Entity

Time filter

Source Type

Pergamino, Argentina

Santalla M.,Catedra de Genetica Molecular | Fesser E.,Catedra de Genetica Molecular | Asad A.S.,Catedra de Genetica Molecular | Acosta D.,Catedra de Genetica Molecular | And 3 more authors.
Archivos de Medicina | Year: 2013

Gene therapy is a treatment that offers an alternative to pharmacological, surgical and conventional approaches that is being developed at an experimental and clinical level. In this review, apart from mentioning advances and presenting an overview of the subject in the biomedical field, our intention is to extend the concept of DNA. DNA is the store of information for protein synthesis and today it is also "a drug". It is expected for the DNA embedded in vectors or directly applied to tissue to perform the function that the defective gene cannot perform by means of its replacement, or to prevent that gene from remaining active through mechanisms of interference. This is not only aimed at the treatment of patients of different ages but also unborn children, as it has been proved by several experimental approaches of intrauterine gene therapy. Currently there are several commercially available products that have emerged from the context of gene therapy. Once those aspects that still represent important risk factors are overcome, ethical agreements are reached and the costs of the interventions are leveled out, this type of treatment will constitute an alternative to conventional methods to treat certain diseases. DNA (and RNA) are proposed as the future drugs for the following decades. © iMedPub.


Santalla M.,Catedra de Genetica Molecular | Fesser E.,Catedra de Genetica Molecular | Asad A.S.,Catedra de Genetica Molecular | Acosta D.,Catedra de Genetica Molecular | And 3 more authors.
Archivos de Medicina | Year: 2013

Gene therapy is a treatment that offers an alternative to pharmacological, surgical and conventional approaches that is being developed at an experimental and clinical level. In this review, apart from mentioning advances and presenting an overview of the subject in the biomedical field, our intention is to extend the concept of DNA. DNA is the store of information for protein synthesis and today it is also "a drug". It is expected for the DNA embedded in vectors or directly applied to tissue to perform the function that the defective gene cannot perform by means of its replacement, or to prevent that gene from remaining active through mechanisms of interference. This is not only aimed at the treatment of patients of different ages but also unborn children, as it has been proved by several experimental approaches of intrauterine gene therapy. Currently there are several commercially available products that have emerged from the context of gene therapy. Once those aspects that still represent important risk factors are overcome, ethical agreements are reached and the costs of the interventions are leveled out, this type of treatment will constitute an alternative to conventional methods to treat certain diseases. DNA (and RNA) are proposed as the future drugs for the following decades. © iMedPub.

Discover hidden collaborations