CAS Yantai Institute of Coastal Zone Research

Shenyang, China

CAS Yantai Institute of Coastal Zone Research

Shenyang, China
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Wang B.-G.,CAS Qingdao Institute of Oceanology | Gloer J.B.,University of Iowa | Ji N.-Y.,CAS Yantai Institute of Coastal Zone Research | Zhao J.-C.,CAS Qingdao Institute of Oceanology
Chemical Reviews | Year: 2013

The article highlights the diversity of halogenated organic molecules produced by marine red algal species in the family Rhodomelaceae. Although no review on the many halogenated molecules derived from marine red algae of the family Rhodomelaceae appeared in the literature up to now, a number of excellent reviews on various aspects of naturally occurring halogenated molecules were published. An excellent review dealing with the structures, biogenetic considerations, and biological activities of both halogenated and nonhalogenated polyethers from red algae and sponges appeared in 2000. Because they possess a variety of novel structures and often display potent biological activities, halogenated organic molecules have attracted considerable attention as challenging targets for partial and total synthesis. A number of elegant synthetic strategies and methodologies were developed and employed for the synthesis of such compounds.


Mu Q.,Shandong University | Mu Q.,Fred Hutchinson Cancer Research Center | Mu Q.,University of Washington | Jiang G.,CAS Research Center for Eco Environmental Sciences | And 5 more authors.
Chemical Reviews | Year: 2014

A recently reported incident of severe pulmonary fibrosis caused by inhaled polymer nanoparticles in seven female workers obtained much attention. In addition to the release of ENM waste from industrial sites, a major release of ENMs to environmental water occurs due to home and personal use of appliances, cosmetics, and personal products, such as shampoo and sunscreen. Airborne and aqueous ENMs pose immediate danger to the human respiratory and gastrointestinal systems. ENMs may enter other human organs after they are absorbed into the bloodstream through the gastrointestinal and respiratory systems. Practically, a thorough understanding of the fundamental chemical interactions between nanoparticles and biological systems has two direct impacts. First, this knowledge will encourage and assist experimental approaches to chemically modify nanoparticle surfaces for various industrial or medicinal applications.


Yu F.,CAS Yantai Institute of Coastal Zone Research | Han X.,CAS Yantai Institute of Coastal Zone Research | Han X.,University of Chinese Academy of Sciences | Chen L.,CAS Yantai Institute of Coastal Zone Research
Chemical Communications | Year: 2014

In comparison with other biological detection technologies, fluorescence bioimaging technology has become a powerful supporting tool for intracellular detection, and can provide attractive facilities for investigating physiological and pathological processes of interest with high spatial and temporal resolution, less invasiveness, and a rapid response. Due to the versatile roles of hydrogen sulfide (H2S) in cellular signal transduction and intracellular redox status regulation, fluorescent probes for the detection of this third signalling gasotransmitter have rapidly increased in number in recent years. These probes can offer powerful means to investigate the physiological actions of H2S in its native environments without disturbing its endogenous distribution. In this feature article, we address the synthesis and design strategies for the development of fluorescent probes for H2S based on the reaction type between H2S and the probes. Moreover, we also highlight fluorescent probes for other reactive sulfur species, such as sulfane sulfurs and SO2 derivatives. This journal is © the Partner Organisations 2014.


Chen L.,CAS Yantai Institute of Coastal Zone Research | Xu S.,CAS Yantai Institute of Coastal Zone Research | Xu S.,University of Chinese Academy of Sciences | Li J.,CAS Yantai Institute of Coastal Zone Research
Chemical Society Reviews | Year: 2011

Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references). © 2011 The Royal Society of Chemistry.


Wang Y.,CAS Yantai Institute of Coastal Zone Research | Wang Y.,Chinese Academy of Sciences | Chen L.,Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes
Nanomedicine: Nanotechnology, Biology, and Medicine | Year: 2011

Quantum dots (QDs) have proven themselves as powerful inorganic fluorescent probes, especially for long term, multiplexed imaging and detection. The newly developed QDs labeling techniques have facilitated the study of drug delivery on the level of living cells and small animals. Moreover, based on QDs and fluorescence imaging system, multifunctional nanocomplex integrated targeting, imaging and therapeutic functionalities have become effective materials for synchronous cancer diagnosis and treatment. In this review, we will summarize the recent advances of QDs in the research of drug delivery system from the following aspects: surface modification strategies of QDs for drug delivery, QDs as drug nanocarriers, QD-labeled drug nanocarriers, QD-based fluorescence resonance energy transfer (FRET) technique for drug release study as well as the development of multifunctional nanomedicines. Possible perspective in this field will also be discussed. © 2010 Elsevier Inc.


Arbuscular mycorrhizal fungi (AMF) were investigated in roots of 18 host plant species in a salinized south coastal plain of Laizhou Bay, China. From 18 clone libraries of 18S rRNA genes, all of the 22 AMF phylotypes were identified into Glomus, of which 18 and 4 were classified in group A and B in the phylogenetic tree, respectively. The phylotypes related to morphologically defined Glomus species occurred generally in soil with higher salinity. AMF phylotype richness, Shannon index, and evenness were not significantly different between root samples from halophytes vs. non-halophytes, invades vs. natives, or annuals vs. perennials. However, AMF diversity estimates frequently differed along the saline gradient or among locations, but not among pH gradients. Moreover, UniFrac tests showed that both plant traits (salt tolerance, life style or origin) and abiotic factors (salinity, pH, or location) significantly affected the community composition of AMF colonizers. Redundancy and variation partitioning analyses revealed that soil salinity and pH, which respectively explained 6.9 and 4.2 % of the variation, were the most influential abiotic variables in shaping the AMF community structure. The presented data indicate that salt tolerance, life style, and origin traits of host species may not significantly affect the AMF diversity in roots, but do influence the community composition in this salinized ecosystem. The findings also highlight the importance of soil salinity and pH in driving the distribution of AMF in plant and soil systems.


Wang Y.,CAS Yantai Institute of Coastal Zone Research | Yan B.,Shandong University | Chen L.,CAS Yantai Institute of Coastal Zone Research
Chemical Reviews | Year: 2013

Surface-enhanced Raman scattering (SERS) is an ultrasensitive vibrational spectroscopic technique to detect molecules on or near the surface of plasmonic nanostructures, greatly extending the role of standard Raman spectroscopy. Since its discovery in the 1970s, SERS has been applied to many analyses, especially in biochemistry and life sciences. Surface-enhanced Raman scattering (SERS) is an ultrasensitive vibrational spectroscopic technique to detect molecules on or near the surface of plasmonic nanostructures, greatly extending the role of standard Raman spectroscopy. The first explanation is that the molecule-surface interaction induces novel charge-transfer intermediates that have higher Raman scattering cross sections than do those of the analyte that is unadsorbed and on the surface.


Gao M.,CAS Yantai Institute of Coastal Zone Research
Ecological Research | Year: 2013

Spatial point pattern is an important tool for describing the spatial distribution of species in ecology. Negative binomial distribution (NBD) is widely used to model spatial aggregation. In this paper, we derive the probability distribution model of event-to-event nearest neighbor distance (distance from a focal individual to its n-th nearest individual). Compared with the probability distribution model of point-to-event nearest neighbor distance (distance from a randomly distributed sampling point to the n-th nearest individual), the new probability distribution model is more flexible. We propose that spatial aggregation can be detected by fitting this probability distribution model to event-to-event nearest neighbor distances. The performance is evaluated using both simulated and empirical spatial point patterns. © 2013 The Ecological Society of Japan.


Wang Y.,CAS Yantai Institute of Coastal Zone Research | Chen L.,CAS Yantai Institute of Coastal Zone Research | Liu P.,CAS Yantai Institute of Coastal Zone Research
Chemistry - A European Journal | Year: 2012

Herein, we report the synthesis of biocompatible triplex Ag@SiO 2@mTiO 2 core-shell nanoparticles (NPs) for simultaneous fluorescence-surface-enhanced Raman scattering (F-SERS) bimodal imaging and drug delivery. Stable Raman signals were created by typical SERS tags that were composed of Ag NPs for optical enhancement, a reporter molecule of 4-mercaptopyridine (4-Mpy) for a spectroscopic signature, and a silica shell for protection. A further coating of mesoporous titania (mTiO 2) on the SERS tags offered high loading capacity for a fluorescence dye (flavin mononucleotide) and an anti-cancer drug (doxorubicin (DOX)), thereby endowing the material with fluorescence-imaging and therapeutic functions. The as-prepared F-SERS dots exhibited strong fluorescence when excited by light at 460 nm whilst a stable, characteristic 4-Mpy SERS signal was detected when the excitation wavelength was changed to longer wavelength (632.8 nm), both in solution and after incorporation inside living cells. Their excellent biocompatibility was demonstrated by low cytotoxicity against MCF-7 cells, even at a high concentration of 100 μg mL -1. In vitro cell cytotoxicity confirmed that DOX-loaded F-SERS dots had a comparable or even greater therapeutic effect compared with the free drug, owing to the increased cell-uptake, which was attributed to the possible endocytosis mechanism of the NPs. To the best of our knowledge, this is the first proof-of-concept investigation on a multifunctional nanomedicine that possessed a combined capacity for fast and multiplexed F-SERS labeling as well as drug-loading for cancer therapy. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Gao X.,CAS Yantai Institute of Coastal Zone Research | Chen C.T.A.,National Sun Yat - sen University
Water Research | Year: 2012

Bohai Bay, the second largest bay of Bohai Sea, largely due to the huge amount of pollutants discharged into it annually and its geohydrologic condition, is considered to be one of the most polluted marine areas in China. To slow down, halt and finally reverse the environmental deterioration of Bohai Sea, some researchers have proposed to connect it with Jiaozhou Bay in the western coast of Southern Yellow Sea by digging an interbasin canal through Shandong Peninsula. In order to assess the heavy metal pollution and provide background information for such a large geoengineering scheme, surface sediments from 42 stations covering both riverine and marine regions of the northwestern coast of Bohai Bay were analyzed for heavy metal content and fractionation (Cd, Cr, Cu, Ni, Pb and Zn). Three empirically derived sediment quality guidelines were used to assess the pollution extent of these metals. The studied metals had low mobility except for Cd at all stations and Zn at some riverine stations. Although a high mobility of Cd was observed, it could hardly cause a bad effect on the environment owing to its low total concentrations. Anthropogenic influence on the accumulation of studied heavy metals in sediments of Bohai Bay was obvious, but their contents were relatively lower to date comparing with some other marine coastal areas that receive important anthropogenic inputs. Taking as a whole, surface sediments of northwestern Bohai Bay had a 21% probability of toxicity based on the mean effects range-median quotient. © 2012.

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