CAS Zhengzhou Research Institute

Henan, China

CAS Zhengzhou Research Institute

Henan, China
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Zhang M.-W.,Zhengzhou Traditional Chinese Medicine Hospital | Zhang S.-F.,CAS Zhengzhou Research Institute | Li Z.-H.,Zhengzhou Traditional Chinese Medicine Hospital | Han F.,Zhengzhou Traditional Chinese Medicine Hospital
Neuroscience Letters | Year: 2016

7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone which possesses good bioavailability. Due to its ability to cross the blood-brain barrier, previous studies have demonstrated that 7,8-DHF was a potent tropomyosin-related kinase B (TrkB) agonist, and produced antidepressant-like effects in mouse forced swimming test and tail suspension test. However, it has not been evaluated in chronic mild stress (CMS), a classical depression model modulating the processes of major depression in human. In the present study, we not only evaluated the depressive-like behaviors, but also measured the key proteins of TrkB signaling in mice exposed to CMS. Our results firstly found that long term but not single injection of 7,8-DHF restored the depressive-like behaviors in sucrose preference test and novelty suppressed feeding test. In addition, 7,8-DHF not only increased TrkB phosphorylation and brain-derived neurotrophic factor (BDNF) levels, but also activated the expression of TrkB downstream synaptic proteins such as PSD95 and synaptophysin. Furthermore, the TrkB antagonist K252a blocked the antidepressant-like effects of 7,8-DHF. In summary, the present results demonstrated that chronic 7,8-DHF treatment exerted significant antidepressant-like effects, which were likely attributed to regulating TrkB signaling and thus promoting synaptic protein expression. © 2016 Elsevier Ireland Ltd


Guo L.,CAS Zhengzhou Research Institute
AIP Conference Proceedings | Year: 2017

With the characteristics of quick, efficient and large amount transport, the subway has become an important way to solve urban traffic congestion. As the subway environment will follow the change of external environment factors such as temperature and load of personnel changes, three-dimensional numerical simulations study is conducted by using CFD software for air distribution of subway platform. The influence of different loads (the supply air temperature and velocity of air condition, personnel load, heat flux of the wall) on the subway platform flow field are also analysed. The orthogonal experiment method is applied to the numerical simulation analysis for human comfort under different parameters. Based on those results, the functional relationship between human comfort and the boundary conditions of the platform is produced by multiple linear regression fitting method, the order of major boundary conditions which affect human comfort is obtained. The above study provides a theoretical basis for the final energy-saving strategies. © 2017 Author(s).


Xie J.,CAS Zhengzhou Research Institute
Acta Tabacaria Sinica | Year: 2017

The important scientific breakthroughs of China tobacco in the past few decades, especially in the last ten years, were reviewed. Innovations and present situation in key field of Chinese style cigarette products were summarized and analyzed. On this basis, four tobacco technology development trends of precise leaf tobacco production, intelligent cigarette processing, digitized product design and harm reduction and less tar delivery were put forward and explained. Given the development situation of China tobacco, it is concluded that Chinese style cigarette will continue to dominate domestic consumption in the foreseeable future. The four development trends of tobacco technology are an inevitably choice to support sustained development of Chinese style cigarette brand, and to ensure consumer recognition and market competitiveness of national brand. © 2017, Editorial Office Chinese Tobacco Society. All right reserved.


Liu Q.-B.,Nanjing Forestry University | Niu J.-J.,CAS Zhengzhou Research Institute
Inorganic Chemistry Communications | Year: 2013

A new compound, namely [Zn1.5(pbdc)(ATAZ)(OH)]n (1 H2pbdc = terephthalic acid, HATAZ = 3-amino-1,2,4-triazole), has been obtained by in situ aminotriazole ligand synthesis and characterized by elemental analysis, thermal analysis, as well as single crystal and powder X-ray diffraction analysis. Compound 1 exhibits a 3D pillar-layer framework based on Zn(II)-aminotriazole layers and pbdc pillars, which can be simplified into a 2-fold interpenetrated pcu topological network. Interestingly, two ATAZ ligands and two OH- ligands bridge three Zn(II) ions together, giving rise to a new trinuclear {Zn3(ATAZ)2(OH)2} subunit. In addition, the luminescent and thermal stability properties for the title compound have also been studied. © 2013 Elsevier B.V.


Zhang X.,CAS Zhengzhou Research Institute
Modern Tunnelling Technology | Year: 2014

In view of the current status of few researches on the fire damage assessment of lining and few guiding specifications, this paper used indexes like apparent damage characteristics, damage depth, residual strength and sound velocity ratios of concrete, etc to analyze fire damage to certain expressway tunnel lining and relevant reinforcement measures. The results show that: qualitative or quantitative assessment of fire damage to lining can be carried out by adopting one or more indexes because of their dependency and consistency. ©, 2015, Editorial Office of "Modern Tunnelling Technology". All right reserved.


Niu J.-J.,CAS Zhengzhou Research Institute | Li D.,CAS Zhengzhou Research Institute
Inorganic Chemistry Communications | Year: 2014

A new Mn(II) compound, namely [Mn3(OABDC)2(H 2O)4]n (1 H3OABDC = 5-oxyacetateisophthalic acid), has been synthesized through combination of H3OABDC and MnCl2 under solvothermal conditions. A single crystal X-ray analysis reveals that 1 is a complicated three-dimensional (3D) framework based on trinuclear [Mn3(COO)4] subunits, which can be simplified into a (3, 6)-connected ant network. Variable temperature magnetic investigation reveals that this compound exhibits antiferromagnetic behavior. © 2013 Elsevier B.V.


Li C.M.,CAS Zhengzhou Research Institute
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji | Year: 2011

We identified and characterized a Chinese family with autosomal dominant Brachydactyly type B1 (BDB1). Linkage analysis revealed that the disease gene of the Chinese BDB1 family was linked to ROR2 locus. Mutational hot spot of ROR2 gene was amplified by polymerase chain reaction (PCR) and sequenced directly. A c.2265C>A heterozygous mutation was detected in all of the patients. This mutation led to the change of p.Y755X in protein level and a truncated ROR2 protein losing integrant domains was generated. The mutation was detected in all the patients, but not in all the normal individuals of this family and 50 normal controls. This paper for the first time reported a c.2265C>A mutation in ROR2 gene of a family with BDB1 in China, which enriches ROR2 gene mutation spectrum in Chinese with BDB1.


Lu J.,Zhejiang University | Cao H.,Zhejiang University | Zhang L.,Zhejiang University | Huang P.,Zhejiang University | And 2 more authors.
PLoS Pathogens | Year: 2014

Because of great challenges and workload in deleting genes on a large scale, the functions of most genes in pathogenic fungi are still unclear. In this study, we developed a high-throughput gene knockout system using a novel yeast-Escherichia-Agrobacterium shuttle vector, pKO1B, in the rice blast fungus Magnaporthe oryzae. Using this method, we deleted 104 fungal-specific Zn2Cys6 transcription factor (TF) genes in M. oryzae. We then analyzed the phenotypes of these mutants with regard to growth, asexual and infection-related development, pathogenesis, and 9 abiotic stresses. The resulting data provide new insights into how this rice pathogen of global significance regulates important traits in the infection cycle through Zn2Cys6TF genes. A large variation in biological functions of Zn2Cys6TF genes was observed under the conditions tested. Sixty-one of 104 Zn2Cys6 TF genes were found to be required for fungal development. In-depth analysis of TF genes revealed that TF genes involved in pathogenicity frequently tend to function in multiple development stages, and disclosed many highly conserved but unidentified functional TF genes of importance in the fungal kingdom. We further found that the virulence-required TF genes GPF1 and CNF2 have similar regulation mechanisms in the gene expression involved in pathogenicity. These experimental validations clearly demonstrated the value of a high-throughput gene knockout system in understanding the biological functions of genes on a genome scale in fungi, and provided a solid foundation for elucidating the gene expression network that regulates the development and pathogenicity of M. oryzae. © 2014 Lu et al.


Zhang W.,Hefei University of Technology | Zhang W.,CAS Zhengzhou Research Institute | Chen B.,Hefei University of Technology | Yu N.,Hefei University of Technology
IEEE Transactions on Image Processing | Year: 2012

In reversible data hiding (RDH), the original cover can be losslessly restored after the embedded information is extracted. Kalker and Willems established a rate-distortion model for RDH, in which they proved out the rate-distortion bound and proposed a recursive code construction. In our previous paper, we improved the recursive construction to approach the rate-distortion bound. In this paper, we generalize the method in our previous paper using a decompression algorithm as the coding scheme for embedding data and prove that the generalized codes can reach the rate-distortion bound as long as the compression algorithm reaches entropy. By the proposed binary codes, we improve three RDH schemes that use binary feature sequence as covers, i.e., an RS scheme for spatial images, one scheme for JPEG images, and a pattern substitution scheme for binary images. The experimental results show that the novel codes can significantly reduce the embedding distortion. Furthermore, by modifying the histogram shift (HS) manner, we also apply this coding method to one scheme that uses HS, showing that the proposed codes can be also exploited to improve integer-operation-based schemes. © 2012 IEEE.


Li X.,CAS Zhengzhou Research Institute
Toxicology in Vitro | Year: 2016

Cigarette smoke is a complex aerosol comprising particulate phase and gaseous vapour phase. The air-liquid interface exposure provides a possible technical means to implement whole smoke exposure for the assessment of tobacco products. In this review, the research progress in the in vitro toxicity testing of cigarette smoke based on the air-liquid interface exposure is summarized. The contents presented involve mainly cytotoxicity, genotoxicity, oxidative stress, inflammation, systems toxicology, 3D culture and cigarette smoke dosimetry related to cigarette smoke, as well as the assessment of electronic cigarette aerosol. Prospect of the application of the air-liquid interface exposure method in assessing the biological effects of tobacco smoke is discussed. © 2016

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