Solihull, United Kingdom
Solihull, United Kingdom
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Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-15-2015 | Award Amount: 6.83M | Year: 2016

CLINICAL PROBLEM AND UNMET NEED There are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic tracheal scaffolds seeded with patients own stem cells. Preliminary data show that these scaffolds are poorly integrated and are susceptible to infection. TETRA PROJECT Our SME-led project will address the limitations of standard clinical care and competitor products under development and will: - Build on our successful compassionate use experience using autologous stem cell seeded scaffold-tracheal transplants in 48 patients - Follow on from our Phase I 4 patient INSPIRE clinical trial which will improve on the clinical prototype used in compassionate use cases - Conduct a 48 patient Phase II pivotal clinical trial to provide robust, quality data with validated GMP manufacturing processes to support an accelerated route to market for commercial exploitation in this orphan indication - Prepare a dossier for MAA submission BENEFITS Our product, an ATMP, aims to eliminate the need for repeated surgical interventions of high risk and limited efficacy, reduce deaths and improve the quality of life for surviving patients. If treating 20% of the patients with severe structural airway disease, we estimate that in Europe our technology will improve the quality and length of patient lives and result in savings of 517 million per year. We plan to further develop our platform technology to generate other complex tissues/organs such as bowel and liver replacements for clinical applications which will impact the lives of tens of thousands of patient in the EU with bowel and liver diseases.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: IoT-02-2016 | Award Amount: 3.53M | Year: 2017

CREATE-IoTs aim is to stimulate collaboration between IoT initiatives, foster the take up of IoT in Europe and support the development and growth of IoT ecosystems based on open technologies and platforms. This requires synchronisation and alignment on strategic and operational terms through frequent, multi-directional exchanges between the various activities under the IoT Focus Areas (FAs). It also requires cross fertilisation of the various IoT Large Scale Pilots (LSPs) for technological and validation issues of common interest across the various application domains and use cases. CREATE-IoT will align the activities with the Alliance for Internet of Things Innovation (AIOTI) and will coordinate and support the upcoming LSPs in sustaining the ecosystems developed during those projects through mapping the pilot architecture approaches, address interoperability and standards approaches at technical and semantic levels for object connectivity, protocols, data formats, privacy, security, trusted IoT, open APIs and share the road-mapping with international initiatives. The project will foster the exchange on requirements for legal accompanying measures, development of common methodologies and KPI for design, testing and validation and for success and impact measurement, federation of pilot activities and transfer to other pilot areas, facilitating the access for IoT entrepreneurs/API developers/makers, SMEs, including combination of ICT & Art. CREATE-IoT will build strong connections with Member States initiatives and other initiatives and will transfer learning points to the broader IoT policy framework that include contractual PPPs (e.g. Big Data, Factories of the Future, 5G-infrastructure), Joint Technology Initiatives (e.g. ECSEL), European Innovation Partnerships (e.g. on Smart Cities) as well as other FAs (e.g. on Autonomous transport). It will also maintain a coordinated working relationship with the parallel CSA that is centere on RRI-SSH.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-16-2015 | Award Amount: 6.00M | Year: 2016

AUTOSTEM will develop closed, scaleable and automated systems for therapeutic cell manufacture. The project vision is a donor-to-patient system where all aspects of processing, from tissue harvest to patient delivery are fully closed and aseptic. The process will involve new methods of biological cell selection from marrow, fat or other tissues, bioreactors to achieve scale and media formulations that are fully xeno-free. Process monitoring will utilise remote sensing and the automated retrieval of cells for microscopy, flow cytometry, karyotyping, differentiation or other tests. The final product will be a cryobag containing a specified cell dose, ready for thawing and clinical delivery. AUTOSTEM will be the factory of the future for therapeutic cell manufacturing. This system could ultimately be scaled for hospital-based use to produce autologous cells or at industrial scale for allogeneic therapy. It will achieve consistent cell production, minimise contamination, maximise scale and reduce cost of goods, thus enabling routine clinical use of cell therapies. The consortium will be a partnership of academic centres and industry with expertise across the disciplines relevant to the research and development goals. It will also include expertise in GMP and regulatory compliance and in healthcare economic analysis.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: IoT-01-2016 | Award Amount: 20.05M | Year: 2017

SynchroniCity represents the first attempt to deliver a Single Digital City Market for Europe by piloting its foundations at scale in 11 reference zones - 8 European cities & 3 more worldwide cities - connecting 34 partners from 11 countries over 4 continents. Building upon a mature European knowledge base derived from initiatives such as OASC, FIWARE, FIRE, EIP-SCC, and including partners with leading roles in standardization bodies, e.g. ITU, ETSI, IEEE, OMA, IETF, SynchroniCity will deliver a harmonized ecosystem for IoT-enabled smart city solutions where IoT device manufacturers, system integrators and solution providers can innovate and openly compete. With an already emerging foundation, SynchroniCity will establish a reference architecture for the envisioned IoT-enabled city market place with identified interoperability points and interfaces and data models for different verticals. This will include tools for co-creation & integration of legacy platforms & IoT devices for urban services and enablers for data discovery, access and licensing lowering the barriers for participation on the market. SynchroniCity will pilot these foundations in the reference zones together with a set of citizen-centred services in three high-impact areas, showing the value to cities, businesses and citizens involved, linked directly to the global market. With a running start, SynchroniCity will serve as lighthouse initiative to inspire others to join the established ecosystem and contribute to the emerging market place. SynchroniCity takes an inclusive approach to grow the ecosystem by inviting businesses and cities to join through an open call, allowing them to participate on the pioneering market place enabling a second wave of successful pilots. They will strengthen the ecosystem by creating a positive ripple effect throughout Europe, and globally, to establish a momentum and critical mass for a strong European presence in a global digital single market of IoT-enabled solutions.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: SCC-01-2015 | Award Amount: 28.05M | Year: 2016

Sharing Cities has four key objectives. 1) To achieve scale in the European smart cities market by proving that properly designed smart city solutions, based around common needs, can be integrated in complex urban environments. This will be done in a way that exhibits their true potential and allows for the significant scale-up and consequent increase in social, economic and environmental value. 2) Adopt a digital first approach which proves the extent to which ICT integration can improve and connect up existing infrastructure, as well as the design and running of new city infrastructure. This will also allow for the creation of a new set of next stage digital services which will help citizens make better and beneficial choices around energy efficiency and mobility, which when scaled up will enhance the citys ability to hit key targets for mobility, housing, energy efficiency and resilience, and economic development. 3) Accelerate the market to understand, develop and trial business, investment and governance models, essential for the true aggregation and replication (through collaboration) of smart city solutions in cities of different sizes and maturities. In doing this, we intend to accelerate the pace by which we make transformative improvements, and enhance sustainability in communities. 4) Share and collaborate for society: to respond to increasing demand for participation; to enhance mechanisms for citizens engagement; to improve local governments capacity for policy making and service delivery through collaboration and co-design; resulting in outcomes that are better for citizens, businesses and visitors. These will be delivered by a range of expert partners across 8 work packages.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: DS-01-2016 | Award Amount: 999.99K | Year: 2017

TRUESSEC.EU is a CSA on certification and labelling of trustworthiness properties from a multidisciplinary SSH-ICT perspective and with emphasis on human rights. The current complexity of ICT products and services makes it difficult to appraise their trustworthiness. Thus, certification becomes a must to restore transparency and trust. TRUESSEC.EU aims at exploring the situation, the barriers, and the benefits of security and privacy labels; engaging stakeholders in the discussions, and issuing recommendations that may foster the adoption and acceptance of labels. With that aim, TRUESSEC.EU works and results are sustained by three pillars: 1) A StakeHolders Online Platform (SHOP), where associated cluster projects and stakeholders from industry, academia, governments and civil society will gather, participate in debates, get informed, and provide their opinions and feedback on the topics of the project. 2) A series of Support Analysis and Studies (SUPPA) from multidisciplinary perspectives on issues of trustworthiness certification and assurance, to study the situation of trust-enhancing labels, barriers/incentives to industry adoption and consumer acceptance. Information will be gathered from both public sources and the interactions with stakeholders through SHOP. Four different approaches will be applied: -Socio-cultural -Legal & ethical -Technological -Business 3) A set of Recommendations on European Trust-Enhancing Labels (ETEL) dealing with: methodological aspects of certification and assurance, a catalogue of criteria for labels and certifications, and regulatory aspects to foster their adoption, plus a strategic agenda. These recommendations reflect the conclusions obtained from the support analysis and from the stakeholders. The community of stakeholders will nourish, among others, from: (a) members of the consortium partners that are stakeholder networks themselves (DIGICAT, APWG, KTN, AUI), and (b) H2020 RIAs & IAs from the associated cluster.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: FTIPilot-01-2016 | Award Amount: 2.70M | Year: 2017

It is crucial to reduce rail operational costs as well as increasing the reliability of service especially in terms of punctuality. Train doors prove to be a critical element with respect to both maintenance cost and cause of train delays. Door actuator defects are the most common found; especially in older trains where door malfunctions amount to 25%-50% of the rolling stock defects. To overcome this, a consortium led by German SME Hitex, have come together with the aim to rapidly seize the business opportunity presented by commercializing the VA-RCM system. VA-RCM is a highly innovative condition monitoring system based on cutting-edge technology involving advanced vibration analysis techniques. Its unique features will enable accurate assessment of train door actuators as well as targeted feedback on subsystem malfunctions well in advance of their potential occurrence. Train operators and passenger train car manufacturers will benefit from the VA-RCM system by improving the efficiency of train doors and reducing the failure rate or downtime of trains, thus reducing maintenance cost. The consortiums vision is to achieve gross sales of 140 million by 2025; a ROI of 60.68 within the first 4 years of commercialisation; and business growth which will create 1298 new jobs. It is our strong belief that the Fast Track to Innovation Pilot is the ideal financial instrument for us to accelerate the commercialization of VA-RCM.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Centre | Award Amount: 72.91M | Year: 2016

Awaiting Public Project Summary


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Centre | Award Amount: 65.26M | Year: 2015

Awaiting Public Project Summary


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Centre | Award Amount: 7.00M | Year: 2016

Awaiting Public Project Summary

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