CAS Shanghai Institute of Organic Chemistry
CAS Shanghai Institute of Organic Chemistry
CAS Shanghai Institute of Organic Chemistry | Date: 2017-07-26
Disclosed are a compound represented by general formula I and a preparation method therefor. The compound can be used as indoleamine-2,3-dioxygenase inhibitor to prepare medicines for preventing and/or treating indoleamine-2,3-dioxygenase-mediated diseases.
CAS Shanghai Institute of Organic Chemistry | Date: 2016-03-23
The present invention discloses a catalytic system for preparing highly branched alkane from olefin, which contains novel nickel or palladium complexes. In the presence of the catalytic system, highly branched oily alkane mixture can be efficiently obtained from olefins (such as ethylene) under mild conditions. The alkane mixture has a low bromine number, and can be used as a processing aid(s) and lubricant base oil with high-performance. Provides also was a method for preparing the catalyst and a method for preparing an oily olefin polymer.
CAS Shanghai Institute of Organic Chemistry | Date: 2017-08-23
Disclosed is a new polyolefin catalyst and preparation therefor. Specifically, disclosed is a catalytic system comprising a new complex of iron, cobalt, nickel, palladium, and platinum. In the presence of the catalytic system, oily polyethylene can be efficiently obtained from simple olefins such as ethylene under mild conditions, highly branched oily alkane mixture is then obtained after hydrogenation. The alkane mixture can be used as a processing aid and a high-performance lubricant base oil. The present invention also provides a method for preparing the catalyst, a method for preparing the highly branched oily alkane mixture and a method for preparing functional polyolefin oil.
Harvard University and CAS Shanghai Institute of Organic Chemistry | Date: 2016-08-26
Ni C.,CAS Shanghai Institute of Organic Chemistry |
Hu M.,CAS Shanghai Institute of Organic Chemistry |
Hu J.,CAS Shanghai Institute of Organic Chemistry
Chemical Reviews | Year: 2015
Organofluorine compounds and materials have found wide applications. Sulfur and fluorine truly form a good partnership in modulating many different types of fluorination and fluoroalkylation reactions through various sulfur/fluorine-containing inorganic and organic compounds/reagents. The historical development of deoxygenative fluorination reagents along the path from SF4, DAST, Deoxo-Fluor to XtalFluors and Fluolead, clearly demonstrates the excellent modulating ability of sulfur-containing groups for efficient and safe fluorination reagents. On the other hand, fluorinated organosulfur compounds, such as sulfones, sulfoximines, sulfinate salts, sulfoxides, sulfilimines, sulfides, among others, often exhibit unique chemical reactivities that are different from their nonfluorinated counterparts. Sulfur-based fluorination and fluoroalkylation reagents will continue to find wide applications in synthesizing new fluorine-containing pharmaceuticals, agrochemicals, and advanced materials.
Zheng C.,CAS Shanghai Institute of Organic Chemistry |
You S.-L.,CAS Shanghai Institute of Organic Chemistry
Chemical Society Reviews | Year: 2012
In recent years, Hantzsch esters and their related organic hydride donors have been widely utilized in biomimetic approaches of asymmetric transfer hydrogenation (ATH) reactions. Various compounds containing C = C, C = N and C = O unsaturated functionalities could be reduced in the presence of organocatalysts or transition metal complexes, affording versatile chiral building blocks in high yields and excellent enantioselectivities under mild conditions. In this critical review, recent advances in this area are summarized and classified according to unsaturated functional groups being reduced and catalytic systems employed. © The Royal Society of Chemistry 2012.
Ding C.-H.,CAS Shanghai Institute of Organic Chemistry |
Hou X.-L.,CAS Shanghai Institute of Organic Chemistry
Chemical Reviews | Year: 2011
Developments of catalytic propargylation reactions are presented. Optically active α-oxazolidinonylallenylstannane, prepared from N-propargyloxazolidinone via a lithiation/stannylation sequence, is an efficient reagent for the asymmetric propargylation of carbonyl compounds. Lai and Soderquist successfully extended the use of chiral organoborane regents containing the 10-trimethylsilyl-9-borabicyclo[3.3.2]-decane (10-TMS-9-BBD) ring system. Denmark and Wynn demonstrated that a weak achiral Lewis acid such as SiCl4 can be activated by a chiral Lewis base to afford a strong chiral Lewis acid. Cozzi, Umani-Ronchi, and co-workers developed the first catalytic enantioselective addition of allylic chloride to aldehydes using the chiral complex [Cr(Salen)] as the catalyst. A transition metal-catalyzed asymmetric version of Friedel-Crafts-type propargylation has been developed by using chiral thiolate-bridge diruthenium complexes.
Wei Y.,CAS Shanghai Institute of Organic Chemistry |
Shi M.,CAS Shanghai Institute of Organic Chemistry
Chemical Reviews | Year: 2013
The latest issue of Chemical Reviews focused on the advancements in asymmetric Morita-Baylis-Hillman (MBH)/aza-MBH reactions from 2009 to 2011. Several researchers conducted kinetic and theoretical studies on the MBH mechanism, while others performed an extensive theoretical study, which supported their own kinetic observations and those of McQuade about the proton transfer step. Two distinct pathways leading to the products were proposed, including a second molecule of aldehyde participates the reaction to form a hemiacetal alkoxide hemi1 followed by rate-limiting proton transfer as proposed by McQuade. Some other researchers presented a detailed computational and experimental reinvestigation on the amine-catalyzed MBH reaction of benzaldehyde with methyl acrylate. Another team of researchers also investigated the mechanism of aza-MBH via the ESI-MS(/MS) technique and proposed a rational mechanism for the aza-MBH reaction. This team monitored the DABCO-catalyzed aza-MBH reaction of methyl acrylate 2 with imine 12 by ESI-MS(/MS) spectrometry and intercepted the key intermediates and a unique bissulfonamide intermediate.
CAS Shanghai Institute of Organic Chemistry | Date: 2016-06-29
The present invention relates to a bimetallic catalyst for olefin polymerization, a preparation method therefor, and the application thereof in catalysis for olefin polymerization. The catalyst is a transitional bimetallic complex of the VIII group with a type of multidentate ligand, and the structural formula thereof is shown as formula (I), wherein the definition for each radical group is described in the description. The catalyst of the present invention has a high activity and a high catalytic efficiency, suitable for olefin polymerization reactions, particularly suitable for the preparation of an olefin polymer having a bimodal distribution of molecular weights.
Harvard University and CAS Shanghai Institute of Organic Chemistry | Date: 2016-06-27
A compound having the following structure (I): or a pharmaceutically acceptable salt, prodrug, stereoisomer or tautomer thereof, is provided. Related compounds, methods for preparation of the same and uses of the compounds for treatment of various indications, including treatment of necrotic cell diseases and/or inflammation, are also provided.