bio-physical, socio-economic and political aspects. Existing information from literature and long term experiments will be analysed to develop a comprehensive methodology for assessing performance of cropping systems at multiple levels. A multi-actor approach will be used to select promising soil-improving cropping systems for scientific evaluation in 16 study sites across Europe covering different pedo-climatic and socio-economic conditions. Implemented cropping systems will be monitored with stakeholder involvement, and will be assessed jointly with scientists. Specific attention will be paid to adoption of soil-improving cropping systems and agronomic techniques within and beyond the study sites. Results from study sites will be up-scaled to the European level to draw general lessons about applicability potentials of soil-improving cropping systems and related profitability and sustainability impacts, including assessing barriers for adoption at that scale. An interactive tool will be developed for end-users to identify and prioritize suitable soil-improving cropping systems anywhere in Europe. Current policies and incentives will be assessed and targeted policy recommendations will be provided. SOILCARE will take an active dissemination approach to achieve impact from local to European level, addressing multiple audiences, to enhance crop production in Europe to remain competitive and sustainable through dedicated soil care.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.53M | Year: 2013

In view of reducing the ecological footprint of machines and vehicles, effective and efficient analysis techniques and adequate measurement technologies are required to produce world-leading products with a high energy-efficiency, without compromising functionality/safety/performance/etc. Combined with the increasing trend towards virtual design and prototyping, to reduce costs and development times, this need for designing green products creates an urgent industrial need for robust and volatile simulation and experimental validation methodologies in machine and vehicle product design. Since nowadays products become more and more multi-disciplinary by the constantly increasing integration of added functionality and product intelligence (i.e. mechanical systems work together with electronic systems, linked through control schemes which are steered using embedded software, etc.) and since energy is a global design attribute which is influenced by all disciplines, the development of energy analysis methodologies, both numerical and experimental, requires an integrated research strategy. This EMVeM ITN brings together research and industrial partners who will collectively train early stage researchers, drawing together skills and expertise in a range of different technical approaches. The industrial partners put forward specific applications, behind which are generic difficulties associated with energy efficiency analysis. The academic and research centre partners bring a diverse range of potential research approaches and the capability of research training, provision of courses and dissemination and outreach to the wider community. Together the consortium can develop and promote research, knowledge and application of energy efficiency management analysis within EU industry and towards the general public.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.3.1 | Award Amount: 5.04M | Year: 2013

Designs in nanoelectronics often lead to problems that are large to simulate and that include strong feedback couplings. Industry demands to include variability to guarantee quality and yield. It also requests to incorporate higher abstraction levels to allow for system simulation in order to shorten design cycles, while preserving accuracy. The nanoCOPS project considers the simulation of two problem classes identified by industry:- Power-MOS devices, with applications in energy harvesting, and which involve couplings between electromagnetics (EM), heat, and stress, and- RF-circuitry in wireless communication, which involves EM-circuits-heat coupling and multirate behaviour, together with analogue-digital signals.Due to the market demands, the scientific challenges are to- create efficient and robust simulation techniques for strongly coupled systems, that exploit the different dynamics of sub-systems and that can deal with signals that differ strongly in the frequency range;- include variability such that robust design, worst case analysis, and yield estimation with tiny failures are possible (including large deviations like 6-sigma);- reduce complexity such that one can still vary parameters and such that the reduced models offer higher abstraction models that are efficient to simulate.Our solutions are- advanced co-simulation/multirate/monolithic techniques, combined with envelope/wavelet approaches;- new generalized techniques from Uncertainty Quantification (UQ) for coupled problems, tuned to the statistical demands from manufacturability;- enhanced, parameterized Model Order Reduction techniques for coupled problems and for UQ.All algorithms will be validated in the industrial design tools provided by our industrial partners.Our consortium covers extensive R&D experience in nanoelectronic IC simulation and complementary expertise. It includes seven universities, one research institute, two large-scale semiconductor companies, and two SMEs.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-2.4.3-1 | Award Amount: 3.86M | Year: 2010

Europe is facing a rapidly growing threat from Type 2 diabetes mellitus (T2D), which is undoubtedly associated with an unhealthy diet and a more sedentary lifestyle. Evidence is accumulating that gestational diabetes mellitus (GDM) may be playing a role in this process. Thus it provides a significant opportunity for preventing future T2D. Not only is GDM prevalence on the rise, but intrauterine exposure to hyperglycaemia predisposes the offspring to diabetes and obesity. Another putative contributing factor is a low vitamin D status, which is also increasing in prevalence and may have causal links with both obesity and decreased glucose tolerance. The main aims of this project are: 1) to establish the current status of the prevalence of GDM in Europe and facilitate the adoption of a single diagnostic approach and 2) to deliver the best strategy that prevents GDM. The latter was deemed as not fully feasible within the scope of this call and our decision was to test the most relevant approaches (diet, exercise, vitamin D, alone or in combination) against surrogate variables of GDM (fasting blood glucose, insulin sensitivity, pregnancy weight gain) to come up with the best intervention for entry into a definitive GDM prevention trial. Deliverables include the sample size and modus operandi for such a trial. Value will be added to the project by 1) Assessing variables modifying the uptake of preventive interventions, 2) Exploring health costs of GDM and potential savings of preventive approaches, 3) Improving pathophysiological understanding by assessing intervention effect on several parameters in mother and foetus and 4) Facilitating future research through a well defined cohort of mother-offspring pairs and comprehensive biobanking.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.2 | Award Amount: 1.32M | Year: 2012

Physically Unclonable Functions (PUFs) are used to uniquely identify electronic components and to protect valuable objects against counterfeiting. They allow creating a root of trust in a hardware system through generating device-unique fingerprints and deriving secret keys from the underlying physical properties of the silicon. Today they are typically found in specially designed hardware components and result from the silicon properties of individual transistors. They exist in many forms, among which are the so-called SRAM PUFs.\n\nThis project intends to study and show the existence of SRAM PUFs and other types of PUFs in standard PCs, laptops, mobile phones and consumer electronics. This has not been attempted so far. The mere existence of physical properties that depend on a component and are reproducible is only the first step to guarantee appropriate robustness, reliability and randomness properties for use as secret keys or trust anchors in mass-market applications. By uncovering the security properties of PUFs in standard components such as graphical processing units, central processing units and PCI connectors, this project will provide the first intrinsic and long-wanted basis for security in everyones most common computing platforms: standard PCs and similar hardware. This new root of trust in turn adds security for mass-market applications, replacing or complementing the role of a trusted platform module and enabling security for applications such as broadcast applications, content protection for the gaming industry and secure day-to-day transactions for everyone. The results of the project will allow for the first time an a priori open platform, the most difficult element to secure in an information-technology system today, to inherit security properties from its own identity and its intrinsic physical properties.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.4.1 | Award Amount: 8.35M | Year: 2011

The goal of AXES is to develop tools that provide various types of users with new engaging ways to interact with audiovisual libraries, helping them discover, browse, navigate, search and enrich archives. In particular, apart from a search-oriented scheme, we will explore how suggestions for audiovisual content exploration can be generated via a myriad of information trails crossing the archive. This will be approached from three perspectives (or axes): users, content, and technology.Within AXES innovative indexing techniques are developed in close cooperation with a number of user communities through tailored use cases and validation stages. Rather than just starting new investments in technical solutions, the co-development is proposed of innovative paradigms of use and novel navigation and search facilities. We will target media professionals, educators, students, amateur researchers, and home users.Based on an existing Open Source service platform for digital libraries, novel navigation and search functionalities will be offered via interfaces tuned to user profiles and workflow. To this end, AXES will develop tools for content analysis deploying weakly supervised classification methods.Information in scripts, audio tracks, wikis or blogs will be used for the cross-modal detection of people, places, events, etc., and for link generation between audiovisual content. Users will be engaged in the annotation process: with the support of selection and feedback tools, they will enable the gradual improvement of tagging performance.AXES technology will open up audiovisual digital libraries, increasing their cultural value and their exposure to the European public and academia at large.The consortium is a perfect match to the multi-disciplinary nature of the project, with professional content owners, academic and industrial experts in audiovisual analysis, retrieval, and user studies, and partners experienced in system integration and project management.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.86M | Year: 2016

Infectious diseases are a major burden to public health and the global economy, not in the least due to antimicrobial resistance. Rapid point of care (POC) in vitro diagnostics (IVD) are key tools in the effective clinical management of patients with infectious diseases. Yet there is still a large unmet clinical need for more rapid POC IVDs generating more clinically relevant, actionable information. Effectively addressing this need requires a change in the current approach in training researchers on IVDs, generating a new breed of IVD researchers capable of closing the gap between the clinical and technological perspective. ND4ID takes up this challenge by offering 15 ESRs a world-class first of its kind training programme where they will be exposed to the full breadth of disciplines spanning clinical, technological and market-oriented viewpoints, from both the academic and non-academic sector. Through a set of synergistic research projects on novel POC assays, targeting the most important and urgent clinical needs at world leading academic or private sector research groups, the ESRs are offered a holistic training program, preparing them to be lead players in the future IVD field. This training through research is augmented by a unique comprehensive network-wide training programme covering clinical, technical and translational knowledge and skills of relevance to IVD research, development and exploitation. As such, ND4ID will deliver ESRs that will be in high demand serving as an example for other academic and non-academic actors active in training IVD researchers and further strengthening Europes position in the internally competitive arena of IVD technology.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 11.27M | Year: 2013

The goal of SHERPA is to develop a mixed ground and aerial robotic platform to support search and rescue activities in a real-world hostile environment like the alpine scenario. The technological platform and the alpine rescuing scenario are the occasion to address a number of research topics about cognition and control pertinent to the call.\nWhat makes the project potentially very rich from a scientific viewpoint is the heterogeneity and the capabilities to be owned by the different actors of the SHERPA system: the human rescuer is the busy genius, working in team with the ground vehicle, as the intelligent donkey, and with the aerial platforms, i.e. the trained wasps and patrolling hawks. Indeed, the research activity focuses on how the busy genius and the SHERPA animals interact and collaborate with each other, with their own features and capabilities, toward the achievement of a common goal.\nA mix of advanced control and cognitive capabilities characterize the SHERPA system, aiming to support the rescuer by improving his awareness of the rescue scene even in tough environments and with the genius often busy in the rescuing activity (and thus unable to supervise the platform). Thus emphasis is placed on robust autonomy of the platform, acquisition of cognitive capabilities, collaboration strategies, natural and implicit interaction between the genius and the SHERPA animals, which motivate the research activity.\nFive benchmarks, inspired by real-world scenarios, drive the research and motivate demonstration activities on realistic testing sites planned during the project.\nSeven top academic groups, two SMEs, and the Italian Association of Alpine Rescuers with the role of end-user and evaluator of the project outcomes for the specific application of search and rescuing in the alpine scenario compose the consortium.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.3.1-5 | Award Amount: 4.03M | Year: 2012

With a share of 38%, orthopaedic and traumatology (O&T) are the worldwide leading markets of implanted biomaterials, involving millions of new patients each year at an increasing trend. Infection related to implanted medical devices is directly related to bacterial capability to establish multilayered, highly structured biofilms on artificial surfaces. Bacterial infections due to implanted biomaterials represent the most devastating complication in O&T, involving millions of European citizens. Aim of the present research is to develop, validate and bring to the market a disposable coating of implanted biomaterial (Implant Disposable Antibacterial Coating, I.D.A.C.). The device, based on a novel, proprietary, resorbable hydrogel, would act as a fast resorbable local delivery carrier of antibiofilm and antibacterial compounds. The active drug (antibiofilm and antibiotic agents) will be mixed at the time of the hydrogel application, allowing the correct choice for any given patient, reducing regulatory requirements, improving storage life and versatility. In particular, I.D.A.C. will be tested as a resorbable carrier of drugs (e.g.: N-acetylcisteine and its derivatives, serratia peptidase and other peptides, etc.) already known from our studies for having excellent antibiofilm properties, while others are able to by-pass the intact biofilm barrier and kill the underlying bacteria, when locally administered. The final purpose of the present research is to set a novel approach to early control of biofilm formation,to prevent bacterial colonization of implanted material and to treat established implant-related infections and chronic wounds, without any risk of inducing new drug resistance and alter the environment. The research will be conducted under the aegis of the European Bone and Joint Infection Society and the European Hip Society, through a network of upper standard European research and clinical centers and experienced SMEs from eight Countries around Europe.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-19-2014 | Award Amount: 4.86M | Year: 2015

A good functioning of the European food system is key to deliver food and nutrition security for all Europeans. However, that system faces many economic, environmental and social challenges as well as opportunities following socio-economic and technological developments, that are not equally distributed throughout the EU. Future policymaking aiming at healthy and resilient systems needs to take into account this differentiation and diversity of approaches, which necessitate foresight activities that take into account both the development of important driving forces as well as the social and spatial diversity. Primary productionthat is agriculture, fisheries and aquacultureforms the foundation of the food system. Its structure and performance is influenced by various conditions shaped by both the public and the private sector. As economic agents, primary producers aim at generating a sufficient amount of income, but their financial conditions are highly dependent on public and private actors, such as government regulators (including the EUs agricultural and fisheries policies), the financial sector, suppliers, the food industry, retailers, etc. In other words, the web of policy requirements as well as input and output market imperfections greatly shape farmers and fishermens livelihoods. Knowledge on the conditions of primary producers and the driving forces influencing these conditions exists, but in a fragmented way: not all primary producers and regions are covered, not all driving forces have been investigated, cross-linkages between them have been insufficiently analysed, future opportunities are not well integrated, etc. The purpose of SUFISA is to identify sustainable practices and policies in the agricultural, fish and food sectors that support the sustainability of primary producers in a context of multi-dimensionsal policy requirements, market uncertainties and globalisation.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.2.2-2 | Award Amount: 3.88M | Year: 2012

Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ageing; (2) this predisposes to age-associated brain diseases including cognitive decline and stroke; (3) epigenetic changes affecting glucocorticoid receptor (GR) sensitivity, altered autonomic nervous system (ANS) reactivity and cerebrovascular tone are important mediators of these processes, (4) these changes represent targets for diagnosis and therapeutic interventions. Our consortium has unique access to well-defined human and non-human primate cohorts (age range 25-115 y equivalents) that have been exposed to different types of prenatal stress. For experimental analysis of mechanisms of prenatal programming, we apply innovative techniques to characterize brain ageing, namely MRI based volumetry, non-linear analysis of EEG and ANS, advanced molecular techniques including epigenetics and metabolomics and neuropsychological and behavioral tests. Human subjects, non-human primates and rodents (including transgenic models) exposed to maternal stress, glucocorticoids or undernutrition are examined in order to: (1) determine structural (MRI based volumetry) and functional (metabolomics, brain function, cerebrovascular tone) indicators of brain age, (2) relate them to susceptibility to stroke and cognitive decline, (3) determine to what extent GR resistance, stress sensitivity, and cerebrovascular contractility mediate premature brain ageing and disease susceptibility; and, (4) dissect mechanisms and pharmacological interventions relevant for aged subjects. Data from the study allow to identify subjects at risk for premature brain ageing and to initiate interventional therapy.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.06M | Year: 2012

Europe is today facing several major challenges. These go beyond the future of the euro and the instability of the financial system to some of the underlying issues concerned with the work activities that underpin the European economy. How can Europe retain manufacturing and production as restructuring and relocation towards lower-wage costs economies gathers pace? As demographic change lifts the proportions of older workers in society and in employment, how can Europe both maintain decent levels of pensions and provide decent jobs for younger workers? As cross-border migration becomes ever easier how can migrant workers be fully integrated and accepted into the European labour market? How can aspirations for decent jobs be squared with the nearly pan-European progression of precarious work? Europes future depends in large part on the answers it can provide to these questions within the context of the vision of a competitive, technologically-innovative economy bolstered by a high road social model that was captured in the Europe 2020 strategy. The aim of the ChangingEmployment programme is to train a cross-European and interdisciplinary network of policy-focused social scientists comprehensively skilled in understanding, analyzing, and responding to social and institutional employment changes. Overall, it will: 1.Explore, societal differences, national variations in employees experiences of working life. 2.Examine historic and changing relations between management and employees. 3.Develop a comparative understanding of the changing quality of work, organisation and employment in the context of the (above) changes. 4.Consider patterns and consequences of workplace inclusion-exclusion in relation to migration, employment and unemployment, shifting inequalities in terms of gender and ethnicity and the implications for older employees of new patterns of work and retirement. 5.Assess impact of the current economic retrenchment on these forms of employment in Europe


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: GC.SST.2012.1-1.;GC.NMP.2012-2 | Award Amount: 10.47M | Year: 2012

Lightweight materials such as carbon-fibre reinforced plastics have been used up to now mostly in high-performance cars with relatively high cost & low production volumes. Instead the electric cars of the future require lightweight solutions that not only enable specific design requirements to be respected but are also cost effective and sustainable throughout their lifecycle. ENLIGHT aims to accelerate the technological development of a portfolio of innovative thermoset, thermoplastic, bio-based and hybrid materials which together offer a strong potential to reduce weight and overall carbon footprint to enable their viable application to medium-high volume EVs in 2020-25. Through the collaboration of EUCAR, CLEPA and EARPA, ENLIGHT will act as an open innovation platform, integrating valuable insights from other EU research projects with a holistic design approach. Five demonstrator modules of a future EV architecture will be developed, validating the performance of the materials in structurally demanding parts of the car. The demonstration and evaluation of the lightweight potential will be supported virtually with a full vehicle model.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SEC-2011.6.5-1 | Award Amount: 4.35M | Year: 2012

The overarching objective and expected impact of this project is to provide alternative and deepened understanding based on empirical evidence of how to handle conflicts in intercultural contexts within democratic societies in order to set up security solutions for communities, which are carried by the active participation of the citizens. ALTERNATIVE has at its core 4 intensive case studies (which mainly take the form of action research) built around, supported by and mutually feeding into 3 more theoretically oriented work packages. These parts together produce a spectrum of theoretically grounded and empirically tested models of dealing with conflicts in intercultural settings by RJ processes. The theoretically oriented work packages deal mainly with alternative epistemologies of justice and security, conflict analysis, and RJ models application and their relevance for European policies. The action research is dedicated to different levels of intercultural conflicts in a few selected security sensitive areas: at the micro-level - everyday conflicts between local residents and residents with migrant background in public/social housing (Vienna); at the meso-level conflicts in a small town with Roma and non-Roma inhabitants (Hungary); at the meso- and macro-level interethnic conflicts within 3 multi-ethnic and multicultural regions: conflicts between Serbs and Albanians, Serbs and Muslims, and Serbs and Croats (Serbia); and at the meso- and macro-level - civil conflicts at 3 different sites: conflicts between a local community and gangs of youths; between long term residents and recent immigrants; and inter-community sectarian conflict (Northern Ireland). Our proposal is fully in line with the main objectives of the Security Theme Work Program; its expected impact is also fully in line with the impact expected in the Topic SEC-2011.6.5-1 Conflict resolution and mediation: To provide alternative understanding of how to handle conflicts within democratic societies.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.1-02 | Award Amount: 7.96M | Year: 2012

Hemp is a sustainable high yielding crop well adapted to most European conditions, with advantageous environmental and agronomical characteristics. Traditionally cultivated for the fibres, seeds and psychoactive substances, it is now considered an ideal crop to produce innovative biomaterials. Once a key industrial crop for fibre, hemp production declined in the last century and was displaced by cotton and synthetic fibres. This explains why hemp has not been subject to the intensive breeding that has driven great improvements in major food crops in the last 50 years. However, cotton has one of the worst environmental footprints of any crop and there is renewed interest in hemp because it requires less water and agrochemicals and provides fibre and oil of superior quality. In the frame of multi-hemp, we will use cutting-edge genomic approaches to achieve rapid targeted improvements in hemp productivity and raw material quality for end-user requirements, whilst also advancing scientific understanding of gene-to-trait relationships in this crop. This work will be combined with innovations in agronomy, harvesting and processing methods to generate sustainable products from improved varieties. The project will include demonstration activities such as field trial and process scale up. The economic and environmental implications of each innovation will be assessed so as to maximise economic return and increase sustainability. This project brings together leading research groups with a vibrant group of industrial participants working from the level of molecular genetics through to end product demonstration. Our ambition is to develop an integrated hemp-based biorefinery in which improved feedstock is subject to efficient and modular processing steps to provide fibre, oil, construction materials, fine chemicals and biofuels using all components of the harvested biomass, and generating new opportunities within the developing knowledge based bioeconomy.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SEC-2013.5.1-1 | Award Amount: 5.13M | Year: 2014

In a disaster situation three things contribute to a success: having the right resource available in the shortest time, with the highest relevance and at the right location. Access to necessary information, communication with other rescuers and stakeholders as well as the availability of resources are key factors in minimizing damage and loss of life. Large scale disasters and crisis situations increase the requirements on man and material exponentially. Additional challenges, in particular in cross border events, include language barriers, knowhow and organizational barriers and technical barriers (communication and data exchange). To address this challenge it will be necessary to analyse three defining factors: 1. Past responses to critical events and disasters in terms of time and cost 2. The data and data management tool used by crisis managers and first responders 3. The organisational structures of the crisis managers and first responders This analysis will enable the definition of a concept for a common information space. A requirement for a successful pan European information space is the definition of a common taxonomy. The common information space, which implies an EU wide standardization activity, will widen the EU wide market for organization developing solutions and tools for crisis management.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: FoF.NMP.2011-5 | Award Amount: 5.60M | Year: 2011

Micro-manufacturing requires Zero-Defect oriented approaches, both in large scale and in short-run production. Current quality control approaches, coming from macro-manufactring, are mainly based on post-process geometric control, which produces a large time lag between the defect generation and its detection, usually leading to large amount of defect parts (large scale) or wasted high value processing (short run). Moreover, this approach does not immediately point the error source to help with error correction, and other criteria such as material integrity, physical properties, surface topography and piece or component functionality are not taken into account typically. There is clear need for extending the final product validation to a process monitoring approach in micro-manufacturing, where all the manufacturing process is monitored, from the raw material to the fabrication processes and the manipulation of the final parts, and where all this information is processed in real time with suitable models for error prediction, automatic detection and process optimization by system correction. The project will give a global solution for the zero defect approach in micro-manufacturing, with a focus on the aspects that are specific to micro-manufacturing. The develop technologies concepts are expected to have in impact in the competitiveness of the micro-manufacturers in the following ways: - reducing process variability detecting defects as soon as they are generated or in the case that it is possible, are going to be generated by predicting models. - allowing the use of less expensive machines, that can reduce their variability through monitoring. - requiring less skilled working force, thanks to acquired process setting knowledge and the development of smart decision-making tools.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: FoF.NMP.2013-8 | Award Amount: 6.21M | Year: 2013

The current maintenance policies, including e.g. RCM (Reliability Centred Maintenance) and TPM (Total Productive Maintenance), can be generally useful in answering questions such as how much maintenance should be done on this machine? How frequently should this part be replaced? How many spare parts should be kept in stock? How should the shutdown be scheduled? It is generally accepted that the vast majority of maintenance models are aimed at answering efficiency questions, i.e. questions of the form How can this particular machine be operated more efficiently? and NOT effectiveness questions (the top 5 ones!), like: Q1: How can reliability, repair and EOL be included in a robust and integrated Life Cycle Cost (LCC) and Life Cycle Assessment (LCA) model of the factory (to be used for decision making along factory life cycle)? Q2: Which are the most cost-effective and optimal Repair strategies we should tailor for sets of components/machines of the factory? Q3: Which machine and/or components should we improve and how can we reduce repair time and cost? Q4: Which are the most environmental-effective EOL strategies we should tailor for sets of components/machines of the factory? Q5: How can we assess the remaining life of Re-usable components and which are most valuable Renovation technologies for the machine tools? the EASE-R3 project aims at developing a novel Integrated framework for a cost-effective and easy Repair, Renovation and Re-use of machine tools within modern Factory (machining shop floor), oriented both to SME and large OEM/end-users, and covering the entire life cycle of the system (from design stage throughout operative life).


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 9.45M | Year: 2012

Enabling robots to competently perform everyday manipulation activities such as household chores exceeds, in terms of task,activity, behavior and context complexity, anything that we have so far investigated in motion planning, cognitive robotics, autonomous robot control and artificial intelligence at large. For achieving robust, adaptive, effective and natural performance of everyday manipulation tasks, it is not feasible to expect that programmers can equip the robots with plan libraries that cover such open-ended task spectrum competently.RoboHow.Cog targets at enabling autonomous robots to perform expanding sets of human-scale everyday manipulation tasks - both in human working and living environments. To this end, RoboHow.Cog will investigate a knowledge-enabled and plan-based approach to robot programming and control where knowledge for accomplishing everyday manipulation tasks is semi-automatically acquired from instructions in the World Wide Web, from human instruction and demonstration (videos), and from haptic demonstration.The knowledge-enabled control will be made possible through extensions of constraint- and optimization-based movement specification and execution methods that allow for the force adaptive control of movements to achieve the desired effects and avoid the unwanted ones. In addition, novel perception mechanisms satisfying the knowledge preconditions of plans and monitoring the effects of actions will make the RoboHow.Cog approach feasible.The software components that will come out of RoboHow.Cog will be integrated into complete generic robot control systems such as ROS, and, in particular, into Aldebarans humanoid platform Romeo. RoboHow.Cog will strive to make the code of many of its components - and even of large parts of the Milestone demonstrations -- publicly available under free/open source software licenses.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.5 | Award Amount: 3.97M | Year: 2011

So far, Hybrid Broadcast Internet applications have mostly linked Internet and broadcast by offering on-demand content in addition to current linear broadcast services and by replacing old-fashioned Teletext. However, many more services are on the horizon, and the market of hybrid and connected TV attracts attention from all stakeholders in the media value chain. The challenge is to take hybrid service to a new level where the wide range of expectations of user groups is met. HBB-NEXT will lay the foundations for advanced hybrid multi-user services by building upon existing standards and by enhancing them.\nThe project seeks to facilitate the convergence of the broadcast and Internet world by researching user- centric technologies for enriching the TV-viewing experience with social networking, multiple device access, group-tailored content recommendations, as well as the seamless mixing of broadcast content, of complementary Internet content and of user-generated content. The project will deliver a set of enablers to allow device-independent applications that can syndicate content from multiple sources, supporting real-time content composition and content distribution for users in geographically distinct areas. Sophisticated technology will be developed for the easy use of content, e.g. advanced synchronisation methods for service components delivered across the Internet and broadcast networks. Data security and protection of user privacy will be an integral part of HBB-NEXT - but in a way that is transparent to the end-user.\nIn liaison with the HbbTV Consortium, HBB-NEXT will define requirements and specifications for a secure multi-user and multi-device TV-viewing experience, thus fostering the implementation of new service concepts and business models.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA.2009.1.1.01 | Award Amount: 4.23M | Year: 2010

Coastal-zone oceanographic predictions seldom appraise the land discharge as a boundary condition. River fluxes are sometimes considered, but neglecting their 3D character, while the distributed continental run-off is not taken into consideration. Moreover, many coastal scale processes, particularly those relevant in geographically restricted domains (coasts with harbours or river mouth areas), are not well parameterized in present simulations. Because of this situation, local predictions still present significant errors and are not robust enough, even being locally wrong for sharp gradient events, such as flash flood discharges into the Mediterranean sea. This hampers decision-making in coastal zones. The FIELD_AC project aims at providing an improved operational service for coastal areas and to generate added value for shelf and regional scale predictions from GMES Marine Core Services. Local assimilation will be analysed together with advanced error metrics to provide a reliable service that can be transferred to public and private parties, using the spin-off company that will result from the project. This will be achieved by the introduction of more comprehensive land boundary conditions, improved local parameterizations and new coupling terms/strategies for the studied field cases. They cover a representative range of meteo-oceanographic drivers for four geometrically restricted domains (Catalan coast, Venice Gulf, Liverpool Bay and the Wadden Sea). FIELD_AC will bridge the gap from shelf predictions to local (river mouth or harbour/beach scales) simulations required at the coastal zone. This will result in a wider demand for operational services and an enhanced use of in-situ and remote observations. Such improvements (services and expertise) will require the advancement of the present state of the art.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.1.5 | Award Amount: 10.47M | Year: 2013

The traditional computing paradigm is experiencing a fundamental shift: organizations no longer completely control their own data, but instead hand it to external untrusted parties - cloud service providers, for processing and storage. There currently exist no satisfactory approach to protect data during computation from cloud providers and from other users of the cloud.\n\nPRACTICE has assembled the key experts throughout Europe and will provide privacy and confidentiality for computations in the cloud. PRACTICE will create a secure cloud framework that allows the realization of advanced and practical cryptographic technologies providing sophisticated security and privacy guarantees for all parties in cloud-computing scenarios. With PRACTICE users no longer need to trust their cloud providers for data confidentiality and integrity: Due to its computation on encrypted data, even insiders can no longer disclose secrets or disrupt the service. This opens new markets, increases their market share, and may allow conquering foreign markets where reach has been limited due to confidentiality and privacy concerns. PRACTICE enables European customers to safe cost by globally outsourcing to the cheapest providers while still maintaining guaranteed security and legal compliance.\n\nPRACTICE will deliver a Secure Platform for Enterprise Applications and Services (SPEAR) providing application servers and automatic tools enabling privacy-sensitive applications on the cloud. SPEAR protects user data from cloud providers and other users, supporting cloud-aided secure computations by mutually distrusting parties and will support the entire software product lifecycle. One goal of SPEAR is to support users in selecting the right approach and mechanisms to address their specific security needs. Our flexible architecture and tools that allow seamless migration from execution on unchanged clouds today towards new platforms while gradually adding levels of protection.\n\nPRACTICE is strongly industry-driven and will demonstrate its results on two end-user defined use cases in statistics and collaborative supply chain management. PRACTICE is based on real-life use cases underpinning the business interest of the partners. Our focus is on near-term and large-scale commercial exploitation of cutting-edge technology where project results are quickly transferred into novel products. PRACTICE is the first project to mitigate insider threats and data leakage for computations in the cloud while maintaining economies of scale. This goes beyond current approaches that can only protect data at rest within storage clouds once insiders may misbehave. Moreover, it will investigate economical and legal frameworks, quantify the economic aspects and return on security investment for SMC deployment as well as evaluate its legal aspects regarding private data processing and outsourcing.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2012-IRSES | Award Amount: 266.70K | Year: 2013

Main postharvest losses are caused by physiological, pathological and physical damage; being these causes in many instances interrelated. Harvested products are highly heterogeneous and conventional postharvest approaches are not sufficient for an optimum profitability of these foodstuffs. These methods are usually based on controlling the physiological and sanitary status on pre-harvest, for which only a part of the harvest is analysed as a representative of the whole group. In order to overcome this problem, REPLAY will develop innovative tools and methodologies for a sustainable management of post harvested food. This objective will be achieved through a staff exchange structure that will contribute to: (i)food quality assessment; (ii)processing technologies; (iii)food chain sustainability assessment; (iv)dissemination and (v)innovation and competitiveness. To strengthen these research areas, the project foresees staff exchange and networking activities between European and Third Country partners, high-level training of personnel and to create and reinforce networks for future joint research projects. The relevance of this proposal lies in increasing the added value and the profitability of harvested food management, starting from their origin, by the prompt sorting of commodities in more accurate and homogeneous subgroups (quality grades). Primary processing techniques and adequate preservation processes would be assessed for the selected commodities to improve their shelf-life. Emerging preservation technologies will facilitate alternatives for low valued raw materials through the development of novel products. The exchange scheme will take advantage of the complementarities and synergies generated by the four European leading partners (AZTI-Spain; DLO-The Netherlands; KUL-Belgium, AGROPARISTECH-France) and six Third Country leading partners (INTI-Argentina; AGRESEARCH-New Zealand; CSIRO-Australia; OSU-United States of America; ITESM-Mexico; USACH-Chile).


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2013.2.5-01 | Award Amount: 4.95M | Year: 2014

TRANSMANGO aims to obtain a comprehensive picture of the effects of the global drivers of change (climate, economic concentration and market structure, financial power, resource competition, marginalization, property rules, geo-political shifts, consumer preferences, consumption patterns and nutritional transition) on European and global food demand and on raw material production (and, consequently, on food flows). The research focuses on the vulnerability and resilience of European food systems in a context of socio-economic, behavioral, technological, institutional and agro-ecological change and aims to enhance understanding of the new challenges and opportunities that the food sector will face in the future. Vulnerability assessment methodologies and dynamic modeling tools will be reviewed, upgraded and developed to assess the resilience of Europes agro-food sector and food security situation and to understand the sustainability frontiers of different food production systems under the new unfolding conditions. The project will collect analytical data that will be used to design scenarios for the desired transition pathways in the food system. Based on these scenarios, TRANSMANGO will provide guidance to support the transition towards sustainability and will offer recommendations to address Europes medium- and long-term food security.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.2-1 | Award Amount: 7.84M | Year: 2013

BIOIMAGE-NMD will develop and apply imaging technology to monitor response to novel therapies in neuromuscular diseases (NMD) and will use Duchenne muscular dystrophy (DMD) as an exemplar disease. DMD is well characterised genetically and clinically but to date a disease modifying treatment is not available. One of the most promising developments for future treatment of NMD is RNA modulation through antisense oligonucleotides (AON). In DMD, AON are used for exon skipping and this is a genuine example of personalised medicine, where patients are treated according to their specific gene mutation. Quantitative Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) are used to assess structural and metabolic muscle pathology in NMD but their effectiveness in monitoring therapy is yet to be shown. The project will apply a simultaneous MRI/MRSI protocol in multi-centre clinical trials of AON therapy in DMD with the aim of establishing a clinical proof of principle that these imaging measures are effective biomarkers of therapeutic response. To enhance the imaging protocol, novel Diffusion Tensor MRI (DTI) methods will be developed and optimised to assess muscle microstructure and applied in these trials. The project will also develop methods for radiolabelling of AON and demonstrate the use of pre-clinical Positron Emission Tomography (PET)/MRI to assess the tissue targeting, bio-distribution and pharmacokinetics of AON in vivo. BIOIMAGE-NMD will deliver PET/MRI and MRI/MRSI technologies for both drug development and clinical evaluation roles which will significantly contribute to bringing personalized therapeutic interventions in rare and common diseases to the market.


Grant
Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2009.1.4 | Award Amount: 5.25M | Year: 2010

The Network of Excellence on Engineering Secure Future Internet Software Services and Systems (NESSoS) aims at constituting and integrating a long lasting research community on engineering secure software-based services and systems.\n\nThe NESSoS engineering of secure software services is based on the principle of addressing security concerns from the very beginning in system analysis and design, thus contributing to reduce the amount of system and service vulnerabilities and enabling the systematic treatment of security needs through the engineering process. In light of the unique security requirements the Future Internet will expose, new results will be achieved by means of an integrated research, as to improve the necessary assurance level and to address risk and cost during the software development cycle in order to prioritize and manage investments. NESSoS will integrate the research labs involved; NESSoS will re-address, integrate, harmonize and foster the research activities in the necessary areas, and will increase and spread the research excellence. NESSoS will also impact training and education activities in Europe to grow a new generation of skilled researchers and practitioners in the area. NESSoS will collaborate with industrial stakeholders to improve the industry best practices and support a rapid growth of software-based service systems in the Future Internet.\n\nThe research excellence of NESSoS will contribute to increase the trustworthiness of the Future Internet by improving the overall security of software services and systems. This will support European competitiveness in this vital area.

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