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Ramesh S.,Catalysis and Peptide Research Unit | Cherkupally P.,Catalysis and Peptide Research Unit | Govender T.,Catalysis and Peptide Research Unit | Kruger H.G.,Catalysis and Peptide Research Unit | And 6 more authors.
Organic Letters | Year: 2015

We report on a novel and user-friendly platform based on a bromomaleimide moiety to obtain branched peptides. The platform is stable for all SPPS conditions. The bromomaleimide core was conjugated to n-copies of thiol-peptide in-solution to obtain two/four/eight-armed dendrimers. Using 2n number of bromomaleimide analogues, 2n ligands were incorporated at both bromo and ene positions via a thioether bond. This method has the advantage of high conversion in a short time, thus enabling effortless purification and characterization processes. © 2015 American Chemical Society.

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