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CAS Kunming Institute of Botany, The Key Laboratory Of Chemistry For Natural Product Of Guizhou Province And Chinese Academy Of, CAS Shanghai Institutes for Biological Sciences and CAS Institute of Zoology | Date: 2014-04-21

The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the compound as pharmaceutically active ingredient, a method for preparing the same, and use thereof in manufacture of an anti-tumor agent. The derivative of 15-oxospiramilactone of the invention have an activity against multiple tumor cell lines, and the anti-tumor activity is positively correlated to an activity inhibiting the Wnt signaling pathway.


Patent
Southern Medical University and CAS Kunming Institute of Botany | Date: 2014-11-03

The invention relates to a use of an urushiol compound (code named GQ-5) in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation. We verify that GQ-5 inhibited the interaction of Smad3 with TGF- type I receptor (TRI), inhibited subsequent phosphorylation of Smad3, reduced nuclear translocation of Smads complex, and suppressed the transcription of major fibrotic genes such as -smooth muscle actin (-SMA), collagen I and fibronectin. Therefore, GQ-5 could be a potent and selective inhibitor of TGF-1-induced Smad3 phosphorylation, and be used to prepare pharmaceutical compositions for inhibiting Smad3 phosphorylation.


Tan Q.-G.,CAS Kunming Institute of Botany | Tan Q.-G.,Guilin Medical University | Luo X.-D.,CAS Kunming Institute of Botany
Chemical Reviews | Year: 2011

Some of the important naturally occurring limonoids from Meliaceae discovered in the last six decades, from 1942 to June 30, 2010, and their various bioactivities, are discussed. The cedrelone-class limonoids are characterized as the 5,6-enol-7-one derivatives and Burke et al. presented the chemical correlation of anthothecol with hirtin. Under mildly acid conditions, the first stage of the ring-opening of havanensin gives a 15-hydroxy-14- carbonium ion, which then either undergoes Wagner-Meerwein rearrangement or loses a proton to give a 15-ketone enolate and involves participation of the oxygenated function at C-7. The photooxidation of salannin and nimbin by UV light in the presence of oxygen led to more polar unstable intermediates that rearranged on silica gel to two final products in which the furan ring had been oxidized to isomeric hydroxybutenolides.


Yang Z.L.,CAS Kunming Institute of Botany
Fungal Diversity | Year: 2011

A brief survey towards an understanding of evolution of Basidiomycota in the last five decades is given. Between 1960-1990 studies were based mainly on morphology, subcellular structure, biochemistry, physiology and ecology. In the last 20 years, molecular methods have revolutionized the study of taxonomy, systematics, phylogeny, biogeography, population and microevolutionary processes in basidiomycetes. A fundamental improvement in the understanding of evolution of basidiomycetes has been achieved. It is anticipated that numerous new taxa at different taxonomic levels will be recognized based on integrated approaches, and new data will soon provide fascinating insights into the origin, evolution and biogeography of basidiomycetes in the coming years. © The Author(s) 2011.


Grumbine R.E.,CAS Kunming Institute of Botany | Pandit M.K.,The Interdisciplinary Center
Science | Year: 2013

Ecosystem damage and population resettlements loom, owing to poor planning and impact assessments.


Patent
CAS Kunming Institute of Botany and New York University | Date: 2014-01-29

Disclosed are heterocyclo compounds that have a formula represented by the following: and wherein X, R^(1), R^(2), R^(3), R^(4), R^(5), R^(6 )and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cancer conditions in mammals including humans, including by way of non-limiting example, prostate, colon, bladder, melanoma, liver, breast, cervical, ovarian, esophagi, glialblastoma, pancreatic and lung cancer.


A low-molecular-weight fucosylated glycosaminoglycan (aTFG) containing 2, 5-anhydrated talose, alditol, glycosylamine or N-substituted glycosylamine monosaccharide composition thereof, preparation method thereof, pharmaceutical compositions containing the aTFG, and use thereof for preventing and/or treating thrombotic diseases are provided. The aTFG has potent anticoagulant activity targeting at intrinsic coagulation factor Xase, and inhibiting thrombogenesis, and therefore can be used as drugs for preventing and/or treating cardiovascular and cerebrovascular diseases.


Patent
CAS Kunming Institute of Botany, Shangahi Institutes For Biological Science and Chinese Academy of Sciences | Date: 2014-02-28

The present invention relates to the pharmaceutical field, in particular to a phenanthridine derivative as shown in general formula (1) a pharmaceutical composition comprising the derivative, its preparation method, and its uses in manufacture of a medicament for the prevention or treatment of a disease related to the activity of Wnt signaling pathway, hepatitis C and hepatitis B.


Provided are a low-molecular-weight fucosylated glycosaminoglycan derivative (derivative of Low molecular weight Fucosylated Glycosaminoglycan, dLFG) having anticoagulant activity, a preparation method thereof, a pharmaceutical composition comprising dLFG or a pharmaceutically acceptable salt thereof, and the useof dLFG and pharmaceutical composition thereof in preparing medicine for treating thrombotic diseases.


Provided are a low-molecular-weight fucosylated glycosaminoglycan derivative (derivative of Low molecular weight Fucosylated Glycosaminoglycan, dLFG) having anticoagulant activity, a preparation method thereof, a pharmaceutical composition comprising dLFG or a pharmaceutically acceptable salt thereof, and the use of dLFG and pharmaceutical composition thereof in preparing medicine for treating thrombotic diseases.

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