Catedra de Fisiologia Humana

Santa Fe de la Vera Cruz, Argentina

Catedra de Fisiologia Humana

Santa Fe de la Vera Cruz, Argentina
SEARCH FILTERS
Time filter
Source Type

Orihuela D.,Catedra de Fisiologia Humana
Journal of Inorganic Biochemistry | Year: 2011

The effects of aluminium (Al) on thyroid function were evaluated in adult Wistar rats intraperitoneally (i.p) injected with 7 mg Al (as lactate)/kg body weight (b.w) per day during a six week period. The time-course kinetics of Na 125I (3 μCi per 100 g b.w, i.p) was analysed by measuring gamma-radioactivity of thyroid, serum, serum protein precipitate and bile, at times ranging from 2 to 96 h post-dosing. In Al-treated group the 125I - thyroid uptake at 24 h (15,840 ± 570 vs. 18,030 ± 630 dpm/mg, P < 0.05) as well as the rate of 125I - release from the gland, calculated as the slope of the plot between 24 and 96 h (84 ± 8 vs. 129 ± 11 dpm/mg/h, P < 0.05) were significantly reduced as compared to control. The biliary 125I - excretion was not modified at all studied times. The Al content and lipid peroxidation (69.1 ± 8.5 vs. 53.2 ± 7.0 nmol MDA/g wet weight, P < 0.05) of thyroid tissue were increased in Al-treated rats. The serum concentrations of total thyroxine (T4, 3.78 ± 0.14 vs. 4.68 ± 0.12 μg/dL, P < 0.05) and total triiodothyronine (T3, 47 ± 4 vs. 66 ± 5 ng/dL, P < 0.05) were decreased by effect of Al, but free-T4 (1.05 ± 0.05 vs. 1.04 ± 0.04 ng/dL, NS) and thyrotropin (TSH, 2.7 ± 0.4 vs. 2.6 ± 0.5 ng/ml, NS) remain unchanged. In spite of the Al could indirectly affect thyroid iodide uptake and hormones secretion by a mechanism involving the induction of an oxidative stress state, however, these changes could be managed by the hypothalamus-pituitary- thyroid endocrine axis. We can conclude that in adult rats the Al would not act as a thyroid disruptor. © 2011 Elsevier Inc.

Loading Catedra de Fisiologia Humana collaborators
Loading Catedra de Fisiologia Humana collaborators