CAS Suzhou Institute of Biomedical Engineering and Technology

Suzhou, China

CAS Suzhou Institute of Biomedical Engineering and Technology

Suzhou, China
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Hu J.,China Jiliang University | Lang T.,China Jiliang University | Shi G.-H.,CAS Suzhou Institute of Biomedical Engineering and Technology
Optics Express | Year: 2017

In this paper, a novel kind of sensors for simultaneous measurement of refractive index and temperature based on all-dielectric metasurfaces is proposed. The metasurfaces are constructed by an array of silicon nanoblocks on top of the bulk fused silica substrate. We used three-dimensional full wave electromagnetic field simulation by finite integral method to accurately calculate the transmission spectrum of the metasurfaces. Two transmission dips corresponding to the electric and magnetic resonances are observed. Both dips shift as the ambient refractive index or the temperature changes. Simulation results show that the sensing sensitivities of two dips to the refractive index are 243.44 nm/RIU and 159.43 nm/RIU, respectively, while the sensitivities to the temperature are 50.47 pm/°C and 75.20 pm/°C, respectively. After introducing four holes into each silicon nanoblock, the electromagnetic field overlap in the surrounding medium can be further promoted, and the sensitivities to the refractive index increase to 306.71 nm/RIU and 204.27 nm/RIU, respectively. Our proposed sensors have advantages of polarization insensitive, small size, and low loss, which offer them high potential applications in physical, biological and chemical sensing fields. © 2017 Optical Society of America


Peng B.,CAS Suzhou Institute of Biomedical Engineering and Technology | Peng B.,University of Chinese Academy of Sciences | Peng B.,CAS Changchun Institute of Optics and Fine Mechanics and Physics | Chen Z.,PLA General Hospital | And 2 more authors.
Neuroscience Letters | Year: 2015

This study is to investigate gray matter volume, cortical thickness, and surface area of the brain in patients with type 2 diabetes mellitus (T2DM). High resolution T1-weighted MR images were obtained from eighteen T2DM and seventeen normal controls. All images were processed using our newly developed BrainLab toolbox. Declines of gray matter volume, cortical thickness, and surface area were found in T2DM patients. Significantly reduced ROIs of gray matter volume happened in subcortical gray nuclei (left caudate and right caudate), and significantly reduced ROIs of cortical thickness occurred in temporal lobe (left superior temporal gyrus), parietal lobe (left angular gyrus), and occipital lobe (right superior occipital gyrus, left middle occipital gyrus and right cuneus). Apparently reduced ROIs of surface area were mainly distributed in frontal lobe (right superior frontal gyrus (dorsal) and left paracentral lobule). The findings indicated that T2DM caused brain changes in specific regions. This work revealed neural alterations of T2DM, which had a great significance in early diagnosis of the disease. © 2015 Elsevier Ireland Ltd.


Miao P.,CAS Suzhou Institute of Biomedical Engineering and Technology | Miao P.,University of Chinese Academy of Sciences | Wang B.,CAS Suzhou Institute of Biomedical Engineering and Technology | Yu Z.,Arizona State University | And 2 more authors.
Biosensors and Bioelectronics | Year: 2015

MicroRNAs play important roles in gene regulation. They can be used as effective biomarkers for diagnosis and prognosis of diseases like cancers. Due to their intrinsic properties of short length, low abundance and sequence homology among family members, it is difficult to realize sensitive and selective detection with economical use of time and cost. Herein, we report an ultrasensitive electrochemical method for microRNA analysis employing two oligonucleotides and one endonuclease. Generally, a glassy carbon electrode is first covered with gold nanoparticles (AuNPs) mediated by poly(diallyldimethylammonium chloride) (PDDA). Then, thiolated capture probe (CP) with methylene blue (MB) labeled at 5' end is modified on the pretreated electrode. Hybridization occurs among target microRNA, CP and auxiliary probe (AP), forming a star trigon structure on the electrode surface. Subsequently, endonuclease recognizes and cleaves CP on CP/AP duplex, releasing microRNA and AP back to the solution. The two regenerated elements can then form another star trigon with other CP molecules, initiating cycles of CP cleavage and MB departure. Significant decrease of electrochemical signals is thus observed, which can be used to reflect the concentration of microRNA. This proposed method has a linear response to microRNA in a wide range from 100. aM to 1. nM and the sensitivity of attomolar level can be achieved. Moreover, it has high selectivity against single-base mismatch sequences and can be used directly in serum samples. Therefore, this method shows great feasibility for the detection of microRNA and may have potential applications in cancer diagnosis and prognosis. © 2014 Elsevier B.V.


Yang D.,CAS Suzhou Institute of Biomedical Engineering and Technology | Tang Y.,CAS Suzhou Institute of Biomedical Engineering and Technology | Miao P.,CAS Suzhou Institute of Biomedical Engineering and Technology
TrAC - Trends in Analytical Chemistry | Year: 2017

Hybridization chain reaction (HCR) is a simple isothermal enzyme-free process with the advantages of high simplicity and versatility. Generally, initiator single-stranded DNA is amplified to form long double-stranded DNA based on a chain reaction, during which recognition and hybridization events between a pair of complementary DNA sequences occur in succession. Repeating units of HCR product can be further utilized as templates for the assembly of various nanospecies, generating complicated DNA superstructures. Therefore, HCR is regarded as an attractive technique for DNA nanotechnology, biosensing, bioimaging and biomedicine. Particularly, HCR has been utilized to develop promising biosensors for the detection of various small molecules, nucleic acids, proteins and cells. In this review, we provide a comprehensive overview of HCR directed DNA superstructures assembly for biosensing applications. We hope this review will offer readers general concept of HCR and stimulate interest, new ideas, and discoveries in the fascinating field. © 2017 Elsevier B.V.


Li J.,University of Electronic Science and Technology of China | Li J.,CAS Suzhou Institute of Biomedical Engineering and Technology | Luo H.,University of Electronic Science and Technology of China | Wang L.,University of Electronic Science and Technology of China | And 4 more authors.
Optics Letters | Year: 2015

We report an 1150-nm diode-pump passively Q-switched Ho3-doped ZBLAN fiber laser using topological insulator (TI): Bi2Te3 as the saturable absorber (SA). The TI: Bi2Te3 prepared using the cost-effective hydrothermal intercalation/exfoliation method was dropped onto a CaF2 substrate to fabricate the free-space SA component. It has a low saturable peak intensity of 2.12 MW/cm2 and a high modulation depth of 51.3% measured at 2 μm. Inserting this component into a linear-cavity Ho3-doped ZBLAN fiber laser, stable Q-switched pulses at 2979.9 nm were obtained with the repetition rate of 81.96 kHz and pulse duration of 1.37 μs. The achieved maximum output power and pulse energy were 327.4 mW at a slope efficiency of 11.6% and 3.99 μJ, respectively, only limited by the available pump power. Our work reveals that the TIs are absolutely a class of promising and reliable SAs for pulse generation at 3-μm mid-infrared waveband. © 2015 Optical Society of America.


Gao J.,CAS Suzhou Institute of Biomedical Engineering and Technology | Dai X.J.,CAS Suzhou Institute of Biomedical Engineering and Technology | Zhang L.,CAS Suzhou Institute of Biomedical Engineering and Technology | Wu X.D.,CAS Suzhou Institute of Biomedical Engineering and Technology
Laser Physics Letters | Year: 2013

We report compact diode-end-pumped continuous-wave laser operation at 1112 nm under 885 nm diode-direct pumping for the first time. On the basis of the R2→Y6 transition in a conventional Nd:YAG (yttrium aluminum garnet) single crystal, the maximum output power of 12.5 W is achieved, with an optical to optical efficiency of 46.6% and a slope efficiency of 52.9%. To the best of our knowledge, this represents the highest output at 1112 nm generated by a diode-end-pumped Nd:YAG laser. Furthermore, it is the highest optical to optical efficiency ever reported for 1112 nm Nd:YAG lasers. The short term power stability is ∼0.32% at 12.0 W output. © 2013 Astro Ltd.


Miao P.,CAS Suzhou Institute of Biomedical Engineering and Technology | Miao P.,Nanjing University | Ning L.,Nanjing University | Li X.,Nanjing University
Analytical Chemistry | Year: 2013

Silver ion (Ag+) is a highly toxic heavy metal ion to fungi, viruses, bacteria, and animals. Therefore, Ag+ monitoring in water or food resources has become extraordinarily important within the scope of human health. Here, we report a gold nanoparticles and enzyme cleavage-based dual signal amplification strategy for ultrasensitive detection of Ag+ using electrochemical techniques. This sensing platform for Ag+ has an extremely low detection limit of 470 fM, which also has satisfactory selectivity. Thus, it can be directly used in drinking water and lake water samples. Moreover, the strategy proposed in this work may have potential to be further developed as a generalized platform for the detection of other analytes by designing new DNA sequences for specific recognition. © 2013 American Chemical Society.


Miao P.,CAS Suzhou Institute of Biomedical Engineering and Technology
RSC Advances | Year: 2013

Endotoxin, also referred to as lipopolysaccharide (LPS), is a membrane constituent of gram-negative bacteria, which can initiate immune responses. However, excessive inflammatory responses to endotoxin may lead to life-threatening conditions like irreversible septic shock and even death. Therefore, sensitive detection systems to trace a small amount of endotoxin in foodstuff and medical supplies are urgently needed for health concern. So far, there is an ongoing and extensive research for the development of various endotoxin sensors. Limulus amebocyte lysate (LAL) test is a widespread standard assay. However, LAL test may suffer defects of inadequate stability, high cost and inconvenience. Recently, many advanced techniques are introduced in the fabrication of endotoxin sensors to overcome these defects, such as fluorescence, chemiluminescence, electrophoresis, as well as electrochemical techniques. Among them, electrochemical systems are proved to be effective alternative detection systems with the advantages of low cost, easy operation, rapid analysis, high sensitivity and selectivity. This review summarises recent advances of the electrochemical strategies for the detection of endotoxin, which are designed based on different recognition mechanisms and signal transformations. © 2013 The Royal Society of Chemistry.


Xia W.,CAS Suzhou Institute of Biomedical Engineering and Technology | Gao X.,CAS Suzhou Institute of Biomedical Engineering and Technology
International Journal of Computer Assisted Radiology and Surgery | Year: 2014

Purpose: A pulmonary respiration model for deformable registration of lung CT for the surgery path planning and surgical navigation is an important, difficult, and time-consuming task. This paper presents a new fast deformable registration method for 4D lung CT in a hybrid framework incorporating point set registration with mutual information registration. Method: The point sets of the lung surface and vessels are automatically extracted. Their displacement vectors are obtained by point set registration. The sumof squared Euclidean distance between the displacement vectors of these point sets and the displacement vectors based on the B-spline transformation model is minimized as a novel similarity measure to derive the rough transformation function. Finally, the rough transformation function is refined by using the mutual information-based registration method. To evaluate the effectiveness of the proposed method, the authors performed registrations on 20 4D lung volume cases from two different CT scanners. The proposed method was compared with the point set-based method, themutual information-based method, and the ANTS method, which is a state-of-the-art deformable registration technique. Results: The results show that the landmark distance errors and computation time of the proposed method decreased an average of 5 and 70%, respectively, when compared to the mutual information-alone-based method. The proposed method results in an average of 28% lower landmark distance error than registration method based on point sets in spite of increase in computation time. Moreover, compared with ANTS, the computation time of the proposed method is reduced by an average of 93% in the case of comparable landmark distance errors. Conclusion: The accuracy and speed of the proposed deformable registrationmethod indicate that themethod is suitable for use in a clinical image-guided intervention system. © CARS 2013.


Zhang Z.,CAS Suzhou Institute of Biomedical Engineering and Technology | Wu Y.,CAS Suzhou Institute of Biomedical Engineering and Technology | Wu Y.,CAS Changchun Institute of Optics and Fine Mechanics and Physics
Langmuir | Year: 2011

A facile method of obtaining chainlike assemblies of gold nanoparticles (AuNPs) on a chemically modified glass surface based on NaBH4 treatment is developed. Citrate-stabilized AuNPs (17 nm) are immobilized on a glutaraldehyde-functionalized glass surface and assembled into chainlike structures after treatment with aqueous sodium borohydride (NaBH4) solution. The production and morphology of the AuNP chainlike assemblies are controlled by the density of the immobilized NPs, the concentration of NaBH 4 solution, and the treatment time. The AuNP assemblies are stable in water and can undergo drying. X-ray photoelectron spectroscopic data show that the number of citrate ions on the AuNPs decreased by 43% after treatment with 5 mg/mL NaBH4 solution. The NaBH4-induced partial removal of the citrate ions and the roughness of the glass surface greatly affect the binding force of AuNPs on the substrate. The immobilized AuNPs begin to move at the solid-liquid interface without desorbing when the strength of the binding force was decreased. These mobile NPs form chainlike assemblies under the driving force of van der Waals interaction and diffusion. This interface-based formation of chainlike assemblies of AuNPs may provide a simple protocol for the 1D assembly of other Au-coated colloidal nanoparticles. © 2011 American Chemical Society.

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