Case Western Reserve University is a private research university in Cleveland, Ohio. The university was created in 1967 by the federation of Case Institute of Technology and Western Reserve University . TIME magazine described the merger as the creation of "Cleveland's Big-Leaguer" university.In U.S. News & World Report's 2013 rankings, Case Western Reserve's undergraduate program ranked 37th among national universities. The University is associated with 16 Nobel laureates. Other notable alumni include Paul Buchheit, creator and lead developer of Gmail; Craig Newmark, founder of craigslist.org; and Peter Tippett, who developed the anti-virus software Vaccine, which Symantec purchased and turned into the popular Norton AntiVirus. Case Western Reserve is particularly well known for its medical school, business school, dental school, law school, Frances Payne Bolton School of Nursing , Department of Biomedical Engineering and its biomedical teaching and research capabilities. Case Western is a member of the Association of American Universities.The university is approximately five miles east of downtown Cleveland in University Circle. It is contained within a 550-acre area containing numerous educational, medical, and cultural institutions. Case Western Reserve has a number of programs taught in conjunction with nearby institutions, including the Cleveland Clinic, the University Hospitals of Cleveland, the Louis Stokes Cleveland Department of Veteran's Affairs Medical Center, Cleveland Institute of Music, the Cleveland Hearing & Speech Center, the Cleveland Museum of Art, the Cleveland Museum of Natural History, and the Cleveland Play House.Case Western Reserve was the site of the famous Michelson-Morley interferometer experiment, conducted in 1887 by Albert A. Michelson of Case School of Applied Science and Edward W. Morley of Western Reserve University. This experiment proved the non-existence of the luminiferous ether and was later cited as convincing evidence in support of special relativity as proposed by Albert Einstein in 1905. Michelson became the first American to win a Nobel Prize in science. The commemorative Michelson-Morley Memorial Fountain is located on campus, near where the actual experiment was performed. Wikipedia.
MTD Products Inc. and Case Western Reserve University | Date: 2017-01-18
This invention provides a method for identifying lawn grass comprising capturing an image of the terrain in front of a mower, segmenting the image into neighborhoods, calculating at least two image statistics for each of the neighborhoods, generating a binary representation of each image statistic. The binary representation of each image statistic is generated by comparing the calculated image statistic values to predetermined image statistic values for grass. The method further comprises weighting each of the binary representations of each image statistic, and summing corresponding neighborhoods for all image statistics. A binary threshold is applied to each of the summed neighborhoods to generate a binary map representing grass containing areas and non-grass containing areas.
Case Western Reserve University and Worcester Polytechnic Institute | Date: 2017-01-11
A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate.
Case Western Reserve University | Date: 2017-04-12
A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive aldehydes and/or inhibit diabetes-induced superoxide generation and capillary degeneration regulated by GPCR signaling pathways.
Case Western Reserve University | Date: 2017-04-05
A sensor for the detection of an analyte in a biological sample includes a substrate, a working electrode and counter electrode formed on a surface of the substrate, and a receptor functionalized or chemically functionalized to a surface of an exposed portion of the working electrode. The receptor can selectively bind to the analyte of interest and the analyte once bound is detectable by measuring the current flow between the working electrode and counter electrode.
Case Western Reserve University | Date: 2017-03-29
One aspect of the present disclosure relates to an analyte sensor device. The analyte sensor device can include an optode layer that undergoes an optical change in the presence of an analyte. The analyte sensor device can also include a selectively-permeable membrane encapsulating the optode layer to form a stable membrane that that minimizes fouling of the analyte sensor device. The analyte sensor device can also include a plurality of microparticles that suppress a background physical interference on a detection of the optical change of the optode layer.
Case Western Reserve University | Date: 2017-02-06
A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a HIGH magnetic state position and a LOW magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the LOW magnetic state position.
Case Western Reserve University | Date: 2017-06-14
A compound includes at least one targeting peptide coupled to a detectable moiety. The targeting peptide binds to EDB-FN or EDA-FN and includes at least one of amino acid sequence selected from the group consisting of SEQ ID NOs: 1-30.
Case Western Reserve University and Swagelok Company | Date: 2017-06-07
A workpiece made from a self passivating metal and having one or more surface regions defining a Beilby layer as a result of a previous metal shaping operation is activated for subsequent low temperature gas hardening by exposing the workpiece to the vapors produced by heating an oxygen-free nitrogen halide salt.
Case Western Reserve University | Date: 2017-03-15
Systems and methods are provided for controlling an entity in response to activity in a peripheral nerve comprising a plurality of fascicles. A multicontact electrode assembly is configured to record activity from the peripheral nerve. A processing component includes a sensor mapping component configured to quantify activity associated with a proper subset of the plurality of fascicles, an evaluation component configured to determine an adjustment of the status of the controlled entity from the quantified activity of the proper subset of the plurality of fascicles, and a controller configured to provide a control signal, representing the adjustment of the status of the controlled entity, to the controlled entity.
Dai L.,Case Western Reserve University
Accounts of Chemical Research | Year: 2013
As global energy consumption accelerates at an alarming rate, the develop- ment of clean and renewable energy conversion and storage systems has become more important than ever. Although the efficiency of energy conversion and storage devices depends on a variety of factors, their overall performance strongly relies on the structure and properties of the component materials. Nanotechnology has opened up new frontiers in materials science and engineering to meet this challenge by creating new materials, particularly carbon nanomaterials, for efficient energy conversion and storage.As a building block for carbon materials of all other dimensionalities (such as 0D buckyball, 1D nanotube, 3D graphite), the two-dimensional (2D) single atomic carbon sheet of graphene has emerged as an attractive candidate for energy applications due to its unique structure and properties. Like other materials, however, a graphene-based material that possesses desirable bulk properties rarely features the surface characteristics required for certain specific applications. Therefore, surface functionalization is essential, and researchers have devised various covalent and noncovalent chemistries for making graphene materials with the bulk and surface properties needed for efficient energy conversion and storage.In this Account, I summarize some of our new ideas and strategies for the controlled functionalization of graphene for the development of efficient energy conversion and storage devices, such as solar cells, fuel cells, supercapacitors, and batteries. The dangling bonds at the edge of graphene can be used for the covalent attachment of various chemical moieties while the graphene basal plane can be modified via either covalent or noncovalent functionalization. The asymmetric functionalization of the two opposite surfaces of individual graphene sheets with different moieties can lead to the self-assembly of graphene sheets into hierarchically structured materials. Judicious application of these site-selective reactions to graphene sheets has opened up a rich field of graphene-based energy materials with enhanced performance in energy conversion and storage.These results reveal the versatility of surface functionalization for making sophisticated graphene materials for energy applications. Even though many covalent and noncovalent functionalization methods have already been reported, vast opportunities remain for developing novel graphene materials for highly efficient energy conversion and storage systems. © 2012 American Chemical Society.