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Cleveland, OH, United States

Case Western Reserve University is a private research university in Cleveland, Ohio. The university was created in 1967 by the federation of Case Institute of Technology and Western Reserve University . TIME magazine described the merger as the creation of "Cleveland's Big-Leaguer" university.In U.S. News & World Report's 2013 rankings, Case Western Reserve's undergraduate program ranked 37th among national universities. The University is associated with 16 Nobel laureates. Other notable alumni include Paul Buchheit, creator and lead developer of Gmail; Craig Newmark, founder of craigslist.org; and Peter Tippett, who developed the anti-virus software Vaccine, which Symantec purchased and turned into the popular Norton AntiVirus. Case Western Reserve is particularly well known for its medical school, business school, dental school, law school, Frances Payne Bolton School of Nursing , Department of Biomedical Engineering and its biomedical teaching and research capabilities. Case Western is a member of the Association of American Universities.The university is approximately five miles east of downtown Cleveland in University Circle. It is contained within a 550-acre area containing numerous educational, medical, and cultural institutions. Case Western Reserve has a number of programs taught in conjunction with nearby institutions, including the Cleveland Clinic, the University Hospitals of Cleveland, the Louis Stokes Cleveland Department of Veteran's Affairs Medical Center, Cleveland Institute of Music, the Cleveland Hearing & Speech Center, the Cleveland Museum of Art, the Cleveland Museum of Natural History, and the Cleveland Play House.Case Western Reserve was the site of the famous Michelson-Morley interferometer experiment, conducted in 1887 by Albert A. Michelson of Case School of Applied Science and Edward W. Morley of Western Reserve University. This experiment proved the non-existence of the luminiferous ether and was later cited as convincing evidence in support of special relativity as proposed by Albert Einstein in 1905. Michelson became the first American to win a Nobel Prize in science. The commemorative Michelson-Morley Memorial Fountain is located on campus, near where the actual experiment was performed. Wikipedia.

Ismail-Beigi F.,Case Western Reserve University
New England Journal of Medicine

A 39-year-old man with a 2-year history of type 2 diabetes mellitus presents for care. He has no microvascular or macrovascular complications. His family history is positive for type 2 diabetes and cardiovascular disease in his mother and older brother. On examination, his weight is 99.8 kg (220 lb), with a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 37, and his blood pressure is 125/85 mm Hg. His glycated hemoglobin level is 8.9%, serum creatinine level 1.0 mg per deciliter (88.4 μmol per liter), low-density lipoprotein (LDL) cholesterol 88 mg per deciliter (2.3 mmol per liter), high-density lipoprotein (HDL) cholesterol 45 mg per deciliter (1.2 mmol per liter), and triglyceride level 130 mg per deciliter (1.5 mmol per liter); he does not have microalbuminuria. His medications include metformin (500 mg twice daily), glipizide (5 mg twice daily), simvastatin (20 mg daily), and lisinopril (10 mg daily). What would you recommend to improve his glycemic control? Copyright © 2012 Massachusetts Medical Society. Source

Jankowsky E.,Case Western Reserve University
Trends in Biochemical Sciences

RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all aspects of RNA metabolism. These proteins bind or remodel RNA or RNA-protein complexes in an ATP-dependent fashion. How RNA helicases physically perform their cellular tasks has been a longstanding question, but in recent years, intriguing models have started to link structure, mechanism and biological function for some RNA helicases. This review outlines our current view on major structural and mechanistic themes of RNA helicase function, and on emerging physical models for cellular roles of these enzymes. © 2010 Elsevier Ltd. Source

Nilsen T.W.,Case Western Reserve University

Methylation of internal adenosine residues in messenger RNA (mRNA) modulates mRNA metabolism in both the nucleus and cytoplasm. Source

Case Western Reserve University | Date: 2015-05-22

A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20) can be added to the solution until the volume ratio of PBS buffer (20) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure.

Case Western Reserve University | Date: 2015-08-17

This disclosure relates generally to printed circuit board authentication, such as for protecting printed circuit boards against counterfeiting. The authentication can be implemented based on measurements from the PCB used to generate a unique signature for the PCB. The generated signature of the PCB can be evaluated to determine if the PCB is authentic or counterfeit.

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