Case Western Reserve University is a private research university in Cleveland, Ohio. The university was created in 1967 by the federation of Case Institute of Technology and Western Reserve University . TIME magazine described the merger as the creation of "Cleveland's Big-Leaguer" university.In U.S. News & World Report's 2013 rankings, Case Western Reserve's undergraduate program ranked 37th among national universities. The University is associated with 16 Nobel laureates. Other notable alumni include Paul Buchheit, creator and lead developer of Gmail; Craig Newmark, founder of craigslist.org; and Peter Tippett, who developed the anti-virus software Vaccine, which Symantec purchased and turned into the popular Norton AntiVirus. Case Western Reserve is particularly well known for its medical school, business school, dental school, law school, Frances Payne Bolton School of Nursing , Department of Biomedical Engineering and its biomedical teaching and research capabilities. Case Western is a member of the Association of American Universities.The university is approximately five miles east of downtown Cleveland in University Circle. It is contained within a 550-acre area containing numerous educational, medical, and cultural institutions. Case Western Reserve has a number of programs taught in conjunction with nearby institutions, including the Cleveland Clinic, the University Hospitals of Cleveland, the Louis Stokes Cleveland Department of Veteran's Affairs Medical Center, Cleveland Institute of Music, the Cleveland Hearing & Speech Center, the Cleveland Museum of Art, the Cleveland Museum of Natural History, and the Cleveland Play House.Case Western Reserve was the site of the famous Michelson-Morley interferometer experiment, conducted in 1887 by Albert A. Michelson of Case School of Applied Science and Edward W. Morley of Western Reserve University. This experiment proved the non-existence of the luminiferous ether and was later cited as convincing evidence in support of special relativity as proposed by Albert Einstein in 1905. Michelson became the first American to win a Nobel Prize in science. The commemorative Michelson-Morley Memorial Fountain is located on campus, near where the actual experiment was performed. Wikipedia.
Case Western Reserve University | Date: 2016-02-29
A system for detecting tumor margins includes a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, means for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell.
Case Western Reserve University | Date: 2016-11-21
A method treating cancer in a subject comprises administering to the subject a therapeutically effective amount of an antimetabolite agent that induces formation of AP sites in cancer cells of the subjects and an amount AP endonuclease inhibitor effective to potentiate the cytotoxicity of the antimetabolite agent to the cancer cells.
Case Western Reserve University | Date: 2016-08-02
A method of treating a T-cell mediated disorders in a tissue includes administering to the tissue of the subject a therapeutically effective amount of a complement antagonist that substantially reduces T-cell differentiation or t-cell inflammatory cytokine generation.
Case Western Reserve University | Date: 2016-09-06
A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one -lactam antibiotic and at least one triazolylmethyl boronic acid.
Case Western Reserve University | Date: 2016-08-02
Methods, apparatus, and other embodiments associated with classifying a region of tissue using quantified vessel tortuosity are described. One example apparatus includes an image acquisition logic that acquires an image of a region of tissue demonstrating cancerous pathology, a delineation logic that distinguishes nodule tissue within the image from the background of the image, a perinodular zone logic that defines a perinodular zone based on the nodule, a feature extraction logic that extracts a set of features from the image including a set of tortuosity features, a probability logic that computes a probability that the nodule is benign, and a classification logic that classifies the nodule tissue based, at least in part, on the set of features or the probability. A prognosis or treatment plan may be provided based on the classification of the image.
Case Western Reserve University and University of Oregon | Date: 2016-09-06
A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP.
MTD Products Inc. and Case Western Reserve University | Date: 2017-01-18
This invention provides a method for identifying lawn grass comprising capturing an image of the terrain in front of a mower, segmenting the image into neighborhoods, calculating at least two image statistics for each of the neighborhoods, generating a binary representation of each image statistic. The binary representation of each image statistic is generated by comparing the calculated image statistic values to predetermined image statistic values for grass. The method further comprises weighting each of the binary representations of each image statistic, and summing corresponding neighborhoods for all image statistics. A binary threshold is applied to each of the summed neighborhoods to generate a binary map representing grass containing areas and non-grass containing areas.
Ismail-Beigi F.,Case Western Reserve University
New England Journal of Medicine | Year: 2012
A 39-year-old man with a 2-year history of type 2 diabetes mellitus presents for care. He has no microvascular or macrovascular complications. His family history is positive for type 2 diabetes and cardiovascular disease in his mother and older brother. On examination, his weight is 99.8 kg (220 lb), with a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 37, and his blood pressure is 125/85 mm Hg. His glycated hemoglobin level is 8.9%, serum creatinine level 1.0 mg per deciliter (88.4 μmol per liter), low-density lipoprotein (LDL) cholesterol 88 mg per deciliter (2.3 mmol per liter), high-density lipoprotein (HDL) cholesterol 45 mg per deciliter (1.2 mmol per liter), and triglyceride level 130 mg per deciliter (1.5 mmol per liter); he does not have microalbuminuria. His medications include metformin (500 mg twice daily), glipizide (5 mg twice daily), simvastatin (20 mg daily), and lisinopril (10 mg daily). What would you recommend to improve his glycemic control? Copyright © 2012 Massachusetts Medical Society.
Jankowsky E.,Case Western Reserve University
Trends in Biochemical Sciences | Year: 2011
RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all aspects of RNA metabolism. These proteins bind or remodel RNA or RNA-protein complexes in an ATP-dependent fashion. How RNA helicases physically perform their cellular tasks has been a longstanding question, but in recent years, intriguing models have started to link structure, mechanism and biological function for some RNA helicases. This review outlines our current view on major structural and mechanistic themes of RNA helicase function, and on emerging physical models for cellular roles of these enzymes. © 2010 Elsevier Ltd.
Dai L.,Case Western Reserve University
Accounts of Chemical Research | Year: 2013
As global energy consumption accelerates at an alarming rate, the develop- ment of clean and renewable energy conversion and storage systems has become more important than ever. Although the efficiency of energy conversion and storage devices depends on a variety of factors, their overall performance strongly relies on the structure and properties of the component materials. Nanotechnology has opened up new frontiers in materials science and engineering to meet this challenge by creating new materials, particularly carbon nanomaterials, for efficient energy conversion and storage.As a building block for carbon materials of all other dimensionalities (such as 0D buckyball, 1D nanotube, 3D graphite), the two-dimensional (2D) single atomic carbon sheet of graphene has emerged as an attractive candidate for energy applications due to its unique structure and properties. Like other materials, however, a graphene-based material that possesses desirable bulk properties rarely features the surface characteristics required for certain specific applications. Therefore, surface functionalization is essential, and researchers have devised various covalent and noncovalent chemistries for making graphene materials with the bulk and surface properties needed for efficient energy conversion and storage.In this Account, I summarize some of our new ideas and strategies for the controlled functionalization of graphene for the development of efficient energy conversion and storage devices, such as solar cells, fuel cells, supercapacitors, and batteries. The dangling bonds at the edge of graphene can be used for the covalent attachment of various chemical moieties while the graphene basal plane can be modified via either covalent or noncovalent functionalization. The asymmetric functionalization of the two opposite surfaces of individual graphene sheets with different moieties can lead to the self-assembly of graphene sheets into hierarchically structured materials. Judicious application of these site-selective reactions to graphene sheets has opened up a rich field of graphene-based energy materials with enhanced performance in energy conversion and storage.These results reveal the versatility of surface functionalization for making sophisticated graphene materials for energy applications. Even though many covalent and noncovalent functionalization methods have already been reported, vast opportunities remain for developing novel graphene materials for highly efficient energy conversion and storage systems. © 2012 American Chemical Society.