Bucheon, South Korea
Bucheon, South Korea

The Catholic University of Korea is a private Roman Catholic institution of higher education in South Korea. It operates campuses in Seoul and in the neighboring Bucheon City. The university's medical school, considered as one of the most prestigious in South Korea, has eight affiliated hospitals in major cities of the country. The university has been consistently ranked as one of the premier universities in South Korea and has been regarded in both national and international university rankings. Wikipedia.


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The present invention relates to an external standard reference system of a type inserted into the coil of a human magnetic resonance imaging equipment, and more specifically, to a system capable of analyzing metabolic components (quantity of metabolites) in a human body without an error and a limited range using an external standard reference analysis method, in order to enhance accuracy of diagnosis by utilizing magnetic resonance spectroscopy of the human magnetic resonance imaging equipment. A system for evaluating performance of magnetic resonance spectroscopy includes an outer container for inserting an RF coil and provided with a plurality of holes; a plurality of inner containers arranged to be inserted into the plurality of holes respectively and capable of being filled with metabolites different from each other in at least a type or a concentration; and a frame for fixing a head of an object arranged inside the outer container.


Patent
Catholic University of Korea | Date: 2015-10-30

The present invention relates to an EBV antigen specific T-cell receptor and the use thereof. Specifically, the present invention provides T cells specific for LMP1 of EBV using a T-cell receptor which is highly specific for specific epitopes derived from an EBV antigen, LMP1. In addition, the EBV antigen specific T-cell can be used in the prevention or treatment of EBV-associated diseases.


Patent
Catholic University of Korea | Date: 2015-01-29

The present invention relates to a voxel-type block phantom for a multifunctional radiation measurement apparatus. A phantom, for adjusting an amount of radiation, has solid pixel blocks, having a radiation measuring device equipped therein and different media and densities from one another, assembled on top of one another so as to be assembled into a 3-dimensional voxel, wherein the phantom is formed by placing a solid block which is appropriate for a density that corresponds to each pixel of the 3-dimensional voxel. An inspector can personally and instantly customize a phantom that is appropriate for a subject to be measured and thus can obtain an accurate measurement value.


Patent
Catholic University of Korea | Date: 2015-04-28

The present invention relates to a method for predicting the prognosis of acute myeloid leukemia relapse. According to the present invention, the prognosis of acute myeloid leukemia relapse can be predicted by analyzing changes in a bone marrow microenvironment during the early diagnosis of leukemia.


Patent
Catholic University of Korea | Date: 2017-03-08

The present invention relates to a method for predicting the prognosis of acute myeloid leukemia relapse. According to the present invention, the prognosis of acute myeloid leukemia relapse can be predicted by analyzing changes in a bone marrow microenvironment during the early diagnosis of leukemia.


Patent
Catholic University of Korea | Date: 2017-02-15

The present invention relates to a novel compound capable of effectively preventing and treating immune diseases and a use thereof. The novel compound of the present invention has effects of inhibiting the formation of proinflammatory cytokines, increasing the activity of regulatory T cells having immunoregulatory functions, inhibiting the production of autoantibodies to regulate excessive immune responses, and inhibiting the differentiation to osteoclasts, and thus can be used for treating immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection diseases, which are caused by abnormal regulation of various kinds of immune responses.


Wee J.-H.,Catholic University of Korea
Applied Energy | Year: 2013

This work reviews the availability and the potential of the carbon capture and storage (CCS) technology using coal fly ash (FA). Because the technology can be effectively applied on-site to coal fired power plants and as FA contains sufficient alkali components, the technology may be another option of CCS technology to a limited extent. The technology can be divided into wet and dry processes. In the former, the available components for CCS in FA are leached into solution by the solvent where they are subsequently consumed for carbonation to store CO2. Particularly, the CO2 storage capacity of CaO-enriched FA solution mixed with brine under high pressure may be equal to or greater than the true CO2 emission reduction achieved by applying FA as a cement additive. In the dry process, FA can be used as a direct support or as the raw material of the sorbent supports for CO2 capture. The dry process is effectively applied for CO2 capture rather than storage because the sorbents should be regenerated. Another advantage of the technology is the stabilization of the harmful components present in FA, which are mostly co-precipitated with carbonated FA during the process. © 2013 Elsevier Ltd.


Wee J.-H.,Catholic University of Korea
Renewable and Sustainable Energy Reviews | Year: 2014

The contribution of the molten carbonate fuel cell system (MCFCs) to carbon dioxide (CO2) emission reduction in power application is analyzed. MCFCs can separate and concentrate CO2 emitted from traditional thermal power plants (PPs) without reducing the plant's overall energy efficiency. MCFCs can also be used by itself as an effective CO2 separator or concentrator by managing the anode gas stream to increase the heat utilization of the system. The CO2 separated and concentrated by MCFCs is most effectively captured by condensation. MCFCs is currently used as a CO2 separator only to a limited extent due to its high cost and relatively small scale operation. However, MCFCs will substantially contribute to reduce CO2 emissions in power generation applications in the near future. © 2014 Elsevier Ltd.


Provided is a technique of allowing a dental implant to be stably placed after extraction, to be accurately placed in a tooth extraction socket, and to be stably placed in the tooth extraction socket according to implantation position and angle. A method of manufacturing a scaffold for treatment of a tooth extraction socket and implantation of a dental implant includes receiving dental implantation information of dental CT data which is previously input via a terminal of a manager; manufacturing, by using a three-dimensional (3D) printer, a 3D model comprising alveolar bones and teeth, which are distinguished therebetween, based on a medical image file that is a medical image file (DICOM file) of the dental CT data; performing virtual tooth-extraction by removing, from the manufactured 3D model, a region corresponding to a tooth in a tooth-extraction target area; and manufacturing, by using the 3D printer, a scaffold to be placed in an actual tooth extraction socket according to a shape of a tooth extraction socket that exists in the manufactured 3D model as a result of the virtual tooth-extraction, wherein, when the scaffold is manufactured, image data of the scaffold is amended to allow a guide hole for implanting the dental implant to be formed in the scaffold based on the dental implantation information.


To examine the regulatory role of interleukin-22 (IL-22) in the expression of RANKL and induction of osteoclastogenesis in rheumatoid arthritis (RA). Concentrations of IL-22 and RANKL in the serum and synovial fluid of RA patients were measured using enzyme-linked immunosorbent assay. RA synovial fibroblasts were treated with recombinant human IL-22 (rhIL-22), and the expression of RANKL messenger RNA (mRNA) and protein was measured using real-time polymerase chain reaction, Western blotting, and intracellular immunostaining. Human monocytes were cocultured with IL-22-prestimulated RA synovial fibroblasts and macrophage colony-stimulating factor, and osteoclastogenesis was assessed by counting the multinucleated cells (those staining positive for tartrate-resistant acid phosphatase). The IL-22 concentration in the synovial fluid was higher in RA patients than in patients with osteoarthritis (OA). The serum IL-22 concentration was also higher in RA patients than in OA patients and healthy volunteers, and this correlated with serum titers of rheumatoid factor and anti-cyclic citrullinated peptide antibodies. In RA synovial fibroblasts treated with rhIL-22, the expression of RANKL mRNA and protein was increased in a dose-dependent manner. IL-22-induced RANKL expression was down-regulated significantly by the inhibition of p38 MAPK/NF-κB or JAK-2/STAT-3 signaling. In human monocytes cocultured with IL-22-prestimulated RA synovial fibroblasts in the absence of exogenous RANKL, the monocytes differentiated into osteoclasts, but this osteoclastogenesis decreased after p38 MAPK/NF-κB or JAK-2/STAT-3 signaling was inhibited. These results show that IL-22 up-regulates RANKL expression in RA synovial fibroblasts and induces osteoclastogenesis. These effects are mediated by the p38 MAPK/NF-κB and JAK-2/STAT-3 signaling pathways. Copyright © 2012 by the American College of Rheumatology.

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