The Catholic University of Daegu is the largest Catholic-affiliated university in South Korea. The main campus is located some distance outside Daegu in neighboring Hayang Town, with two smaller campuses within Daegu. The university enrolls about 17,000 students. Wikipedia.
Joo S.H.,Catholic University of Daegu
Biomolecules and Therapeutics | Year: 2012
There are many cyclic peptides with diverse biological activities, such as antibacterial activity, immunosuppressive activity, and anti-tumor activity, and so on. Encouraged by natural cyclic peptides with biological activity, efforts have been made to develop cyclic peptides with both genetic and synthetic methods. The genetic methods include phage display, intein-based cyclic peptides, and mRNA display. The synthetic methods involve individual synthesis, parallel synthesis, as well as split-and-pool synthesis. Recent development of cyclic peptide library based on split-and-pool synthesis allows on-bead screening, in-solution screening, and microarray screening of cyclic peptides for biological activity. Cyclic peptides will be useful as receptor agonist/antagonist, RNA binding molecule, enzyme inhibitor and so on, and more cyclic peptides will emerge as therapeutic agents and biochemical tools. © 2012 The Korean Society of Applied Pharmacology.
Yang J.-H.,Catholic University of Daegu
Chemosphere | Year: 2010
Widespread contamination of perfluorooctanoic acid (PFOA) in the marine environment draws a great concern over its ecotoxicological impact on marine mammals and wildlife. In the present study, male Japanese medaka (Oryzias latipes) was adapted to seawater to mimic the marine environment and was then exposed to the nominal concentrations of 10, 50, 100mgL-1 PFOA for 7d. There were no impact on survival, relative liver and gonad size, and condition factor (measure of growth) at any concentration tested. Peroxisomal acyl-CoA oxidase (ACO) activity was elevated at the highest dose with a marginal significance (P=0.06). The increase of ACO activity was paralleled by the significant upregulation of PPAR-α expression at the same dose. PFOA induced a significant inhibition of catalase (CAT) activity at high doses with no changes of superoxide dismutase (SOD) or glutathione peroxidase (GPx) activities in the liver. These results strongly suggest that PFOA may induce peroxisomal fatty acid oxidation and impose the oxidative stress through the alteration of cellular oxidative homeostasis in the liver. PFOA increased the mRNA levels of proinflammatory cytokines such as IL-6, TNF-α and IL-1β, suggesting that it may be involved in inflammation and tissue injury. This study may contribute to understanding the mechanism of PFOA-induced hepatic toxicity in Japanese medaka and assessing the potential risk of PFOA in marine fish and wildlife. In addition, the present results obtained at the high concentrations may provide important biological endpoints relevant to situations such as environmental spills. © 2010 Elsevier Ltd.
Loladze I.,Catholic University of Daegu
eLife | Year: 2014
Mineral malnutrition stemming from undiversified plant-based diets is a top global challenge. In C3 plants (e.g. rice, wheat), elevated concentrations of atmospheric carbon dioxide (eCO2) reduce protein and nitrogen concentrations, and can increase the total nonstructural carbohydrates (TNC; mainly starch, sugars). However, contradictory findings have obscured the effect of eCO2 on the ionome - the mineral and trace-element composition - of plants. Consequently, CO2-induced shifts in plant quality have been ignored in the estimation of the impact of global change on humans. This study shows that eCO2 reduces the overall mineral concentrations (-8%, 95% confidence interval: -9.1 to -6.9, p<0.00001) and increases TNC:minerals > carbon:minerals in C3 plants. The meta-analysis of 7,761 observations, including 2,264 observations at state of the art FACE centers, covers 130 species/cultivars. The attained statistical power reveals that the shift is systemic and global. Its potential to exacerbate the prevalence of 'hidden hunger' and obesity is discussed.
Yang J.-M.,Catholic University of Daegu
IEEE Transactions on Automatic Control | Year: 2010
In this note, we examine the control of asynchronous sequential machines with adversarial inputs. The considered asynchronous machine is of input/output type, where access to the state of the machine is not available. The adversarial input represents an unknown disturbance that can provoke unauthorized state transitions. The problem is to develop output feedback controllers that counteract the effects of the adversarial input, while controlling the machine so that the closed-loop system can match a prescribed model. The existence of appropriate corrective controllers depends on certain reachability and detectability properties of the machine and the model. © 2010 IEEE.
Park G.Y.,Catholic University of Daegu
American journal of physical medicine & rehabilitation / Association of Academic Physiatrists | Year: 2011
Real-time sonoelastography is a recently developed ultrasound-based technique that evaluates tissue elasticity in real time, and it is based on the principle that the compression of tissue produces a strain (displacement) that is lower in hard tissue and higher in soft tissue. Real-time sonoelastography provides information on tissue elasticity, in addition to the shape or vascularity, which is obtained via B-mode ultrasound. Similar to B-mode ultrasound, freehand manipulation with the transducer and real-time visualization are now available for real-time sonoelastography in actual clinical practice. Tissue elasticity not only varies among different tissues but also seems to reflect disease-induced alternations in tissue properties. Real-time sonoelastography was recently applied to the normal and pathologic tissues in muscle and tendon disorders, and it showed promising results and new potentialities. Therefore, it is expected to be a useful modality for providing novel diagnostic information in musculoskeletal diseases because tissue elasticity is closely related to its pathology. It can also be used as a research tool to provide insight into the biomechanics and pathophysiology of tissue abnormality.