News Article | May 2, 2017
CARACAS (Reuters) - Venezuela's opposition blocked streets in Caracas on Tuesday to denounce a decision by leftist President Nicolas Maduro to create a "constituent assembly," a move critics said was a veiled attempt to cling to power by avoiding elections. After a month of near-daily protests by opponents demanding early general elections, the unpopular leader announced on Monday he planned to set up the super-body popular assembly with the power to rewrite the constitution. The socialist government said the opposition was promoting street violence and refusing dialogue, so it had no choice but to shake up Venezuela's power structure. Critics of the president said he was increasingly dictatorial and planned to staff the assembly with supporters and avoid elections he would likely lose during a crushing recession in the oil-producing country. Regional elections that were scheduled for last year have yet to be called and a presidential election is due for 2018. Asked about elections in an interview on state television on Tuesday, the Socialist Party official in charge of the constituent assembly said the electoral schedule would be respected. However the official, Elias Jaua, also suggested that current political turmoil was hindering setting a quick date. "One of the aims of the constituent assembly is to seek the conditions of stability to be able to go to those electoral processes," Jaua said. "Those conditions of normality do not exist," he added, citing protests and institutional clashes between authorities and the opposition-led National Assembly. The United States, as well as fellow Latin American countries Argentina and Chile, on Tuesday expressed worry about Maduro's move. "We have deep concerns about the motivation for this constituent assembly which overrides the will of the Venezuelan people and further erodes Venezuelan democracy," said Michael Fitzpatrick, deputy assistant secretary of state for the Western hemisphere, in a phone call with reporters. Fitzpatrick said Maduro was trying to yet again "change the rules of the game" in an effort to remain in power. 'MORE FUEL TO THE FIRE' Maduro's critics worry the new body would further sideline the current opposition-led legislature and pave the way for undemocratic changes to the constitution. The controversial decision was likely to add more energy to anti-government protests, already the most sustained since 2014, as they seek to end 18 years of socialist rule that began under late leader Hugo Chavez. Opposition barricades snarled traffic in and around Caracas on Tuesday morning, with demonstrators using garbage bags, branches, bottles, and cardboard boxes to block roads. Security forces used tear gas to disperse some demonstrators. "We don't believe in Maduro's fake peace, what he's done is add more fuel to the fire," said Jesus Gutierrez, 64, who was with about 100 demonstrators blocking one of the main avenues in the capital. "The people have to react, and that's what they've been doing." Some 29 people have been killed, more than 400 people injured and hundreds more arrested since the anti-Maduro unrest began in early April. The government has responded with shows of force by security forces and counter-demonstrations by Maduro supporters. Many details remain unclear about the constituent assembly, although foes say it would be excessively powerful. "According to the government, it would have all powers," said Jose Ignacio Hernandez, law professor at Venezuela's Catholic University. "It could dissolve the National Assembly, name a new electoral council, dismiss governors, and dismiss mayors." The opposition planned more marches on Wednesday.
News Article | April 17, 2017
Ronald E. Quirk, Jr., Head of the Internet of Things (IoT) Practice Group at Marashlian & Donahue, PLLC, The CommLaw Group, has joined The Expert Network©, an invitation-only service for distinguished professionals. Mr. Quirk has been chosen as a Distinguished Lawyer™ based on peer reviews and ratings, dozens of recognitions, and accomplishments achieved throughout his career. Mr. Quirk outshines others in his field due to his extensive educational background, numerous awards and recognitions, and career longevity. He received his B.A. in Communication from George Mason University in 1988 and his J.D. from the Catholic University of America, Columbus School of Law in 1994. He also holds a certificate from the Institute for Communications Law Studies. Today, Mr. Quirk is a leading expert in matters relating to the Internet of Things (IoT). He focuses his practice on serving the comprehensive needs of the burgeoning and complex industry, including: contracts and commercial law, privacy, cybersecurity, spectrum access, radiofrequency (RF) equipment authorization, marketing, and importation, tax, risk assessment, regulatory compliance planning, enforcement proceedings, and more. His career has spanned more than two decades years, including several years at AMLAW 100 firms and the Federal Communications Commission (FCC). Mr. Quirk has successfully represented a wide variety of clients before the FCC, federal courts, and state regulatory agencies. These clients include wireless and wireline carriers, Voice over Internet providers, broadcasters, public safety entities, and RF equipment manufacturers. With over 20 years dedicated to law, Mr. Quirk brings a wealth of knowledge to his industry and, in particular, to his areas of specialization, the fields of federal, state, and international telecommunications law, regulation, and policy. When asked about his decision to pursue a career in this specialty, Mr. Quirk said: "As an undergraduate, I worked with a professor who taught international telecommunications and I then went to work for a well-known telecommunications publishing company. My writing and editing experience really piqued my interest in telecommunications law, so I decided to attend the Catholic University Law School and obtain a certificate from their Institute for Communications Law Studies, now known as the Law and Technology Institute." As a thought-leader in his field, Mr. Quirk’s background in journalism, publishing, and communications sets him apart from his peers. In addition to his work at Marashlian & Donahue, Mr. Quirk has published numerous articles and papers on various topical telecommunications issues, from FCC compliance and spectrum auctions to wireless telecommunications tax and bankruptcy. He also moderates events. As a leader in his field, he makes sure to pay attention to prevailing trends in his quickly-developing industry. He noted: "One trend I have been paying attention to is how the way in which the FCC is going to be issuing wireless spectrum for communications is heading more and more towards unlicensed spectrum. Instead of having the licenses that allow various regulatory agencies to prevent interference based on frequencies, the equipment is going to have to filter out the interference and it's going to be interesting. We’re heading towards unlicensed communications, wireless communications." For more information, visit Mr. Quirk's profile on The Expert Network© here: https://expertnetwork.co/members/ronald-e-quirk-jr/176574fc0551a147 The Expert Network© has written this news release with approval and/or contributions from Ronald E. Quirk, Jr. The Expert Network© is an invitation-only reputation management service that is dedicated to helping professionals stand out, network, and gain a competitive edge. The Expert Network© selects a limited number of professionals based on their individual recognitions and history of personal excellence.
News Article | April 17, 2017
The University of St. Thomas, Houston’s Catholic University, has unveiled an interactive online tool called MBABuilder™. The first of its kind in Houston, it allows degree seekers to customize their own MBA degree plan quickly and easily. Future Houston MBA students specify when they wish to begin classes, attain their degree and their preferred concentration. The tool generates a sequence, complete with course names, descriptions, and options for the user to choose elective courses related to their preferred MBA concentration. “We are always striving to empower prospective students with the knowledge and resources to advance their career,” said Todd Boutte, Director of Graduate Admissions for the University of St. Thomas. “MBABuilder™ provides them with personalized, practical and relevant information that is not easily accessible on most higher education websites.” When a user is satisfied with their MBA degree plan they can email it to themselves for future discussion with a University of St. Thomas graduate admissions counselor. “Before engaging with a brand, consumers want to do as much research as possible on their own,” said Mike Kramer, Director of Digital Marketing and Media. “They are able to put themselves in the mindset of an MBA student to see how the flexibility of the curriculum will fit into their lives.” The program is administered by the Cameron School of Business, accredited by the Association to Advance Collegiate Schools of Business. AACSB is the ultimate elite accrediting body in business education worldwide. Only 5% of all institutions internationally have gained accreditation by this agency. The Cameron School of Business educates students of diverse backgrounds, instilling a deep appreciation for ethical behavior and judgment. Alumni are currently working in senior leadership positions for companies such as AIG, Memorial Hermann, Hewlett Packard, WalMart, Shell, General Electric, BBVA Compass and many others. ABOUT UNIVERSITY OF ST. THOMAS The University of St. Thomas is currently celebrating its 70th anniversary. It was founded in 1947 by the Basilian Fathers as an independent, Catholic, coeducational university in Houston, TX. Centrally located in the city’s Museum District, the University enrolls over 3,000 students. Set against the backdrop of the Texas Medical Center, UST has been ranked among the region’s best colleges by U.S. News and World Report for over 20 consecutive years.
News Article | May 8, 2017
May 3, 2017, Napa, CA – Blends, an international portfolio of family-owned wineries, is pleased to announce the hiring of Eduardo Hidalgo as the new Northeast Regional Sales Manager. Mr. Hildalgo, who holds a BA in Marketing and Communications, a Level 4 WSET certification, and graduated from the Culinary Institute Wine Business Program, is responsible for overseeing all aspects of sales, distributor relations, and promotion for the entire Northeastern region from Delaware to Maine. He is based in New York City and reports directly to Heather Price, Blends Executive Vice President of Sales and Marketing. Eduardo Hidalgo brings an impressive range of experience working with international wine brands to his new position. After graduating from the Catholic University in his native country of Chile, Eduardo began his career in the U.S. working at Dean & Deluca and Robert Sinskey Winery, both in Napa Valley, California. He then went on to hold strategic sales positions at the renowned Cousino Macul Winery where he worked as the North American Brand Manager (Canada, the U.S. and Puerto Rico) and, most recently, he was with the Winebow Group in New York. In his spare time, you will find Eduardo enjoying the open road on his beloved Ducati motorcycle. “I am very excited to be stepping into the role of Northeast Regional Sales Manager,” says Eduardo. “Blends has assembled a diverse portfolio of wineries from some of the world’s most respected wine regions. That, coupled with an emphasis on quality, make it particularly well-suited for the variety of markets and sales channels that I will be covering.” “Eduardo brings a great understanding of the wines we represent and an infectious enthusiasm”, says Executive Vice President, Heather Price. “He knows the market, has incredible wine knowledge and established relationships with both distributors and key accounts that will make his transition seamless. We are excited to have him join our team.” Blends is an international family of wine estates owned by Alejandro P. Bulgheroni that produces fine wines from some of the world’s most renowned wine regions. The portfolio includes: Renwood Winery from California’s Amador County, The Cleaver from California, Bodega Vistalba, Tomero, Arido and Bodega Argento wineries from Argentina’s Mendoza region, Bodega Garzón of Uruguay, and Chateau Suau in Bordeaux, France. For more information, visit blendsinc.com.
Mercuri E.,Catholic University |
Mercuri E.,University College London |
Muntoni F.,University College London
The Lancet | Year: 2013
Muscular dystrophies are a heterogeneous group of inherited disorders that share similar clinical features and dystrophic changes on muscle biopsy. An improved understanding of their molecular bases has led to more accurate definitions of the clinical features associated with known subtypes. Knowledge of disease-specific complications, implementation of anticipatory care, and medical advances have changed the standard of care, with an overall improvement in the clinical course, survival, and quality of life of affected people. A better understanding of the mechanisms underlying the molecular pathogenesis of several disorders and the availability of preclinical models are leading to several new experimental approaches, some of which are already in clinical trials. In this Seminar, we provide a comprehensive review that integrates clinical manifestations, molecular pathogenesis, diagnostic strategy, and therapeutic developments.
Patrono C.,Catholic University
Journal of the American College of Cardiology | Year: 2015
Inactivation of platelet cyclooxygenase (COX)-1 by low-dose aspirin leads to long-lasting suppression of thromboxane (TX) A2 production and TXA2-mediated platelet activation and aggregation. This effect is necessary and sufficient to explain aspirin's unique (among other COX-1 inhibitors) effectiveness in preventing atherothrombosis, as well as its shared (with other antiplatelet agents) bleeding liability. However, different mechanisms of action have been suggested to explain other beneficial effects of aspirin, such as prevention of venous thromboembolism, chemoprevention of colorectal (and other) cancers, and reduced risk of dementia. These mechanisms include acetylation of other proteins in blood coagulation, inhibition of COX-2 activity, and other COX-independent mechanisms. The intent of this review is to develop the concept that the multifaceted therapeutic effects of low-dose aspirin may reflect pleiotropic consequences of platelet inhibition on pathophysiological tissue repair processes. Furthermore, the clinical implications of this concept will be discussed in terms of current clinical practice and future research. © 2015 American College of Cardiology Foundation.
Evoli A.,Catholic University
Current Opinion in Neurology | Year: 2010
Purpose of review: This review discusses recent studies on myasthenia gravis with onset in childhood (juvenile myasthenia gravis) and neonatal myasthenia gravis. Recent findings: The occurrence of myasthenia gravis in childhood is strongly influenced by genetic and environmental factors. Juvenile myasthenia gravis is associated with antibodies to the acetylcholine receptor (AChR) in most patients. Thymoma is rare, but often malignant in children. The frequency of juvenile myasthenia gravis with antibodies to the muscle-specific kinase (MuSK) varies markedly in different countries; some distinct features have been described. Management of juvenile myasthenia gravis does not differ, on the whole, from that of adult myasthenia gravis. Timing of thymectomy in young children is still controversial.Maternal antifetal type AChR antibodies can cause persistent focal weakness in the offspring, while neonatal myasthenia gravis associated with MuSK antibodies is often a severe and protracted albeit transient disease. Summary: Juvenile myasthenia gravis, like its adult-onset counterpart, is a heterogeneous disease. Clinical presentation is influenced by antibody status, ethnicity and age of onset. Treatment is very effective, but guidelines and controlled trials are needed.The risk for neonatal myasthenia gravis appears to be markedly influenced by maternal antibody subclass and antigen specificity. Adequate treatment in mothers can reduce both frequency and severity of neonatal disease. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Scatena R.,Catholic University
Advances in Experimental Medicine and Biology | Year: 2012
At the beginning of the twentieth century, Otto Warburg demonstrated that cancer cells have a peculiar metabolism. These cells preferentially utilise glycolysis for energetic and anabolic purposes, producing large quantities of lactic acid. He defined this unusual metabolism "aerobic glycolysis". At the same time, Warburg hypothesised that a disruption of mitochondrial activities played a precise pathogenic role in cancer. Because of this so-called "Warburg effect", mitochondrial physiology and cellular respiration in particular have been overlooked in pathophysiological studies of cancer. Over time, however, many studies have shown that mitochondria play a fundamental role in cell death by apoptosis or necrosis. Moreover, metabolic enzymes of the Krebs cycle have also recently been recognised as oncosuppressors. Recently, a series of studies were undertaken to re-evaluate the role of oxidative mitochondrial metabolism in cancer cell growth and progression. Some of these data indicate that modulation of mitochondrial respiration may induce an arrest of cancer cell proliferation and differentiation (pseudodifferentiation) and/or or death, suggesting that iatrogenic manipulation of some mitochondrial activities may induce anticancer effects. Moreover, studying the role of mitochondria in cancer cell dedifferentiation/differentiation processes may allow further insight into the pathophysiology and therapy of so-called cancer stem cells. © 2012 Springer Science+Business Media B.V.
Crea F.,Catholic University |
Liuzzo G.,Catholic University
Journal of the American College of Cardiology | Year: 2013
Experimental models of atherogenesis have provided a growing body of information about molecular mechanisms of plaque growth; however, transition from coronary stability to instability is less well understood due to the lack of animal models reflective of human disease. The abrupt clinical presentation of acute coronary syndromes gives a strong signal of discontinuity in the natural history of atherothrombosis. The causes of such discontinuity are complex, probably multiple, and still largely unknown. A better knowledge of the causes of coronary instability might allow identification of new therapeutic targets aimed at the preservation of plaque stability in those subjects in whom primary prevention fails to prevent plaque growth. The goal of this review was to propose a pathogenetic classification of acute coronary syndromes that might help in the search of new diagnostic algorithms and therapeutic targets. © 2013 American College of Cardiology Foundation.
Iorio R.,Catholic University |
Lennon V.A.,Mayo Medical School
Immunological Reviews | Year: 2012
Neural-specific autoantibodies have been documented and their diagnostic utility validated in diseases affecting the neuraxis from cerebral cortex to the somatic, autonomic, and enteric nervous system and skeletal muscle. These neurological disorders occur both idiopathically and in a paraneoplastic context. Molecular identification of the antigens has expedited development of confirmatory and high-throughput tests for serum and cerebrospinal fluid, which permit early diagnosis and reveal the underlying molecular pathogenic mechanisms. The autoantibodies are classifiable on the basis of antigen location: intracellular (nuclear or cytoplasmic) or plasma membrane. Immunohistopathological studies of patients' biopsied and autopsied tissues suggest that effector T cells mediate the autoimmune neurological disorders for which defining autoantibodies recognize intracellular antigens. Antigens within intact cells are inaccessible to circulating antibody, and the associated neurological deficits rarely improve with antibody-depleting therapies. Tumoricidal therapies may arrest neurological progression, but symptom reversal is rare. In contrast, autoantibodies specific for plasma membrane antigens have pathogenic potential, and the associated neurological deficits are often amenable to antibody-depleting immunotherapy, such as plasma exchange and anti-B-cell monoclonal antibody therapy. These reversible neurological disorders are frequently misdiagnosed as neurodegenerative. The focus of this review is the immunobiology, pathophysiology, and clinical spectrum of autoimmune neurological disorders accompanied by neural-specific IgGs. © 2012 John Wiley & Sons A/S.