CAS Hefei Institutes of Physical Science

Hefei, China

CAS Hefei Institutes of Physical Science

Hefei, China
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Patent
CAS Hefei Institutes of Physical Science and Anhui New Star Pharmaceutical Development Co. | Date: 2017-04-26

The present invention provides a Brutons tyrosine kinase inhibitor, which is a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method and use of using the Brutons tyrosine kinase inhibitor to inhibit the tyrosine kinase activity or treat diseases, disorders or symptoms benefiting from the inhibition of the Brutons tyrosine kinase (Btk) activity.


Patent
CAS Hefei Institutes of Physical Science and Anhui New Star Pharmceutical Development Co. | Date: 2015-01-27

The present invention provides a Brutons tyrosine kinase inhibitor, which is a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method and use of using the Brutons tyrosine kinase inhibitor to inhibit the tyrosine kinase activity or treat diseases, disorders or symptoms benefiting from the inhibition of the Brutons tyrosine kinase (Btk) activity.


Yu X.-Y.,Nanyang Technological University | Yu X.-Y.,CAS Hefei Institutes of Physical Science | Hu H.,Nanyang Technological University | Wang Y.,Nanyang Technological University | And 2 more authors.
Angewandte Chemie - International Edition | Year: 2015

Molybdenum disulfide (MoS2) has received considerable interest for electrochemical energy storage and conversion. In this work, we have designed and synthesized a unique hybrid hollow structure by growing ultrathin MoS2 nanosheets on N-doped carbon shells (denoted as C@MoS2 nanoboxes). The N-doped carbon shells can greatly improve the conductivity of the hybrid structure and effectively prevent the aggregation of MoS2 nanosheets. The ultrathin MoS2 nanosheets could provide more active sites for electrochemical reactions. When evaluated as an anode material for lithium-ion batteries, these C@MoS2 nanoboxes show high specific capacity of around 1000 mAh g-1, excellent cycling stability up to 200 cycles, and superior rate performance. Moreover, they also show enhanced electrocatalytic activity for the electrochemical hydrogen evolution. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Zhang J.,CAS Hefei Institutes of Physical Science | Zhang L.,CAS Hefei Institutes of Physical Science
Advances in Optics and Photonics | Year: 2012

Surface plasmons (SPs) are electromagnetic excitations existing at the interface between a metal and a dielectric material. Control and manipulation of light based on SPs at the nanometer scale offers significant advantages in nanophotonic devices with very small elements, since the peculiar properties of SPs can be tailored by construction of nanostructures with various interfaces between metals and dielectric materials. Recent progress in nanostructures for SPs is reviewed. Resonance frequencies or wavelengths of SPs can be tuned by design of metal nanostructures, such as nanoparticles, nanorods, nanowires, nanosheets, and nanodisks. Moreover, SP resonance modes can also be tuned by control of the shapes and sizes of nanostructures, where the resonance modes include longitudinal and transversal resonances, dipolar and multipolar resonances, and Fano resonances. Based on SP coupling for metal nanostructures, metal-semiconductor nanostructures, metal-dielectric nanostructures, and metal-polymer nanostructures, propagating and guiding of SP can be achieved through the metal nanostructures and the hybrid structures. Additionally, metal nanostructures exhibit remarkable field enhancement effects (e.g., local near-field enhancement, and optical transmission enhancement) due to SP coupling. Furthermore, SP nanostructures perform unique focusing and imaging characteristics at the nanometer scale beyond the diffraction limit. Tailoring SPs by control of the nanostructures is expected to be used for design and development of high-performance optical components and circuits, which offer both potential and challenges for new generations of nanophotonic devices. © 2012 Optical Society of America.


Wu Z.,CAS Hefei Institutes of Physical Science
Angewandte Chemie - International Edition | Year: 2012

Unexpected: Anti-galvanic reduction (AGR), that is, metal ions are reduced by more-noble metals, was found in small thiolated gold (see figure) and silver nanoparticles! These findings are not only unexpected considering the classic galvanic theory, but also provide a facile and mild method to make alloys on the nanoscale or tune the compositions, structures, and properties of nanostructures that are otherwise difficult to obtain. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Li Y.,CAS Hefei Institutes of Physical Science | Duan G.,CAS Hefei Institutes of Physical Science | Liu G.,CAS Hefei Institutes of Physical Science | Cai W.,CAS Hefei Institutes of Physical Science
Chemical Society Reviews | Year: 2013

It has been proven that the use of colloidal templates is a facile, flexible strategy to create the periodic micro/nanostructured arrays in comparison with photolithography, electron beam lithography etc. Utilizing colloidal monolayers as templates or masks, different periodic micro/nanostructured arrays including nanoparticle arrays, pore arrays, nanoring arrays and nanorod/nanotube arrays can be fabricated by chemical and physical processes. Chemical routes, including direct solution/sol dipping strategy, wet chemical etching, electrodeposition, electrophoretic deposition etc. have advantages of simple operation and low costs. However, they have some disadvantages of impurities on surface of arrays due to incomplete decomposition of precursors, residue of surfactants in self-assembling or electrochemical deposition. More importantly, it is quite difficult to achieve very uniform morphology of micro/nanostructure arrays on a large-area by the above routes. Whereas another method, a physical route (for instance: reactive ion etching, pulsed laser deposition, thermal evaporation deposition, atomic layer deposition, sputtering deposition), combining with colloidal monolayer template can well resolve these problems. In this review, we focus on introducing the recent progress in creating micro/nanostructured arrays based on colloidal templates with physical routes. The parameters of the microstructure or nanostructure can be tuned by colloidal templates with different periodicity and experimental conditions of the physical processes. The applications of micro/nanostructured arrays with controllable morphology and arrangement parameters in self-cleaning surfaces, enhanced catalytic properties, field emitters etc. are also presented in the following sections. © 2013 The Royal Society of Chemistry.


Hu C.,CAS Hefei Institutes of Physical Science
Plasma Science and Technology | Year: 2012

Neutral beam injection (NBI) system with two neutral beam injections will be constructed on the Experimental Advanced Superconducting Tokamak (EAST) in two stages for high power auxiliary plasmas heating and non-inductive current drive. Each NBI can deliver 2∼4 MW beam power with 50∼80 keV beam energy in 10∼100 s pulse length. Each elements of the NBI system are presented in this contribution.


Welding wire for gas protective welding of reduced activation ferritic/martensitic steel and the manufacturing method, chemical components (weight percentage, wt %): C: 0.10.15, Cr: 8.09.0, W: 1.01.6, V: 0.150.25, Ta: 0.100.17, Mn: 0.500.70, Si: 00.05, N: 00.02, O, Ni, Cu, Al, and Co: 00.01 respectively, P, S, Ag, Mo, and Nb: 00.005 respectively, and balance of Fe. The welding wire has Cr equivalent weight of less than 11, Ni equivalent weight of greater than 3.5. It is manufactured with a wire rod through multi-pass drawing. The rod is subject to annealing heat treatment, tempering treatment performed between the passes of drawing. The annealing process is: the rod is at 9401020 for 2060 minutes, and the n cooled to below 650 C. at rate of less than 45 C./hour, air-cooled to room temperature. The tempering process is: the rod is at 760820 for 0.52 hours. It reduces forming of ferrites in welded joints.


Patent
CAS Hefei Institutes of Physical Science | Date: 2014-05-09

A type of High Magnetic Field Assisted PLD System consisting of pulsed laser and PLD cylindrical vacuum chamber inclusive of double-layer clip-sheath cylindrical chamber with water cooling located in the bore hole of superconducting magnet is disclosed. A flange plate in one side of the double-layer clip sheath is equipped with substrate heating table or laser heating table and rotating mechanism; the flange plate in another side is equipped with target components and moving/rotating mechanism. Either the substrate heating table or laser heating table is located in the center area of magnetic field of the superconducting magnet. A PLD (pulsed laser deposition) cylindrical vacuum chamber is located in the slide rail. A sealed laser leading-in chamber and a vacuum-sealed video-unit leading-in chamber is installed on the flange plate in one side of double-layer clip sheath cylindrical chamber.


Zhang L.,CAS Hefei Institutes of Physical Science | Fang M.,CAS Hefei Institutes of Physical Science
Nano Today | Year: 2010

Clean environment is essential to human health. The world is facing formidable challenges in meeting rising requirement to clean environment. Recently, persistent organic pollutants (POPs), heavy metals, etc. pollutants in water and soil are the key factors which make the environment worse. Even trace pollutants can enter human body and do harm to human health. Trace detection and treatment of these pollutants become an eagerly solved problem. Nanomaterials and nanotechnology provide a powerful method for detection and treatment of trace pollutants in the environment. This article reviews the recent progress of detection and treatment of POPs and heavy metal by using nanomaterials and analytical nanotechnology. And the application of nanomaterials and nanotechnology through enhancement of Raman scattering, surface plasmon resonance, fluorescent detection and electrochemical detection were described. We highlight recent advances on the development of novel nanomaterials and nanostructures and processes for treatment of POPs and heavy metals in water and soil. We also discussed the mechanisms of POPs degradation and heavy metal treatment. © 2010 Elsevier Ltd. All rights reserved.

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